Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Plekha6 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PLEKHA6 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | multiple interactions | ISO | Plekha6 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PLEKHA6 mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | increases expression | ISO | Plekha6 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of PLEKHA6 mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Estradiol results in increased expression of PLEKHA6 mRNA | CTD | PMID:19484750 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PLEKHA6 mRNA | CTD | PMID:32145629 | 17beta-estradiol | multiple interactions | ISO | PLEKHA6 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of PLEKHA6 mRNA | CTD | PMID:30165855 | 17beta-estradiol | increases expression | ISO | Plekha6 (Mus musculus) | 6480464 | Estradiol results in increased expression of PLEKHA6 mRNA | CTD | PMID:19484750 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Plekha6 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Plekha6 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:36804509 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLEKHA6 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Plekha6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLEKHA6 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PLEKHA6 mRNA | CTD | PMID:21215274 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of PLEKHA6 mRNA | CTD | PMID:21346803 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:32119087 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Plekha6 (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of PLEKHA6 mRNA | CTD | PMID:25172293 | 3-methylcholanthrene | multiple interactions | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to PLEKHA6 promoter] | CTD | PMID:20348232 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Plekha6 (Mus musculus) | 6480464 | bisphenol S affects the methylation of PLEKHA6 gene | CTD | PMID:31683443 | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of PLEKHA6 mRNA | CTD | PMID:21346803 | 4-hydroxyphenyl retinamide | increases expression | ISO | Plekha6 (Mus musculus) | 6480464 | Fenretinide results in increased expression of PLEKHA6 mRNA | CTD | PMID:28973697 | all-trans-retinoic acid | increases expression | ISO | Plekha6 (Mus musculus) | 6480464 | Tretinoin results in increased expression of PLEKHA6 mRNA | CTD | PMID:16788091 | all-trans-retinoic acid | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of PLEKHA6 mRNA | CTD | PMID:21934132 and PMID:23724009 | aristolochic acid A | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of PLEKHA6 mRNA | CTD | PMID:33212167 | arsane | multiple interactions | ISO | PLEKHA6 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of PLEKHA6 mRNA | CTD | PMID:32525701 | arsane | affects methylation | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PLEKHA6 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PLEKHA6 gene | CTD | PMID:25304211 | arsenic atom | multiple interactions | ISO | PLEKHA6 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of PLEKHA6 mRNA | CTD | PMID:32525701 | arsenite(3-) | multiple interactions | ISO | PLEKHA6 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PLEKHA6 mRNA] | CTD | PMID:32406909 | arsenous acid | decreases response to substance | ISO | PLEKHA6 (Homo sapiens) | 6480464 | PLEKHA6 protein results in decreased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | atrazine | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of PLEKHA6 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases expression | ISO | Plekha6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of PLEKHA6 mRNA | CTD | PMID:21569818 and PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PLEKHA6 5' UTR and Benzo(a)pyrene affects the methylation of PLEKHA6 promoter | CTD | PMID:27901495 | bisphenol A | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PLEKHA6 mRNA | CTD | PMID:22576693 | bisphenol A | increases expression | ISO | Plekha6 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PLEKHA6 mRNA | CTD | PMID:32156529 and PMID:34585602 | bisphenol A | decreases methylation | ISO | Plekha6 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of PLEKHA6 promoter | CTD | PMID:27312807 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PLEKHA6 mRNA | CTD | PMID:25181051 and PMID:32145629 | bisphenol A | increases methylation | ISO | PLEKHA6 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of PLEKHA6 gene | CTD | PMID:22576693 | buta-1,3-diene | decreases expression | ISO | Plekha6 (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of PLEKHA6 mRNA | CTD | PMID:29038090 | butanal | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of PLEKHA6 mRNA | CTD | PMID:26079696 | caffeine | affects phosphorylation | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of PLEKHA6 protein | CTD | PMID:35688186 | calcitriol | multiple interactions | ISO | PLEKHA6 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PLEKHA6 mRNA | CTD | PMID:21592394 | calcitriol | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of PLEKHA6 mRNA | CTD | PMID:21592394 and PMID:26485663 | carbamazepine | affects expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of PLEKHA6 mRNA | CTD | PMID:25979313 | carbon nanotube | decreases expression | ISO | Plekha6 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of PLEKHA6 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | PLEKHA6 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PLEKHA6 gene] | CTD | PMID:28238834 | chloroprene | decreases expression | ISO | Plekha6 (Mus musculus) | 6480464 | Chloroprene results in decreased expression of PLEKHA6 mRNA | CTD | PMID:23125180 | cisplatin | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of PLEKHA6 mRNA | CTD | PMID:27392435 | copper(II) sulfate | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PLEKHA6 mRNA | CTD | PMID:19549813 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of PLEKHA6 mRNA | CTD | PMID:26577399 | cyclosporin A | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PLEKHA6 mRNA | CTD | PMID:25562108 | deoxynivalenol | affects phosphorylation | ISO | Plekha6 (Mus musculus) | 6480464 | deoxynivalenol affects the phosphorylation of PLEKHA6 protein | CTD | PMID:23811945 | diarsenic trioxide | decreases response to substance | ISO | PLEKHA6 (Homo sapiens) | 6480464 | PLEKHA6 protein results in decreased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of PLEKHA6 mRNA | CTD | PMID:21266533 | dicrotophos | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of PLEKHA6 mRNA | CTD | PMID:28302478 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PLEKHA6 mRNA | CTD | PMID:25152437 | epoxiconazole | decreases expression | ISO | Plekha6 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of PLEKHA6 mRNA | CTD | PMID:35436446 | ethanol | affects splicing | ISO | Plekha6 (Mus musculus) | 6480464 | Ethanol affects the splicing of PLEKHA6 mRNA | CTD | PMID:30319688 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of PLEKHA6 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Plekha6 