Wdr35 (WD repeat domain 35) - Rat Genome Database

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Gene: Wdr35 (WD repeat domain 35) Rattus norvegicus
Analyze
Symbol: Wdr35
Name: WD repeat domain 35
RGD ID: 1564116
Description: Involved in several processes, including liver regeneration; negative regulation of cellular biosynthetic process; and positive regulation of release of cytochrome c from mitochondria. Predicted to be located in centrosome and ciliary basal body. Predicted to be part of intraciliary transport particle A. Predicted to be active in axoneme. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC503018; naofen; RGD1564116; similar to WD repeat domain 35; WD repeat domain 35-like; WD repeat-containing protein 35; Wdr35l
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8637,490,557 - 37,550,391 (+)NCBIGRCr8
mRatBN7.2631,771,315 - 31,831,450 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl631,771,360 - 31,831,029 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx632,063,354 - 32,123,025 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0632,379,221 - 32,438,891 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0631,853,826 - 31,913,503 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0634,094,291 - 34,152,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl634,094,306 - 34,151,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0643,875,468 - 43,932,876 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4632,522,578 - 32,523,842 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera631,219,791 - 31,278,025 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Roles of naofen, a novel WD-repeat-2 protein, in the CCl4-treated livers--a possible relationship to cell proliferation. An J, etal., Eur J Pharmacol. 2008 Jun 10;587(1-3):285-90. doi: 10.1016/j.ejphar.2008.04.022. Epub 2008 Apr 13.
2. WDR35 mutation in siblings with Sensenbrenner syndrome: a ciliopathy with variable phenotype. Bacino CA, etal., Am J Med Genet A. 2012 Nov;158A(11):2917-24. doi: 10.1002/ajmg.a.35608. Epub 2012 Sep 17.
3. Specific variants in WDR35 cause a distinctive form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium. Caparros-Martin JA, etal., Hum Mol Genet. 2015 Jul 15;24(14):4126-37. doi: 10.1093/hmg/ddv152. Epub 2015 Apr 23.
4. Naofen promotes TNF-alpha-mediated apoptosis of hepatocytes by activating caspase-3 in lipopolysaccharide-treated rats. Fan JH, etal., World J Gastroenterol. 2014 May 7;20(17):4963-71. doi: 10.3748/wjg.v20.i17.4963.
5. Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis. Feng GG, etal., Biochem Biophys Res Commun. 2010 Mar 26;394(1):153-7. doi: 10.1016/j.bbrc.2010.02.133. Epub 2010 Mar 1.
6. Role of naofen, a novel WD repeat-containing protein, in reducing nitric oxide-induced relaxation. Feng GG, etal., Clin Exp Pharmacol Physiol. 2008 Dec;35(12):1447-53. doi: 10.1111/j.1440-1681.2008.05008.x. Epub 2008 Jul 29.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Enhanced expression of naofen in kidney of streptozotocin-induced diabetic rats: possible correlation to apoptosis of tubular epithelial cells. Sato Y, etal., Clin Exp Nephrol. 2010 Jun;14(3):205-12. doi: 10.1007/s10157-010-0276-1. Epub 2010 Mar 12.
12. Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation. Tsunekawa K, etal., BMC Neurosci. 2013 Jan 7;14:4. doi: 10.1186/1471-2202-14-4.
