C14h4orf36 (similar to human chromosome 4 open reading frame 36) - Rat Genome Database

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Gene: C14h4orf36 (similar to human chromosome 4 open reading frame 36) Rattus norvegicus
Analyze
Symbol: C14h4orf36
Name: similar to human chromosome 4 open reading frame 36
RGD ID: 1564576
Description: Orthologous to human C4orf36 (chromosome 4 open reading frame 36); INTERACTS WITH bisphenol A; oxybenzone; 3-methylcholanthrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AFF1 antisense RNA 1; Aff1-as1; hypothetical protein LOC498330; LOC102546454; LOC498330; similar to hypothetical protein MGC26744; uncharacterized LOC102546454; uncharacterized protein C4orf36 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,363,170 - 6,370,479 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl146,363,215 - 6,370,478 (+)EnsemblGRCr8
mRatBN7.2146,058,581 - 6,065,848 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl146,058,581 - 6,065,847 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx146,027,730 - 6,035,036 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,327,981 - 7,335,287 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0146,025,792 - 6,033,122 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,581,189 - 7,636,823 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,581,189 - 7,636,822 (+)Ensemblrn6Rnor6.0
Rnor_5.0147,609,873 - 7,611,192 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0147,559,461 - 7,560,448 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4147,222,291 - 7,230,296 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera146,198,302 - 6,205,552 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334  


Genomics

Comparative Map Data
C14h4orf36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,363,170 - 6,370,479 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl146,363,215 - 6,370,478 (+)EnsemblGRCr8
mRatBN7.2146,058,581 - 6,065,848 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl146,058,581 - 6,065,847 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx146,027,730 - 6,035,036 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,327,981 - 7,335,287 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0146,025,792 - 6,033,122 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,581,189 - 7,636,823 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,581,189 - 7,636,822 (+)Ensemblrn6Rnor6.0
Rnor_5.0147,609,873 - 7,611,192 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0147,559,461 - 7,560,448 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4147,222,291 - 7,230,296 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera146,198,302 - 6,205,552 (+)NCBICelera
Cytogenetic Map14p22NCBI
C4orf36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38486,876,205 - 86,936,204 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl486,886,472 - 86,936,178 (-)Ensemblhg38GRCh38
GRCh38.p14 Ensembl486,876,205 - 86,892,813 (-)Ensemblhg38GRCh38
GRCh37487,797,358 - 87,857,356 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,016,382 - 88,032,599 (-)NCBIBuild 36Build 36hg18NCBI36
Celera485,086,805 - 85,103,009 (-)NCBICelera
Cytogenetic Map4q21.3NCBI
HuRef483,542,250 - 83,558,464 (-)NCBIHuRef
CHM1_1487,773,837 - 87,791,111 (-)NCBICHM1_1
T2T-CHM13v2.0490,205,627 - 90,265,613 (-)NCBIT2T-CHM13v2.0
1700016H13Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395103,796,449 - 103,803,898 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5103,795,905 - 103,803,876 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385103,648,583 - 103,656,032 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5103,648,039 - 103,656,010 (-)Ensemblmm10GRCm38
MGSCv375104,077,606 - 104,084,751 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365103,888,895 - 103,896,034 (-)NCBIMGSCv36mm8
Celera5100,952,801 - 100,959,912 (-)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.45NCBI
CUNH4orf36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554742,935,017 - 2,937,271 (+)Ensembl
ChiLan1.0NW_0049554742,934,400 - 2,939,999 (+)NCBIChiLan1.0ChiLan1.0
C3H4orf36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2384,904,151 - 84,911,161 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1485,161,252 - 85,173,171 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0479,191,018 - 79,239,311 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1489,909,051 - 89,926,449 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl489,919,937 - 89,926,449 (-)EnsemblpanPan2panpan1.1
C32H4orf36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13210,362,183 - 10,392,017 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3210,335,528 - 10,392,170 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3231,561,722 - 31,591,907 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03210,385,295 - 10,415,528 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3210,383,815 - 10,415,103 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13210,496,529 - 10,526,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03210,323,275 - 10,353,633 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03229,601,240 - 29,631,627 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CUNH4orf36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405285279,480 - 320,776 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936920263,286 - 266,665 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936920263,257 - 266,769 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C8H4orf36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,969,291 - 131,976,753 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18131,969,371 - 132,023,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28141,244,386 - 141,288,918 (+)NCBISscrofa10.2Sscrofa10.2susScr3
C7H4orf36
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1735,257,412 - 35,263,122 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl735,254,501 - 35,262,261 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603713,952,304 - 13,957,598 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH4orf36
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248723,455,986 - 3,459,545 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248723,455,943 - 3,459,549 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
C11H4orf36
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11113,738,864 - 13,746,024 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in C14h4orf36
85 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1439578789393298Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 4 51 127 17 26 5 10 5 6 141 73 5 119 47 80 21 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000077215   ⟹   ENSRNOP00000069716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl146,363,215 - 6,370,478 (+)Ensembl
mRatBN7.2 Ensembl146,058,581 - 6,065,847 (+)Ensembl
Rnor_6.0 Ensembl147,581,189 - 7,636,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091581   ⟹   ENSRNOP00000069046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl147,630,482 - 7,636,787 (+)Ensembl
RefSeq Acc Id: NM_001017495   ⟹   NP_001017495
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,363,215 - 6,370,479 (+)NCBI
mRatBN7.2146,058,581 - 6,065,848 (+)NCBI
Rnor_6.0147,581,189 - 7,636,823 (+)NCBI
Rnor_5.0147,559,461 - 7,560,448 (+)NCBI
Rnor_5.0147,609,873 - 7,611,192 (+)NCBI
RGSC_v3.4147,222,291 - 7,230,296 (+)RGD
Celera146,198,302 - 6,205,552 (+)RGD
Sequence:
RefSeq Acc Id: XM_017599327   ⟹   XP_017454816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,363,170 - 6,370,479 (+)NCBI
mRatBN7.2146,058,853 - 6,065,819 (+)NCBI
Rnor_6.0147,630,465 - 7,636,244 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063273452   ⟹   XP_063129522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,363,170 - 6,370,479 (+)NCBI
RefSeq Acc Id: NP_001017495   ⟸   NM_001017495
- UniProtKB: Q6AY31 (UniProtKB/Swiss-Prot),   A6K5U9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454816   ⟸   XM_017599327
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000069716   ⟸   ENSRNOT00000077215
Ensembl Acc Id: ENSRNOP00000069046   ⟸   ENSRNOT00000091581
RefSeq Acc Id: XP_063129522   ⟸   XM_063273452
- Peptide Label: isoform X1
- UniProtKB: Q6AY31 (UniProtKB/Swiss-Prot),   A6K5U9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY31-F1-model_v2 AlphaFold Q6AY31 1-117 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564576 AgrOrtholog
BioCyc Gene G2FUF-16486 BioCyc
Ensembl Genes ENSRNOG00000060245 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077215 ENTREZGENE
  ENSRNOT00000077215.2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7131874 IMAGE-MGC_LOAD
InterPro DUF4522 UniProtKB/Swiss-Prot
KEGG Report rno:498330 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94277 IMAGE-MGC_LOAD
NCBI Gene 498330 ENTREZGENE
PANTHER CHROMOSOME 4 C4ORF36 HOMOLOG UniProtKB/Swiss-Prot
  PTHR38002 UniProtKB/Swiss-Prot
Pfam DUF4522 UniProtKB/Swiss-Prot
PhenoGen C14h4orf36 PhenoGen
RatGTEx ENSRNOG00000060245 RatGTEx
UniProt A6K5U9 ENTREZGENE, UniProtKB/TrEMBL
  CD036_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-02-13 C14h4orf36  similar to human chromosome 4 open reading frame 36  Aff1-as1  AFF1 antisense RNA 1  Name and Symbol changed 629549 APPROVED
2021-03-09 Aff1-as1  AFF1 antisense RNA 1  LOC102546454  uncharacterized LOC102546454  Data merged from RGD:7718381 737654 PROVISIONAL
2017-05-23 Aff1-as1  AFF1 antisense RNA 1  LOC498330  similar to hypothetical protein MGC26744  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102546454  uncharacterized LOC102546454      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-02-09 LOC498330  similar to hypothetical protein MGC26744      Symbol and Name status set to provisional 70820 PROVISIONAL