Steep1 (STING1 ER exit protein 1) - Rat Genome Database

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Gene: Steep1 (STING1 ER exit protein 1) Rattus norvegicus
Analyze
Symbol: Steep1
Name: STING1 ER exit protein 1
RGD ID: 1564541
Description: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in endoplasmic reticulum membrane organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and protein exit from endoplasmic reticulum. Predicted to act upstream of or within cGAS/STING signaling pathway and positive regulation of type I interferon production. Predicted to be located in cell body; cytoplasm; and nucleus. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 107. Orthologous to human STEEP1 (STING1 ER exit protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC313433; LOC313433; RGD1564541; similar to hypothetical protein FLJ22965; uncharacterized protein LOC313433; UPF0428 protein CXorf56 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X120,953,335 - 120,979,861 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX120,926,647 - 120,979,861 (-)EnsemblGRCr8
mRatBN7.2X116,087,626 - 116,114,159 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,060,929 - 116,114,159 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX118,189,843 - 118,217,563 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X121,758,973 - 121,786,697 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,305,139 - 119,332,856 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,460,280 - 123,486,814 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,460,280 - 123,486,814 (-)Ensemblrn6Rnor6.0
Rnor_5.0X123,605,221 - 123,631,755 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X7,992,595 - 8,019,120 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX115,317,375 - 115,344,394 (-)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell body  (IEA,ISO)
cytoplasm  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
endoplasmic reticulum membrane  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:29374277  


Genomics

Comparative Map Data
Steep1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X120,953,335 - 120,979,861 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX120,926,647 - 120,979,861 (-)EnsemblGRCr8
mRatBN7.2X116,087,626 - 116,114,159 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,060,929 - 116,114,159 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX118,189,843 - 118,217,563 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X121,758,973 - 121,786,697 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,305,139 - 119,332,856 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,460,280 - 123,486,814 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,460,280 - 123,486,814 (-)Ensemblrn6Rnor6.0
Rnor_5.0X123,605,221 - 123,631,755 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X7,992,595 - 8,019,120 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX115,317,375 - 115,344,394 (-)NCBICelera
Cytogenetic MapXq34NCBI
STEEP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X119,538,149 - 119,565,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX119,535,669 - 119,565,409 (-)Ensemblhg38GRCh38
GRCh37X118,672,112 - 118,699,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X118,557,529 - 118,583,392 (-)NCBIBuild 36Build 36hg18NCBI36
CeleraX119,126,840 - 119,154,108 (-)NCBICelera
Cytogenetic MapXq24NCBI
HuRefX108,165,833 - 108,192,856 (-)NCBIHuRef
CHM1_1X118,583,359 - 118,610,624 (-)NCBICHM1_1
T2T-CHM13v2.0X117,915,908 - 117,943,135 (-)NCBIT2T-CHM13v2.0
Steep1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X36,087,388 - 36,127,956 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX36,087,390 - 36,137,764 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X36,827,161 - 36,864,303 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX36,823,737 - 36,874,111 (-)Ensemblmm10GRCm38
MGSCv37X34,388,538 - 34,404,241 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X33,255,180 - 33,305,588 (-)NCBIMGSCv36mm8
CeleraX23,572,190 - 23,587,885 (-)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX21.23NCBI
Steep1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955534429,029 - 476,987 (+)Ensembl
ChiLan1.0NW_004955534429,207 - 443,810 (+)NCBIChiLan1.0ChiLan1.0
STEEP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X118,918,801 - 118,947,108 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X118,923,387 - 118,950,670 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X108,570,634 - 108,598,045 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X118,997,850 - 119,024,661 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX118,997,850 - 119,024,661 (-)EnsemblpanPan2panpan1.1
STEEP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X91,573,392 - 91,598,523 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX91,575,882 - 91,598,425 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX77,648,136 - 77,673,310 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X93,312,436 - 93,337,629 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX93,312,910 - 93,337,616 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X90,765,359 - 90,790,317 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X92,523,931 - 92,549,044 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X92,253,041 - 92,278,233 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Steep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X90,612,443 - 90,636,476 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647910,351,059 - 10,404,657 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647910,351,016 - 10,373,416 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STEEP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX97,974,604 - 97,986,278 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X97,974,596 - 97,986,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X113,678,599 - 113,690,302 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STEEP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606532,291,932 - 32,316,567 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Steep1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248953,497,784 - 3,536,122 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248953,522,085 - 3,535,934 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Steep1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X103,031,032 - 103,042,325 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Steep1
45 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:999
Count of miRNA genes:342
Interacting mature miRNAs:483
Transcripts:ENSRNOT00000016993
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X120028026141353710Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X120028026141353710Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X105468858125434318Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
RH130940  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X116,087,909 - 116,088,106 (+)MAPPERmRatBN7.2
Rnor_6.0X123,460,564 - 123,460,760NCBIRnor6.0
Rnor_5.0X123,605,505 - 123,605,701UniSTSRnor5.0
RGSC_v3.4X8,018,640 - 8,018,836UniSTSRGSC3.4
CeleraX115,317,659 - 115,317,855UniSTS
Cytogenetic MapXq12UniSTS
RH126553  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X120,954,035 - 120,954,283 (+)Marker Load Pipeline
mRatBN7.2X116,088,325 - 116,088,574 (+)MAPPERmRatBN7.2
Rnor_6.0X123,460,980 - 123,461,228NCBIRnor6.0
Rnor_5.0X123,605,921 - 123,606,169UniSTSRnor5.0
RGSC_v3.4X8,018,172 - 8,018,420UniSTSRGSC3.4
CeleraX115,318,075 - 115,318,323UniSTS
Cytogenetic MapXq12UniSTS
MARC_21759-21760:1023907404:5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X116,091,612 - 116,092,364 (+)MAPPERmRatBN7.2
Rnor_6.0X123,464,266 - 123,465,017NCBIRnor6.0
Rnor_5.0X123,609,207 - 123,609,958UniSTSRnor5.0
RGSC_v3.4X8,014,383 - 8,015,134UniSTSRGSC3.4
CeleraX115,321,361 - 115,322,112UniSTS
Cytogenetic MapXq12UniSTS
px-14c7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X116,106,432 - 116,106,569 (+)MAPPERmRatBN7.2
Rnor_6.0X123,479,092 - 123,479,228NCBIRnor6.0
Rnor_5.0X123,624,033 - 123,624,169UniSTSRnor5.0
RGSC_v3.4X8,000,181 - 8,000,317UniSTSRGSC3.4
CeleraX115,335,842 - 115,335,978UniSTS
Cytogenetic MapXq12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016993   ⟹   ENSRNOP00000016993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX120,953,335 - 120,979,861 (-)Ensembl
mRatBN7.2 EnsemblX116,087,626 - 116,114,159 (-)Ensembl
Rnor_6.0 EnsemblX123,460,280 - 123,486,814 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092415   ⟹   ENSRNOP00000075789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX123,472,761 - 123,474,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092455   ⟹   ENSRNOP00000075907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX120,926,647 - 120,979,861 (-)Ensembl
mRatBN7.2 EnsemblX116,060,929 - 116,101,527 (-)Ensembl
Rnor_6.0 EnsemblX123,462,333 - 123,474,288 (-)Ensembl
RefSeq Acc Id: NM_001107950   ⟹   NP_001101420
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X120,953,335 - 120,979,861 (-)NCBI
mRatBN7.2X116,087,626 - 116,114,159 (-)NCBI
Rnor_6.0X123,460,280 - 123,486,814 (-)NCBI
Rnor_5.0X123,605,221 - 123,631,755 (-)NCBI
RGSC_v3.4X7,992,595 - 8,019,120 (+)RGD
CeleraX115,317,375 - 115,344,394 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101420 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10824 (Get FASTA)   NCBI Sequence Viewer  
  EDM10825 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016993
  ENSRNOP00000016993.4
  ENSRNOP00000075907.2
RefSeq Acc Id: NP_001101420   ⟸   NM_001107950
- UniProtKB: D4A067 (UniProtKB/TrEMBL),   A6JMG3 (UniProtKB/TrEMBL),   A0A0U1RS26 (UniProtKB/TrEMBL),   A6JMG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075789   ⟸   ENSRNOT00000092415
Ensembl Acc Id: ENSRNOP00000075907   ⟸   ENSRNOT00000092455
Ensembl Acc Id: ENSRNOP00000016993   ⟸   ENSRNOT00000016993

