Fer1l6 (fer-1-like family member 6) - Rat Genome Database

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Gene: Fer1l6 (fer-1-like family member 6) Rattus norvegicus
Analyze
Symbol: Fer1l6
Name: fer-1-like family member 6
RGD ID: 1564703
Description: Predicted to enable metal ion binding activity. Predicted to be involved in plasma membrane organization. Predicted to act upstream of or within response to bacterium. Predicted to be located in plasma membrane; recycling endosome; and trans-Golgi network. Orthologous to human FER1L6 (fer-1 like family member 6); INTERACTS WITH atrazine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fer-1-like 6; fer-1-like 6 (C. elegans); fer-1-like protein 6; LOC314997; RGD1564703; similar to mKIAA0493 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8791,951,174 - 92,106,617 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl791,939,589 - 92,106,397 (+)EnsemblGRCr8
mRatBN7.2790,093,567 - 90,216,907 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl790,061,924 - 90,215,214 (+)EnsemblmRatBN7.2
Rnor_6.0798,399,207 - 98,555,215 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl798,432,024 - 98,553,096 (+)Ensemblrn6Rnor6.0
Rnor_5.0798,998,421 - 99,152,741 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4795,281,291 - 95,419,204 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera786,826,752 - 86,982,137 (+)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23012479  


Genomics

Comparative Map Data
Fer1l6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8791,951,174 - 92,106,617 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl791,939,589 - 92,106,397 (+)EnsemblGRCr8
mRatBN7.2790,093,567 - 90,216,907 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl790,061,924 - 90,215,214 (+)EnsemblmRatBN7.2
Rnor_6.0798,399,207 - 98,555,215 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl798,432,024 - 98,553,096 (+)Ensemblrn6Rnor6.0
Rnor_5.0798,998,421 - 99,152,741 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4795,281,291 - 95,419,204 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera786,826,752 - 86,982,137 (+)NCBICelera
Cytogenetic Map7q33NCBI
FER1L6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388123,851,987 - 124,120,061 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8123,851,987 - 124,120,061 (+)Ensemblhg38GRCh38
GRCh378124,864,227 - 125,132,302 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368124,933,408 - 125,201,483 (+)NCBIBuild 36Build 36hg18NCBI36
Celera8121,142,008 - 121,320,410 (+)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8120,190,920 - 120,458,990 (+)NCBIHuRef
CHM1_18124,904,515 - 125,172,589 (+)NCBICHM1_1
T2T-CHM13v2.08124,984,227 - 125,252,427 (+)NCBIT2T-CHM13v2.0
Fer1l6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391558,381,897 - 58,536,936 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1558,381,897 - 58,536,941 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381558,510,048 - 58,665,087 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1558,510,048 - 58,665,092 (+)Ensemblmm10GRCm38
MGSCv371558,341,609 - 58,494,449 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361558,340,131 - 58,492,977 (+)NCBIMGSCv36mm8
Celera1560,038,948 - 60,192,509 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1524.88NCBI
Fer1l6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555402,686,221 - 2,834,896 (+)Ensembl
ChiLan1.0NW_0049555402,686,227 - 2,834,877 (+)NCBIChiLan1.0ChiLan1.0
FER1L6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27141,339,832 - 141,546,929 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18116,854,531 - 117,058,246 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08120,643,916 - 120,808,269 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18123,399,020 - 123,562,429 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8123,395,712 - 123,562,429 (+)EnsemblpanPan2panpan1.1
FER1L6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11322,172,348 - 22,291,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1322,137,080 - 22,290,989 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1322,102,580 - 22,258,237 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01322,478,877 - 22,634,393 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1322,478,842 - 22,633,035 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11322,205,709 - 22,361,362 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01322,309,451 - 22,465,151 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01322,551,795 - 22,707,327 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fer1l6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530316,003,716 - 16,100,496 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647023,431,641 - 23,544,510 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647023,430,982 - 23,544,510 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FER1L6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl415,435,063 - 15,610,320 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1415,435,621 - 15,610,496 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FER1L6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18118,483,862 - 118,690,710 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8118,526,691 - 118,690,288 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603921,516,948 - 21,683,512 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fer1l6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473531,001,085 - 31,114,191 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473531,000,479 - 31,186,392 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fer1l6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11233,051,010 - 233,198,188 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fer1l6
1269 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:84
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000038973
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78211124596700643Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78211124595485241Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
Fer1l6rgdv775925951-C  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8792,058,260 - 92,058,524 (+)Marker Load Pipeline
Rnor_6.0798,507,649 - 98,507,649 (+)RGDRnor6.0


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 51 105 87 86 55 45 55 6 247 127 10 85 41 81 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000038973   ⟹   ENSRNOP00000032894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl790,061,924 - 90,215,214 (+)Ensembl
Rnor_6.0 Ensembl798,432,442 - 98,553,096 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091077   ⟹   ENSRNOP00000069165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl791,939,589 - 92,106,397 (+)Ensembl
mRatBN7.2 Ensembl790,061,953 - 90,215,214 (+)Ensembl
Rnor_6.0 Ensembl798,432,024 - 98,553,093 (+)Ensembl
RefSeq Acc Id: XM_039080186   ⟹   XP_038936114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8791,951,174 - 92,106,617 (+)NCBI
mRatBN7.2790,093,567 - 90,216,907 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038936114 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069165
  ENSRNOP00000069165.3
Ensembl Acc Id: ENSRNOP00000032894   ⟸   ENSRNOT00000038973
Ensembl Acc Id: ENSRNOP00000069165   ⟸   ENSRNOT00000091077
RefSeq Acc Id: XP_038936114   ⟸   XM_039080186
- UniProtKB: A0A0G2JUN6 (UniProtKB/TrEMBL),   F1LXL6 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564703 AgrOrtholog
BioCyc Gene G2FUF-33310 BioCyc
Ensembl Genes ENSRNOG00000025300 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091077 ENTREZGENE
  ENSRNOT00000091077.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
InterPro C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2B_Ferlin UniProtKB/TrEMBL
  C2C_Ferlin UniProtKB/TrEMBL
  C2D_Ferlin UniProtKB/TrEMBL
  C2E_Ferlin UniProtKB/TrEMBL
  C2F_Ferlin UniProtKB/TrEMBL
  FerIin-domain UniProtKB/TrEMBL
  Ferlin UniProtKB/TrEMBL
  Ferlin_B-domain UniProtKB/TrEMBL
  Ferlin_C UniProtKB/TrEMBL
  Ferlin_DSRM UniProtKB/TrEMBL
NCBI Gene 314997 ENTREZGENE
PANTHER PTHR12546 UniProtKB/TrEMBL
  PTHR12546:SF37 UniProtKB/TrEMBL
Pfam dsrm_Ferlin UniProtKB/TrEMBL
  FerB UniProtKB/TrEMBL
  FerI UniProtKB/TrEMBL
  Ferlin_C UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
PhenoGen Fer1l6 PhenoGen
PROSITE PS50004 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025300 RatGTEx
SMART FerB UniProtKB/TrEMBL
  FerI UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
UniProt A0A0G2JUN6 ENTREZGENE, UniProtKB/TrEMBL
  F1LXL6 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-09 Fer1l6  fer-1-like family member 6  Fer1l6  fer-1-like 6 (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fer1l6  fer-1-like 6 (C. elegans)  RGD1564703_predicted  similar to mKIAA0493 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564703_predicted  similar to mKIAA0493 protein (predicted)  LOC314997  similar to mKIAA0493 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC314997  similar to mKIAA0493 protein      Symbol and Name status set to provisional 70820 PROVISIONAL