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Gene: Acot3 (acyl-CoA thioesterase 3) Rattus norvegicus

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Symbol:

Acot3

Name:

acyl-CoA thioesterase 3

RGD ID:

1564089

Description:

Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and carboxylic acid metabolic process. Predicted to be located in cytosol and peroxisome. Orthologous to human ACOT2 (acyl-CoA thioesterase 2); PARTICIPATES IN unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC314304; RGD1564089; similar to peroxisomal long chain acyl-CoA thioesterase Ia

RGD Orthologs

Mouse

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Acot3 (acyl-CoA thioesterase 3)	RGD	RGD
Other homologs ²
Homo sapiens (human):	ACOT1 (acyl-CoA thioesterase 1)	HGNC	Ensembl, HomoloGene, Inparanoid, Panther
Homo sapiens (human):	ACOT2 (acyl-CoA thioesterase 2)	HGNC	Ensembl, Panther
Alliance orthologs ³
Mus musculus (house mouse):	Acot3 (acyl-CoA thioesterase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Acot3 (acyl-CoA thioesterase 3)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ACOT2 (acyl-CoA thioesterase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Homo sapiens (human):	ACOT2 (acyl-CoA thioesterase 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ACOT1 (acyl-CoA thioesterase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C31H5.6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	K05B2.4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T05E7.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T05E7.1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	acot20	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	W03D8.8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	acot22	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	acot22	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	acot21	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	acot21	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	acot2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	109,413,617 - 109,419,840 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	109,413,534 - 109,421,427 (+)	Ensembl				GRCr8
GRCr8 Ensembl	6	109,453,391 - 109,461,035 (-)	Ensembl				GRCr8
mRatBN7.2	6	103,682,518 - 103,688,735 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	103,682,596 - 103,688,427 (+)	Ensembl				mRatBN7.2
mRatBN7.2 Ensembl	6	103,723,326 - 103,729,482 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	103,844,339 - 103,850,278 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	104,143,555 - 104,149,494 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	103,513,007 - 103,518,946 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	107,531,508 - 107,537,446 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	107,531,528 - 107,536,789 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	118,006,796 - 118,012,735 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	108,089,349 - 108,095,288 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	101,512,523 - 101,518,456 (+)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

Acetyl tributyl citrate (ISO)

aflatoxin B1 (EXP)

amiodarone (ISO)

amitrole (EXP)

amphetamine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

ciprofibrate (EXP,ISO)

clofibrate (EXP,ISO)

Cuprizon (EXP)

cyproconazole (EXP)

decabromodiphenyl ether (EXP)

dibenzofurans (ISO)

dichloroacetic acid (ISO)

diquat (ISO)

epoxiconazole (EXP,ISO)

ethanol (ISO)

fenofibrate (EXP)

finasteride (EXP)

folic acid (ISO)

GW 4064 (ISO)

GW 7647 (ISO)

indole-3-methanol (EXP)

indometacin (EXP)

inulin (ISO)

metformin (EXP)

methotrexate (ISO)

N-nitrosodiethylamine (EXP)

paracetamol (ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

permethrin (ISO)

phenobarbital (EXP,ISO)

pirinixic acid (EXP,ISO)

pravastatin (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

prochloraz (EXP)

quercetin (ISO)

rotenone (EXP)

senecionine (ISO)

sodium arsenite (ISO)

sulfasalazine (ISO)

tamoxifen (ISO)

tetrachloroethene (ISO)

titanium dioxide (ISO)

tributylstannane (ISO)

trichloroethene (ISO)

Triptolide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vancomycin (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acyl-CoA metabolic process (IBA,IEA,ISO)

fatty acid metabolic process (IBA,IEA)

lipid metabolic process (IEA)

long-chain fatty acid metabolic process (IEA,ISO)

saturated monocarboxylic acid metabolic process (IEA,ISO)

unsaturated monocarboxylic acid metabolic process (IEA,ISO)

very long-chain fatty acid metabolic process (IEA,ISO)

Cellular Component

cytosol (IEA,ISO)

peroxisome (IEA,ISO)

Molecular Function

fatty acyl-CoA hydrolase activity (IBA,IEA,ISO)

thiolester hydrolase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

unsaturated fatty acid biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15007068	PMID:16940157

