Tlr11 (toll-like receptor 11) - Rat Genome Database

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Pathways
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Gene: Tlr11 (toll-like receptor 11) Rattus norvegicus
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Symbol: Tlr11
Name: toll-like receptor 11
RGD ID: 1564460
Description: Predicted to enable signaling receptor activity. Predicted to be involved in inflammatory response and toll-like receptor signaling pathway. Predicted to act upstream of or within response to bacterium. Predicted to be located in membrane; PARTICIPATES IN toxoplasmosis pathway; INTERACTS WITH bisphenol A; 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog); 2,2',5,5'-tetrachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498491; RGD1564460; similar to toll-like receptor 11
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,018,987 - 26,023,426 (+)NCBIGRCr8
mRatBN7.21523,545,408 - 23,549,849 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1523,545,408 - 23,549,849 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,316,647 - 26,321,080 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,277,986 - 27,282,425 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01525,525,198 - 25,529,637 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,177,900 - 27,182,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,177,900 - 27,182,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,114,731 - 31,119,170 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,073,335 - 26,076,214 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1523,877,213 - 23,881,652 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15001781   PMID:17314314   PMID:19703144  


Genomics

Comparative Map Data
Tlr11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,018,987 - 26,023,426 (+)NCBIGRCr8
mRatBN7.21523,545,408 - 23,549,849 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1523,545,408 - 23,549,849 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,316,647 - 26,321,080 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,277,986 - 27,282,425 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01525,525,198 - 25,529,637 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,177,900 - 27,182,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,177,900 - 27,182,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,114,731 - 31,119,170 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,073,335 - 26,076,214 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1523,877,213 - 23,881,652 (+)NCBICelera
Cytogenetic Map15p14NCBI
Tlr11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391450,595,371 - 50,601,120 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1450,595,371 - 50,601,120 (+)EnsemblGRCm39 Ensembl
GRCm381450,357,914 - 50,363,663 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,357,914 - 50,363,663 (+)EnsemblGRCm38mm10GRCm38
MGSCv371450,980,177 - 50,983,338 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,282,453 - 49,285,445 (+)NCBIMGSCv36mm8
Celera1446,598,260 - 46,601,421 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.07NCBI

Variants

.
Variants in Tlr11
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:24
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000039925
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6
Low 2 1 12 4 13 4 2 6 9
Below cutoff 1 11 26 21 21 8 10 3 21 14 2 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039925   ⟹   ENSRNOP00000051449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1523,545,408 - 23,549,849 (+)Ensembl
Rnor_6.0 Ensembl1527,177,900 - 27,182,339 (+)Ensembl
RefSeq Acc Id: NM_001144779   ⟹   NP_001138251
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,018,987 - 26,023,426 (+)NCBI
mRatBN7.21523,545,408 - 23,549,849 (+)NCBI
Rnor_6.01527,177,900 - 27,182,339 (+)NCBI
Rnor_5.01531,114,731 - 31,119,170 (+)NCBI
RGSC_v3.41526,073,335 - 26,076,214 (+)RGD
Celera1523,877,213 - 23,881,652 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001138251 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACL80330 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051449
  ENSRNOP00000051449.4
Reference Protein Sequences
RefSeq Acc Id: NP_001138251   ⟸   NM_001144779
- UniProtKB: F7EMB9 (UniProtKB/TrEMBL),   B8YJH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051449   ⟸   ENSRNOT00000039925
Protein Domains
TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7EMB9-F1-model_v2 AlphaFold F7EMB9 1-932 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564460 AgrOrtholog
BioCyc Gene G2FUF-14083 BioCyc
Ensembl Genes ENSRNOG00000032368 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039925 ENTREZGENE
  ENSRNOT00000039925.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  Toll-Interleukin_rcpt UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report rno:498491 UniProtKB/TrEMBL
NCBI Gene 498491 ENTREZGENE
PANTHER MSTPROX-RELATED UniProtKB/TrEMBL
  PTHR24365 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  TIR_2 UniProtKB/TrEMBL
PhenoGen Tlr11 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032368 RatGTEx
SMART LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
UniProt B8YJH0 ENTREZGENE, UniProtKB/TrEMBL
  F7EMB9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Tlr11  toll-like receptor 11  RGD1564460_predicted  similar to toll-like receptor 11 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564460_predicted  similar to toll-like receptor 11 (predicted)  LOC498491  similar to toll-like receptor 11  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498491  similar to toll-like receptor 11      Symbol and Name status set to provisional 70820 PROVISIONAL