Hephl1 (hephaestin-like 1) - Rat Genome Database

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Gene: Hephl1 (hephaestin-like 1) Rattus norvegicus
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Symbol: Hephl1
Name: hephaestin-like 1
RGD ID: 1564835
Description: Predicted to enable ferroxidase activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human HEPHL1 (hephaestin like 1); INTERACTS WITH alpha-Zearalanol; bisphenol A; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ferroxidase HEPHL1; hephaestin-like protein 1; LOC500946; RGD1564835; similar to hephaestin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8820,178,190 - 20,246,698 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl820,178,190 - 20,246,698 (-)EnsemblGRCr8
mRatBN7.2811,896,768 - 11,965,282 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,898,532 - 11,965,267 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx815,880,896 - 15,949,552 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0814,178,657 - 14,247,294 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0812,160,022 - 12,228,389 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,614,800 - 13,680,870 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,614,800 - 13,680,870 (-)Ensemblrn6Rnor6.0
Rnor_5.0813,555,911 - 13,622,279 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4811,858,152 - 11,925,452 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera813,367,554 - 13,434,143 (-)NCBICelera
Cytogenetic Map8q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20685892   PMID:31125343  


Genomics

Comparative Map Data
Hephl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8820,178,190 - 20,246,698 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl820,178,190 - 20,246,698 (-)EnsemblGRCr8
mRatBN7.2811,896,768 - 11,965,282 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,898,532 - 11,965,267 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx815,880,896 - 15,949,552 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0814,178,657 - 14,247,294 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0812,160,022 - 12,228,389 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,614,800 - 13,680,870 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,614,800 - 13,680,870 (-)Ensemblrn6Rnor6.0
Rnor_5.0813,555,911 - 13,622,279 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4811,858,152 - 11,925,452 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera813,367,554 - 13,434,143 (-)NCBICelera
Cytogenetic Map8q12NCBI
HEPHL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381194,021,354 - 94,114,208 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1194,021,354 - 94,114,208 (+)Ensemblhg38GRCh38
GRCh371193,754,520 - 93,847,374 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,394,026 - 93,487,022 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1191,042,195 - 91,135,169 (+)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1189,829,206 - 89,922,514 (+)NCBIHuRef
CHM1_11193,637,403 - 93,730,368 (+)NCBICHM1_1
T2T-CHM13v2.01193,938,102 - 94,030,957 (+)NCBIT2T-CHM13v2.0
Hephl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,963,137 - 15,023,466 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl914,963,137 - 15,023,404 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38915,051,841 - 15,112,170 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl915,051,841 - 15,112,108 (-)Ensemblmm10GRCm38
MGSCv37914,856,285 - 14,916,552 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36914,804,011 - 14,862,497 (-)NCBIMGSCv36mm8
Celera912,332,719 - 12,393,081 (-)NCBICelera
Cytogenetic Map9A2NCBI
Hephl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955414461,212 - 551,323 (-)Ensembl
ChiLan1.0NW_004955414461,212 - 551,323 (-)NCBIChiLan1.0ChiLan1.0
HEPHL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2994,875,671 - 94,969,244 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11195,967,401 - 96,060,643 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,035,265 - 89,127,508 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,521,421 - 92,613,455 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,521,421 - 92,613,455 (+)EnsemblpanPan2panpan1.1
HEPHL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,720,472 - 6,813,946 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,716,562 - 6,814,486 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha216,729,881 - 6,823,331 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0216,900,421 - 6,994,141 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl216,901,997 - 6,994,165 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,681,088 - 6,774,590 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0216,750,370 - 6,844,426 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0216,800,696 - 6,894,096 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hephl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,045,306 - 79,115,031 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936674778,160 - 846,119 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936674778,160 - 846,119 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEPHL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,355,996 - 26,437,442 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1926,356,159 - 26,438,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,088,640 - 30,170,534 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HEPHL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,268,791 - 85,348,816 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,269,726 - 85,346,988 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604340,462,062 - 40,538,402 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hephl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473538,687,298 - 38,755,523 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473538,687,298 - 38,757,256 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hephl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1810,850,010 - 10,915,066 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hephl1
195 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:78
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000043669
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 3 15 121 53 58 29 39 29 6 158 69 7 105 45 78 29 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000081616   ⟹   ENSRNOP00000074695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl820,178,190 - 20,246,698 (-)Ensembl
mRatBN7.2 Ensembl811,898,532 - 11,965,267 (-)Ensembl
Rnor_6.0 Ensembl813,614,800 - 13,680,870 (-)Ensembl
RefSeq Acc Id: NM_001191993   ⟹   NP_001178922
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8820,178,190 - 20,246,698 (-)NCBI
mRatBN7.2811,896,768 - 11,965,282 (-)NCBI
Rnor_6.0813,614,800 - 13,680,870 (-)NCBI
Rnor_5.0813,555,911 - 13,622,279 (-)NCBI
Celera813,367,554 - 13,434,143 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178922 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL78454 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074695
  ENSRNOP00000074695.2
RefSeq Acc Id: NP_001178922   ⟸   NM_001191993
- UniProtKB: A0A0G2K8Q3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074695   ⟸   ENSRNOT00000081616
Protein Domains
Plastocyanin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8Q3-F1-model_v2 AlphaFold A0A0G2K8Q3 1-1132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564835 AgrOrtholog
BioCyc Gene G2FUF-31675 BioCyc
Ensembl Genes ENSRNOG00000056092 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081616 ENTREZGENE
  ENSRNOT00000081616.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.420 UniProtKB/TrEMBL
InterPro Cu-oxidase_2 UniProtKB/TrEMBL
  Cu-oxidase_3 UniProtKB/TrEMBL
  Cu-oxidase_fam UniProtKB/TrEMBL
  Cu_oxidase_CS UniProtKB/TrEMBL
  Cu_oxidase_Cu_BS UniProtKB/TrEMBL
  Cupredoxin UniProtKB/TrEMBL
NCBI Gene 500946 ENTREZGENE
PANTHER FERROXIDASE HEPHL1 UniProtKB/TrEMBL
  MULTI-COPPER OXIDASE UniProtKB/TrEMBL
Pfam Cu-oxidase_2 UniProtKB/TrEMBL
  Cu-oxidase_3 UniProtKB/TrEMBL
PhenoGen Hephl1 PhenoGen
PROSITE MULTICOPPER_OXIDASE1 UniProtKB/TrEMBL
  MULTICOPPER_OXIDASE2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056092 RatGTEx
Superfamily-SCOP Cupredoxin UniProtKB/TrEMBL
UniProt A0A0G2K8Q3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Hephl1  hephaestin-like 1  RGD1564835_predicted  similar to hephaestin (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564835_predicted  similar to hephaestin (predicted)  LOC500946  similar to hephaestin  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500946  similar to hephaestin      Symbol and Name status set to provisional 70820 PROVISIONAL