Dok6 (docking protein 6) - Rat Genome Database

Name: Dok6
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Dok6 (docking protein 6) Rattus norvegicus

Analyze

Symbol:

Dok6

Name:

docking protein 6

RGD ID:

1564376

Description:

Predicted to be involved in Ras protein signal transduction; positive regulation of MAPK cascade; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. Orthologous to human DOK6 (docking protein 6); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC498898; RGD1564376; similar to docking protein 5-like

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DOK6 (docking protein 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Dok6 (docking protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dok6 (docking protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DOK6 (docking protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DOK6 (docking protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dok6 (docking protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DOK6 (docking protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DOK6 (docking protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dok6 (docking protein 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DOK5 (docking protein 5)	HGNC	OrthoDB
Homo sapiens (human):	STMN4 (stathmin 4)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DOK6 (docking protein 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dok6 (docking protein 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dok6 (docking protein 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	84,847,491 - 85,290,647 (-)	NCBI		GRCr8
mRatBN7.2	18	82,572,762 - 83,015,951 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	82,572,762 - 83,015,951 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	84,628,290 - 85,080,040 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	85,301,509 - 85,753,259 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	83,176,734 - 83,625,187 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	86,420,361 - 86,878,142 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	86,420,361 - 86,878,142 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	85,459,997 - 85,911,591 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	86,187,885 - 86,659,098 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	18	81,122,464 - 81,565,298 (-)	NCBI		Celera
Cytogenetic Map	18	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 18q deletion syndrome (ISO)

genetic disease (ISO)

intellectual disability (ISO)

intestinal volvulus (ISO)

Neurodevelopmental Disorders (ISO)

pulmonary valve stenosis (ISO)

Volvulus Of Midgut (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

fulvestrant (ISO)

gentamycin (EXP)

irinotecan (ISO)

lead(0) (ISO)

leflunomide (ISO)

methotrexate (ISO)

methoxychlor (EXP)

paracetamol (ISO)

paraquat (EXP)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

quercetin (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

testosterone (EXP,ISO)

trichloroethene (EXP)

triclosan (ISO)

valproic acid (EXP,ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor protein tyrosine kinase signaling pathway (IBA)

positive regulation of MAPK cascade (IBA)

Ras protein signal transduction (IBA)

Cellular Component

cytoplasm (IBA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:20078947

Genomics

Comparative Map Data

Dok6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	84,847,491 - 85,290,647 (-)	NCBI		GRCr8
mRatBN7.2	18	82,572,762 - 83,015,951 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	82,572,762 - 83,015,951 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	84,628,290 - 85,080,040 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	85,301,509 - 85,753,259 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	83,176,734 - 83,625,187 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	86,420,361 - 86,878,142 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	86,420,361 - 86,878,142 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	85,459,997 - 85,911,591 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	86,187,885 - 86,659,098 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	18	81,122,464 - 81,565,298 (-)	NCBI		Celera
Cytogenetic Map	18	q13	NCBI

DOK6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	69,400,888 - 69,849,087 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	69,400,888 - 69,849,087 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	67,068,124 - 67,516,323 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	65,219,271 - 65,660,373 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	65,219,270 - 65,660,357	NCBI
Celera	18	63,915,922 - 64,363,842 (+)	NCBI		Celera
Cytogenetic Map	18	q22.2	NCBI
HuRef	18	63,951,465 - 64,234,898 (+)	NCBI		HuRef
CHM1_1	18	67,063,839 - 67,511,610 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	69,617,516 - 70,065,867 (+)	NCBI		T2T-CHM13v2.0

Dok6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	89,310,547 - 89,787,664 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	89,310,548 - 89,787,652 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	89,292,423 - 89,769,540 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	89,292,424 - 89,769,528 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	89,470,527 - 89,938,528 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	89,435,328 - 89,903,334 (-)	NCBI		MGSCv36	mm8
Celera	18	91,029,062 - 91,494,197 (-)	NCBI		Celera
Cytogenetic Map	18	E4	NCBI
cM Map	18	59.05	NCBI

