Prr18 (proline rich 18) - Rat Genome Database

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Gene: Prr18 (proline rich 18) Rattus norvegicus
Analyze
Symbol: Prr18
Name: proline rich 18
RGD ID: 1564079
Description: Orthologous to human PRR18 (proline rich 18); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361481; proline rich region 18; proline rich region 18-like; proline-rich protein 18; RGD1564079; similar to RIKEN cDNA 9630019K15 gene
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,947,775 - 54,951,558 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl154,947,351 - 54,959,997 (-)EnsemblGRCr8
mRatBN7.2152,400,215 - 52,403,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,400,215 - 52,404,309 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx153,101,686 - 53,105,468 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0159,093,402 - 59,097,185 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,177,286 - 53,181,068 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,989,076 - 52,994,843 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,991,287 - 52,992,213 (-)Ensemblrn6Rnor6.0
Rnor_5.0154,238,725 - 54,244,493 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4147,040,962 - 47,043,972 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera148,165,402 - 48,166,328 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse:




References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Prr18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,947,775 - 54,951,558 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl154,947,351 - 54,959,997 (-)EnsemblGRCr8
mRatBN7.2152,400,215 - 52,403,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,400,215 - 52,404,309 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx153,101,686 - 53,105,468 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0159,093,402 - 59,097,185 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,177,286 - 53,181,068 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,989,076 - 52,994,843 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,991,287 - 52,992,213 (-)Ensemblrn6Rnor6.0
Rnor_5.0154,238,725 - 54,244,493 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4147,040,962 - 47,043,972 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera148,165,402 - 48,166,328 (-)NCBICelera
Cytogenetic Map1q12NCBI
PRR18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386166,305,300 - 166,308,392 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6166,305,300 - 166,308,448 (-)Ensemblhg38GRCh38
GRCh376166,718,788 - 166,721,880 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366166,639,158 - 166,641,861 (-)NCBIBuild 36Build 36hg18NCBI36
Celera6167,458,534 - 167,461,239 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6164,190,116 - 164,192,821 (-)NCBIHuRef
CHM1_16166,983,004 - 166,985,707 (-)NCBICHM1_1
T2T-CHM13v2.06167,682,227 - 167,685,319 (-)NCBIT2T-CHM13v2.0
Prr18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,546,378 - 8,562,945 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl178,556,291 - 8,562,945 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38178,340,406 - 8,344,113 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,337,459 - 8,344,113 (+)Ensemblmm10GRCm38
MGSCv37178,533,271 - 8,536,978 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36178,178,580 - 8,182,287 (+)NCBIMGSCv36mm8
Celera178,373,567 - 8,381,650 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.92NCBI
PRR18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25186,513,327 - 186,516,540 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16184,409,213 - 184,412,426 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06164,271,969 - 164,275,450 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRR18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha155,114,831 - 55,115,496 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0154,504,940 - 54,505,608 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1154,401,022 - 54,401,690 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,251,440 - 54,252,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,875,075 - 54,875,737 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prr18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049455,093,497 - 5,101,998 (-)NCBIHiC_Itri_2
PRR18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.112,600,779 - 2,604,733 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213,739,460 - 3,743,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRR18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11394,016,082 - 94,019,447 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604065,846,191 - 65,851,064 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prr18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478512,952,610 - 12,953,278 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Prr18
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12187,196,438 - 187,198,667 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prr18
40 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:152
Interacting mature miRNAs:166
Transcripts:ENSRNOT00000033528
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
RH143615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,403,761 - 52,403,967 (+)MAPPERmRatBN7.2
Rnor_6.0152,992,623 - 52,992,828NCBIRnor6.0
Rnor_5.0154,242,272 - 54,242,477UniSTSRnor5.0
RGSC_v3.4147,043,738 - 47,043,943UniSTSRGSC3.4
Celera148,166,738 - 48,166,943UniSTS
RH 3.4 Map1613.2UniSTS
Cytogenetic Map1q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 3 26 152 48 48 20 77 20 6 210 132 10 132 40 75 28 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000033528   ⟹   ENSRNOP00000031623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl152,991,287 - 52,992,213 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099132   ⟹   ENSRNOP00000092165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl154,947,775 - 54,951,177 (-)Ensembl
mRatBN7.2 Ensembl152,400,215 - 52,404,309 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000151490   ⟹   ENSRNOP00000110275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl154,947,820 - 54,959,997 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169865   ⟹   ENSRNOP00000099335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl154,947,351 - 54,959,997 (-)Ensembl
RefSeq Acc Id: NM_001108464   ⟹   NP_001101934
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8154,947,775 - 54,951,177 (-)NCBI
mRatBN7.2152,400,215 - 52,403,617 (-)NCBI
Rnor_6.0152,991,287 - 52,992,213 (-)NCBI
Rnor_5.0154,238,725 - 54,244,493 (-)NCBI
Celera148,165,402 - 48,166,328 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001399593   ⟹   NP_001386522
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8154,947,775 - 54,951,558 (-)NCBI
mRatBN7.2152,400,215 - 52,403,998 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101934 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386522 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83116 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000092165
  ENSRNOP00000092165.2
  ENSRNOP00000099335
  ENSRNOP00000099335.1
  ENSRNOP00000110275.1
RefSeq Acc Id: NP_001101934   ⟸   NM_001108464
- UniProtKB: A6KK23 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031623   ⟸   ENSRNOT00000033528
Ensembl Acc Id: ENSRNOP00000092165   ⟸   ENSRNOT00000099132
RefSeq Acc Id: NP_001386522   ⟸   NM_001399593
- UniProtKB: A6KK23 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110275   ⟸   ENSRNOT00000151490
Ensembl Acc Id: ENSRNOP00000099335   ⟸   ENSRNOT00000169865

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDS0-F1-model_v2 AlphaFold D3ZDS0 1-308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564079 AgrOrtholog
BioCyc Gene G2FUF-61513 BioCyc
Ensembl Genes ENSRNOG00000024149 Ensembl
  ENSRNOG00000070586 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000099132 ENTREZGENE
  ENSRNOT00000099132.2 UniProtKB/TrEMBL
  ENSRNOT00000151490.1 UniProtKB/TrEMBL
  ENSRNOT00000169865 ENTREZGENE
  ENSRNOT00000169865.1 UniProtKB/TrEMBL
InterPro PRR18 UniProtKB/TrEMBL
KEGG Report rno:361481 UniProtKB/TrEMBL
NCBI Gene 361481 ENTREZGENE
Pfam PRR18 UniProtKB/TrEMBL
PhenoGen Prr18 PhenoGen
RatGTEx ENSRNOG00000024149 RatGTEx
  ENSRNOG00000070586 RatGTEx
UniProt A0A8I6AGM4_RAT UniProtKB/TrEMBL
  A6KK23 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Prr18  proline rich 18  LOC100361700  proline rich region 18-like  Data merged from RGD:2319574 1643240 APPROVED
2011-08-02 Prr18  proline rich 18  Prr18  proline rich region 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361700  proline rich region 18-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Prr18  proline rich region 18  RGD1564079_predicted  similar to RIKEN cDNA 9630019K15 gene (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564079_predicted  similar to RIKEN cDNA 9630019K15 gene (predicted)  LOC361481  similar to RIKEN cDNA 9630019K15 gene  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC361481  similar to RIKEN cDNA 9630019K15 gene      Symbol and Name status set to provisional 70820 PROVISIONAL