Zfp846 (zinc finger protein 846) - Rat Genome Database

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Gene: Zfp846 (zinc finger protein 846) Rattus norvegicus
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Symbol: Zfp846
Name: zinc finger protein 846
RGD ID: 1564241
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF846 (zinc finger protein 846); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363022; RGD1564241; similar to zinc finger protein 426; Zfp426l2; zinc finger protein 426; zinc finger protein 426-like 2; Znf426; Znf846
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,395,326 - 27,413,700 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl827,396,326 - 27,413,700 (+)EnsemblGRCr8
mRatBN7.2819,119,788 - 19,137,120 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,119,945 - 19,137,281 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,140,195 - 23,157,272 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,438,031 - 21,455,108 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,349,821 - 19,366,865 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,601,021 - 21,618,389 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,611,319 - 21,617,736 (+)Ensemblrn6Rnor6.0
Rnor_5.0821,657,181 - 21,674,450 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4819,600,202 - 19,617,244 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera820,515,377 - 20,532,419 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp846
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,395,326 - 27,413,700 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl827,396,326 - 27,413,700 (+)EnsemblGRCr8
mRatBN7.2819,119,788 - 19,137,120 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,119,945 - 19,137,281 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,140,195 - 23,157,272 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,438,031 - 21,455,108 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,349,821 - 19,366,865 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,601,021 - 21,618,389 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,611,319 - 21,617,736 (+)Ensemblrn6Rnor6.0
Rnor_5.0821,657,181 - 21,674,450 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4819,600,202 - 19,617,244 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera820,515,377 - 20,532,419 (+)NCBICelera
Cytogenetic Map8q13NCBI
ZNF846
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,748,619 - 9,786,160 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl199,751,993 - 9,793,180 (-)Ensemblhg38GRCh38
GRCh37199,859,295 - 9,896,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map19p13.2NCBI
HuRef199,448,978 - 9,460,191 (-)NCBIHuRef
CHM1_1199,867,781 - 9,879,040 (-)NCBICHM1_1
T2T-CHM13v2.0199,874,759 - 9,912,301 (-)NCBIT2T-CHM13v2.0
Zfp846
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,492,595 - 20,516,706 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,492,587 - 20,516,705 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38920,581,299 - 20,605,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,581,291 - 20,605,409 (+)Ensemblmm10GRCm38
MGSCv37920,385,772 - 20,399,637 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36920,331,927 - 20,345,598 (+)NCBIMGSCv36mm8
Celera917,858,174 - 17,872,033 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.58NCBI
ZNF699
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12051,361,483 - 51,376,795 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2051,365,371 - 51,372,232 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2051,225,027 - 51,240,327 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02051,882,745 - 51,898,058 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,882,759 - 51,894,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12051,090,255 - 51,105,557 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,515,356 - 51,526,827 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,756,557 - 51,771,188 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

