Fam98b (family with sequence similarity 98, member B) - Rat Genome Database

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Gene: Fam98b (family with sequence similarity 98, member B) Rattus norvegicus
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Symbol: Fam98b
Name: family with sequence similarity 98, member B
RGD ID: 1564603
Description: Predicted to enable identical protein binding activity and protein methyltransferase activity. Predicted to be involved in positive regulation of cell population proliferation and positive regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Predicted to be part of tRNA-splicing ligase complex. Orthologous to human FAM98B (family with sequence similarity 98 member B); INTERACTS WITH dibutyl phthalate; flutamide; methoxychlor.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07053472.1; LOC499866; RGD1564603; similar to hypothetical protein FLJ38426
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Fam98b-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83124,588,827 - 124,618,275 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3124,588,827 - 124,618,275 (+)EnsemblGRCr8
mRatBN7.23104,134,803 - 104,164,249 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3104,134,824 - 104,163,704 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3107,790,464 - 107,814,412 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03116,385,973 - 116,409,921 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03114,046,366 - 114,070,315 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03108,944,094 - 108,977,480 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3108,944,141 - 108,977,721 (+)NCBIrn6Rnor6.0
Rnor_5.03115,501,086 - 115,531,871 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43103,335,362 - 103,366,217 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3103,063,719 - 103,094,105 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21311021   PMID:22658674   PMID:22681889   PMID:24608264   PMID:24870230   PMID:28040436  


Genomics

Comparative Map Data
Fam98b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83124,588,827 - 124,618,275 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3124,588,827 - 124,618,275 (+)EnsemblGRCr8
mRatBN7.23104,134,803 - 104,164,249 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3104,134,824 - 104,163,704 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3107,790,464 - 107,814,412 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03116,385,973 - 116,409,921 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03114,046,366 - 114,070,315 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03108,944,094 - 108,977,480 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3108,944,141 - 108,977,721 (+)NCBIrn6Rnor6.0
Rnor_5.03115,501,086 - 115,531,871 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43103,335,362 - 103,366,217 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3103,063,719 - 103,094,105 (+)NCBICelera
Cytogenetic Map3q35NCBI
FAM98B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381538,454,127 - 38,487,710 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1538,454,127 - 38,487,710 (+)Ensemblhg38GRCh38
GRCh371538,746,328 - 38,779,911 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361536,533,620 - 36,564,355 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1515,513,352 - 15,544,221 (+)NCBICelera
Cytogenetic Map15q14NCBI
HuRef1515,591,076 - 15,621,710 (+)NCBIHuRef
CHM1_11538,865,511 - 38,896,190 (+)NCBICHM1_1
T2T-CHM13v2.01536,259,418 - 36,292,996 (+)NCBIT2T-CHM13v2.0
Fam98b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392117,080,150 - 117,102,021 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2117,080,220 - 117,102,021 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382117,249,713 - 117,271,540 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2117,249,739 - 117,271,540 (+)Ensemblmm10GRCm38
MGSCv372117,075,475 - 117,097,276 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362116,941,180 - 116,962,981 (+)NCBIMGSCv36mm8
Celera2118,378,397 - 118,400,195 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.15NCBI
Fam98b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554165,457,274 - 5,487,042 (+)Ensembl
ChiLan1.0NW_0049554165,457,232 - 5,486,744 (+)NCBIChiLan1.0ChiLan1.0
FAM98B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21627,680,855 - 27,715,933 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11531,834,076 - 31,866,456 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01517,383,298 - 17,415,682 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11535,638,932 - 35,671,206 (+)NCBIPanPan1.1PanPan1.1panPan2
FAM98B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1305,802,656 - 5,839,256 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl305,802,734 - 5,837,657 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha305,854,122 - 5,891,225 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0305,923,614 - 5,960,713 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl305,923,650 - 5,960,711 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1305,849,236 - 5,886,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0305,948,447 - 5,985,532 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0306,083,787 - 6,120,889 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fam98b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864084,270,675 - 84,301,278 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364712,118,820 - 2,148,767 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364712,118,797 - 2,149,346 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM98B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1132,789,275 - 132,819,489 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11132,786,198 - 132,819,291 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21148,274,497 - 148,303,757 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAM98B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12644,484,020 - 44,523,548 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604896,407,976 - 96,441,507 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam98b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248045,660,307 - 5,691,409 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248045,660,628 - 5,690,325 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fam98b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1595,419,118 - 95,443,042 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fam98b
140 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:24
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000034950
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
BF390227  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23104,157,825 - 104,157,975 (+)MAPPERmRatBN7.2
Rnor_6.03108,972,936 - 108,973,085NCBIRnor6.0
Rnor_5.03115,528,689 - 115,528,838UniSTSRnor5.0
RGSC_v3.43103,359,692 - 103,359,841UniSTSRGSC3.4
Celera3103,085,716 - 103,085,865UniSTS
RH 3.4 Map3784.99UniSTS
Cytogenetic Map3q35UniSTS
RH132470  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1032,725,508 - 32,725,722UniSTS
Celera3117,450,208 - 117,450,421UniSTS
Cytogenetic Map3q35UniSTS
Cytogenetic Map3q36UniSTS
Cytogenetic Map10q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 67 138 95 11 51 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000034950   ⟹   ENSRNOP00000038007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3124,588,827 - 124,618,275 (+)Ensembl
mRatBN7.2 Ensembl3104,134,824 - 104,163,704 (+)Ensembl
RefSeq Acc Id: NM_001401945   ⟹   NP_001388874
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83124,588,827 - 124,618,275 (+)NCBI
mRatBN7.23104,134,803 - 104,164,249 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388874 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038007
  ENSRNOP00000038007.7
Ensembl Acc Id: ENSRNOP00000038007   ⟸   ENSRNOT00000034950
RefSeq Acc Id: NP_001388874   ⟸   NM_001401945
- UniProtKB: D4AE02 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AE02-F1-model_v2 AlphaFold D4AE02 1-433 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564603 AgrOrtholog
BioCyc Gene G2FUF-48276 BioCyc
Ensembl Genes ENSRNOG00000005366 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034950 ENTREZGENE
  ENSRNOT00000034950.8 UniProtKB/TrEMBL
InterPro FAM98 UniProtKB/TrEMBL
NCBI Gene 499866 ENTREZGENE
PANTHER PROTEIN FAM98B UniProtKB/TrEMBL
  PTHR31353 UniProtKB/TrEMBL
Pfam DUF2465 UniProtKB/TrEMBL
PhenoGen Fam98b PhenoGen
PRINTS EGGSHELL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005366 RatGTEx
UniProt D4AE02 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Fam98b  family with sequence similarity 98, member B  AABR07053472.1    Data merged from RGD:15003292 737654 PROVISIONAL
2019-11-08 AABR07053472.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-03-06 Fam98b  family with sequence similarity 98, member B  RGD1564603_predicted  similar to hypothetical protein FLJ38426 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564603_predicted  similar to hypothetical protein FLJ38426 (predicted)  LOC499866  similar to hypothetical protein FLJ38426  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499866  similar to hypothetical protein FLJ38426      Symbol and Name status set to provisional 70820 PROVISIONAL