H3f3al3 (H3.3 histone A like 3) - Rat Genome Database

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Gene: H3f3al3 (H3.3 histone A like 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: H3f3al3
Name: H3.3 histone A like 3
RGD ID: 1564447
Description: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus; PARTICIPATES IN systemic lupus erythematosus pathway; INTERACTS WITH bisphenol A; indole-3-methanol; lead diacetate.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histone H3.3-like; histone H3.3A-like; LOC367254; RGD1564447; similar to Zgc:56193
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8949,989,995 - 49,990,754 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl949,989,547 - 49,994,630 (-)EnsemblGRCr8
mRatBN7.2942,494,007 - 42,495,112 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,494,353 - 42,494,763 (-)EnsemblmRatBN7.2
Rnor_6.0946,951,420 - 46,951,862 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,951,437 - 46,951,847 (-)Ensemblrn6Rnor6.0
Rnor_5.0946,636,544 - 46,636,954 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4939,389,043 - 39,389,453 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera940,239,960 - 40,240,402 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in H3f3al3
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:66
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000051231
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
D9Uia9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2942,495,164 - 42,495,343 (+)MAPPERmRatBN7.2
Rnor_6.0946,952,249 - 46,952,427NCBIRnor6.0
Rnor_5.0946,637,356 - 46,637,534UniSTSRnor5.0
RGSC_v3.4939,389,854 - 39,390,033RGDRGSC3.4
RGSC_v3.4939,389,855 - 39,390,033UniSTSRGSC3.4
Celera940,240,789 - 40,240,967UniSTS
RGSC_v3.1939,391,268 - 39,391,447RGD
Cytogenetic Map9q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 5 23 39 43 43 15 24 15 6 107 62 19 18 47 28

Sequence


Ensembl Acc Id: ENSRNOT00000051231   ⟹   ENSRNOP00000073598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl949,989,547 - 49,994,502 (-)Ensembl
mRatBN7.2 Ensembl942,494,353 - 42,494,763 (-)Ensembl
Rnor_6.0 Ensembl946,951,437 - 46,951,847 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123160   ⟹   ENSRNOP00000112007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl949,989,548 - 49,994,630 (-)Ensembl
RefSeq Acc Id: XM_346041   ⟹   XP_346042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,989,995 - 49,990,754 (-)NCBI
mRatBN7.2942,494,007 - 42,495,112 (-)NCBI
Rnor_6.0946,951,420 - 46,951,862 (-)NCBI
Rnor_5.0946,636,544 - 46,636,954 (-)NCBI
RGSC_v3.4939,389,043 - 39,389,453 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_346042 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073598.1
  ENSRNOP00000112007
  ENSRNOP00000112007.1
RefSeq Acc Id: XP_346042   ⟸   XM_346041
- UniProtKB: A0A0G2K5X7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073598   ⟸   ENSRNOT00000051231
Ensembl Acc Id: ENSRNOP00000112007   ⟸   ENSRNOT00000123160
Protein Domains
Histone H2A/H2B/H3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5X7-F1-model_v2 AlphaFold A0A0G2K5X7 1-136 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564447 AgrOrtholog
BioCyc Gene G2FUF-27726 BioCyc
Ensembl Genes ENSRNOG00000032108 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051231.5 UniProtKB/TrEMBL
  ENSRNOT00000123160 ENTREZGENE
  ENSRNOT00000123160.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
InterPro Histone-fold UniProtKB/TrEMBL
  Histone_H2A/H2B/H3 UniProtKB/TrEMBL
  Histone_H3/CENP-A UniProtKB/TrEMBL
KEGG Report rno:367254 UniProtKB/TrEMBL
NCBI Gene 367254 ENTREZGENE
PANTHER PTHR11426 UniProtKB/TrEMBL
Pfam Histone UniProtKB/TrEMBL
PhenoGen H3f3al3 PhenoGen
PRINTS HISTONEH3 UniProtKB/TrEMBL
PROSITE HISTONE_H3_1 UniProtKB/TrEMBL
  HISTONE_H3_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032108 RatGTEx
SMART SM00428 UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/TrEMBL
UniProt A0A0G2K5X7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 H3f3al3  H3.3 histone A like 3  RGD1564447  similar to Zgc:56193  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1564447  similar to Zgc:56193   RGD1564447_predicted  similar to Zgc:56193 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564447_predicted  similar to Zgc:56193 (predicted)  LOC367254  similar to Zgc:56193  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC367254  similar to Zgc:56193      Symbol and Name status set to provisional 70820 PROVISIONAL