Variants

.
Variants in Zfp846
147 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:58
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000068461
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
D8Got300  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,120,563 - 19,120,723 (+)MAPPERmRatBN7.2
Rnor_6.0821,601,836 - 21,601,995NCBIRnor6.0
Rnor_5.0821,657,897 - 21,658,056UniSTSRnor5.0
RGSC_v3.4819,600,691 - 19,600,850UniSTSRGSC3.4
Celera820,515,866 - 20,516,025UniSTS
Cytogenetic Map8q13UniSTS
AW526015  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,136,406 - 19,136,505 (+)MAPPERmRatBN7.2
Rnor_6.0821,617,679 - 21,617,777NCBIRnor6.0
Rnor_5.0821,673,740 - 21,673,838UniSTSRnor5.0
RGSC_v3.4819,616,534 - 19,616,632UniSTSRGSC3.4
Celera820,531,709 - 20,531,807UniSTS
RH 3.4 Map2015.8UniSTS
Cytogenetic Map8q13UniSTS
BF399279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,136,899 - 19,137,068 (+)MAPPERmRatBN7.2
Rnor_6.0821,618,172 - 21,618,340NCBIRnor6.0
Rnor_5.0821,674,233 - 21,674,401UniSTSRnor5.0
RGSC_v3.4819,617,027 - 19,617,195UniSTSRGSC3.4
Celera820,532,202 - 20,532,370UniSTS
Cytogenetic Map8q13UniSTS
RH138238  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,137,293 - 19,137,486 (+)MAPPERmRatBN7.2
Rnor_6.0821,618,566 - 21,618,758NCBIRnor6.0
Rnor_5.0821,674,627 - 21,674,819UniSTSRnor5.0
RGSC_v3.4819,617,421 - 19,617,613UniSTSRGSC3.4
Celera820,532,596 - 20,532,788UniSTS
RH 3.4 Map8177.3UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000068461   ⟹   ENSRNOP00000063156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl827,396,326 - 27,413,700 (+)Ensembl
mRatBN7.2 Ensembl819,120,181 - 19,137,117 (+)Ensembl
Rnor_6.0 Ensembl821,611,319 - 21,617,736 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108566   ⟹   ENSRNOP00000096568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,119,945 - 19,137,117 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110234   ⟹   ENSRNOP00000078184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl827,396,380 - 27,413,700 (+)Ensembl
mRatBN7.2 Ensembl819,119,972 - 19,137,281 (+)Ensembl
RefSeq Acc Id: NM_001134585   ⟹   NP_001128057
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,396,311 - 27,413,353 (+)NCBI
mRatBN7.2819,120,075 - 19,137,117 (+)NCBI
Rnor_6.0821,601,347 - 21,618,389 (+)NCBI
Rnor_5.0821,657,181 - 21,674,450 (+)NCBI
RGSC_v3.4819,600,202 - 19,617,244 (+)RGD
Celera820,515,377 - 20,532,419 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242647   ⟹   XP_006242709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,395,326 - 27,413,700 (+)NCBI
mRatBN7.2819,119,788 - 19,137,120 (+)NCBI
Rnor_6.0821,601,118 - 21,618,389 (+)NCBI
Rnor_5.0821,657,181 - 21,674,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063265726   ⟹   XP_063121796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,395,326 - 27,413,700 (+)NCBI
RefSeq Acc Id: XM_063265727   ⟹   XP_063121797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,395,326 - 27,413,352 (+)NCBI
RefSeq Acc Id: NP_001128057   ⟸   NM_001134585
- UniProtKB: A6JNJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242709   ⟸   XM_006242647
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AQ54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063156   ⟸   ENSRNOT00000068461
Ensembl Acc Id: ENSRNOP00000078184   ⟸   ENSRNOT00000110234
Ensembl Acc Id: ENSRNOP00000096568   ⟸   ENSRNOT00000108566
RefSeq Acc Id: XP_063121796   ⟸   XM_063265726
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AQ54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121797   ⟸   XM_063265727
- Peptide Label: isoform X2
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYI6-F1-model_v2 AlphaFold D3ZYI6 1-547 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564241 AgrOrtholog
BioCyc Gene G2FUF-31471 BioCyc
Ensembl Genes ENSRNOG00000020356 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068461.4 UniProtKB/TrEMBL
  ENSRNOT00000110234 ENTREZGENE
  ENSRNOT00000110234.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:363022 UniProtKB/TrEMBL
NCBI Gene 363022 ENTREZGENE
PANTHER C2H2-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ENDOTHELIAL ZINC FINGER PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 383 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-H2C2_2 UniProtKB/TrEMBL
PhenoGen Zfp846 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020356 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5Y768_RAT UniProtKB/TrEMBL
  A0A8I6AQ54 ENTREZGENE
  A6JNJ7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYI6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-27 Znf846  zinc finger protein 846  Zfp426l2  zinc finger protein 426-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-11-27 Zfp846  zinc finger protein 846  Znf846  zinc finger protein 846  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-01-21 Zfp426l2  zinc finger protein 426-like 2  RGD1564241  similar to zinc finger protein 426   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564241  similar to zinc finger protein 426   RGD1564241_predicted  similar to zinc finger protein 426 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564241_predicted  similar to zinc finger protein 426 (predicted)  LOC363022  similar to zinc finger protein 426  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363022  similar to zinc finger protein 426      Symbol and Name status set to provisional 70820 PROVISIONAL