Zdhhc11 (zDHHC palmitoyltransferase 11) - Rat Genome Database

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Gene: Zdhhc11 (zDHHC palmitoyltransferase 11) Rattus norvegicus
Analyze
Symbol: Zdhhc11
Name: zDHHC palmitoyltransferase 11 (Ensembl:zinc finger, DHHC-type containing 11)
RGD ID: 1564281
Description: Predicted to enable protein-cysteine S-palmitoyltransferase activity and signaling adaptor activity. Predicted to be involved in antiviral innate immune response; positive regulation of defense response to virus by host; and protein targeting to membrane. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to several human genes including ZDHHC11 (zinc finger DHHC-type containing 11); INTERACTS WITH bisphenol A; DDT; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DHHC-containing protein 10; LOC499000; membrane-associated DHHC11 zinc finger protein; probable palmitoyltransferase ZDHHC11; similar to DHHC-containing protein 10; Zdhhc20; zinc finger, DHHC domain containing 11; zinc finger, DHHC-type containing 11; Znf399
RGD Orthologs
Human
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,124,900 - 31,156,075 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl131,124,900 - 31,155,498 (-)EnsemblGRCr8
mRatBN7.2129,296,334 - 29,327,227 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,296,334 - 29,326,898 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx129,097,732 - 29,128,405 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,097,587 - 35,128,260 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,298,346 - 29,329,029 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0131,906,049 - 31,936,603 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,906,064 - 31,936,537 (-)Ensemblrn6Rnor6.0
Rnor_5.0133,330,626 - 33,360,881 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4130,102,541 - 30,133,646 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,947,528 - 27,976,087 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16647879   PMID:23687301   PMID:29429998  


Genomics

Comparative Map Data
Zdhhc11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,124,900 - 31,156,075 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl131,124,900 - 31,155,498 (-)EnsemblGRCr8
mRatBN7.2129,296,334 - 29,327,227 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,296,334 - 29,326,898 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx129,097,732 - 29,128,405 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,097,587 - 35,128,260 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,298,346 - 29,329,029 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0131,906,049 - 31,936,603 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,906,064 - 31,936,537 (-)Ensemblrn6Rnor6.0
Rnor_5.0133,330,626 - 33,360,881 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4130,102,541 - 30,133,646 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,947,528 - 27,976,087 (-)NCBICelera
Cytogenetic Map1p11NCBI
ZDHHC11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385795,605 - 860,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5795,605 - 858,973 (-)Ensemblhg38GRCh38
GRCh375795,720 - 851,101 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365848,722 - 904,101 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345848,721 - 904,101NCBI
Celera54,577 - 11,091 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef5779,861 - 833,985 (-)NCBIHuRef
CHM1_15795,441 - 850,829 (-)NCBICHM1_1
T2T-CHM13v2.05701,646 - 766,615 (-)NCBIT2T-CHM13v2.0
ZDHHC11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.14574,114 - 704,677 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606427,736,839 - 27,743,821 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zdhhc11
131 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:106
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000060971
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 1 11 96 21 24 10 10 10 5 69 28 87 23 51 14 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000060971   ⟹   ENSRNOP00000057691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl131,124,900 - 31,155,498 (-)Ensembl
mRatBN7.2 Ensembl129,296,334 - 29,326,898 (-)Ensembl
Rnor_6.0 Ensembl131,906,064 - 31,936,537 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117184   ⟹   ENSRNOP00000094386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl131,134,635 - 31,155,464 (-)Ensembl
mRatBN7.2 Ensembl129,306,042 - 29,326,200 (-)Ensembl
RefSeq Acc Id: NM_001039342   ⟹   NP_001034431
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,124,900 - 31,155,498 (-)NCBI
mRatBN7.2129,296,334 - 29,326,932 (-)NCBI
Rnor_6.0131,906,064 - 31,936,536 (-)NCBI
Rnor_5.0133,330,626 - 33,360,881 (-)NCBI
RGSC_v3.4130,102,541 - 30,133,646 (-)RGD
Celera127,947,528 - 27,976,087 (-)RGD
Sequence:
RefSeq Acc Id: NM_001419501   ⟹   NP_001406430
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,124,900 - 31,155,498 (-)NCBI
mRatBN7.2129,296,334 - 29,326,932 (-)NCBI
RefSeq Acc Id: XM_039086784   ⟹   XP_038942712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,124,912 - 31,156,075 (-)NCBI
mRatBN7.2129,296,366 - 29,327,227 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001034431 (Get FASTA)   NCBI Sequence Viewer  
  NP_001406430 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942712 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAX73389 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057691
  ENSRNOP00000057691.5
  ENSRNOP00000094386
  ENSRNOP00000094386.2
RefSeq Acc Id: NP_001034431   ⟸   NM_001039342
- Peptide Label: isoform 1
- UniProtKB: Q2TGJ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057691   ⟸   ENSRNOT00000060971
RefSeq Acc Id: XP_038942712   ⟸   XM_039086784
- Peptide Label: isoform X1
- UniProtKB: Q2TGJ8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094386   ⟸   ENSRNOT00000117184
RefSeq Acc Id: NP_001406430   ⟸   NM_001419501
- Peptide Label: isoform 2
- UniProtKB: F1M6X9 (UniProtKB/TrEMBL),   Q2TGJ8 (UniProtKB/TrEMBL)
Protein Domains
Palmitoyltransferase DHHC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M6X9-F1-model_v2 AlphaFold F1M6X9 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689562
Promoter ID:EPDNEW_R86
Type:single initiation site
Name:Zdhhc11_1
Description:zinc finger, DHHC-type containing 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0131,936,571 - 31,936,631EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564281 AgrOrtholog
BioCyc Gene G2FUF-61936 BioCyc
Ensembl Genes ENSRNOG00000039743 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060971 ENTREZGENE
  ENSRNOT00000060971.5 UniProtKB/TrEMBL
  ENSRNOT00000117184 ENTREZGENE
  ENSRNOT00000117184.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7453233 IMAGE-MGC_LOAD
InterPro PFA4/ZDH16/20/ERF2-like UniProtKB/TrEMBL
  Znf_DHHC_palmitoyltrfase UniProtKB/TrEMBL
MGC_CLONE MGC:125090 IMAGE-MGC_LOAD
NCBI Gene 499000 ENTREZGENE
PANTHER PALMITOYLTRANSFERASE ZDHHC11-RELATED UniProtKB/TrEMBL
  ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam zf-DHHC UniProtKB/TrEMBL
PhenoGen Zdhhc11 PhenoGen
PROSITE DHHC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039743 RatGTEx
UniProt A0A8I6ALH7_RAT UniProtKB/TrEMBL
  F1M6X9 ENTREZGENE, UniProtKB/TrEMBL
  Q2TGJ8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Zdhhc11  zDHHC palmitoyltransferase 11  Zdhhc11  zinc finger, DHHC-type containing 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Zdhhc11  zinc finger, DHHC-type containing 11  Zdhhc11  zinc finger, DHHC domain containing 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Zdhhc11  zinc finger, DHHC domain containing 11  LOC499000  similar to DHHC-containing protein 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC499000  similar to DHHC-containing protein 10      Symbol and Name status set to provisional 70820 PROVISIONAL