Tmem182 (transmembrane protein 182) - Rat Genome Database

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Gene: Tmem182 (transmembrane protein 182) Rattus norvegicus
Analyze
Symbol: Tmem182
Name: transmembrane protein 182
RGD ID: 1563696
Description: Predicted to be involved in myotube cell development involved in skeletal muscle regeneration; negative regulation of myoblast differentiation; and negative regulation of myoblast fusion. Predicted to be located in plasma membrane. Orthologous to human TMEM182 (transmembrane protein 182); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC501129; RGD1563696; similar to hypothetical protein FLJ30294
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,555,029 - 50,606,908 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl950,550,462 - 50,606,907 (+)EnsemblGRCr8
mRatBN7.2943,059,432 - 43,111,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl943,059,439 - 43,111,317 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx951,559,572 - 51,611,474 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,682,285 - 56,734,191 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,960,106 - 55,011,959 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,536,824 - 47,588,677 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,536,824 - 47,588,677 (+)Ensemblrn6Rnor6.0
Rnor_5.0947,219,880 - 47,271,733 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4939,961,253 - 40,013,106 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera940,801,817 - 40,853,670 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tmem182
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,555,029 - 50,606,908 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl950,550,462 - 50,606,907 (+)EnsemblGRCr8
mRatBN7.2943,059,432 - 43,111,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl943,059,439 - 43,111,317 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx951,559,572 - 51,611,474 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,682,285 - 56,734,191 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,960,106 - 55,011,959 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,536,824 - 47,588,677 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,536,824 - 47,588,677 (+)Ensemblrn6Rnor6.0
Rnor_5.0947,219,880 - 47,271,733 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4939,961,253 - 40,013,106 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera940,801,817 - 40,853,670 (+)NCBICelera
Cytogenetic Map9q22NCBI
TMEM182
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382102,736,935 - 102,843,838 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2102,736,905 - 103,019,900 (+)Ensemblhg38GRCh38
GRCh372103,353,394 - 103,434,138 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,744,967 - 102,800,302 (+)NCBIBuild 36Build 36hg18NCBI36
Celera297,579,654 - 97,635,286 (+)NCBICelera
Cytogenetic Map2q12.1NCBI
HuRef297,142,775 - 97,198,421 (+)NCBIHuRef
CHM1_12103,382,806 - 103,438,454 (+)NCBICHM1_1
T2T-CHM13v2.02103,195,615 - 103,302,530 (+)NCBIT2T-CHM13v2.0
Tmem182
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,844,738 - 40,896,047 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,844,761 - 40,896,047 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38140,805,573 - 40,856,887 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,805,601 - 40,856,887 (+)Ensemblmm10GRCm38
MGSCv37140,862,446 - 40,912,112 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36140,750,147 - 40,799,813 (+)NCBIMGSCv36mm8
Celera140,617,368 - 40,666,776 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map120.01NCBI
Tmem182
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554708,173,829 - 8,218,494 (+)Ensembl
ChiLan1.0NW_0049554708,173,845 - 8,218,325 (+)NCBIChiLan1.0ChiLan1.0
TMEM182
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21224,892,901 - 24,972,703 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A24,864,824 - 24,975,474 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A98,889,198 - 99,085,883 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A103,859,045 - 103,915,619 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A103,858,473 - 104,030,989 (+)EnsemblpanPan2panpan1.1
TMEM182
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,227,230 - 40,283,747 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,102,097 - 40,283,703 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1040,150,794 - 40,210,020 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01041,091,118 - 41,150,390 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1040,968,513 - 41,150,368 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11040,805,674 - 40,865,099 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01041,086,767 - 41,146,005 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01041,278,981 - 41,338,262 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem182
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629289,697,207 - 89,749,628 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367131,383,371 - 1,436,206 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367131,383,371 - 1,436,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM182
