Morc2b (microrchidia 2B) - Rat Genome Database

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Gene: Morc2b (microrchidia 2B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Morc2b
Name: microrchidia 2B
RGD ID: 1564020
Description: Predicted to enable ATP binding activity; hydrolase activity; and zinc ion binding activity. Predicted to be involved in double-strand break repair involved in meiotic recombination; gamete generation; and homologous chromosome pairing at meiosis. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2); INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100911941; LOC299555; MORC family CW-type zinc finger protein 2B; MORC family CW-type zinc finger protein 2B-like; RGD1564020; similar to hypothetical protein 4932411A10
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8712,964,822 - 12,968,902 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl712,964,825 - 12,969,026 (-)EnsemblGRCr8
mRatBN7.2712,314,341 - 12,318,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl712,314,349 - 12,318,421 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx715,120,635 - 15,124,711 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0716,998,036 - 17,002,112 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0714,873,265 - 14,877,345 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd715,648,412 - 15,652,488 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive715,811,827 - 15,815,903 (-)NCBILyon_Normotensive
Lyon_Hypertensive715,886,792 - 15,890,868 (-)NCBILyon_Hypertensive
F344_StmMcwi714,252,452 - 14,256,528 (-)NCBIF344_StmMcwi
Rnor_6.0715,479,754 - 15,483,834 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl715,479,762 - 15,483,834 (-)Ensemblrn6Rnor6.0
Rnor_5.0715,650,756 - 15,654,836 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4713,894,054 - 13,898,134 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera710,407,720 - 10,411,800 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Morc2b
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000057608
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
1 2 2 9 6 9 4 4 4 1 14 7 9 20 5

Sequence


Ensembl Acc Id: ENSRNOT00000057608   ⟹   ENSRNOP00000054417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,964,825 - 12,969,026 (-)Ensembl
mRatBN7.2 Ensembl712,314,349 - 12,318,421 (-)Ensembl
Rnor_6.0 Ensembl715,479,762 - 15,483,834 (-)Ensembl
RefSeq Acc Id: NM_001106764   ⟹   NP_001100234
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,964,822 - 12,968,902 (-)NCBI
mRatBN7.2712,314,341 - 12,318,421 (-)NCBI
Dahl_SR_JrHsd715,648,412 - 15,652,488 (-)NCBI
Lyon_Normotensive715,811,827 - 15,815,903 (-)NCBI
Lyon_Hypertensive715,886,792 - 15,890,868 (-)NCBI
F344_StmMcwi714,252,452 - 14,256,528 (-)NCBI
Rnor_6.0715,479,754 - 15,483,834 (-)NCBI
Rnor_5.0715,650,756 - 15,654,836 (-)NCBI
RGSC_v3.4713,894,054 - 13,898,134 (-)RGD
Celera710,407,720 - 10,411,800 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100234 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89503 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054417
  ENSRNOP00000054417.2
RefSeq Acc Id: NP_001100234   ⟸   NM_001106764
- UniProtKB: D4A8J3 (UniProtKB/TrEMBL),   A6K983 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054417   ⟸   ENSRNOT00000057608
Protein Domains
CW-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8J3-F1-model_v2 AlphaFold D4A8J3 1-1019 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695077
Promoter ID:EPDNEW_R5602
Type:single initiation site
Name:Morc2b_1
Description:microrchidia 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0715,483,778 - 15,483,838EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564020 AgrOrtholog
BioCyc Gene G2FUF-34783 BioCyc
Ensembl Genes ENSRNOG00000004501 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057608 ENTREZGENE
  ENSRNOT00000057608.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.100 UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/TrEMBL
InterPro Chromo_MORC2_6th UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/TrEMBL
  Morc_S5 UniProtKB/TrEMBL
  Znf_CW UniProtKB/TrEMBL
KEGG Report rno:299555 UniProtKB/TrEMBL
NCBI Gene 299555 ENTREZGENE
PANTHER ATPASE MORC2B UniProtKB/TrEMBL
  ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1 UniProtKB/TrEMBL
Pfam Chromo_MORC2_6th UniProtKB/TrEMBL
  HATPase_c_3 UniProtKB/TrEMBL
  Morc6_S5 UniProtKB/TrEMBL
  zf-CW UniProtKB/TrEMBL
PhenoGen Morc2b PhenoGen
PROSITE ZF_CW UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004501 RatGTEx
Superfamily-SCOP ATP_bd_ATPase UniProtKB/TrEMBL
UniProt A6K983 ENTREZGENE, UniProtKB/TrEMBL
  D4A8J3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Morc2b  microrchidia 2B  LOC100911941  MORC family CW-type zinc finger protein 2B-like  Data merged from RGD:6489739 737654 PROVISIONAL
2012-07-05 LOC100911941  MORC family CW-type zinc finger protein 2B-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Morc2b  microrchidia 2B  RGD1564020_predicted  similar to hypothetical protein 4932411A10 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564020_predicted  similar to hypothetical protein 4932411A10 (predicted)  LOC299555  similar to hypothetical protein 4932411A10  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC299555  similar to hypothetical protein 4932411A10      Symbol and Name status set to provisional 70820 PROVISIONAL