Slc5a1l1 (solute carrier family 5 member 1 like 1) - Rat Genome Database

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Gene: Slc5a1l1 (solute carrier family 5 member 1 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Slc5a1l1
Name: solute carrier family 5 member 1 like 1
RGD ID: 1563815
Description: Predicted to enable D-glucose:sodium symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane; INTERACTS WITH acrylamide; bisphenol A; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC365549; LOC100909546; LOC365549; RGD1563815; similar to sodium-glucose cotransporter-like 1; sodium/glucose cotransporter 1-like; uncharacterized protein LOC365549
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,663,819 - 12,713,293 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2012,663,826 - 12,713,142 (-)EnsemblGRCr8
mRatBN7.22012,664,388 - 12,713,968 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,664,387 - 12,713,716 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2013,366,170 - 13,413,411 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,727,099 - 12,774,331 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,198,887 - 13,246,124 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,603,644 - 13,653,006 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,603,651 - 13,652,909 (-)Ensemblrn6Rnor6.0
Rnor_5.02015,759,033 - 15,808,503 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42013,065,552 - 13,112,525 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2014,158,389 - 14,205,012 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14986005  


Genomics

Variants

.
Variants in Slc5a1l1
931 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:34
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000058343
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
D20Mco1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82012,675,667 - 12,675,811 (+)Marker Load Pipeline
mRatBN7.22012,676,228 - 12,676,372 (+)MAPPERmRatBN7.2
Rnor_6.02013,615,493 - 13,615,636NCBIRnor6.0
Rnor_5.02015,770,876 - 15,771,019UniSTSRnor5.0
RGSC_v3.42013,074,769 - 13,074,913RGDRGSC3.4
RGSC_v3.42013,074,770 - 13,074,913UniSTSRGSC3.4
Celera2014,167,591 - 14,167,734UniSTS
RGSC_v3.12013,074,996 - 13,075,140RGD
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
1 1 14 5 15 9 5 12 5 42 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000058343   ⟹   ENSRNOP00000055145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,663,826 - 12,713,142 (-)Ensembl
mRatBN7.2 Ensembl2012,664,387 - 12,713,701 (-)Ensembl
Rnor_6.0 Ensembl2013,606,289 - 13,652,909 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077297   ⟹   ENSRNOP00000072044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,664,387 - 12,713,716 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083190   ⟹   ENSRNOP00000069755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,664,387 - 12,705,459 (-)Ensembl
Rnor_6.0 Ensembl2013,603,651 - 13,647,581 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088587   ⟹   ENSRNOP00000072375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,664,387 - 12,713,716 (-)Ensembl
RefSeq Acc Id: NM_001127556   ⟹   NP_001121028
RefSeq Status: PREDICTED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,666,464 - 12,713,142 (-)NCBI
mRatBN7.22012,667,025 - 12,713,701 (-)NCBI
Rnor_6.02013,606,289 - 13,652,909 (-)NCBI
Rnor_5.02015,759,033 - 15,808,503 (-)NCBI
RGSC_v3.42013,065,552 - 13,112,525 (-)RGD
Celera2014,158,389 - 14,205,012 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256320   ⟹   XP_006256382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,663,819 - 12,713,293 (-)NCBI
mRatBN7.22012,664,388 - 12,713,961 (-)NCBI
Rnor_6.02013,603,644 - 13,653,004 (-)NCBI
Rnor_5.02015,759,033 - 15,808,503 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601697   ⟹   XP_017457186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,663,819 - 12,713,028 (-)NCBI
mRatBN7.22012,664,388 - 12,713,587 (-)NCBI
Rnor_6.02013,603,644 - 13,652,745 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601699   ⟹   XP_017457188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,663,819 - 12,713,182 (-)NCBI
mRatBN7.22012,665,248 - 12,713,968 (-)NCBI
Rnor_6.02013,604,570 - 13,653,006 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001121028   ⟸   NM_001127556
- UniProtKB: D3ZEM7 (UniProtKB/TrEMBL),   A6JKE7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256382   ⟸   XM_006256320
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457186   ⟸   XM_017601697
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K2U1 (UniProtKB/TrEMBL),   B1WBT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457188   ⟸   XM_017601699
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000055145   ⟸   ENSRNOT00000058343
Ensembl Acc Id: ENSRNOP00000069755   ⟸   ENSRNOT00000083190
Ensembl Acc Id: ENSRNOP00000072375   ⟸   ENSRNOT00000088587
Ensembl Acc Id: ENSRNOP00000072044   ⟸   ENSRNOT00000077297

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WBT6-F1-model_v2 AlphaFold B1WBT6 1-628 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563815 AgrOrtholog
BioCyc Gene G2FUF-4173 BioCyc
Ensembl Genes ENSRNOG00000029979 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058343 ENTREZGENE
  ENSRNOT00000058343.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1730.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131276 IMAGE-MGC_LOAD
InterPro Na/Glc_symporter_sf UniProtKB/TrEMBL
  Na/solute_symporter UniProtKB/TrEMBL
KEGG Report rno:365549 UniProtKB/TrEMBL
MGC_CLONE MGC:187451 IMAGE-MGC_LOAD
NCBI Gene 365549 ENTREZGENE
PANTHER GENE 5134-RELATED UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 5 UniProtKB/TrEMBL
Pfam SSF UniProtKB/TrEMBL
PhenoGen Slc5a1l1 PhenoGen
PROSITE NA_SOLUT_SYMP_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029979 RatGTEx
UniProt A0A0G2K1Z3 ENTREZGENE
  A0A0G2K2U1 ENTREZGENE
  A6JKE7 ENTREZGENE, UniProtKB/TrEMBL
  B1WBT6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZEM7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Slc5a1l1  solute carrier family 5 member 1 like 1  RGD1563815  similar to sodium-glucose cotransporter-like 1  Symbol and Name Changed 1299863 APPROVED
2021-03-09 RGD1563815  similar to sodium-glucose cotransporter-like 1  LOC100909546  sodium/glucose cotransporter 1-like  Data merged from RGD:6502921 737654 PROVISIONAL
2012-07-05 LOC100909546  sodium/glucose cotransporter 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1563815  similar to sodium-glucose cotransporter-like 1   RGD1563815_predicted  similar to sodium-glucose cotransporter-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563815_predicted  similar to sodium-glucose cotransporter-like 1 (predicted)  LOC365549  similar to sodium-glucose cotransporter-like 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC365549  similar to sodium-glucose cotransporter-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL