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Gene: Shisa8 (shisa family member 8) Rattus norvegicus

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Symbol:

Shisa8

Name:

shisa family member 8

RGD ID:

1563996

Description:

Predicted to be involved in regulation of short-term neuronal synaptic plasticity. Predicted to be located in membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendritic spine membrane; postsynaptic density; and postsynaptic membrane. Orthologous to human SHISA8 (shisa family member 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

INFERRED

Previously known as:

LOC315163; putative protein shisa-8; RGD1563996; shisa homolog 8; shisa homolog 8 (Xenopus laevis); similar to Protein UNQ9166/PRO28631 precursor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SHISA8 (shisa family member 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Shisa8 (shisa family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Shisa8 (shisa family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SHISA8 (shisa family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SHISA8 (shisa family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Shisa8 (shisa family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SHISA8 (shisa family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SHISA8 (shisa family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Shisa8 (shisa family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Shisa8 (shisa family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SHISA8 (shisa family member 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Shisa8 (shisa family member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	shisa8b (shisa family member 8b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	shisa8b (shisa family member 8b)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	shisa8	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	115,602,503 - 115,607,953 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	115,602,503 - 115,608,188 (-)	Ensembl				GRCr8
mRatBN7.2	7	113,722,408 - 113,727,858 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	113,722,408 - 113,727,858 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	115,478,377 - 115,483,827 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	117,701,884 - 117,707,334 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	117,671,325 - 117,676,775 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	123,440,163 - 123,445,613 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	123,440,163 - 123,445,613 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	123,423,854 - 123,429,304 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	120,581,770 - 120,595,508 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	110,037,571 - 110,043,021 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,7-dihydropurine-6-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

benzo[a]pyrene (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

chlordecone (ISO)

dibutyl phthalate (EXP)

fenvalerate (EXP)

manganese(II) chloride (EXP)

mercaptopurine (EXP)

methyl methanesulfonate (ISO)

ozone (ISO)

purine-6-thiol (EXP)

sodium arsenite (ISO)

titanium dioxide (EXP)

trichloroethene (EXP)

triclosan (ISO)

triptonide (ISO)

vincristine (ISO)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of short-term neuronal synaptic plasticity (IBA)

Cellular Component

AMPA glutamate receptor complex (IBA)

dendritic spine membrane (IBA)

membrane (IEA)

postsynaptic density (IBA)

postsynaptic membrane (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Shisa8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	115,602,503 - 115,607,953 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	115,602,503 - 115,608,188 (-)	Ensembl				GRCr8
mRatBN7.2	7	113,722,408 - 113,727,858 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	113,722,408 - 113,727,858 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	115,478,377 - 115,483,827 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	117,701,884 - 117,707,334 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	117,671,325 - 117,676,775 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	123,440,163 - 123,445,613 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	123,440,163 - 123,445,613 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	123,423,854 - 123,429,304 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	120,581,770 - 120,595,508 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	110,037,571 - 110,043,021 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

SHISA8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	41,909,543 - 41,915,074 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	41,909,543 - 41,915,074 (-)	Ensembl			hg38	GRCh38
GRCh37	22	42,305,547 - 42,311,078 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	40,635,715 - 40,640,617 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	22	26,112,003 - 26,116,905 (-)	NCBI		Celera
Cytogenetic Map	22	q13.2	NCBI
HuRef	22	25,271,257 - 25,276,248 (-)	NCBI		HuRef
CHM1_1	22	42,265,766 - 42,270,869 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	42,388,416 - 42,393,946 (-)	NCBI		T2T-CHM13v2.0

Shisa8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	82,091,153 - 82,097,004 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	82,090,369 - 82,097,016 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	82,206,173 - 82,212,848 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	82,206,168 - 82,212,815 (-)	Ensembl			mm10	GRCm38
MGSCv37	15	82,037,382 - 82,052,260 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	82,034,207 - 82,049,085 (-)	NCBI		MGSCv36	mm8
Celera	15	84,330,672 - 84,336,537 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI

Shisa8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955413	27,328,632 - 27,330,304 (-)	NCBI	ChiLan1.0	ChiLan1.0

SHISA8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	51,739,276 - 51,744,426 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	54,438,476 - 54,443,664 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	22,802,111 - 22,807,652 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	40,887,263 - 40,889,441 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

SHISA8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	23,444,051 - 23,448,692 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	23,376,889 - 23,382,774 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	24,187,797 - 24,193,682 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	24,188,891 - 24,193,887 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	23,904,791 - 23,910,675 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	24,226,041 - 24,232,175 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	24,400,174 - 24,406,059 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Shisa8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	7,098,337 - 7,103,351 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	108,750 - 113,781 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	108,751 - 113,765 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SHISA8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	6,711,336 - 6,717,365 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	6,711,089 - 6,716,644 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SHISA8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	24,441,962 - 24,447,204 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	100,964,732 - 100,970,285 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Shisa8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	6,808,295 - 6,813,216 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624752	6,808,295 - 6,813,039 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Shisa8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	251,937,034 - 251,942,099 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Shisa8
65 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	136
Count of miRNA genes:	108
Interacting mature miRNAs:	119
Transcripts:	ENSRNOT00000070937
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	92388565	119280177	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	82111245	123048330	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	73618702	118618702	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	93302009	131686183	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	115313999	136544683	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	85043242	130043242	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	85497398	130497398	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	83626689	128626689	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	82111382	132099989	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
631201	Panci1	Pancreas inflammation QTL 1	0	0.001	pancreas integrity trait (VT:0010560)	percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)	7	73557047	118557047	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	82111245	123048330	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	40540077	123682549	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	96700404	118618702	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	49682832	115766396	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
10450862	Kidm55	Kidney mass QTL 55	4.9		kidney mass (VT:0002707)	kidney weight (CMO:0000081)	7	72725037	117725037	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
10450856	Livw4	Liver weight QTL 4	3.8		liver mass (VT:0003402)	liver weight (CMO:0000092)	7	72725037	117725037	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	49682832	115766396	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	78682549	123682549	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	49682832	115766396	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	71621154	119349044	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	9	44	157	66	65	35	71	35	6	244	142	7	133	46	77	30	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001207022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC113253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000070937 ⟹ ENSRNOP00000064575

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	115,602,503 - 115,607,953 (-)	Ensembl
mRatBN7.2 Ensembl	7	113,722,408 - 113,727,858 (-)	Ensembl
Rnor_6.0 Ensembl	7	123,440,163 - 123,445,613 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000120226 ⟹ ENSRNOP00000096710

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	115,602,503 - 115,608,188 (-)	Ensembl
mRatBN7.2 Ensembl	7	113,722,408 - 113,727,832 (-)	Ensembl

RefSeq Acc Id:

NM_001207022 ⟹ NP_001193951

RefSeq Status:

INFERRED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	115,602,503 - 115,607,953 (-)	NCBI
mRatBN7.2	7	113,722,408 - 113,727,858 (-)	NCBI
Rnor_6.0	7	123,440,163 - 123,445,613 (-)	NCBI
Rnor_5.0	7	123,423,854 - 123,429,304 (-)	NCBI
Celera	7	110,037,571 - 110,043,021 (-)	NCBI