Genomics

Comparative Map Data

Acot3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	109,413,617 - 109,419,840 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	109,413,534 - 109,421,427 (+)	Ensembl				GRCr8
GRCr8 Ensembl	6	109,453,391 - 109,461,035 (-)	Ensembl				GRCr8
mRatBN7.2	6	103,682,518 - 103,688,735 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	103,682,596 - 103,688,427 (+)	Ensembl				mRatBN7.2
mRatBN7.2 Ensembl	6	103,723,326 - 103,729,482 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	103,844,339 - 103,850,278 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	104,143,555 - 104,149,494 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	103,513,007 - 103,518,946 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	107,531,508 - 107,537,446 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	107,531,528 - 107,536,789 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	118,006,796 - 118,012,735 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	108,089,349 - 108,095,288 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	101,512,523 - 101,518,456 (+)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

Acot3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	84,098,918 - 84,107,174 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	84,098,918 - 84,107,176 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	84,052,144 - 84,060,400 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	84,052,144 - 84,060,402 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	85,393,101 - 85,400,515 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	84,941,899 - 84,949,313 (+)	NCBI		MGSCv36	mm8
Celera	12	85,498,576 - 85,506,034 (+)	NCBI		Celera
Cytogenetic Map	12	D1	NCBI
cM Map	12	39.02	NCBI

Variants

Variants in Acot3
90 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	84
Count of miRNA genes:	68
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000051235
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293088	Iddm28	Insulin dependent diabetes mellitus QTL 28	5.21		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	68767270	135411972	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	88019181	136741135	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	106095977	147156653	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	84490437	129490437	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	101593607	138161926	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	99437079	125323237	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	86494122	112380234	Rat
1331722	Thshl1	Thyroid stimulating hormone level QTL 1	11.7	0.0001	blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	6	99708426	112483760	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	71278722	116278722	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	93560258	136550638	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	90871046	135871046	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	98944780	143944780	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	100704576	136029228	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	79198463	144254945	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	46050607	116278722	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	93778632	138778632	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
2293837	Kiddil1	Kidney dilation QTL 1	3.7		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	86867923	110125012	Rat
2293842	Kiddil3	Kidney dilation QTL 3	4.3		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	86867923	110125012	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	90871046	135871046	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	93560258	136550638	Rat
1576302	Schws4	Schwannoma susceptibility QTL 4		0.0078	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	78204640	123204640	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	93560258	136550638	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	76937178	121937178	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	101593607	146593607	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	90	59	6	354	190	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128618	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000039048 ⟹ ENSRNOP00000086778

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	109,413,534 - 109,421,427 (+)	Ensembl
mRatBN7.2 Ensembl	6	103,682,596 - 103,688,427 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077555 ⟹ ENSRNOP00000073103

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	109,453,391 - 109,461,035 (-)	Ensembl
mRatBN7.2 Ensembl	6	103,723,326 - 103,729,482 (-)	Ensembl
Rnor_6.0 Ensembl	6	107,531,528 - 107,536,789 (+)	Ensembl

RefSeq Acc Id:

NM_001108041 ⟹ NP_001101511

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	109,413,697 - 109,419,636 (+)	NCBI
mRatBN7.2	6	103,682,596 - 103,688,535 (+)	NCBI
Rnor_6.0	6	107,531,508 - 107,537,446 (+)	NCBI
Rnor_5.0	6	118,006,796 - 118,012,735 (-)	NCBI
RGSC_v3.4	6	108,089,349 - 108,095,288 (+)	RGD
Celera	6	101,512,523 - 101,518,456 (+)	RGD

Sequence:

show sequence

CCCAGCCACAATCTGAAGCAATGCACGCATTTACCACCCAGAACCGGATGGCACCCACAGTGAT
CCTGGAGCCCGCGGTTGGCTGCCTTTGCGACCAGCCGGTGCACATCACCGTGCGCGGCCTGGGC
CCCGAGCAGCCCGTCACGCTGCGCGCGGCCCTGCGCGACGAGAAGGGCGCGCTCTTCCGAGCCC
ACGCGCGCTACCGCGCCGACGCCCATGGAGTGCTGGACCTGGAGCGCGCGCCCGCGCTGGGCGG
CAGCTTCACCGGGCTCGAGCCCATGGGGCTGATCTGGGCCATGGAACCCGAACGGCCTTTCTGG
CGTCTGGTCAAGCGCGACGTGCAGACGCCCTTCGTGGTGGAGCTGGAGGTGCTGGACGGACACG
AGCCCGACGGCGGGCGGCTGCTGGCGCAGGCGGTGCACGAGCGTCACTTCATGGCTCCCGGGGT
GCGGCGCGTGCCGGTGCGCGAGGGCCGGGTGCGCGCCACGCTCTTCCTGCCCCCAGGGAATGGA
TCCTTTCCTGGAATCATAGACCTTTTTGGACTTGGAGGCGGCCTTCTGGAGTACCGGGCGAGTC
TGCTGGCTGGGAAGGGCTTTGCCGTCATGGCTCTGGCTTATTACAACTACGACGACCTCCCCAA
GGACGTGGACATTATCCACCTGGAGTACTTTGAGGAAGCGGTGAACTACCTGCTCAGTCACCCT
CAGGTAAAAGGTTCAGGAGTTGGGGTGCTTGGCATTTCCAAGGGGGGTGAACTTGGCTTTGCCA
TGGCCACCTTCCTGAAAAATATCACAGCTGCTGTCATTATCAATGGCTCTGTAGCCAACGTCGG
TGGAACCTTACAGTACAGGGATGAGACCATACTCCCGGTGGGCATGAGCACCAAACGAATCAAG
AGGATCAAAGATGGCCTCAAAGACATTGTGGATGCCCTGAACAATCCTCTGGAAGGAGCTGACC
AGAAGAGCTTGATCCCTGTGGAAAGGTCTGACACAACCTTCCTGTTCCTCGTTGGTCAGGATGA
CCACAACTGGAAGAGCGAGTTCTATGCCAGAGAGGCCTCCAAACGCTTGCAGGCCCATGGGAAG
GAGAAGCCCCAGATCATCTGTTACCCAGAGACAGGCCACTATATTGAGCCTCCTTATTTCCCCT
TGTGTAAGGCTTCCCTGCACAGCCTGGTGGGCGGTCCTGTCATCTGGGGAGGGGAGCCCAGGGC
TCACGCCATGGCCCAGGTTGATGCTTGGCAGCAACTCCAGACTTTTTTCCACAAACATTTGGGT
GGGGAAAAGAAGACAATCCCAGCAAAACTGTGATTTTTATTTAAGTTTTATTTTACTTAAGATC
TCTGATGCTACTCTCTCCTGGGGAAGCCTCCACTGTTTTGTGTGTGTGTGTGAGTGTGTGTGTG
TGTGTGTTTCTCTTTTACATCAATGTAGTGTCTTCCTTCCTCCAACATTCTTTTAAACTGCAGG
CCTCACTGATAAGTCTTGGAGGGGAGTGATTATAGAGAAACATAAGGCACGGCAAAAGCTGGTC
TCTTGCTGAGGCCCAGGCTGCCAGTGCGCTGTAGCCTGAGAGAAAGGCCAAGTCACTGCTAAAT
CCTGGACTTCAGGGATTACTTGCTAAATGGCTGGTTAAAGACAAACAGATGGTTACCTGCTGCT
TAGACAAACATCAAAAAGAACTGGGCAGATGGCTAACCAGTTAAGGGCCCACACTACTCCTATA
GGACCCAAGTTCAGTTCCCAGCACCAGGACCAAGCAGCTATCAATTGACTACAACTCCAGCTCT
GAGAGATACAGGGCTCTGCATTCATCTGACCTCCTTGGGCACCCATACCCATGTGTTCATACAC
ACATGTCTCCGTTGCATAATTTCGGACTACACACACACACACGTACACATGCCCCATACACACA
CACACACACACACACACATACACATGAACAAAAACACATGGTTT

hide sequence

RefSeq Acc Id:

XM_039112303 ⟹ XP_038968231

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	109,413,620 - 109,419,840 (+)	NCBI
mRatBN7.2	6	103,682,520 - 103,688,735 (+)	NCBI

RefSeq Acc Id:

XM_039112305 ⟹ XP_038968233

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	109,413,619 - 109,419,840 (+)	NCBI
mRatBN7.2	6	103,682,519 - 103,687,843 (+)	NCBI

RefSeq Acc Id:

XM_039112306 ⟹ XP_038968234

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	109,413,617 - 109,419,025 (+)	NCBI
mRatBN7.2	6	103,682,518 - 103,687,843 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101511	(Get FASTA)	NCBI Sequence Viewer
	XP_038968231	(Get FASTA)	NCBI Sequence Viewer
	XP_038968233	(Get FASTA)	NCBI Sequence Viewer
	XP_038968234	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL81472	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000086778
	ENSRNOP00000086778.2

RefSeq Acc Id:

NP_001101511 ⟸ NM_001108041

- UniProtKB:

A0A8I6A6H9 (UniProtKB/TrEMBL), A6JDS8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHAFTTQNRMAPTVILEPAVGCLCDQPVHITVRGLGPEQPVTLRAALRDEKGALFRAHARYRAD
AHGVLDLERAPALGGSFTGLEPMGLIWAMEPERPFWRLVKRDVQTPFVVELEVLDGHEPDGGRL
LAQAVHERHFMAPGVRRVPVREGRVRATLFLPPGNGSFPGIIDLFGLGGGLLEYRASLLAGKGF
AVMALAYYNYDDLPKDVDIIHLEYFEEAVNYLLSHPQVKGSGVGVLGISKGGELGFAMATFLKN
ITAAVIINGSVANVGGTLQYRDETILPVGMSTKRIKRIKDGLKDIVDALNNPLEGADQKSLIPV
ERSDTTFLFLVGQDDHNWKSEFYAREASKRLQAHGKEKPQIICYPETGHYIEPPYFPLCKASLH
SLVGGPVIWGGEPRAHAMAQVDAWQQLQTFFHKHLGGEKKTIPAKL

hide sequence

Ensembl Acc Id:

ENSRNOP00000073103 ⟸ ENSRNOT00000077555

RefSeq Acc Id:	XP_038968234 ⟸ XM_039112306
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038968233 ⟸ XM_039112305
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038968231 ⟸ XM_039112303
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000086778 ⟸ ENSRNOT00000039048

Protein Domains

Acyl-CoA thioester hydrolase/bile acid-CoA amino BAAT/Acyl-CoA thioester hydrolase C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K4M8-F1-model_v2	AlphaFold	A0A0G2K4M8	1-429	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694717

Promoter ID:

EPDNEW_R5241

Type:

initiation region

Name:

Acot3_1

Description:

acyl-CoA thioesterase 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	107,531,465 - 107,531,525	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564089	AgrOrtholog
BioCyc Gene	G2FUF-36843	BioCyc
BioCyc Pathway	PWY-5148 [acyl-CoA hydrolysis]	BioCyc
	PWY-5972 [stearate biosynthesis I (animals)]	BioCyc
	PWY-5996 [oleate biosynthesis II (animals and fungi)]	BioCyc
	PWY-8042 [acylceramide biosynthesis]	BioCyc
	PWY3O-1801 [palmitoleate biosynthesis IV (fungi and animals)]	BioCyc
BioCyc Pathway Image	PWY-5148	BioCyc
	PWY-5972	BioCyc
	PWY-5996	BioCyc
	PWY-8042	BioCyc
	PWY3O-1801	BioCyc
Ensembl Genes	ENSRNOG00000027960	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000053460	Ensembl
Ensembl Transcript	ENSRNOT00000039048	ENTREZGENE
	ENSRNOT00000039048.7	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.2240	UniProtKB/TrEMBL
	3.40.50.1820	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	Acyl-CoA_thioEstase_long-chain	UniProtKB/TrEMBL
	BAAT_C	UniProtKB/TrEMBL
	Thio_Ohase/aa_AcTrfase	UniProtKB/TrEMBL
	Thio_Ohase/BAAT_N	UniProtKB/TrEMBL
KEGG Report	rno:314304	UniProtKB/TrEMBL
NCBI Gene	314304	ENTREZGENE
PANTHER	ACYL-COENZYME A THIOESTERASE 1-RELATED	UniProtKB/TrEMBL
	ACYL-COENZYME A THIOESTERASE-RELATED	UniProtKB/TrEMBL
Pfam	BAAT_C	UniProtKB/TrEMBL
	Bile_Hydr_Trans	UniProtKB/TrEMBL
PhenoGen	Acot3	PhenoGen
PIRSF	Acyl-CoA_hydro	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000027960	RatGTEx
	ENSRNOG00000053460	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	A0A8I6A6H9	ENTREZGENE, UniProtKB/TrEMBL
	A6JDS8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Acot3	acyl-CoA thioesterase 3	RGD1564089_predicted	similar to peroxisomal long chain acyl-CoA thioesterase Ia (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1564089_predicted	similar to peroxisomal long chain acyl-CoA thioesterase Ia (predicted)	LOC314304	similar to peroxisomal long chain acyl-CoA thioesterase Ia	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC314304	similar to peroxisomal long chain acyl-CoA thioesterase Ia			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Annotations - KEGG (archival)

BioCyc Pathways