Cfhr4 (complement factor H-related 4) - Rat Genome Database

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Gene: Cfhr4 (complement factor H-related 4) Rattus norvegicus
Analyze
Symbol: Cfhr4
Name: complement factor H-related 4
RGD ID: 1564614
Description: Predicted to enable complement component C3b binding activity and heparin binding activity. Predicted to be involved in complement activation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CFHR4 (complement factor H related 4); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: complement factor H-related protein; complement factor H-related protein-like; LOC498241; RGD1564614; similar to complement component factor H; similar to complement factor H-related protein
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81353,973,301 - 54,042,179 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1353,973,301 - 54,042,179 (-)EnsemblGRCr8
mRatBN7.21351,422,592 - 51,491,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,422,592 - 51,491,502 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1354,007,567 - 54,074,828 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01355,295,485 - 55,362,752 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,562,200 - 52,634,394 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,889,669 - 56,958,549 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,889,669 - 56,958,561 (-)Ensemblrn6Rnor6.0
Rnor_5.01361,895,974 - 61,976,734 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41353,162,400 - 53,231,360 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1351,682,465 - 51,749,642 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12374811   PMID:17028856   PMID:22516433   PMID:23533145  


Genomics

Comparative Map Data
Cfhr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81353,973,301 - 54,042,179 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1353,973,301 - 54,042,179 (-)EnsemblGRCr8
mRatBN7.21351,422,592 - 51,491,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,422,592 - 51,491,502 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1354,007,567 - 54,074,828 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01355,295,485 - 55,362,752 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,562,200 - 52,634,394 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,889,669 - 56,958,549 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,889,669 - 56,958,561 (-)Ensemblrn6Rnor6.0
Rnor_5.01361,895,974 - 61,976,734 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41353,162,400 - 53,231,360 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1351,682,465 - 51,749,642 (-)NCBICelera
Cytogenetic Map13q13NCBI
CFHR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381196,888,052 - 196,918,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1196,888,014 - 196,920,294 (+)Ensemblhg38GRCh38
GRCh371196,857,182 - 196,887,763 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361195,123,835 - 195,154,386 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341193,588,868 - 193,619,419NCBI
Celera1169,971,227 - 170,001,824 (+)NCBICelera
Cytogenetic Map1q31.3NCBI
HuRef1168,014,575 - 168,045,285 (+)NCBIHuRef
CHM1_11198,279,376 - 198,310,085 (+)NCBICHM1_1
T2T-CHM13v2.01196,149,839 - 196,180,430 (+)NCBIT2T-CHM13v2.0
Cfhr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391139,625,657 - 139,708,977 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1139,625,361 - 139,708,981 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381139,697,919 - 139,781,239 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1139,697,623 - 139,781,243 (-)Ensemblmm10GRCm38
MGSCv371141,594,496 - 141,677,816 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361141,514,046 - 141,597,647 (-)NCBIMGSCv36mm8
Celera1142,332,928 - 142,428,269 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.62NCBI
LOC117975341
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2152,582,266 - 52,616,962 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1152,523,990 - 52,558,684 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,355,204 - 172,389,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3

Variants

.
Variants in Cfhr4
615 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:52
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000017293
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat

Markers in Region
UniSTS:464794  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21351,425,686 - 51,425,842 (+)MAPPERmRatBN7.2
Rnor_6.01356,892,764 - 56,892,919NCBIRnor6.0
Rnor_5.01361,910,941 - 61,911,096UniSTSRnor5.0
RGSC_v3.41353,165,495 - 53,165,650UniSTSRGSC3.4
Celera1351,685,560 - 51,685,715UniSTS
Cytogenetic Map13q13UniSTS
Oct4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21351,425,619 - 51,425,820 (+)MAPPERmRatBN7.2
Rnor_6.01356,892,697 - 56,892,897NCBIRnor6.0
Rnor_5.01361,910,874 - 61,911,074UniSTSRnor5.0
RGSC_v3.41353,165,428 - 53,165,628UniSTSRGSC3.4
Celera1351,685,493 - 51,685,693UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 8 14 78 90 88 59 27 59 6 174 66 5 53 34 57 29 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000017293   ⟹   ENSRNOP00000017293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1353,973,301 - 54,042,179 (-)Ensembl
mRatBN7.2 Ensembl1351,422,592 - 51,491,476 (-)Ensembl
Rnor_6.0 Ensembl1356,889,669 - 56,958,549 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000017749   ⟹   ENSRNOP00000017749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1353,973,301 - 54,025,251 (-)Ensembl
mRatBN7.2 Ensembl1351,422,592 - 51,474,548 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083912   ⟹   ENSRNOP00000074888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1353,973,301 - 54,042,130 (-)Ensembl
mRatBN7.2 Ensembl1351,422,592 - 51,491,502 (-)Ensembl
Rnor_6.0 Ensembl1356,890,191 - 56,958,561 (-)Ensembl
RefSeq Acc Id: NM_001134792   ⟹   NP_001128264
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81353,973,301 - 54,042,179 (-)NCBI
mRatBN7.21351,422,592 - 51,491,476 (-)NCBI
Rnor_6.01356,889,669 - 56,958,549 (-)NCBI
Rnor_5.01361,895,974 - 61,976,734 (-)NCBI
RGSC_v3.41353,162,400 - 53,231,360 (-)RGD
Celera1351,682,465 - 51,749,642 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128264 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL25802 (Get FASTA)   NCBI Sequence Viewer  
  EDM09617 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017293
  ENSRNOP00000017293.1
  ENSRNOP00000017749.6
  ENSRNOP00000074888.1
RefSeq Acc Id: NP_001128264   ⟸   NM_001134792
- Peptide Label: precursor
- UniProtKB: G3V7P5 (UniProtKB/TrEMBL),   A6ICN0 (UniProtKB/TrEMBL),   Q91WX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017293   ⟸   ENSRNOT00000017293
Ensembl Acc Id: ENSRNOP00000074888   ⟸   ENSRNOT00000083912
Ensembl Acc Id: ENSRNOP00000017749   ⟸   ENSRNOT00000017749
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K975-F1-model_v2 AlphaFold A0A0G2K975 1-764 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698868
Promoter ID:EPDNEW_R9393
Type:initiation region
Name:RGD1564614_1
Description:similar to complement factor H-related protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01356,958,546 - 56,958,606EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564614 AgrOrtholog
BioCyc Gene G2FUF-18067 BioCyc
Ensembl Genes ENSRNOG00000042369 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017293 ENTREZGENE
  ENSRNOT00000017293.5 UniProtKB/TrEMBL
  ENSRNOT00000017749.8 UniProtKB/TrEMBL
  ENSRNOT00000083912.3 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/TrEMBL
InterPro ComplSys_Reg/VirEntry_Med UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/TrEMBL
KEGG Report rno:498241 UniProtKB/TrEMBL
NCBI Gene 498241 ENTREZGENE
PANTHER COMPLEMENT FACTOR H UniProtKB/TrEMBL
  COMPLEMENT FACTOR H-RELATED UniProtKB/TrEMBL
Pfam Sushi UniProtKB/TrEMBL
PhenoGen Cfhr4 PhenoGen
PROSITE SUSHI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042369 RatGTEx
SMART CCP UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/TrEMBL
UniProt A0A0G2K975_RAT UniProtKB/TrEMBL
  A6ICN0 ENTREZGENE, UniProtKB/TrEMBL
  F1M983_RAT UniProtKB/TrEMBL
  G3V7P5 ENTREZGENE, UniProtKB/TrEMBL
  Q91WX0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-09-14 Cfhr4  complement factor H-related 4  RGD1564614  similar to complement factor H-related protein  Name and Symbol changed 629549 APPROVED
2013-05-24 RGD1564614  similar to complement factor H-related protein  LOC683775  similar to complement component factor H  Data merged from RGD:1583320 1643240 APPROVED
2008-04-30 RGD1564614  similar to complement factor H-related protein   RGD1564614_predicted  similar to complement factor H-related protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC683775  similar to complement component factor H      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1564614_predicted  similar to complement factor H-related protein (predicted)  LOC498241  similar to complement factor H-related protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498241  similar to complement factor H-related protein      Symbol and Name status set to provisional 70820 PROVISIONAL