Dok6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	53,029,420 - 53,448,138 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	53,029,311 - 53,454,223 (+)	NCBI	ChiLan1.0	ChiLan1.0

DOK6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	86,936,668 - 87,379,921 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	72,629,500 - 73,071,207 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	62,785,687 - 63,227,505 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	66,234,257 - 66,519,934 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	66,236,817 - 66,512,229 (+)	Ensembl	panpan1.1		panPan2

DOK6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	8,446,332 - 8,707,600 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	8,453,714 - 8,707,173 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	9,456,930 - 9,825,124 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	8,276,623 - 8,645,420 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	8,276,642 - 8,646,172 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	8,297,671 - 8,665,954 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	8,257,939 - 8,626,876 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	8,468,505 - 8,837,239 (-)	NCBI		UU_Cfam_GSD_1.0

Dok6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	22,200,289 - 22,370,694 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936781	56,078 - 218,115 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936781	55,643 - 217,946 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DOK6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	152,997,319 - 153,393,418 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	152,990,887 - 153,393,432 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	169,782,518 - 170,053,245 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DOK6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	9,917,538 - 10,348,944 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666060	15,455,137 - 15,887,186 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dok6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624840	109,066 - 500,400 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624840	108,761 - 500,280 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dok6
2650 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	120
Count of miRNA genes:	93
Interacting mature miRNAs:	105
Transcripts:	ENSRNOT00000058139
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31359408	83218561	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	38192455	83192455	Rat
1598826	Anxrr20	Anxiety related response QTL 20	3.04		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	18	41432971	83828827	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	43345022	83828827	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	46640675	83828827	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	46640675	83828827	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	46640675	83828827	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	48520044	83828827	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	48520044	83828827	Rat
738008	Hcar14	Hepatocarcinoma resistance QTL 14	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion number (CMO:0001462)	18	51464733	83218561	Rat
1298072	Cia26	Collagen induced arthritis QTL 26	3.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	54709769	83828827	Rat
724542	Kidm2	Kidney mass QTL 2	2.6		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	18	59172115	83828827	Rat
6903353	Bp353	Blood pressure QTL 353	2.8		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	59796478	83828827	Rat
6903356	Bp354	Blood pressure QTL 354	4.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	59796478	83828827	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									56
Low		2	16		16		3	3	18	23	25	8	3
Below cutoff	2	29	8	8	3	8	5	5		10	16	3	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000058139 ⟹ ENSRNOP00000054944

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	82,572,762 - 83,015,951 (-)	Ensembl
Rnor_6.0 Ensembl	18	86,420,361 - 86,878,142 (-)	Ensembl

RefSeq Acc Id:

NM_001191943 ⟹ NP_001178872

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	84,847,491 - 85,290,647 (-)	NCBI
mRatBN7.2	18	82,572,762 - 83,015,951 (-)	NCBI
Rnor_6.0	18	86,420,361 - 86,878,142 (-)	NCBI
Rnor_5.0	18	85,459,997 - 85,911,591 (-)	NCBI
Celera	18	81,122,464 - 81,565,298 (-)	NCBI

Sequence:

