Fat4 (FAT atypical cadherin 4) - Rat Genome Database

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Gene: Fat4 (FAT atypical cadherin 4) Rattus norvegicus
Analyze
Symbol: Fat4
Name: FAT atypical cadherin 4
RGD ID: 1564291
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by cadherin; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and nervous system development. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; condensed mesenchymal cell proliferation; and ossification involved in bone maturation. Predicted to be located in apical part of cell. Predicted to be active in adherens junction and plasma membrane. Human ortholog(s) of this gene implicated in Hennekam syndrome and Van Maldergem syndrome 2. Orthologous to human FAT4 (FAT atypical cadherin 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FAT tumor suppressor homolog 4; FAT tumor suppressor homolog 4 (Drosophila); LOC108348049; LOC310341; protocadherin Fat 4; protocadherin Fat 4-like; RGD1564291; similar to FAT tumor suppressor homolog 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82123,855,289 - 123,984,716 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2123,855,289 - 123,984,716 (+)EnsemblGRCr8
mRatBN7.22121,927,266 - 122,056,700 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2121,927,942 - 122,056,707 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2128,499,081 - 128,627,276 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02126,611,655 - 126,739,826 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02121,240,615 - 121,368,809 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02125,751,818 - 125,879,398 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2126,267,658 - 126,284,238 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl2125,752,130 - 125,879,387 (+)Ensemblrn6Rnor6.0
Rnor_5.02145,349,239 - 145,477,455 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02145,864,192 - 145,880,594 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42125,847,465 - 125,975,620 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2116,853,380 - 116,981,485 (+)NCBICelera
Cytogenetic Map2q25NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
ketamine  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
melphalan  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
pentanal  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19506035   PMID:21303848   PMID:23376485   PMID:23533145   PMID:23974041   PMID:24056717   PMID:26116661  


