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Gene: Cactin (cactin, spliceosome C complex subunit) Rattus norvegicus

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Symbol:

Cactin

Name:

cactin, spliceosome C complex subunit

RGD ID:

1563634

Description:

Predicted to be involved in several processes, including cellular response to cytokine stimulus; negative regulation of cytokine production; and negative regulation of signal transduction. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in cytoplasm. Orthologous to human CACTIN (cactin, spliceosome C complex subunit); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC500790; RGD1563634; similar to R31449_3; splicing factor Cactin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CACTIN (cactin, spliceosome C complex subunit)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cactin (cactin, spliceosome C complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cactin (cactin, spliceosome C complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CACTIN (cactin, spliceosome C complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CACTIN (cactin, spliceosome C complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cactin (cactin, spliceosome C complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CACTIN (cactin, spliceosome C complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CACTIN (cactin, spliceosome C complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cactin (cactin, spliceosome C complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cactin (cactin, spliceosome C complex subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Cactin (cactin, spliceosome C complex subunit)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CACTIN (cactin, spliceosome C complex subunit)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cactin	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cacn-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cacn-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	cactin	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	egfl8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cactin	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cactin	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	9,042,125 - 9,047,807 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	9,042,129 - 9,047,558 (-)	Ensembl				GRCr8
mRatBN7.2	7	8,391,396 - 8,397,219 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,391,397 - 8,396,829 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	11,276,976 - 11,281,781 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	13,152,460 - 13,157,265 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	11,020,088 - 11,024,893 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	11,258,526 - 11,266,509 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,261,201 - 11,266,630 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	11,423,847 - 11,433,847 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	9,875,757 - 9,880,563 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	6,580,348 - 6,585,153 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

aristolochic acid A (ISO)

beta-lapachone (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

Dibutyl phosphate (ISO)

endosulfan (EXP)

FR900359 (ISO)

fulvestrant (ISO)

hydrogen cyanide (ISO)

nitrates (ISO)

okadaic acid (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (ISO)

potassium cyanide (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

thiram (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to interleukin-1 (IEA,ISO)

cellular response to lipopolysaccharide (IEA,ISO)

cellular response to tumor necrosis factor (IEA,ISO)

mRNA cis splicing, via spliceosome (IBA)

mRNA splicing, via spliceosome (IEA,ISO)

negative regulation of canonical NF-kappaB signal transduction (IEA,ISO)

negative regulation of innate immune response (IBA)

negative regulation of interferon-beta production (IEA,ISO)

negative regulation of interleukin-8 production (IEA,ISO)

negative regulation of lipopolysaccharide-mediated signaling pathway (IEA,ISO)

negative regulation of protein phosphorylation (ISO)

negative regulation of toll-like receptor signaling pathway (IEA,ISO)

negative regulation of tumor necrosis factor production (IEA,ISO)

negative regulation of type I interferon-mediated signaling pathway (IEA,ISO)

RNA splicing (IEA)

Cellular Component

catalytic step 2 spliceosome (IEA,ISO)

cytoplasm (IBA)

nuclear speck (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

spliceosomal complex (IBA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11991638	PMID:12477932	PMID:15302935	PMID:20829348	PMID:22681889	PMID:23376485	PMID:26363554

Genomics

Comparative Map Data

Cactin
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	9,042,125 - 9,047,807 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	9,042,129 - 9,047,558 (-)	Ensembl				GRCr8
mRatBN7.2	7	8,391,396 - 8,397,219 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,391,397 - 8,396,829 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	11,276,976 - 11,281,781 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	13,152,460 - 13,157,265 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	11,020,088 - 11,024,893 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	11,258,526 - 11,266,509 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,261,201 - 11,266,630 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	11,423,847 - 11,433,847 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	9,875,757 - 9,880,563 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	6,580,348 - 6,585,153 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

CACTIN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	3,610,645 - 3,626,790 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	3,610,645 - 3,626,815 (-)	Ensembl			hg38	GRCh38
GRCh37	19	3,610,643 - 3,626,788 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	3,561,626 - 3,577,813 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	3,561,644 - 3,564,536	NCBI
Celera	19	3,547,464 - 3,563,656 (-)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	3,375,947 - 3,392,139 (-)	NCBI		HuRef
CHM1_1	19	3,610,218 - 3,626,407 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	3,588,768 - 3,604,917 (-)	NCBI		T2T-CHM13v2.0