show sequence

TCCGGGGAGCGGATCGCCCAGCAGAGGAGCCCGACCGCGCTGGCCATGGCCTCCAACTTTAACG
ACATAGTCAAGCAGGGATACGTGAAAATCCGCAGCAGGAAGCTCGGGATATTCAGACGATGCTG
GTTAGTTTTTAAGAAGGCTTCTAGCAAGGGACCCAGAAGGCTAGAAAAGTTTCCAGATGAAAAG
GCAGCTTATTTCAGAAACTTTCACAAGGTAACTGAACTGCACAACATCAAAAATATAACCAGGC
TGCCTCGAGAGACAAAGAAGCATGCAGTGGCAATTATCTTTCATGACGAAACGTCAAAGACATT
TGCTTGTGAGTCAGAGCTGGAGGCTGAGGAATGGTGCAAACATCTTTGCATGGAATGCCTGGGG
ACAAGGCTGAATGACATCAGCCTAGGGGAGCCTGACCTGCTGGCAGCTGGTGTGCAGCGGGAAC
AGAATGAACGATTCAATGTTTATCTTATGCCTACACCCAACCTTGATATTTATGGTGAATGCAC
AATGCAGATCACTCATGAGAATATCTATCTCTGGGATATCCACAATGCCAAGGTCAAGCTGGTG
ATGTGGCCTCTTAGCTCACTGAGGAGATATGGTCGGGATTCAACTTGGTTCACCTTCGAGTCAG
GAAGAATGTGTGACACAGGAGAAGGACTATTCACTTTTCAAACAAGGGAAGGAGAAATGATCTA
TCAGAAGGTCCACTCTGCAACACTGGCTATCGCTGAGCAACACGAAAGACTAATGCTAGAAATG
GAGCAGAAAGCCCGGCTTCAGACAAGCTTGACTGAACCAATGACGTTATCGAAATCCATCTCTC
TTCCTCGCAGTGCATACTGGCATCACATTACACGTCAGAACAGCGTTGGAGAAATCTACAGCTT
GCAAGGTCATGGGTTTGGTTCATCAAAGATGTCCAGGGCACAGACATTTCCCAGCTATGCTCCA
GAACAGAGTGAAGAGGCTCAGCCACCGTTGTCACGGTCCAGCAGCTATGGATTCAGCTATAGCT
CCAGCCTCATTCAATGACACACAGAGGCCACCAATGACCAGCAAGACAGTCTACCCTGGACCTG
CCATGGGGTCATTTCGCCCTATGCTTCCTGGAAGACCAATTGCAGTACAATTTAACATTGGTAG
GGCATAGCCCCAACTAGAAGGTTAAAAACTGGAGTTCTGCTTCCTTGATTCAGTGGTTAAGTCC
TTTATTTATTGAATTTCTATGGGGGAAAAATCTATGTTTTACAAAAAATAGAATCCAATAATAT
GAACACTCATCTAAATAAGAAAAATTCTTTGTGTCTGACATTAGCAGAAGTTTTGGTACTGGGA
AATTTTCCACTCCAGTTTGAGCCTGGGTGGCACTGACATTTGTCCTTAAGGTTAGGTGCTTTTG
TTTGAACATAGGGCCTGACTTTAAACATATGATGACC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001178872	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL75158	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000054944
	ENSRNOP00000054944.3

RefSeq Acc Id:

NP_001178872 ⟸ NM_001191943

- UniProtKB:

F1M038 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHN
IKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLA
AGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDST
WFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMT
LSKSISLPRSAYWHHITRQNSVGEIYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQPPLSRSSS
YGFSYSSSLIQ

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RefSeq Acc Id:

ENSRNOP00000054944 ⟸ ENSRNOT00000058139

Protein Domains

IRS-type PTB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M038-F1-model_v2	AlphaFold	F1M038	1-331	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700900

Promoter ID:

EPDNEW_R11423

Type:

single initiation site

Name:

Dok6_1

Description:

docking protein 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	86,878,137 - 86,878,197	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564376	AgrOrtholog
BioCyc Gene	G2FUF-6688	BioCyc
Ensembl Genes	ENSRNOG00000038190	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000058139	ENTREZGENE
	ENSRNOT00000058139.4	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
InterPro	DOK4/5/6_PH	UniProtKB/TrEMBL
	Insln_rcpt_S1	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
KEGG Report	rno:498898	UniProtKB/TrEMBL
NCBI Gene	498898	ENTREZGENE
PANTHER	DOCKING PROTEIN 6	UniProtKB/TrEMBL
	DOCKING PROTEIN RELATED	UniProtKB/TrEMBL
Pfam	IRS	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
PhenoGen	Dok6	PhenoGen
PROSITE	IRS_PTB	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000038190	RatGTEx
SMART	IRS	UniProtKB/TrEMBL
	PTBI	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
UniProt	F1M038	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Dok6	docking protein 6	RGD1564376_predicted	similar to docking protein 5-like (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1564376_predicted	similar to docking protein 5-like (predicted)	LOC498898	similar to docking protein 5-like	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498898	similar to docking protein 5-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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