Genomics

Comparative Map Data
Fat4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82123,855,289 - 123,984,716 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2123,855,289 - 123,984,716 (+)EnsemblGRCr8
mRatBN7.22121,927,266 - 122,056,700 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2121,927,942 - 122,056,707 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2128,499,081 - 128,627,276 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02126,611,655 - 126,739,826 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02121,240,615 - 121,368,809 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02125,751,818 - 125,879,398 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2126,267,658 - 126,284,238 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl2125,752,130 - 125,879,387 (+)Ensemblrn6Rnor6.0
Rnor_5.02145,349,239 - 145,477,455 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02145,864,192 - 145,880,594 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42125,847,465 - 125,975,620 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2116,853,380 - 116,981,485 (+)NCBICelera
Cytogenetic Map2q25NCBI
FAT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384125,314,955 - 125,492,932 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4125,314,918 - 125,492,932 (+)Ensemblhg38GRCh38
GRCh374126,236,110 - 126,414,087 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364126,457,017 - 126,632,373 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344126,672,695 - 126,770,528NCBI
Celera4123,617,849 - 123,794,372 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4121,965,923 - 122,142,399 (+)NCBIHuRef
CHM1_14126,214,142 - 126,390,638 (+)NCBICHM1_1
T2T-CHM13v2.04128,617,253 - 128,795,252 (+)NCBIT2T-CHM13v2.0
Fat4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39338,939,867 - 39,066,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl338,941,089 - 39,066,134 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38338,884,667 - 39,011,992 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl338,886,940 - 39,011,985 (+)Ensemblmm10GRCm38
MGSCv37338,785,862 - 38,910,907 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36339,078,489 - 39,203,530 (+)NCBIMGSCv36mm8
Celera338,729,877 - 38,854,312 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.72NCBI
Fat4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542815,622,498 - 15,810,896 (-)Ensembl
ChiLan1.0NW_00495542815,621,333 - 15,812,167 (-)NCBIChiLan1.0ChiLan1.0
FAT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23123,095,738 - 123,273,598 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14123,362,918 - 123,540,913 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04117,494,842 - 117,674,382 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14128,637,516 - 128,814,413 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4128,637,516 - 128,814,407 (+)EnsemblpanPan2panpan1.1
FAT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11915,157,595 - 15,332,821 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1915,158,922 - 15,332,045 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1915,363,356 - 15,537,231 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01915,259,451 - 15,431,654 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1915,259,604 - 15,430,959 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11915,223,649 - 15,398,514 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01915,500,460 - 15,675,303 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01915,965,180 - 16,139,594 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fat4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530163,414,526 - 63,583,319 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366623,537,925 - 3,690,877 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366623,537,917 - 3,704,012 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl899,148,496 - 99,310,519 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1899,141,967 - 99,312,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28105,998,766 - 106,018,349 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1772,498,182 - 72,686,607 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl772,500,264 - 72,685,546 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603751,514,689 - 51,708,405 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fat4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247776,095,643 - 6,292,980 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247776,095,166 - 6,293,142 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fat4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13114,972,446 - 115,101,813 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fat4
566 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:589
Count of miRNA genes:266
Interacting mature miRNAs:338
Transcripts:ENSRNOT00000038703
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
D3Mit295  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22121,968,795 - 121,968,881 (+)MAPPERmRatBN7.2
Rnor_6.02125,792,028 - 125,792,113NCBIRnor6.0
Rnor_5.02145,390,197 - 145,390,282UniSTSRnor5.0
RGSC_v3.42125,887,748 - 125,887,833UniSTSRGSC3.4
Celera2116,893,663 - 116,893,748UniSTS
Cytogenetic Map2q25UniSTS
RH133227  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22122,047,969 - 122,048,189 (+)MAPPERmRatBN7.2
Rnor_6.02126,275,456 - 126,275,675NCBIRnor6.0
Rnor_6.02125,870,661 - 125,870,880NCBIRnor6.0
Rnor_5.02145,871,857 - 145,872,076UniSTSRnor5.0
Rnor_5.02145,468,718 - 145,468,937UniSTSRnor5.0
RGSC_v3.42125,966,883 - 125,967,102UniSTSRGSC3.4
Celera2116,972,748 - 116,972,967UniSTS
RH 3.4 Map2666.5UniSTS
Cytogenetic Map2q25UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 159 89 88 57 72 57 6 331 171 11 138 79 91 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000038703   ⟹   ENSRNOP00000036219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2123,855,289 - 123,984,716 (+)Ensembl
mRatBN7.2 Ensembl2121,927,942 - 122,056,707 (+)Ensembl
Rnor_6.0 Ensembl2125,752,130 - 125,879,387 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2126,267,658 - 126,284,238 (+)Ensembl
RefSeq Acc Id: NM_001415042   ⟹   NP_001401971
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82123,855,289 - 123,984,716 (+)NCBI
mRatBN7.22121,927,266 - 122,056,700 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001401971 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM01323 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036219
  ENSRNOP00000036219.8
Ensembl Acc Id: ENSRNOP00000036219   ⟸   ENSRNOT00000038703
RefSeq Acc Id: NP_001401971   ⟸   NM_001415042
- UniProtKB: D3ZEH1 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564291 AgrOrtholog
BioCyc Gene G2FUF-53274 BioCyc
Ensembl Genes ENSRNOG00000028335 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000057060 Ensembl
Ensembl Transcript ENSRNOT00000038703 ENTREZGENE
  ENSRNOT00000038703.9 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  Cadherins UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  ConA-like_subgrp UniProtKB/TrEMBL
  EGF-like_reg_CS UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_Ca-bd UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_N_dom UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
NCBI Gene 310341 ENTREZGENE
PANTHER FAT ATYPICAL CADHERIN-RELATED UniProtKB/TrEMBL
  PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  Cadherin_FAT4_N UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
PhenoGen Fat4 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028335 RatGTEx
  ENSRNOG00000057060 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
  SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
  ConA_like_lec_gl UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt D3ZEH1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fat4  FAT atypical cadherin 4  LOC108348049  protocadherin Fat 4-like  Data merged from RGD:11459080 737654 PROVISIONAL
2016-08-02 LOC108348049  protocadherin Fat 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-06-05 Fat4  FAT atypical cadherin 4  Fat4  FAT tumor suppressor homolog 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fat4  FAT tumor suppressor homolog 4 (Drosophila)  RGD1564291_predicted  similar to FAT tumor suppressor homolog 4 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564291_predicted  similar to FAT tumor suppressor homolog 4 (predicted)  LOC310341  similar to FAT tumor suppressor homolog 4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC310341  similar to FAT tumor suppressor homolog 4      Symbol and Name status set to provisional 70820 PROVISIONAL