Sequence:

show sequence

CGGCCGCGCTCCTCCCCCAGTTCTGCCTCCCTCCCGCCCTCCTCCCCTCGCTCCCTCTCCCGCC
CGCCCAAGCCCGCGCCGAGCCCGCGCCGGAGCCAGAGCCGGAGCCAGAGCGCGGGCACCGCGGA
GCGGGCGGCGGGAAGGCAGAGGTGTCCGGCGACCCGCCGCCCGGCTCAGTCCCCGAAAGACCCA
GGACCCGCACGTCCGCCGGGGCCAAAGGGACCCGGGGACTGTGCAGACGAGCACCTGCCTCCCG
CCTTCACGGTGCACAGTCCGAGGTGAGCCCCGGAGGAGAACGCGCCCACCGGAGATCCAGCCCC
GCGAACTCCACACGGAGCTCACTTGTGTCTGGAACTGCGGACGCACCAGGAGGCGTCGGCCCGG
AGCCAGCGCGGGCAGCTGGGCGACCAGGCGACAGGTCTCGGAGGGCTGGGGGAGCCTGGCAGAG
CGGCCACGCGCCGAGCCATGAGCGGGGCGCAATAACAGGAGGAGCGGGCCGCATGGAGCGCGCT
GGGGCGCGGGGACAGCGTTGTGGCCGGCGCCCGCATGGGCTCCCGCTCGCGCTCCGGCTGGCGC
TGCTGCTGGCGGGGTCGCCGTCGGGCCGCGCGGGGGCTCCCGAGGCGCAGGAGACCGCAGCGTC
CGGCACCGTGGCACCGGCGGGAGGGGACCGCTGCCGCGGCTATTACGACGTGATGGGCCAGTGG
GACCCGCCCTTCAACTGCAGCTCCGGTGTCTACAGCTTCTGCTGCGGCACGTGCGGCTACCGCT
TCTGTTGCCACGACGGCCCGCGCCGCCTGGACCAGAGCCGCTGCTCCAACTACGACACACCGGC
CTGGGTGCAGACTGGCCGCCCGCCCGCCCGCGCCCGTGACACCGCCGCTCCGCGCGACCCGGCC
CGCGAGCGCAGCCACACTGCGGTCTACGCGGTGTGCGGTGTCGCCGCACTGCTCGTGCTGGTCG
GCATCGGGGCACGCCTGGGTCTGGAGAGAGCGCACAGCCCCCGCGCTCGCCGCACGGTGACCAG
GACACTGACAGAACTTCTCAAGCAGCCAAGCCCCCAAGAACCACTGCCTCCACCTCTGGGTCCA
TCCTTGGGTAACTGCGTCCAGGTACAAATGGGTGACGGTGTTCTCCGGGGTTCTCCCCACAACA
GCACAGACAAGAAACGTCTCAATAATGCGCCTCTGGGGTCCGCCACCCCAGGACCCCCGCGCGG
TCCGCGGCCGCAGGGTGGTGGCAGCCTGACGTTGCAGCCTGACTATGCCAAGTTTGCTACTCTC
AAAGCAGCTGCGCTCAAGGCCACAGAGGCTGCGCCCCAGGACTTCTATCAACGTTTTCCCTCTA
CCGAGTCGGGCCCGCGGACTCTCCCTGCGCGGGTCCCGCGGCCTCCAGAGGACTTGCCTGCGCT
GCTCGACGCCTGTCCCTGGGCCCCTCCGGGTTATGTACCTCCCGCCGGCCCTGTCTCGTCCGTC
CCTTATGCGGCCTGGACCGCAGGCCGCCCCGCGAGACCGCTCCCCCGTAGCCACTTGGTGGCTC
AGGTTTCTCCAGCGCCCCGGCGGCCCAGCCACGCGCCGCGGCGTCAGTTCAGCGTGGAGAAGCT
GCCCGAGGCCTTCAGCGCGCAGCCCACGAGCTTTTACAGCAGCGCGGGCAGAGGACCCCGGCAT
CTAAGCACCAACAGCAAAGCTGAGGTTACTGTTTAAAGCGGAACCATTGGAGCCTTCTGCACGG
TCCTGGGACCCAGGTCGTGGAGTTGCAGTGCAGGTCTCAATCCAAACAGGAATGAGGGCATTTG
GAGCCTGTGGCTAAAGGGTCAAAAGGGCCAGGTGTTCTGTTCTTGGGAATGTAGGGCTATCCTT
ACTTGTGTAAATAAACCCTCTAATGTGGTTCCCGTCCCAAA

hide sequence

RefSeq Acc Id:

XM_039079285 ⟹ XP_038935213

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	115,602,503 - 115,607,905 (-)	NCBI
mRatBN7.2	7	113,722,408 - 113,727,809 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001193951	(Get FASTA)	NCBI Sequence Viewer
	XP_038935213	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM15673	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064575
	ENSRNOP00000064575.1
	ENSRNOP00000096710.2

RefSeq Acc Id:	NP_001193951 ⟸ NM_001207022
- Peptide Label:	precursor
- UniProtKB:	M0R5B1 (UniProtKB/TrEMBL), A6HT49 (UniProtKB/TrEMBL)
- Sequence:	show sequence MERAGARGQRCGRRPHGLPLALRLALLLAGSPSGRAGAPEAQETAASGTVAPAGGDRCRGYYDV MGQWDPPFNCSSGVYSFCCGTCGYRFCCHDGPRRLDQSRCSNYDTPAWVQTGRPPARARDTAAP RDPARERSHTAVYAVCGVAALLVLVGIGARLGLERAHSPRARRTVTRTLTELLKQPSPQEPLPP PLGPSLGNCVQVQMGDGVLRGSPHNSTDKKRLNNAPLGSATPGPPRGPRPQGGGSLTLQPDYAK FATLKAAALKATEAAPQDFYQRFPSTESGPRTLPARVPRPPEDLPALLDACPWAPPGYVPPAGP VSSVPYAAWTAGRPARPLPRSHLVAQVSPAPRRPSHAPRRQFSVEKLPEAFSAQPTSFYSSAGR GPRHLSTNSKAEVTV hide sequence

Ensembl Acc Id:

ENSRNOP00000064575 ⟸ ENSRNOT00000070937

RefSeq Acc Id:	XP_038935213 ⟸ XM_039079285
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000096710 ⟸ ENSRNOT00000120226

Protein Domains

Shisa N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0R5B1-F1-model_v2	AlphaFold	M0R5B1	1-399	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563996	AgrOrtholog
BioCyc Gene	G2FUF-32638	BioCyc
Ensembl Genes	ENSRNOG00000049407	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000070937	ENTREZGENE
	ENSRNOT00000070937.3	UniProtKB/TrEMBL
	ENSRNOT00000120226.2	UniProtKB/TrEMBL
InterPro	Shisa	UniProtKB/TrEMBL
	Shisa_N	UniProtKB/TrEMBL
KEGG Report	rno:315163	UniProtKB/TrEMBL
NCBI Gene	315163	ENTREZGENE
PANTHER	PROTEIN SHISA-8	UniProtKB/TrEMBL
	PTHR31774	UniProtKB/TrEMBL
Pfam	Shisa	UniProtKB/TrEMBL
PhenoGen	Shisa8	PhenoGen
RatGTEx	ENSRNOG00000049407	RatGTEx
UniProt	A0A8I6AMC5_RAT	UniProtKB/TrEMBL
	A6HT49	ENTREZGENE, UniProtKB/TrEMBL
	M0R5B1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-07	Shisa8	shisa family member 8	Shisa8	shisa homolog 8 (Xenopus laevis)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-05-26	Shisa8	shisa homolog 8 (Xenopus laevis)	RGD1563996	similar to Protein UNQ9166/PRO28631 precursor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1563996	similar to Protein UNQ9166/PRO28631 precursor	RGD1563996_predicted	similar to Protein UNQ9166/PRO28631 precursor (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1563996_predicted	similar to Protein UNQ9166/PRO28631 precursor (predicted)	LOC315163	similar to Protein UNQ9166/PRO28631 precursor	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC315163	similar to Protein UNQ9166/PRO28631 precursor			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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