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A067-F1-model_v2 AlphaFold D4A067 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701987
Promoter ID:EPDNEW_R12507
Type:multiple initiation site
Name:RGD1564541_1
Description:similar to hypothetical protein FLJ22965
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X123,474,135 - 123,474,195EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564541 AgrOrtholog
BioCyc Gene G2FUF-1304 BioCyc
Ensembl Genes ENSRNOG00000012564 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016993 ENTREZGENE
  ENSRNOT00000016993.7 UniProtKB/TrEMBL
  ENSRNOT00000092455.3 UniProtKB/TrEMBL
InterPro UPF0428 UniProtKB/TrEMBL
KEGG Report rno:313433 UniProtKB/TrEMBL
NCBI Gene 313433 ENTREZGENE
PANTHER PTHR46355 UniProtKB/TrEMBL
  STING ER EXIT PROTEIN UniProtKB/TrEMBL
Pfam STEEP1 UniProtKB/TrEMBL
PhenoGen Steep1 PhenoGen
RatGTEx ENSRNOG00000012564 RatGTEx
UniProt A0A0U1RS26 ENTREZGENE, UniProtKB/TrEMBL
  A6JMG2 ENTREZGENE, UniProtKB/TrEMBL
  A6JMG3 ENTREZGENE, UniProtKB/TrEMBL
  D4A067 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-10 Steep1  STING1 ER exit protein 1  RGD1564541  similar to hypothetical protein FLJ22965  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564541  similar to hypothetical protein FLJ22965   RGD1564541_predicted  similar to hypothetical protein FLJ22965 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564541_predicted  similar to hypothetical protein FLJ22965 (predicted)  LOC313433  similar to hypothetical protein FLJ22965  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC313433  similar to hypothetical protein FLJ22965      Symbol and Name status set to provisional 70820 PROVISIONAL