Additional References at PubMed
PMID:20439489   PMID:20889716   PMID:21473986   PMID:27932497   PMID:29220510  


Genomics

Comparative Map Data
Wdr35
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8637,490,557 - 37,550,391 (+)NCBIGRCr8
mRatBN7.2631,771,315 - 31,831,450 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl631,771,360 - 31,831,029 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx632,063,354 - 32,123,025 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0632,379,221 - 32,438,891 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0631,853,826 - 31,913,503 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0634,094,291 - 34,152,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl634,094,306 - 34,151,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0643,875,468 - 43,932,876 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4632,522,578 - 32,523,842 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera631,219,791 - 31,278,025 (+)NCBICelera
Cytogenetic Map6q14NCBI
WDR35
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38219,910,263 - 19,990,105 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl219,910,263 - 19,990,105 (-)EnsemblGRCh38hg38GRCh38
GRCh37220,110,024 - 20,189,866 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36219,973,505 - 20,053,365 (-)NCBINCBI36Build 36hg18NCBI36
Build 34220,031,658 - 20,111,512NCBI
Celera219,972,385 - 20,052,221 (-)NCBICelera
Cytogenetic Map2p24.1NCBI
HuRef219,867,423 - 19,947,167 (-)NCBIHuRef
CHM1_1220,039,380 - 20,119,218 (-)NCBICHM1_1
T2T-CHM13v2.0219,943,794 - 20,023,609 (-)NCBIT2T-CHM13v2.0
Wdr35
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39129,023,897 - 9,078,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl129,023,892 - 9,078,847 (+)EnsemblGRCm39 Ensembl
GRCm38128,973,998 - 9,028,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl128,973,892 - 9,028,847 (+)EnsemblGRCm38mm10GRCm38
MGSCv37128,980,807 - 9,035,653 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36128,999,900 - 9,054,855 (+)NCBIMGSCv36mm8
Celera129,360,456 - 9,414,687 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map123.97NCBI
Wdr35
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554692,482,353 - 2,546,578 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554692,484,972 - 2,546,562 (-)NCBIChiLan1.0ChiLan1.0
WDR35
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212106,537,513 - 106,615,551 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A106,541,562 - 106,619,523 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A19,896,498 - 19,977,295 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A20,014,127 - 20,093,794 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A20,014,127 - 20,093,810 (-)Ensemblpanpan1.1panPan2
WDR35
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11714,976,662 - 15,034,918 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1714,977,457 - 15,034,748 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1714,936,610 - 14,994,995 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01715,124,117 - 15,182,623 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1715,124,121 - 15,182,628 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11714,978,142 - 15,036,297 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01714,984,409 - 15,042,802 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01715,016,240 - 15,074,493 (-)NCBIUU_Cfam_GSD_1.0
Wdr35
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629259,403,787 - 59,464,922 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649311,374,671 - 11,436,233 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649311,374,681 - 11,435,792 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR35
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3118,209,139 - 118,269,452 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13118,209,112 - 118,279,050 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23126,240,426 - 126,299,259 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR35
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11487,732,034 - 87,801,687 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1487,732,049 - 87,801,852 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604524,429,782 - 24,497,638 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr35
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247382,618,738 - 2,623,166 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla_female_1.0 EnsemblNW_0046247382,642,690 - 2,719,744 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247382,618,464 - 2,720,567 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wdr35
198 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:56
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000051970
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat

Markers in Region
RH132111  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2631,831,127 - 31,831,339 (+)MAPPERmRatBN7.2
Rnor_6.0634,151,721 - 34,151,932NCBIRnor6.0
Rnor_5.0643,932,549 - 43,932,760UniSTSRnor5.0
RGSC_v3.4632,522,268 - 32,522,479UniSTSRGSC3.4
Celera631,278,124 - 31,278,335UniSTS
RH 3.4 Map6123.91UniSTS
Cytogenetic Map6q14UniSTS
RH142951  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2631,830,316 - 31,830,435 (+)MAPPERmRatBN7.2
