Zfp706 (zinc finger protein 706) - Rat Genome Database

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Gene: Zfp706 (zinc finger protein 706) Rattus norvegicus
Analyze
Symbol: Zfp706
Name: zinc finger protein 706
RGD ID: 1563959
Description: Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of stem cell population maintenance. Predicted to be located in cytoplasm and nucleus. Orthologous to human ZNF706 (zinc finger protein 706); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC500855; LOC500855; Znf706
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8770,050,960 - 70,059,588 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl770,052,534 - 70,059,159 (-)EnsemblGRCr8
mRatBN7.2768,167,496 - 68,174,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl768,166,323 - 68,174,148 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx770,055,864 - 70,062,512 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0772,258,479 - 72,265,127 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0772,126,368 - 72,133,016 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0775,803,310 - 75,809,853 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl775,801,735 - 75,809,836 (-)Ensemblrn6Rnor6.0
Rnor_5.0775,945,357 - 75,951,900 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4772,511,133 - 72,517,676 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera765,244,549 - 65,251,092 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Comprehensive gene review and curation RGD comprehensive gene curation
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:24412312  


Genomics

Comparative Map Data
Zfp706
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8770,050,960 - 70,059,588 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl770,052,534 - 70,059,159 (-)EnsemblGRCr8
mRatBN7.2768,167,496 - 68,174,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl768,166,323 - 68,174,148 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx770,055,864 - 70,062,512 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0772,258,479 - 72,265,127 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0772,126,368 - 72,133,016 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0775,803,310 - 75,809,853 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl775,801,735 - 75,809,836 (-)Ensemblrn6Rnor6.0
Rnor_5.0775,945,357 - 75,951,900 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4772,511,133 - 72,517,676 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera765,244,549 - 65,251,092 (-)NCBICelera
Cytogenetic Map7q22NCBI
ZNF706
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388101,197,052 - 101,206,222 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8101,177,720 - 101,207,085 (-)Ensemblhg38GRCh38
GRCh378102,209,280 - 102,218,450 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368102,278,442 - 102,287,166 (-)NCBIBuild 36Build 36hg18NCBI36
Celera898,394,217 - 98,402,912 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef897,407,169 - 97,416,179 (-)NCBIHuRef
CHM1_18102,249,557 - 102,258,585 (-)NCBICHM1_1
T2T-CHM13v2.08102,322,770 - 102,331,941 (-)NCBIT2T-CHM13v2.0
Zfp706
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391536,997,271 - 37,007,646 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1536,997,271 - 37,008,017 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381536,997,027 - 37,007,402 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1536,997,027 - 37,007,773 (-)Ensemblmm10GRCm38
MGSCv371536,926,782 - 36,937,157 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361536,941,616 - 36,951,991 (-)NCBIMGSCv36mm8
Celera1537,596,719 - 37,635,153 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1514.59NCBI
Znf706
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541716,263,846 - 16,268,527 (-)Ensembl
ChiLan1.0NW_00495541716,263,846 - 16,268,526 (-)NCBIChiLan1.0ChiLan1.0
ZNF706
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27118,548,086 - 118,555,144 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1894,083,869 - 94,093,307 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0897,835,750 - 97,845,132 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18100,004,219 - 100,012,125 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8100,004,227 - 100,012,127 (-)EnsemblpanPan2panpan1.1
ZNF706
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1132,967,884 - 2,978,040 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl132,969,983 - 2,976,279 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha132,967,797 - 2,978,050 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0133,125,325 - 3,135,591 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl133,125,329 - 3,135,252 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1132,968,884 - 2,979,130 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0133,081,781 - 3,091,993 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0133,098,385 - 3,108,693 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Znf706
