Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Wtap | Rat | 1,2-dichloroethane | increases expression | ISO | Wtap (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of WTAP mRNA | CTD | PMID:28960355 | Wtap | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Wtap (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of WTAP mRNA | CTD | PMID:22206623 | Wtap | Rat | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Wtap (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | Wtap | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Wtap (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of WTAP mRNA | CTD | PMID:21354282 | Wtap | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Wtap (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of WTAP mRNA | CTD | PMID:24680724 | Wtap | Rat | 2,4,6-tribromophenol | increases expression | ISO | Wtap (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38157273 | Wtap | Rat | 2,4,6-tribromophenol | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:38157273 | Wtap | Rat | 2,4,6-trichlorophenol | increases expression | ISO | Wtap (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38157273 | Wtap | Rat | 5-fluorouracil | multiple interactions | ISO | WTAP (Homo sapiens) | 6480464 | TP53 protein affects the reaction [Fluorouracil results in decreased expression of WTAP mRNA] | CTD | PMID:15016801 | Wtap | Rat | all-trans-retinoic acid | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Tretinoin results in increased expression of WTAP mRNA | CTD | PMID:23724009 | Wtap | Rat | amiodarone | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Amiodarone results in increased expression of WTAP mRNA | CTD | PMID:19774075 | Wtap | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of WTAP mRNA | CTD | PMID:38685447 | Wtap | Rat | antirheumatic drug | decreases expression | ISO | WTAP (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of WTAP mRNA | CTD | PMID:24449571 | Wtap | Rat | Aroclor 1254 | decreases expression | ISO | Wtap (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of WTAP mRNA | CTD | PMID:23650126 | Wtap | Rat | arsane | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Arsenic results in increased expression of WTAP | CTD | PMID:35363433 | Wtap | Rat | arsenic atom | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Arsenic results in increased expression of WTAP | CTD | PMID:35363433 | Wtap | Rat | benzo[a]pyrene | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of WTAP mRNA | CTD | PMID:17879257 | Wtap | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | WTAP (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 | Wtap | Rat | bis(2-ethylhexyl) phthalate | increases expression | ISO | Wtap (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of WTAP mRNA | CTD | PMID:36423848 | Wtap | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of WTAP mRNA | CTD | PMID:25181051 | Wtap | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of WTAP protein | CTD | PMID:37495067 | Wtap | Rat | bisphenol A | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | bisphenol A results in increased expression of WTAP protein | CTD | PMID:34186270 | Wtap | Rat | bisphenol AF | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | bisphenol AF results in increased expression of WTAP protein | CTD | PMID:34186270 | Wtap | Rat | bisphenol F | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | bisphenol F results in increased expression of WTAP protein | CTD | PMID:34186270 | Wtap | Rat | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of WTAP mRNA | CTD | PMID:33453195 | Wtap | Rat | cadmium dichloride | decreases expression | ISO | WTAP (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of WTAP mRNA | CTD | PMID:38568856 | Wtap | Rat | cadmium dichloride | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of WTAP mRNA | CTD | PMID:26472689 | Wtap | Rat | casticin | decreases expression | ISO | Wtap (Mus musculus) | 6480464 | casticin results in decreased expression of WTAP mRNA | CTD | PMID:28444820 | Wtap | Rat | CGP 52608 | multiple interactions | ISO | WTAP (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to WTAP gene] | CTD | PMID:28238834 | Wtap | Rat | clobetasol | decreases expression | ISO | Wtap (Mus musculus) | 6480464 | Clobetasol results in decreased expression of WTAP mRNA | CTD | PMID:27462272 | Wtap | Rat | cobalt atom | decreases expression | ISO | Wtap (Mus musculus) | 6480464 | Cobalt results in decreased expression of WTAP protein | CTD | PMID:32827984 | Wtap | Rat | cobalt atom | affects expression | ISO | Wtap (Mus musculus) | 6480464 | Cobalt affects the expression of WTAP mRNA | CTD | PMID:32827984 | Wtap | Rat | cobalt atom | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Cobalt results in increased expression of WTAP mRNA and Cobalt results in increased expression of WTAP protein | CTD | PMID:32827984 | Wtap | Rat | crocidolite asbestos | affects expression | ISO | WTAP (Homo sapiens) | 6480464 | Asbestos and Crocidolite affects the expression of WTAP mRNA | CTD | PMID:25757056 | Wtap | Rat | crocidolite asbestos | decreases expression | ISO | Wtap (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of WTAP mRNA | CTD | PMID:29279043 | Wtap | Rat | cyclosporin A | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of WTAP mRNA | CTD | PMID:20106945 | Wtap | Rat | disodium selenite | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of WTAP mRNA | CTD | PMID:18175754 | Wtap | Rat | enzyme inhibitor | multiple interactions | ISO | WTAP (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of WTAP protein | CTD | PMID:23301498 | Wtap | Rat | ethanol | increases expression | ISO | Wtap (Mus musculus) | 6480464 | Ethanol results in increased expression of WTAP mRNA | CTD | PMID:30319688 | Wtap | Rat | ethanol | affects splicing | ISO | Wtap (Mus musculus) | 6480464 | Ethanol affects the splicing of WTAP mRNA | CTD | PMID:30319688 | Wtap | Rat | folic acid | decreases expression | ISO | Wtap (Mus musculus) | 6480464 | Folic Acid results in decreased expression of WTAP mRNA | CTD | PMID:25629700 | Wtap | Rat | formaldehyde | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of WTAP mRNA | CTD | PMID:20655997 | Wtap | Rat | FR900359 | affects phosphorylation | ISO | WTAP (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of WTAP protein | CTD | PMID:37730182 | Wtap | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of WTAP mRNA | CTD | PMID:22061828 | Wtap | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of WTAP mRNA | CTD | PMID:33387578 | Wtap | Rat | hydrogen peroxide | multiple interactions | ISO | WTAP (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WTAP protein | CTD | PMID:18951874 | Wtap | Rat | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of WTAP mRNA | CTD | PMID:20080153 | Wtap | Rat | lipopolysaccharide | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of WTAP mRNA | CTD | PMID:35811015 | Wtap | Rat | lipopolysaccharide | multiple interactions | ISO | WTAP (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | Wtap | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of WTAP mRNA | CTD | PMID:38685447 | Wtap | Rat | methyl methanesulfonate | decreases expression | ISO | WTAP (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of WTAP mRNA | CTD | PMID:23649840 | Wtap | Rat | miconazole | decreases expression | ISO | Wtap (Mus musculus) | 6480464 | Miconazole results in decreased expression of WTAP mRNA | CTD | PMID:27462272 | Wtap | Rat | mitomycin C | affects response to substance | ISO | WTAP (Homo sapiens) | 6480464 | WTAP protein affects the susceptibility to Mitomycin | CTD | PMID:16217747 | Wtap | Rat | mono(2-ethylhexyl) phthalate | increases expression | ISO | Wtap (Mus musculus) | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of WTAP mRNA | CTD | PMID:36174712 | Wtap | Rat | N-acetyl-L-cysteine | multiple interactions | ISO | WTAP (Homo sapiens) | 6480464 | Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of WTAP mRNA] and Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of WTAP protein] | CTD | PMID:31004932 | Wtap | Rat | nickel sulfate | decreases expression | ISO | WTAP (Homo sapiens) | 6480464 | nickel sulfate results in decreased expression of WTAP mRNA | CTD | PMID:22714537 | Wtap | Rat | paracetamol | affects expression | ISO | Wtap (Mus musculus) | 6480464 | Acetaminophen affects the expression of WTAP mRNA | CTD | PMID:17562736 | Wtap | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of WTAP mRNA | CTD | PMID:33387578 | Wtap | Rat | pentachlorophenol | increases expression | ISO | Wtap (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of WTAP mRNA | CTD | PMID:23892564 | Wtap | Rat | PhIP | decreases expression | ISO | WTAP (Homo sapiens) | 6480464 | 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in decreased expression of WTAP mRNA | CTD | PMID:20816883 | Wtap | Rat | pirinixic acid | decreases expression | ISO | Wtap (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of WTAP mRNA | CTD | PMID:17426115 | Wtap | Rat | poly(I:C) | multiple interactions | ISO | WTAP (Homo sapiens) | 6480464 | [TL8-506 co-treated with Poly I-C] results in increased expression of WTAP mRNA | CTD | PMID:35688559 | Wtap | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | WTAP (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | Wtap | Rat | sodium arsenite | decreases expression | ISO | WTAP (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of WTAP mRNA | CTD | PMID:22714537 more ... | Wtap | Rat | sodium arsenite | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of WTAP mRNA and sodium arsenite results in increased expression of WTAP protein | CTD | PMID:31004932 | Wtap | Rat | sodium arsenite | multiple interactions | ISO | WTAP (Homo sapiens) | 6480464 | Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of WTAP mRNA] and Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of WTAP protein] | CTD | PMID:31004932 | Wtap | Rat | sodium arsenite | affects expression | ISO | WTAP (Homo sapiens) | 6480464 | sodium arsenite affects the expression of WTAP mRNA and sodium arsenite affects the expression of WTAP protein | CTD | PMID:29680375 and PMID:30654086 | Wtap | Rat | sodium arsenite | increases expression | ISO | Wtap (Mus musculus) | 6480464 | sodium arsenite results in increased expression of WTAP protein | CTD | PMID:37061066 | Wtap | Rat | sunitinib | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Sunitinib results in increased expression of WTAP mRNA | CTD | PMID:31533062 | Wtap | Rat | tamoxifen | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Tamoxifen results in increased expression of WTAP mRNA | CTD | PMID:15604281 | Wtap | Rat | temozolomide | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | Temozolomide results in increased expression of WTAP mRNA | CTD | PMID:31758290 | Wtap | Rat | theophylline | multiple interactions | ISO | WTAP (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WTAP protein | CTD | PMID:18951874 | Wtap | Rat | thiram | decreases expression | ISO | WTAP (Homo sapiens) | 6480464 | Thiram results in decreased expression of WTAP mRNA | CTD | PMID:38568856 | Wtap | Rat | titanium dioxide | decreases methylation | ISO | Wtap (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of WTAP promoter | CTD | PMID:35295148 | Wtap | Rat | triphenyl phosphate | affects expression | ISO | WTAP (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of WTAP mRNA | CTD | PMID:37042841 | Wtap | Rat | valproic acid | decreases methylation | ISO | WTAP (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of WTAP gene | CTD | PMID:29154799 | Wtap | Rat | valproic acid | affects expression | ISO | Wtap (Mus musculus) | 6480464 | Valproic Acid affects the expression of WTAP mRNA | CTD | PMID:17963808 | Wtap | Rat | valproic acid | decreases expression | ISO | Wtap (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of WTAP mRNA | CTD | PMID:20546886 | Wtap | Rat | valproic acid | affects expression | ISO | WTAP (Homo sapiens) | 6480464 | Valproic Acid affects the expression of WTAP mRNA | CTD | PMID:25979313 | Wtap | Rat | valproic acid | decreases expression | ISO | WTAP (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of WTAP mRNA | CTD | PMID:23179753 more ... | Wtap | Rat | zoledronic acid | increases expression | ISO | WTAP (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of WTAP mRNA | CTD | PMID:24714768 | |