Lancl3 (LanC like family member 3) - Rat Genome Database

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Pathways
Gene: Lancl3 (LanC like family member 3) Rattus norvegicus
Analyze
Symbol: Lancl3
Name: LanC like family member 3
RGD ID: 1563642
Description: Predicted to be involved in carbohydrate metabolic process and peptide modification. Predicted to be active in plasma membrane. Orthologous to human LANCL3 (LanC like family member 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LanC lantibiotic synthetase component C-like 3; LanC lantibiotic synthetase component C-like 3 (bacterial); LanC like 3; lanC-like protein 3; lanC-like protein 3-like; LOC100909554; LOC302540; RGD1563642; similar to LanC lantibiotic synthetase component C-like 3; similar to RIKEN cDNA 6030463G20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X16,150,991 - 16,282,425 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX16,150,991 - 16,282,425 (-)EnsemblGRCr8
mRatBN7.2X13,478,499 - 13,609,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX13,480,311 - 13,609,678 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX13,668,026 - 13,802,683 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X17,164,957 - 17,299,612 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X13,421,537 - 13,556,192 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X14,358,224 - 14,490,340 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX14,358,224 - 14,490,340 (+)Ensemblrn6Rnor6.0
Rnor_5.0X15,139,374 - 15,271,030 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X25,632,939 - 25,763,093 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX13,918,129 - 13,943,497 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Lancl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X16,150,991 - 16,282,425 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX16,150,991 - 16,282,425 (-)EnsemblGRCr8
mRatBN7.2X13,478,499 - 13,609,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX13,480,311 - 13,609,678 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX13,668,026 - 13,802,683 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X17,164,957 - 17,299,612 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X13,421,537 - 13,556,192 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X14,358,224 - 14,490,340 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX14,358,224 - 14,490,340 (+)Ensemblrn6Rnor6.0
Rnor_5.0X15,139,374 - 15,271,030 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X25,632,939 - 25,763,093 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX13,918,129 - 13,943,497 (+)NCBICelera
Cytogenetic MapXq12NCBI
LANCL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X37,571,661 - 37,684,463 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX37,571,569 - 37,684,463 (+)Ensemblhg38GRCh38
GRCh37X37,430,914 - 37,543,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X37,315,741 - 37,421,668 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X37,187,013 - 37,292,941NCBI
CeleraX41,568,483 - 41,674,412 (+)NCBICelera
Cytogenetic MapXp21.1NCBI
HuRefX35,177,392 - 35,283,210 (+)NCBIHuRef
CHM1_1X37,461,942 - 37,567,881 (+)NCBICHM1_1
T2T-CHM13v2.0X36,975,217 - 37,088,020 (+)NCBIT2T-CHM13v2.0
Lancl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X9,066,212 - 9,134,324 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX9,066,141 - 9,134,324 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X9,199,973 - 9,268,085 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX9,199,902 - 9,268,085 (+)Ensemblmm10GRCm38
MGSCv37X8,777,099 - 8,845,211 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X8,356,932 - 8,425,044 (+)NCBIMGSCv36mm8
CeleraX6,939,793 - 7,007,686 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX4.18NCBI
Lancl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955587556,105 - 658,735 (+)Ensembl
ChiLan1.0NW_004955587556,105 - 658,735 (+)NCBIChiLan1.0ChiLan1.0
LANCL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X39,219,967 - 39,333,348 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X39,223,341 - 39,336,722 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X30,021,481 - 30,134,830 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X37,731,552 - 37,838,564 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX37,731,552 - 37,838,564 (+)EnsemblpanPan2panpan1.1
LANCL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X32,349,007 - 32,452,130 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX32,349,269 - 32,443,254 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX19,697,168 - 19,799,843 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X32,388,686 - 32,489,931 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX32,388,634 - 32,482,657 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X32,475,050 - 32,577,678 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X32,439,725 - 32,542,739 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X32,487,876 - 32,590,728 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lancl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X24,578,494 - 24,681,314 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365024,419,474 - 4,520,795 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365024,419,279 - 4,522,025 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LANCL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX33,427,444 - 33,541,304 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X33,426,731 - 33,543,506 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X37,128,910 - 37,198,298 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LANCL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605638,041,100 - 38,147,980 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lancl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476217,925,158 - 18,033,734 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476217,916,148 - 18,033,799 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lancl3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X11,900,009 - 11,925,217 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lancl3
754 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:74
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000005042
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X400149324470521Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 58 132 69 65 39 70 39 6 283 151 3 114 70 90 26 16 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000005042   ⟹   ENSRNOP00000005042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX16,150,991 - 16,282,425 (-)Ensembl
mRatBN7.2 EnsemblX13,480,311 - 13,609,678 (-)Ensembl
Rnor_6.0 EnsemblX14,358,224 - 14,490,340 (+)Ensembl
RefSeq Acc Id: NM_001191728   ⟹   NP_001178657
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X16,150,991 - 16,282,425 (-)NCBI
mRatBN7.2X13,478,499 - 13,609,934 (-)NCBI
Rnor_6.0X14,358,224 - 14,490,340 (+)NCBI
Rnor_5.0X15,139,374 - 15,271,030 (+)NCBI
CeleraX13,918,129 - 13,943,497 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178657 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005042
  ENSRNOP00000005042.5
RefSeq Acc Id: NP_001178657   ⟸   NM_001191728
- UniProtKB: D3ZG98 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005042   ⟸   ENSRNOT00000005042

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZG98-F1-model_v2 AlphaFold D3ZG98 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563642 AgrOrtholog
BioCyc Gene G2FUF-2975 BioCyc
Ensembl Genes ENSRNOG00000003756 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005042 ENTREZGENE
  ENSRNOT00000005042.7 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
InterPro 6hp_glycosidase-like_sf UniProtKB/TrEMBL
  LANC-like UniProtKB/TrEMBL
  LanC-like_prot_euk UniProtKB/TrEMBL
KEGG Report rno:302540 UniProtKB/TrEMBL
NCBI Gene 302540 ENTREZGENE
PANTHER LANC-LIKE PROTEIN UniProtKB/TrEMBL
  LANC-LIKE PROTEIN 3 UniProtKB/TrEMBL
Pfam LANC_like UniProtKB/TrEMBL
PhenoGen Lancl3 PhenoGen
PRINTS LANCEUKARYTE UniProtKB/TrEMBL
  LANCSUPER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003756 RatGTEx
SMART LANC_like UniProtKB/TrEMBL
Superfamily-SCOP LanC-like UniProtKB/TrEMBL
UniProt D3ZG98 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Lancl3  LanC like family member 3  Lancl3  LanC like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Lancl3  LanC like 3  LOC100909554  lanC-like protein 3-like  Data merged from RGD:6502978 737654 PROVISIONAL
2016-01-13 Lancl3  LanC like 3  Lancl3  LanC lantibiotic synthetase component C-like 3 (bacterial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Lancl3  LanC lantibiotic synthetase component C-like 3 (bacterial)  LOC682660  similar to LanC lantibiotic synthetase component C-like 3  Data merged from RGD:1596632 1643240 APPROVED
2013-05-24 Lancl3  LanC lantibiotic synthetase component C-like 3 (bacterial)  LOC679199  similar to LanC lantibiotic synthetase component C-like 3  Data merged from RGD:1591800 1643240 APPROVED
2012-07-05 LOC100909554  lanC-like protein 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Lancl3  LanC lantibiotic synthetase component C-like 3 (bacterial)   Lancl3_predicted  LanC lantibiotic synthetase component C-like 3 (bacterial) (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC682660  similar to LanC lantibiotic synthetase component C-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC679199  similar to LanC lantibiotic synthetase component C-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Lancl3_predicted  LanC lantibiotic synthetase component C-like 3 (bacterial) (predicted)  RGD1563642_predicted  similar to RIKEN cDNA 6030463G20 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1563642_predicted  similar to RIKEN cDNA 6030463G20 (predicted)  LOC302540  similar to RIKEN cDNA 6030463G20  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302540  similar to RIKEN cDNA 6030463G20      Symbol and Name status set to provisional 70820 PROVISIONAL