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530334,813,862 - 34,827,393 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647042,245,765 - 42,251,590 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647042,245,657 - 42,253,492 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF706
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl435,768,190 - 35,774,386 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1435,768,087 - 35,777,048 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2438,717,300 - 38,724,418 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF706
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1896,062,498 - 96,072,104 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl896,064,379 - 96,067,511 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603944,610,321 - 44,619,573 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf706
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247637,936,268 - 7,941,014 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247637,934,894 - 7,942,900 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Znf706
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11210,516,231 - 210,521,032 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zfp706
75 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:93
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000010801
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH133363  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8770,052,690 - 70,053,564 (+)Marker Load Pipeline
mRatBN7.2768,167,652 - 68,168,526 (+)MAPPERmRatBN7.2
Rnor_6.0775,803,464 - 75,804,337NCBIRnor6.0
Rnor_5.0775,945,511 - 75,946,384UniSTSRnor5.0
RGSC_v3.4772,511,287 - 72,512,160UniSTSRGSC3.4
Celera765,244,703 - 65,245,576UniSTS
RH 3.4 Map7641.2UniSTS
Cytogenetic Map7q22UniSTS
9STS01  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2932,970,527 - 32,970,666 (+)MAPPERmRatBN7.2
mRatBN7.2768,167,660 - 68,167,799 (+)MAPPERmRatBN7.2
Rnor_6.0775,803,472 - 75,803,610NCBIRnor6.0
Rnor_6.0936,980,942 - 36,981,080NCBIRnor6.0
Rnor_5.0935,785,865 - 35,786,003UniSTSRnor5.0
Rnor_5.0775,945,519 - 75,945,657UniSTSRnor5.0
RGSC_v3.4772,511,295 - 72,511,433UniSTSRGSC3.4
RGSC_v3.4929,371,308 - 29,371,446UniSTSRGSC3.4
Celera930,790,902 - 30,791,040UniSTS
Celera765,244,711 - 65,244,849UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000084114   ⟹   ENSRNOP00000071758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl770,052,534 - 70,059,159 (-)Ensembl
mRatBN7.2 Ensembl768,166,323 - 68,174,148 (-)Ensembl
Rnor_6.0 Ensembl775,801,735 - 75,809,836 (-)Ensembl
RefSeq Acc Id: NM_001394374   ⟹   NP_001381303
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8770,052,534 - 70,059,159 (-)NCBI
mRatBN7.2768,167,496 - 68,174,121 (-)NCBI
RefSeq Acc Id: XM_063264113   ⟹   XP_063120183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8770,050,960 - 70,059,588 (-)NCBI
Ensembl Acc Id: ENSRNOP00000071758   ⟸   ENSRNOT00000084114
RefSeq Acc Id: NP_001381303   ⟸   NM_001394374
- UniProtKB: A6HR39 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120183   ⟸   XM_063264113
- Peptide Label: isoform X1
- UniProtKB: A6HR39 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type   Small EDRK-rich factor-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K1A1-F1-model_v2 AlphaFold A0A0G2K1A1 1-76 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695311
Promoter ID:EPDNEW_R5820
Type:initiation region
Name:Zfp706_1
Description:zinc finger protein 706
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0775,809,861 - 75,809,921EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563959 AgrOrtholog
BioCyc Gene G2FUF-33634 BioCyc
Ensembl Genes ENSRNOG00000060956 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084114 ENTREZGENE
  ENSRNOT00000084114.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1050.10 UniProtKB/TrEMBL
InterPro MBS1/2-like UniProtKB/TrEMBL
  Uncharacterised_SERF UniProtKB/TrEMBL
  ZNF706/At2g23090_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene 500855 ENTREZGENE
PANTHER PTHR21213 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 706 UniProtKB/TrEMBL
Pfam 4F5 UniProtKB/TrEMBL
  zf-met UniProtKB/TrEMBL
PharmGKB ZNF706 RGD
PhenoGen Zfp706 PhenoGen
RatGTEx ENSRNOG00000060956 RatGTEx
Superfamily-SCOP Expressed protein At2g23090/F21P24.15 UniProtKB/TrEMBL
UniProt A0A0G2K1A1_RAT UniProtKB/TrEMBL
  A6HR39 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJE5_RAT UniProtKB/TrEMBL
UniProt Secondary Q5XI92 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-03-15 Zfp706  zinc finger protein 706  Znf706  zinc finger protein 706  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Znf706  zinc finger protein 706  Zfp706  zinc finger protein 706  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Zfp706  zinc finger protein 706  LOC500855  hypothetical protein LOC500855  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500855  hypothetical protein LOC500855      Symbol and Name status set to provisional 70820 PROVISIONAL