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Gene: Lrrc74a (leucine rich repeat containing 74A) Rattus norvegicus

Analyze

Symbol:

Lrrc74a

Name:

leucine rich repeat containing 74A

RGD ID:

1564488

Description:

Orthologous to human LRRC74A (leucine rich repeat containing 74A); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hypothetical protein LOC314328; leucine rich repeat containing 74; leucine-rich repeat-containing protein 74; leucine-rich repeat-containing protein 74A; LOC103692680; LOC314328; Lrrc74; MGC114373; MGC156476; similar to chromosome 14 open reading frame 166B; uncharacterized LOC103692680; uncharacterized protein C14orf166B homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	112,117,226 - 112,147,152 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	112,117,241 - 112,148,068 (+)	Ensembl				GRCr8
mRatBN7.2	6	106,386,276 - 106,417,112 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	106,386,347 - 106,416,193 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	106,555,126 - 106,585,042 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	106,853,984 - 106,883,902 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	106,223,640 - 106,253,544 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	110,681,551 - 110,776,904 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	110,749,705 - 110,776,775 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	119,978,629 - 120,072,131 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	110,862,558 - 110,892,572 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	104,208,223 - 104,237,842 (+)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

heptanal (ISO)

hexanal (ISO)

methapyrilene (ISO)

nonanal (ISO)

octanal (ISO)

pentanal (ISO)

propanal (ISO)

testosterone (EXP)

References

References - curated

#	Reference Title	Reference Citation
1.	GOA pipeline	RGD automated data pipeline
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data

Lrrc74a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	112,117,226 - 112,147,152 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	112,117,241 - 112,148,068 (+)	Ensembl				GRCr8
mRatBN7.2	6	106,386,276 - 106,417,112 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	106,386,347 - 106,416,193 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	106,555,126 - 106,585,042 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	106,853,984 - 106,883,902 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	106,223,640 - 106,253,544 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	110,681,551 - 110,776,904 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	110,749,705 - 110,776,775 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	119,978,629 - 120,072,131 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	110,862,558 - 110,892,572 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	104,208,223 - 104,237,842 (+)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

LRRC74A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	76,826,408 - 76,870,304 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	76,826,372 - 76,870,304 (+)	Ensembl			hg38	GRCh38
GRCh37	14	77,292,751 - 77,336,647 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	76,362,630 - 76,406,302 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	76,362,479 - 76,406,392	NCBI
Celera	14	57,331,332 - 57,375,219 (+)	NCBI		Celera
Cytogenetic Map	14	q24.3	NCBI
HuRef	14	57,461,178 - 57,505,039 (+)	NCBI		HuRef
CHM1_1	14	77,230,493 - 77,274,426 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	71,036,112 - 71,080,030 (+)	NCBI		T2T-CHM13v2.0

Lrrc74a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	86,781,119 - 86,815,799 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	86,781,143 - 86,810,571 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	86,734,345 - 86,769,025 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	86,734,369 - 86,763,797 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	88,075,319 - 88,104,756 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	87,623,758 - 87,652,898 (+)	NCBI		MGSCv36	mm8
Celera	12	88,196,422 - 88,225,856 (+)	NCBI		Celera
Cytogenetic Map	12	D2	NCBI
cM Map	12	40.9	NCBI

Lrrc74a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	805,448 - 831,590 (+)	Ensembl
ChiLan1.0	NW_004955438	805,119 - 834,335 (+)	NCBI	ChiLan1.0	ChiLan1.0

LRRC74A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	77,910,201 - 77,954,840 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	77,126,708 - 77,171,046 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	57,379,637 - 57,423,906 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	76,585,575 - 76,629,198 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	76,585,575 - 76,629,198 (+)	Ensembl			panPan2	panpan1.1

