Ccdc110 (coiled-coil domain containing 110) - Rat Genome Database

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Gene: Ccdc110 (coiled-coil domain containing 110) Rattus norvegicus
Analyze
Symbol: Ccdc110
Name: coiled-coil domain containing 110
RGD ID: 1564538
Description: Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoskeleton. Orthologous to human CCDC110 (coiled-coil domain containing 110); INTERACTS WITH benzo[a]pyrene; bisphenol A; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: coiled-coil domain-containing protein 110; coiled-coil domain-containing protein 110-like; LOC100911140; LOC290755; MGC188094; RGD1564538; similar to hypothetical protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,048,305 - 53,069,606 (-)NCBIGRCr8
mRatBN7.21646,315,745 - 46,337,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,315,745 - 46,337,021 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01649,509,885 - 49,522,094 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1647,151,520 - 47,163,898 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1649,509,876 - 49,522,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,236,399 - 49,256,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41649,597,036 - 49,610,956 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1644,314,008 - 44,334,950 (-)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoskeleton  (IBA)
cytosol  (ISO)
nucleoplasm  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Ccdc110
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,048,305 - 53,069,606 (-)NCBIGRCr8
mRatBN7.21646,315,745 - 46,337,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,315,745 - 46,337,021 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01649,509,885 - 49,522,094 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1647,151,520 - 47,163,898 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1649,509,876 - 49,522,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,236,399 - 49,256,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41649,597,036 - 49,610,956 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1644,314,008 - 44,334,950 (-)NCBICelera
Cytogenetic Map16q11NCBI
CCDC110
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384185,445,182 - 185,471,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4185,445,182 - 185,471,752 (-)EnsemblGRCh38hg38GRCh38
GRCh374186,366,336 - 186,392,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364186,603,341 - 186,629,871 (-)NCBINCBI36Build 36hg18NCBI36
Celera4183,693,987 - 183,720,463 (-)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4182,120,079 - 182,146,758 (-)NCBIHuRef
CHM1_14186,342,774 - 186,369,536 (-)NCBICHM1_1
T2T-CHM13v2.04188,788,463 - 188,815,286 (-)NCBIT2T-CHM13v2.0
Ccdc110
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39846,387,656 - 46,398,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl846,387,656 - 46,397,182 (+)EnsemblGRCm39 Ensembl
GRCm38845,934,619 - 45,945,606 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,934,619 - 45,944,145 (+)EnsemblGRCm38mm10GRCm38
MGSCv37847,020,003 - 47,029,499 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36847,433,466 - 47,442,962 (+)NCBIMGSCv36mm8
Celera848,617,570 - 48,627,073 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map825.92NCBI
Ccdc110
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540323,593,235 - 23,619,838 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540323,593,610 - 23,616,959 (+)NCBIChiLan1.0ChiLan1.0
CCDC110
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23183,180,123 - 183,211,362 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14183,528,472 - 183,555,290 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04177,608,169 - 177,634,974 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14189,824,259 - 189,850,789 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4189,824,586 - 189,850,715 (-)Ensemblpanpan1.1panPan2
CCDC110
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11645,158,092 - 45,180,280 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1645,159,502 - 45,193,767 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1645,644,502 - 45,665,563 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01647,372,722 - 47,393,801 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1647,372,776 - 47,409,710 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11645,340,749 - 45,361,812 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01645,953,177 - 45,974,216 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01646,084,958 - 46,105,931 (+)NCBIUU_Cfam_GSD_1.0
Ccdc110
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494334,202,070 - 34,220,385 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365543,889,680 - 3,903,338 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365543,889,921 - 3,903,338 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCDC110
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1546,491,805 - 46,546,501 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11546,494,535 - 46,503,676 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21553,276,160 - 53,285,276 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCDC110
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17131,395,027 - 131,421,396 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037111,656,728 - 111,683,365 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccdc110
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476916,310,048 - 16,328,789 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476916,309,257 - 16,329,154 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccdc110
151 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
13 2 12 62 52 53 16 16 16 11 86 50 38 7 44 37

Sequence


Ensembl Acc Id: ENSRNOT00000074490   ⟹   ENSRNOP00000065930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,315,751 - 46,337,009 (-)Ensembl
Rnor_6.0 Ensembl1647,151,520 - 47,163,898 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081642   ⟹   ENSRNOP00000070254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,315,751 - 46,337,021 (-)Ensembl
Rnor_6.0 Ensembl1649,509,876 - 49,522,341 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116429   ⟹   ENSRNOP00000085692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,321,170 - 46,337,021 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120143   ⟹   ENSRNOP00000091543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,315,745 - 46,337,021 (-)Ensembl
RefSeq Acc Id: XM_039094894   ⟹   XP_038950822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,054,717 - 53,069,606 (-)NCBI
mRatBN7.21646,322,157 - 46,337,050 (-)NCBI
RefSeq Acc Id: XM_039094895   ⟹   XP_038950823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,048,305 - 53,069,605 (-)NCBI
mRatBN7.21646,315,745 - 46,337,050 (-)NCBI
Ensembl Acc Id: ENSRNOP00000070254   ⟸   ENSRNOT00000081642
Ensembl Acc Id: ENSRNOP00000065930   ⟸   ENSRNOT00000074490
RefSeq Acc Id: XP_038950823   ⟸   XM_039094895
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038950822   ⟸   XM_039094894
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3X1 (UniProtKB/TrEMBL),   A0A8I6AFM1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085692   ⟸   ENSRNOT00000116429
Ensembl Acc Id: ENSRNOP00000091543   ⟸   ENSRNOT00000120143

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GV42-F1-model_v2 AlphaFold B2GV42 1-763 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564538 AgrOrtholog
BioCyc Gene G2FUF-11329 BioCyc
Ensembl Genes ENSRNOG00000045697 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000056363 Ensembl
Ensembl Transcript ENSRNOT00000074490.3 UniProtKB/TrEMBL
  ENSRNOT00000081642.2 UniProtKB/TrEMBL
  ENSRNOT00000116429.1 UniProtKB/TrEMBL
  ENSRNOT00000120143.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132003 IMAGE-MGC_LOAD
MGC_CLONE MGC:188094 IMAGE-MGC_LOAD
NCBI Gene 290755 ENTREZGENE
PANTHER CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED UniProtKB/TrEMBL
  COILED-COIL DOMAIN-CONTAINING PROTEIN 110 UniProtKB/TrEMBL
PhenoGen Ccdc110 PhenoGen
RatGTEx ENSRNOG00000045697 RatGTEx
  ENSRNOG00000056363 RatGTEx
UniProt A0A0G2JXF8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3X1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFM1 ENTREZGENE, UniProtKB/TrEMBL
  A6JPQ6_RAT UniProtKB/TrEMBL
  B2GV42_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ccdc110  coiled-coil domain containing 110  LOC100911140  coiled-coil domain-containing protein 110-like  Data merged from RGD:6494612 737654 PROVISIONAL
2012-07-05 LOC100911140  coiled-coil domain-containing protein 110-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Ccdc110  coiled-coil domain containing 110  RGD1564538_predicted  similar to hypothetical protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564538_predicted  similar to hypothetical protein (predicted)  LOC290755  similar to hypothetical protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC290755  similar to hypothetical protein      Symbol and Name status set to provisional 70820 PROVISIONAL