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl351,400,171 - 51,496,293 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1351,258,464 - 51,492,690 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2353,685,308 - 53,918,906 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM182
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,392,878 - 6,475,192 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl146,418,384 - 6,476,881 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041174,076,752 - 174,162,877 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem182
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247497,230,420 - 7,273,668 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247497,230,488 - 7,276,763 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem182
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14117,028,515 - 117,077,569 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem182
349 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:441
Count of miRNA genes:229
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000049349
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 12 66 84 53 52 21 28 21 6 227 127 11 56 62 84 31 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000049349   ⟹   ENSRNOP00000049496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl950,555,054 - 50,606,907 (+)Ensembl
mRatBN7.2 Ensembl943,059,439 - 43,111,317 (+)Ensembl
Rnor_6.0 Ensembl947,536,824 - 47,588,677 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129783   ⟹   ENSRNOP00000105474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl950,550,462 - 50,606,907 (+)Ensembl
RefSeq Acc Id: NM_001109305   ⟹   NP_001102775
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,555,054 - 50,606,907 (+)NCBI
mRatBN7.2943,059,458 - 43,111,317 (+)NCBI
Rnor_6.0947,536,824 - 47,588,677 (+)NCBI
Rnor_5.0947,219,880 - 47,271,733 (+)NCBI
RGSC_v3.4939,961,253 - 40,013,106 (+)RGD
Celera940,801,817 - 40,853,670 (+)RGD
Sequence:
RefSeq Acc Id: XM_039084077   ⟹   XP_038940005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,555,030 - 50,606,908 (+)NCBI
mRatBN7.2943,059,434 - 43,111,318 (+)NCBI
RefSeq Acc Id: XM_039084078   ⟹   XP_038940006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,555,199 - 50,606,908 (+)NCBI
mRatBN7.2943,059,434 - 43,111,318 (+)NCBI
RefSeq Acc Id: XM_039084079   ⟹   XP_038940007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,555,029 - 50,606,908 (+)NCBI
mRatBN7.2943,059,433 - 43,111,318 (+)NCBI
RefSeq Acc Id: XM_039084080   ⟹   XP_038940008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,555,199 - 50,606,908 (+)NCBI
mRatBN7.2943,059,432 - 43,111,318 (+)NCBI
RefSeq Acc Id: XM_039084081   ⟹   XP_038940009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,555,029 - 50,558,061 (+)NCBI
mRatBN7.2943,059,434 - 43,062,465 (+)NCBI
RefSeq Acc Id: NP_001102775   ⟸   NM_001109305
- UniProtKB: A6INP7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049496   ⟸   ENSRNOT00000049349
RefSeq Acc Id: XP_038940008   ⟸   XM_039084080
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038940007   ⟸   XM_039084079
- Peptide Label: isoform X2
- UniProtKB: D3ZZT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940005   ⟸   XM_039084077
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038940006   ⟸   XM_039084078
- Peptide Label: isoform X2
- UniProtKB: D3ZZT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940009   ⟸   XM_039084081
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000105474   ⟸   ENSRNOT00000129783

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZT3-F1-model_v2 AlphaFold D3ZZT3 1-229 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696636
Promoter ID:EPDNEW_R7161
Type:multiple initiation site
Name:Tmem182_1
Description:transmembrane protein 182
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0947,536,851 - 47,536,911EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563696 AgrOrtholog
BioCyc Gene G2FUF-27715 BioCyc
Ensembl Genes ENSRNOG00000028945 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049349 ENTREZGENE
  ENSRNOT00000049349.5 UniProtKB/TrEMBL
  ENSRNOT00000129783.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/TrEMBL
InterPro PMP22/EMP/MP20/Claudin UniProtKB/TrEMBL
  TMEM182 UniProtKB/TrEMBL
KEGG Report rno:501129 UniProtKB/TrEMBL
NCBI Gene 501129 ENTREZGENE
PANTHER PTHR32012 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 182 UniProtKB/TrEMBL
Pfam Claudin_2 UniProtKB/TrEMBL
PhenoGen Tmem182 PhenoGen
RatGTEx ENSRNOG00000028945 RatGTEx
UniProt A0ABK0LTB3_RAT UniProtKB/TrEMBL
  A6INP7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZT3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Tmem182  transmembrane protein 182  RGD1563696_predicted  similar to hypothetical protein FLJ30294 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563696_predicted  similar to hypothetical protein FLJ30294 (predicted)  LOC501129  similar to hypothetical protein FLJ30294  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501129  similar to hypothetical protein FLJ30294      Symbol and Name status set to provisional 70820 PROVISIONAL