LRRC74A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	49,697,033 - 49,731,532 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	49,685,784 - 49,731,532 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	49,385,321 - 49,419,847 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	49,928,277 - 49,965,274 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	49,917,001 - 49,965,274 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	49,593,855 - 49,628,352 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	49,616,845 - 49,651,343 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	50,014,982 - 50,049,537 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lrrc74a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	26,312,984 - 26,343,246 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	5,726,114 - 5,753,107 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936488	5,725,898 - 5,753,862 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRC74A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	99,974,275 - 100,002,655 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	99,974,552 - 100,002,655 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	106,005,340 - 106,036,240 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRRC74A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	54,090,696 - 54,130,968 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	54,090,494 - 54,131,628 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666053	42,289,699 - 42,333,659 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrc74a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	24,973,091 - 25,000,273 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624734	24,970,216 - 25,007,824 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lrrc74a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	100,825,028 - 100,855,146 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lrrc74a
312 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	71278722	116278722	Rat
2293088	Iddm28	Insulin dependent diabetes mellitus QTL 28	5.21		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	68767270	135411972	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	88019181	136741135	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	93560258	136550638	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	90871046	135871046	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	98944780	143944780	Rat
71111	Iddm8	Insulin dependent diabetes mellitus QTL 8	1.9	0.002	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	6	110921244	147156653	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	100704576	136029228	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	79198463	144254945	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	106095977	147156653	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	46050607	116278722	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	93778632	138778632	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	84490437	129490437	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	90871046	135871046	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	93560258	136550638	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	101593607	138161926	Rat
1576302	Schws4	Schwannoma susceptibility QTL 4		0.0078	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	78204640	123204640	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	93560258	136550638	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	76937178	121937178	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	99437079	125323237	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	86494122	112380234	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	101593607	146593607	Rat
1331722	Thshl1	Thyroid stimulating hormone level QTL 1	11.7	0.0001	blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	6	99708426	112483760	Rat

Markers in Region

D6Got142

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	106,409,980 - 106,410,139 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	110,770,691 - 110,770,849	NCBI	Rnor6.0
Rnor_5.0	6	120,066,157 - 120,066,315	UniSTS	Rnor5.0
RGSC_v3.4	6	110,886,444 - 110,886,603	RGD	RGSC3.4
RGSC_v3.4	6	110,886,445 - 110,886,603	UniSTS	RGSC3.4
Celera	6	104,231,631 - 104,231,789	UniSTS
RGSC_v3.1	6	110,889,976 - 110,890,134	RGD
RH 3.4 Map	6	742.8	UniSTS
RH 3.4 Map	6	742.8	RGD
RH 2.0 Map	6	988.6	RGD
Cytogenetic Map	6	q31	UniSTS

RH131642

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	103,885,682 - 103,885,890 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	110,708,907 - 110,709,114	NCBI	Rnor6.0
Rnor_5.0	6	120,004,673 - 120,004,880	UniSTS	Rnor5.0
RGSC_v3.4	6	108,302,614 - 108,302,821	UniSTS	RGSC3.4
Celera	6	101,714,849 - 101,715,056	UniSTS
RH 3.4 Map	6	741.6	UniSTS
Cytogenetic Map	6	q31	UniSTS

RH142982

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	103,855,192 - 103,855,337 (+)	MAPPER	mRatBN7.2
mRatBN7.2	6	103,855,192 - 103,855,337 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	110,739,229 - 110,739,373	NCBI	Rnor6.0
Rnor_6.0	6	107,704,168 - 107,704,312	NCBI	Rnor6.0
Rnor_5.0	6	120,034,695 - 120,034,839	UniSTS	Rnor5.0
RGSC_v3.4	6	108,271,384 - 108,271,528	UniSTS	RGSC3.4
Celera	6	101,684,127 - 101,684,271	UniSTS
RH 3.4 Map	6	733.1	UniSTS
Cytogenetic Map	6	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	4	7	43	32	30	15	9	15	6	77	34	5	27	16	50	15	4	4

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001037783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098927	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC127444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR475527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000078206

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	110,696,575 - 110,697,927 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084348 ⟹ ENSRNOP00000069836

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	112,118,376 - 112,148,068 (+)	Ensembl
mRatBN7.2 Ensembl	6	106,387,424 - 106,416,193 (+)	Ensembl
Rnor_6.0 Ensembl	6	110,749,705 - 110,776,775 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098897 ⟹ ENSRNOP00000086029

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	112,117,241 - 112,148,068 (+)	Ensembl
mRatBN7.2 Ensembl	6	106,386,347 - 106,416,193 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118016 ⟹ ENSRNOP00000085143

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	112,117,265 - 112,147,151 (+)	Ensembl
mRatBN7.2 Ensembl	6	106,386,351 - 106,416,192 (+)	Ensembl

RefSeq Acc Id:

NM_001037783 ⟹ NP_001032872

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,117,299 - 112,147,152 (+)	NCBI
mRatBN7.2	6	106,386,347 - 106,416,193 (+)	NCBI
Rnor_6.0	6	110,681,551 - 110,776,904 (+)	NCBI
Rnor_5.0	6	119,978,629 - 120,072,131 (+)	NCBI
RGSC_v3.4	6	110,862,558 - 110,892,572 (+)	RGD
Celera	6	104,208,223 - 104,237,842 (+)	NCBI

Sequence:

show sequence

CCGATGAGCCCCAGGCCTAGCTGGTGACAAATCCATACATGCCGGATTCCCATCAAAGCCGGCT
CTCCTCCAAGCTTGCTGGGATGAAAAAATAGCTACAGATTCCCTTGGGATTCACCCTCAAGAGA
ACAGTGCACATAGTTTGAAACAGAGCCTAATGGACAGGTGTGCACCTTAGGGAAGCAGCTACCA
GGGGACAAGAAGCTGTCACCAGCCCCCAAGGGAGTCCTGGCAGCATGGACGACGACGATATTGA
GCCTCTTGAGTACGAGACCAAAGATGAAACTGAAGCTGCCTTGGCACCTCAGAGCAGCGAAGAC
ACCCTCTACTGTGAGGCTGAAGCCGCTCCAAGTGTTGAGAAAGAGAAACCTACCAGGGAGGATT
CGGAGACAGACCTGGAAATTGAAGACACAGAGAAATTCTTCAGCATCGGACAGAAGGAGCTGTA
CTTGGAGGCCTGCAAACTGGTGGGTGTGGTCCCTGTCTCCTACTTCATCCGGAACATGGAGGAG
TCCTGCATGAACCTCAACCACCATGGTCTGGGCCCCATGGGTATCAAAGCCATTGCTATAACTC
TGGTGTCCAACACCACGGTCCTCAAACTGGAGCTGGAAGACAACTCCATCCAGGAGGAGGGCAT
CCTGAGTCTGATGGAGATGCTGCATGAGAACTACTACCTACAGGAGCTAAATGTGTCTGACAAT
AACCTTGGTTTGGAAGGAGCCAGGATCATCTCGGACTTCCTCCAGGAGAATAACTCATCGCTCT
GGAAACTGAAACTCTCAGGAAACAAATTCAAGGAAGAATGTGCCTTACTTTTATGCCAAGCCTT
GTCGTCCAATTACCGAATCAGGTCACTGAATCTCAGCCACAACGAGTTCTCTGACACTGCAGGG
GAGTACCTGGGACAGATGCTGGCCCTCAACGTAGGGCTCCAGTCACTGAACCTGAGCTGGAATC
ATTTCAATGTTCGTGGAGCTGTGGCCCTGTGTAATGGTCTCCGGACTAATGTGACCCTGAAGAA
ACTGGACGTATCCATGAATGGCTTTGGGAATGATGGTGCCTTGGCCCTGGGAGATACCCTCAAG
CTCAACAGCTGTCTGGTCTACGTGGATGTCAGTAGAAATGGCATCACCAATGAGGGGGCCTCCA
GGATCAGCAAGGGCCTAGAAAATAATGAGTGTCTCCAAGTGCTGAAGCTTTTCCTGAACCCTGT
GAGCTTGGAGGGGGCATATTCCCTTATCTTGGCGATCAAGAGGAACCCCAAATCCAGGATGGAA
GACCTTGACATTTCTAACGTACTGGTTTCAGAGCAGTTCGTCAAAGTCTTGGATGGAGTCTGTG
CCATTCACCCTCAGTTAGATGTGGTATACAAGGGATTGCAGGGTCTCTCCACCAAGAAAACCGT
CTCCCTGGAGACCAACCCCATAAAGCTGATCCAGAACTATACAGACCAAAACAAGATCTCAGTA
GTGGAGTTCTTCAAGAGCTTGAATCCTTCTGGATTAATGACCATGCCTGTGGGAGACTTCCGGA
AAGCCATAATCCAGCAAACCAATATTCCCATCAACCGGTACCAGGCGAGGGAGCTGATAAAGAA
GCTGGAAGAGAAGAATGGTATGGTTAACTTCAGTGGTTTTAAAAGCCTGAAAGTCACAGCAGCT
GGTCAGCTCTGAAGAGAAGTGCCAATAAAAGAAGTCCTGGCAAGTCGTGTGGCTCTGAGGAGAC
TAAGCCAAAGGCCAGATGGAAAGATACCACGACCAGAGCTAAGTGTGAGCAAATAAAATCTGGC
TTGATTCTGGGCAAAA

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RefSeq Acc Id:

XM_039112313 ⟹ XP_038968241

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,117,226 - 112,147,041 (+)	NCBI
mRatBN7.2	6	106,386,279 - 106,416,193 (+)	NCBI

RefSeq Acc Id:

XM_039112314 ⟹ XP_038968242

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,117,226 - 112,147,152 (+)	NCBI
mRatBN7.2	6	106,386,278 - 106,417,112 (+)	NCBI

RefSeq Acc Id:

XM_039112315 ⟹ XP_038968243

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,117,226 - 112,147,152 (+)	NCBI
mRatBN7.2	6	106,386,278 - 106,417,112 (+)	NCBI

RefSeq Acc Id:

XM_039112316 ⟹ XP_038968244

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,117,226 - 112,142,600 (+)	NCBI
mRatBN7.2	6	106,386,276 - 106,411,593 (+)	NCBI

RefSeq Acc Id:

XM_039112317 ⟹ XP_038968245

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,123,039 - 112,147,152 (+)	NCBI
mRatBN7.2	6	106,392,087 - 106,417,112 (+)	NCBI

RefSeq Acc Id:

XM_039112318 ⟹ XP_038968246

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,117,226 - 112,142,600 (+)	NCBI
mRatBN7.2	6	106,386,278 - 106,411,593 (+)	NCBI

RefSeq Acc Id:

XM_039112319 ⟹ XP_038968247

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,117,226 - 112,134,450 (+)	NCBI
mRatBN7.2	6	106,386,277 - 106,403,495 (+)	NCBI

RefSeq Acc Id:

XM_039112325 ⟹ XP_038968253

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,117,226 - 112,133,183 (+)	NCBI
mRatBN7.2	6	106,386,277 - 106,402,226 (+)	NCBI

RefSeq Acc Id:

XM_063261945 ⟹ XP_063118015

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,117,226 - 112,134,414 (+)	NCBI

RefSeq Acc Id:

XM_063261946 ⟹ XP_063118016

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,117,226 - 112,134,406 (+)	NCBI

RefSeq Acc Id:

XM_063261947 ⟹ XP_063118017

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	112,117,226 - 112,134,346 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001032872	(Get FASTA)	NCBI Sequence Viewer
	XP_038968241	(Get FASTA)	NCBI Sequence Viewer
	XP_038968242	(Get FASTA)	NCBI Sequence Viewer
	XP_038968243	(Get FASTA)	NCBI Sequence Viewer
	XP_038968244	(Get FASTA)	NCBI Sequence Viewer
	XP_038968245	(Get FASTA)	NCBI Sequence Viewer
	XP_038968246	(Get FASTA)	NCBI Sequence Viewer
	XP_038968247	(Get FASTA)	NCBI Sequence Viewer
	XP_038968253	(Get FASTA)	NCBI Sequence Viewer
	XP_063118015	(Get FASTA)	NCBI Sequence Viewer
	XP_063118016	(Get FASTA)	NCBI Sequence Viewer
	XP_063118017	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A0JPI9	(Get FASTA)	NCBI Sequence Viewer
	AAI27445	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000085143
	ENSRNOP00000086029
	ENSRNOP00000086029.1

RefSeq Acc Id:

NP_001032872 ⟸ NM_001037783

- UniProtKB:

Q4KLZ5 (UniProtKB/Swiss-Prot), A0JPI9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MDDDDIEPLEYETKDETEAALAPQSSEDTLYCEAEAAPSVEKEKPTREDSETDLEIEDTEKFFS
IGQKELYLEACKLVGVVPVSYFIRNMEESCMNLNHHGLGPMGIKAIAITLVSNTTVLKLELEDN
SIQEEGILSLMEMLHENYYLQELNVSDNNLGLEGARIISDFLQENNSSLWKLKLSGNKFKEECA
LLLCQALSSNYRIRSLNLSHNEFSDTAGEYLGQMLALNVGLQSLNLSWNHFNVRGAVALCNGLR
TNVTLKKLDVSMNGFGNDGALALGDTLKLNSCLVYVDVSRNGITNEGASRISKGLENNECLQVL
KLFLNPVSLEGAYSLILAIKRNPKSRMEDLDISNVLVSEQFVKVLDGVCAIHPQLDVVYKGLQG
LSTKKTVSLETNPIKLIQNYTDQNKISVVEFFKSLNPSGLMTMPVGDFRKAIIQQTNIPINRYQ
ARELIKKLEEKNGMVNFSGFKSLKVTAAGQL

hide sequence

Ensembl Acc Id:

ENSRNOP00000069836 ⟸ ENSRNOT00000084348

RefSeq Acc Id:	XP_038968244 ⟸ XM_039112316
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038968247 ⟸ XM_039112319
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_038968253 ⟸ XM_039112325
- Peptide Label:	isoform X9

RefSeq Acc Id:	XP_038968243 ⟸ XM_039112315
- Peptide Label:	isoform X3
- UniProtKB:	A0A0G2JWD4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968242 ⟸ XM_039112314
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038968246 ⟸ XM_039112318
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038968241 ⟸ XM_039112313
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A2M8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968245 ⟸ XM_039112317
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000086029 ⟸ ENSRNOT00000098897

Ensembl Acc Id:

ENSRNOP00000085143 ⟸ ENSRNOT00000118016

RefSeq Acc Id:	XP_063118015 ⟸ XM_063261945
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_063118016 ⟸ XM_063261946
- Peptide Label:	isoform X8

RefSeq Acc Id:	XP_063118017 ⟸ XM_063261947
- Peptide Label:	isoform X9

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0JPI9-F1-model_v2	AlphaFold	A0JPI9	1-479	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564488	AgrOrtholog
BioCyc Gene	G2FUF-36753	BioCyc
Ensembl Genes	ENSRNOG00000052456	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00000057343	Ensembl
Ensembl Transcript	ENSRNOT00000098897	ENTREZGENE
	ENSRNOT00000098897.1	UniProtKB/Swiss-Prot
	ENSRNOT00000118016	ENTREZGENE
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7111899	IMAGE-MGC_LOAD
	IMAGE:7135116	IMAGE-MGC_LOAD
InterPro	Leu-rich_rpt	UniProtKB/Swiss-Prot
	LRR-containing	UniProtKB/Swiss-Prot
	LRR_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:314328	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156476	IMAGE-MGC_LOAD
	MGC:93854	IMAGE-MGC_LOAD
NCBI Gene	314328	ENTREZGENE
PANTHER	LEUCINE RICH REPEAT FAMILY PROTEIN	UniProtKB/Swiss-Prot
	LEUCINE-RICH REPEAT-CONTAINING PROTEIN 74A	UniProtKB/Swiss-Prot
Pfam	LRR_6	UniProtKB/Swiss-Prot
PhenoGen	Lrrc74a	PhenoGen
RatGTEx	ENSRNOG00000052456	RatGTEx
	ENSRNOG00000057343	RatGTEx
SMART	LRR_RI	UniProtKB/Swiss-Prot
Superfamily-SCOP	RNI-like	UniProtKB/Swiss-Prot
UniProt	A0A0G2JWD4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A2M8	ENTREZGENE, UniProtKB/TrEMBL
	A0JPI9	ENTREZGENE, UniProtKB/Swiss-Prot
	Q4KLZ5	ENTREZGENE
UniProt Secondary	Q4KLZ5	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Lrrc74a	leucine rich repeat containing 74A	LOC103692680	uncharacterized LOC103692680	Data merged from RGD:9274273	737654	PROVISIONAL
2015-08-11	Lrrc74a	leucine rich repeat containing 74A	Lrrc74	leucine rich repeat containing 74	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-08-25	LOC103692680	uncharacterized LOC103692680			Symbol and Name status set to provisional	70820	PROVISIONAL
2014-03-07	Lrrc74	leucine rich repeat containing 74	LOC314328	similar to chromosome 14 open reading frame 166B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC314328	similar to chromosome 14 open reading frame 166B			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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