Rnor_6.0634,150,910 - 34,151,028NCBIRnor6.0
Rnor_5.0643,931,738 - 43,931,856UniSTSRnor5.0
RGSC_v3.4632,523,172 - 32,523,290UniSTSRGSC3.4
Celera631,277,313 - 31,277,431UniSTS
Cytogenetic Map6q14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 5 4 4 74 35 41 11
Low 3 27 52 37 19 37 8 11 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000051970   ⟹   ENSRNOP00000042019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl631,771,360 - 31,831,029 (+)Ensembl
Rnor_6.0 Ensembl634,094,306 - 34,151,622 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094116   ⟹   ENSRNOP00000083199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl631,771,360 - 31,831,029 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095530   ⟹   ENSRNOP00000089979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl631,771,360 - 31,831,029 (+)Ensembl
RefSeq Acc Id: NM_001099340   ⟹   NP_001092810
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8637,490,571 - 37,550,231 (+)NCBI
mRatBN7.2631,771,360 - 31,831,029 (+)NCBI
Rnor_6.0634,094,306 - 34,151,622 (+)NCBI
Rnor_5.0643,875,468 - 43,932,876 (+)NCBI
RGSC_v3.4632,522,578 - 32,523,842 (-)RGD
Celera631,219,791 - 31,278,025 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239885   ⟹   XP_006239947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8637,490,557 - 37,550,391 (+)NCBI
mRatBN7.2631,771,315 - 31,831,450 (+)NCBI
Rnor_6.0634,094,291 - 34,152,048 (+)NCBI
Rnor_5.0643,875,468 - 43,932,876 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112765   ⟹   XP_038968693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8637,490,557 - 37,550,391 (+)NCBI
mRatBN7.2631,771,315 - 31,831,450 (+)NCBI
RefSeq Acc Id: XM_063262347   ⟹   XP_063118417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8637,490,557 - 37,550,391 (+)NCBI
RefSeq Acc Id: NP_001092810   ⟸   NM_001099340
- UniProtKB: A6N6J5 (UniProtKB/Swiss-Prot),   A0A8I5ZVK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239947   ⟸   XM_006239885
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ABI7 (UniProtKB/TrEMBL),   A0A8I5ZVK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042019   ⟸   ENSRNOT00000051970
RefSeq Acc Id: XP_038968693   ⟸   XM_039112765
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZVK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089979   ⟸   ENSRNOT00000095530
RefSeq Acc Id: ENSRNOP00000083199   ⟸   ENSRNOT00000094116
RefSeq Acc Id: XP_063118417   ⟸   XM_063262347
- Peptide Label: isoform X3
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6N6J5-F1-model_v2 AlphaFold A6N6J5 1-1170 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694488
Promoter ID:EPDNEW_R5013
Type:initiation region
Name:Wdr35_1
Description:WD repeat domain 35
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0634,094,299 - 34,094,359EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564116 AgrOrtholog
BioCyc Gene G2FUF-38169 BioCyc
Ensembl Genes ENSRNOG00000028783 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005753 UniProtKB/Swiss-Prot
  ENSRNOG00060003647 UniProtKB/Swiss-Prot
  ENSRNOG00065005377 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000051970 ENTREZGENE
  ENSRNOT00000051970.5 UniProtKB/Swiss-Prot
  ENSRNOT00000094116.1 UniProtKB/TrEMBL
  ENSRNOT00000095530.1 UniProtKB/TrEMBL
  ENSRNOT00055009287 UniProtKB/Swiss-Prot
  ENSRNOT00060006028 UniProtKB/Swiss-Prot
  ENSRNOT00065007945 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.470 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Apc4_WD40_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ift122/121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WDR35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:503018 UniProtKB/Swiss-Prot
NCBI Gene 503018 ENTREZGENE
PANTHER WD REPEAT DOMAIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 55 HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANAPC4_WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wdr35 PhenoGen
PIRSF WD_repeat_p35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028783 RatGTEx
  ENSRNOG00055005753 RatGTEx
  ENSRNOG00060003647 RatGTEx
  ENSRNOG00065005377 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP DPP6 N-terminal domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Putative isomerase YbhE UniProtKB/TrEMBL
  SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZVK7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABI7 ENTREZGENE, UniProtKB/TrEMBL
  A6N6J5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-26 Wdr35  WD repeat domain 35  Wdr35l  WD repeat domain 35-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Wdr35l  WD repeat domain 35-like  Wdr35l  naofen  Name updated 1299863 APPROVED
2008-09-19 Wdr35l  naofen  RGD1564116  similar to WD repeat domain 35   Symbol and Name updated 1299863 PROVISIONAL
2008-04-30 RGD1564116  similar to WD repeat domain 35   RGD1564116_predicted  similar to WD repeat domain 35 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564116_predicted  similar to WD repeat domain 35 (predicted)  LOC503018  similar to WD repeat domain 35  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC503018  similar to WD repeat domain 35      Symbol and Name status set to provisional 70820 PROVISIONAL