Cactin
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	81,156,937 - 81,162,085 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	81,156,937 - 81,162,076 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	81,321,103 - 81,326,251 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	81,321,103 - 81,326,242 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	80,783,848 - 80,788,996 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	80,724,326 - 80,729,380 (+)	NCBI		MGSCv36	mm8
Celera	10	82,341,838 - 82,346,986 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Cactin
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	5,561,979 - 5,571,682 (-)	Ensembl
ChiLan1.0	NW_004955495	5,561,359 - 5,571,945 (-)	NCBI	ChiLan1.0	ChiLan1.0

CACTIN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	8,007,655 - 8,023,856 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	7,239,420 - 7,255,632 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	2,636,129 - 2,652,332 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	3,585,688 - 3,602,031 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	3,586,983 - 3,601,990 (-)	Ensembl			panPan2	panpan1.1

CACTIN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	55,803,494 - 55,817,467 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	55,803,530 - 55,816,549 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	55,528,852 - 55,542,830 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	56,463,626 - 56,477,605 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	56,463,635 - 56,477,591 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	55,519,269 - 55,533,242 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	56,002,747 - 56,016,723 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	56,201,412 - 56,215,404 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cactin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	215,773,107 - 215,783,147 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	2,052,425 - 2,061,641 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	2,051,636 - 2,061,651 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CACTIN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	75,049,261 - 75,065,299 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	75,049,250 - 75,065,990 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CACTIN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	3,369,445 - 3,386,684 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	3,369,279 - 3,383,226 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666081	5,076,260 - 5,119,125 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cactin
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	6,313,867 - 6,322,764 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624828	6,313,165 - 6,322,837 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cactin
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	153,564,878 - 153,570,371 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cactin
16 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	225
Count of miRNA genes:	151
Interacting mature miRNAs:	173
Transcripts:	ENSRNOT00000027926
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1669658	46669658	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	1	23748937	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	7216097	52216097	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	1	31777942	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1709527	46709527	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	32612984	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	29716167	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34650782	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	32612984	Rat

Markers in Region

RH135245

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	8,391,609 - 8,391,804 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	11,261,411 - 11,261,605	NCBI	Rnor6.0
Rnor_5.0	7	11,428,149 - 11,428,343	UniSTS	Rnor5.0
RGSC_v3.4	7	9,875,970 - 9,876,164	UniSTS	RGSC3.4
Celera	7	6,580,561 - 6,580,755	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001081447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001439798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY934505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027926 ⟹ ENSRNOP00000027926

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	9,042,129 - 9,047,558 (-)	Ensembl
mRatBN7.2 Ensembl	7	8,391,400 - 8,396,829 (-)	Ensembl
Rnor_6.0 Ensembl	7	11,261,201 - 11,266,630 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117213 ⟹ ENSRNOP00000077177

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	8,391,397 - 8,396,454 (-)	Ensembl

RefSeq Acc Id:

NM_001081447 ⟹ NP_001074916

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	9,042,126 - 9,046,931 (-)	NCBI
mRatBN7.2	7	8,391,397 - 8,396,202 (-)	NCBI
Rnor_6.0	7	11,261,198 - 11,266,003 (-)	NCBI
Rnor_5.0	7	11,423,847 - 11,433,847 (-)	NCBI
RGSC_v3.4	7	9,875,757 - 9,880,563 (-)	RGD
Celera	7	6,580,348 - 6,585,153 (-)	RGD

Sequence:

show sequence

CGCGCATGCGCGGCGCGGGCCGCCAAATGGGTTCGCACTCTCGCTCGCGCTCACGATCTGCGGG
TCGTAGGAGTCGGAAGCAGCGGAGTAGGAGTAGAAGCTGCAGCAGGAGCCGGAGCCGAAGCCGG
AGCCGGAGCCGGAGCCGGAGCCATGGGGGGAGCGGCCGAAGGCGACGGGAACATGAGCGGCGGC
GCGAACGCAAACGGCGCAGTCGAGGGCGCAGGTCAGATTCGGAAGGAAACCGTGTGCAGAAGTC
TAGGAGGCGAAGCCGGAGCCTTCGGCCACCCCGATGGCACTCACAGGACCGGTCCTCACACTCT
GACTCGGGTGAGGAGCAAGCACAGGGCTCCCGAGCCCGGAAGGGTCACAGGCATTCGTGGTCCC
CAGGGTCATCAGCATCTAGCTCTGACTCCCCAAGACGCTCCCGGAGTCCTGGAGTAGCTGCCCT
GGCCGCGAGTCAGCAGCAGAGCCTTCAGGAACGGCTGCGGCTTCGTGAGGAGCGAAAGCAGCAA
GAAGAGCTGCTCAAGGCCTTCGAGACACCCGAGGAGAAGCGTGCCCGGCGACTGGCCAAGAAAG
AAGCTAAGGAGCGCAAGAAGCGTGAGAAGATGGGCTGGGGTGAGGAGTACATGGGCTACACCAA
CACCGACAACCCCTTTGGAGACAACAACCTGCTGGGCACTTTTATCTGGAACAAAGCCTTGGAG
AAAAAAGGCATCGGTCACCTGGAGGAAAAGGAGCTGAAGGAACGTAACAAGAGGATCCAGGAGG
AGAACCGGCTAGAGCTGCAAAAGGTAAAACAGCTGCGGCTGGAGCGGGAACGGGAGAAGGCCAT
GCGGGAGCAGGAACTGGAACTGTTGCAACGGGAGAAGGAGGCAGAGCACTTTAAGACCTGGGAG
GAGCAGGAGGACAGCTTCCACTTGCGGCAGGCCAAGCTTCGTTCCAAGATCCGAATCCGAGACG
GGCGGGCCAAGCCCATTGACTTGCTGGCCAAGTACATCAGTGCAGAGGACGATGACCTGGCAGT
GGAGATGCATGAACCTTACACCTTCCTCAACGGCCTCACGGTGGCAGACATGGAGGACCTGCTA
GAGGACATCCAGGTGTACATGGAGCTGGAGCAGGGCAAGAACGTGGACTTCTGGCGAGACATGA
CAACCATCACAGAGGATGAGATTGCCAAGCTCCGCAAGCTGGAGGCCTCGGGCAAGGGCCCAGG
TGAGCGCCGTGAGGGGGTCAACGCCTCGGTCAGCTCTGACGTGCAGTCCGTCTTCAAGGGAAAG
ACGTACAACCAGCTGCAGGTCATCTTCCAGGGCATCGAAGGCAAGATCCGTGCCGGCGGCCCCA
ACCTCGACATGGGCTACTGGGAGAGCCTGCTGCAGCAGTTGCGCGCGCACATGGCCAGGGCCAG
GCTCCGTGAGCGCCACCAAGATGTCCTTAGACAGAAGCTGTTCAAACTGAAGCAGGAGCAGGGT
GTGGAGAGTGAGCCGCTGTTTCCCATCCTCAAGTCAGAGCCCACAGCCACTCACAGCCCTGAAC
CTGAGGAACGGCCTCCCAGCCCTGGGACTTCAGTGGACCCCGTGGAACCCGAGGAGACCACAGC
AGCAGGCGAGGCAGAGGGAGAGGCAGATGGCGAGGCAGTGCTGATGGAGGAGGACCTGATCCAG
CAGAGCCTGGCAGACTATGACGCTGGCCGCTACAGCCCACGACTGCTCACCGCGCACGAGTTGC
CTTTGGACGCGCATGTGCTGGAGCCGCATGAGGACCTGCAGCGCCTGCAGCTGTCTCGCCAGCA
GCTTCAGGCTACAGGTGACGCGAGCGAGAGTGCTGAGGACATCTTCTTCCGGCGTGCGAGGGAG
GGCATGGGGCAGGATGAGGCACAGTTCAGCGTGGAGATGCCACTGGGTGGCCGCGCCTACCTGT
GGGCCGACAAGTATCGGCCGCGGAAGCCGCGATTCTTTAACCGTGTGCACACAGGCTTTGAATG
GAACAAATATAACCAGACACATTATGACTTTGACAACCCTCCACCCAAGATCGTGCAGGGCTAC
AAATTTAACATCTTCTACCCGGACCTCATCCGCAAACGTGCCACACCAGAGTACTTCCTGGAGG
CCTGCGCTGACAACCGGGACTTTGCCATCCTGCGTTTCCACGCAGGCCCGCCCTACGAGGACAT
CGCCTTCAAGATCGTCAGTCGAGAATGGGAGTACTCGCACCGCCATGGCTTCCGCTGCCAGTTT
GCCAATGGAATCTTCCAGCTCTGGTTCCACTTCAAGCGCTACCGCTACCGCCGGTGACGCCTGT
GGGCAGGCTGCCCGCCCCTGCCATGCTGGCCCCTGGACAGCTCCTGGATGGGAAGGTTGAGAGG
ACCAGGAGGTCTTCTTCAGAAGCCTTGGGGATCCGTGGACCACCTCTGGGCTTCAGTCACCAGC
ACTGTGCTGGCCGCAGCCCCTCTGGCAGGTCCCTTCCTGTCTTGAAAGGATTTTAGAAAGACTG
CTTGAGGTGGCAGAAACCCTTTGTTCCTGTTCCCGTGGACTTATTCAACCGCGGAGCCCTACAT
GGTTTTGATACGTTTAATAGAAAGCTTATTCTAAA

hide sequence

RefSeq Acc Id:

XM_039079732 ⟹ XP_038935660

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	9,042,125 - 9,047,807 (-)	NCBI
mRatBN7.2	7	8,391,396 - 8,397,219 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001074916	(Get FASTA)	NCBI Sequence Viewer
	NP_001426727	(Get FASTA)	NCBI Sequence Viewer
	XP_038935660	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66406	(Get FASTA)	NCBI Sequence Viewer
	AAY17368	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027926
	ENSRNOP00000027926.6

RefSeq Acc Id:

NP_001074916 ⟸ NM_001081447

- UniProtKB:

A1L014 (UniProtKB/TrEMBL), A0A8I5Y601 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRGAGRQMGSHSRSRSRSAGRRSRKQRSRSRSCSRSRSRSRSRSRSRSHGGSGRRRREHERRRE
RKRRSRGRRSDSEGNRVQKSRRRSRSLRPPRWHSQDRSSHSDSGEEQAQGSRARKGHRHSWSPG
SSASSSDSPRRSRSPGVAALAASQQQSLQERLRLREERKQQEELLKAFETPEEKRARRLAKKEA
KERKKREKMGWGEEYMGYTNTDNPFGDNNLLGTFIWNKALEKKGIGHLEEKELKERNKRIQEEN
RLELQKVKQLRLEREREKAMREQELELLQREKEAEHFKTWEEQEDSFHLRQAKLRSKIRIRDGR
AKPIDLLAKYISAEDDDLAVEMHEPYTFLNGLTVADMEDLLEDIQVYMELEQGKNVDFWRDMTT
ITEDEIAKLRKLEASGKGPGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIEGKIRAGGPNL
DMGYWESLLQQLRAHMARARLRERHQDVLRQKLFKLKQEQGVESEPLFPILKSEPTATHSPEPE
ERPPSPGTSVDPVEPEETTAAGEAEGEADGEAVLMEEDLIQQSLADYDAGRYSPRLLTAHELPL
DAHVLEPHEDLQRLQLSRQQLQATGDASESAEDIFFRRAREGMGQDEAQFSVEMPLGGRAYLWA
DKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIRKRATPEYFLEAC
ADNRDFAILRFHAGPPYEDIAFKIVSREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR

hide sequence

Ensembl Acc Id:

ENSRNOP00000027926 ⟸ ENSRNOT00000027926

RefSeq Acc Id:	XP_038935660 ⟸ XM_039079732
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000077177 ⟸ ENSRNOT00000117213

Protein Domains

Splicing factor Cactin C-terminal Splicing factor cactin central

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2GUU0-F1-model_v2	AlphaFold	B2GUU0	1-764	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563634	AgrOrtholog
BioCyc Gene	G2FUF-35014	BioCyc
Ensembl Genes	ENSRNOG00000039852	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027926	ENTREZGENE
	ENSRNOT00000027926.9	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9028620	IMAGE-MGC_LOAD
InterPro	Cactin_cactus-bd_C	UniProtKB/TrEMBL
	Cactin_central	UniProtKB/TrEMBL
KEGG Report	rno:500790	UniProtKB/TrEMBL
MGC_CLONE	MGC:187226	IMAGE-MGC_LOAD
NCBI Gene	500790	ENTREZGENE
PANTHER	CACTIN	UniProtKB/TrEMBL
	POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3	UniProtKB/TrEMBL
Pfam	Cactin_mid	UniProtKB/TrEMBL
	CactinC_cactus	UniProtKB/TrEMBL
PhenoGen	Cactin	PhenoGen
RatGTEx	ENSRNOG00000039852	RatGTEx
SMART	CactinC_cactus	UniProtKB/TrEMBL
UniProt	A0A8I5Y601	ENTREZGENE
	A1L014	ENTREZGENE, UniProtKB/TrEMBL
	B2GUU0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-12	Cactin	cactin, spliceosome C complex subunit	RGD1563634	similar to R31449_3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1563634	similar to R31449_3	RGD1563634_predicted	similar to R31449_3 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1563634_predicted	similar to R31449_3 (predicted)	LOC500790	similar to R31449_3	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500790	similar to R31449_3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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