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PLEKHA6 mRNA] | CTD | PMID:22206623 | hydrogen peroxide | affects expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of PLEKHA6 mRNA | CTD | PMID:20044591 and PMID:21179406 | inulin | multiple interactions | ISO | Plekha6 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of PLEKHA6 mRNA | CTD | PMID:36331819 | lithium chloride | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Lithium Chloride results in decreased expression of PLEKHA6 mRNA | CTD | PMID:23527032 | menadione | affects expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of PLEKHA6 mRNA | CTD | PMID:20044591 | methamphetamine | increases expression | ISO | Plekha6 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of PLEKHA6 mRNA | CTD | PMID:26307267 | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | decreases expression | ISO | Plekha6 (Mus musculus) | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PLEKHA6 mRNA | CTD | PMID:25566086 | nickel atom | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Nickel results in decreased expression of PLEKHA6 mRNA | CTD | PMID:25583101 | ozone | multiple interactions | ISO | Plekha6 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of PLEKHA6 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of PLEKHA6 mRNA | CTD | PMID:34911549 | paracetamol | affects expression | ISO | Plekha6 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PLEKHA6 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PLEKHA6 mRNA | CTD | PMID:29067470 | paracetamol | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PLEKHA6 mRNA | CTD | PMID:22230336 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of PLEKHA6 mRNA | CTD | PMID:32680482 | PCB138 | multiple interactions | ISO | Plekha6 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Plekha6 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PLEKHA6 mRNA and [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of PLEKHA6 mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | Plekha6 (Mus musculus) | 6480464 | Phenobarbital affects the expression of PLEKHA6 mRNA | CTD | PMID:23091169 | propanal | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | propionaldehyde results in decreased expression of PLEKHA6 mRNA | CTD | PMID:26079696 | quercetin | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Quercetin results in increased expression of PLEKHA6 mRNA | CTD | PMID:21632981 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of PLEKHA6 mRNA | CTD | PMID:33725128 | silicon dioxide | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of PLEKHA6 mRNA | CTD | PMID:25895662 | sodium arsenate | multiple interactions | ISO | PLEKHA6 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of PLEKHA6 mRNA | CTD | PMID:32525701 | sodium arsenite | affects expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of PLEKHA6 mRNA | CTD | PMID:34032870 | sunitinib | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PLEKHA6 mRNA | CTD | PMID:31533062 | testosterone | multiple interactions | ISO | PLEKHA6 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PLEKHA6 mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | Plekha6 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of PLEKHA6 mRNA | CTD | PMID:33848595 | testosterone | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Testosterone results in increased expression of PLEKHA6 mRNA | CTD | PMID:21592394 | tetrachloromethane | decreases expression | ISO | Plekha6 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of PLEKHA6 mRNA | CTD | PMID:31919559 | Theaflavin 3,3'-digallate | affects expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | theaflavin-3 and 3'-digallate affects the expression of PLEKHA6 mRNA | CTD | PMID:34925699 | thimerosal | decreases expression | ISO | Plekha6 (Mus musculus) | 6480464 | Thimerosal results in decreased expression of PLEKHA6 mRNA | CTD | PMID:24675092 | titanium dioxide | decreases expression | ISO | Plekha6 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PLEKHA6 mRNA | CTD | PMID:27760801 | titanium dioxide | increases expression | ISO | Plekha6 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of PLEKHA6 mRNA | CTD | PMID:29264374 | triclosan | increases methylation | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Triclosan results in increased methylation of PLEKHA6 gene | CTD | PMID:34523531 | trimellitic anhydride | decreases expression | ISO | Plekha6 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of PLEKHA6 mRNA | CTD | PMID:19042947 | valproic acid | increases methylation | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of PLEKHA6 gene | CTD | PMID:29154799 | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of PLEKHA6 mRNA | CTD | PMID:29427782 | valproic acid | increases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PLEKHA6 mRNA | CTD | PMID:28001369 | vorinostat | decreases expression | ISO | PLEKHA6 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of PLEKHA6 mRNA | CTD | PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
Welcome {{ username}}
Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{gene.symbol}}: {{ gene.description }}
|
| You must be logged in to use this feature |
| {{ loginError }} |
|
|
Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
 Gviewer (Genome Viewer) unavailable |
 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
GViewer (Genome Viewer) |
Variant Visualizer (Damaging Variants) |
 Gene Annotator (Annotation Comparison) unavailable |
 OLGA (Gene List Generator) unavailable |
 |
Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
 GOLF (Gene-Ortholog Location Finder) unavailable |
|
MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
|
||||||||||
Gene Ontology Annotations Click to see Annotation Detail View
Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
Click to see Annotation Detail View
|
|
Gene-Chemical Interaction Annotations
Click to see Annotation Detail View
Gene Ontology Annotations
Click to see Annotation Detail View
Phenotype Annotations
Click to see Annotation Detail View
References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Congenic mapping and sequence analysis of the Renin locus. | Flister MJ, etal., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4. |
| 2. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 3. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Genomics
Comparative Map Data
| Plekha6 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PLEKHA6 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Plekha6 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Plekha6 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PLEKHA6 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PLEKHA6 (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Plekha6 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PLEKHA6 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PLEKHA6 (Chlorocebus sabaeus - green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Plekha6 (Heterocephalus glaber - naked mole-rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Variants
.
Variants in Plekha6
739 total Variants 
|
