Znrf4 (zinc and ring finger 4) - Rat Genome Database

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Gene: Znrf4 (zinc and ring finger 4) Rattus norvegicus
Analyze
Symbol: Znrf4
Name: zinc and ring finger 4
RGD ID: 1563631
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of cell cycle; negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within defense response to bacterium and nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ZNRF4 (zinc and ring finger 4); INTERACTS WITH bisphenol A; cadmium dichloride; Cuprizon.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin-protein ligase ZNRF4; zinc/RING finger protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,440,444 - 1,441,632 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,440,445 - 1,441,689 (-)EnsemblGRCr8
mRatBN7.291,353,308 - 1,354,496 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,353,306 - 1,354,584 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx91,787,383 - 1,788,572 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,137,058 - 7,138,246 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,092,586 - 6,093,775 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,535,340 - 10,536,528 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,535,340 - 10,536,528 (+)Ensemblrn6Rnor6.0
Rnor_5.099,530,159 - 9,531,347 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera97,158,413 - 7,159,601 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10191088   PMID:21205830  


Genomics

Comparative Map Data
Znrf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,440,444 - 1,441,632 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,440,445 - 1,441,689 (-)EnsemblGRCr8
mRatBN7.291,353,308 - 1,354,496 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,353,306 - 1,354,584 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx91,787,383 - 1,788,572 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,137,058 - 7,138,246 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,092,586 - 6,093,775 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,535,340 - 10,536,528 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,535,340 - 10,536,528 (+)Ensemblrn6Rnor6.0
Rnor_5.099,530,159 - 9,531,347 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera97,158,413 - 7,159,601 (+)NCBICelera
Cytogenetic Map9q11NCBI
ZNRF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38195,455,417 - 5,456,856 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl195,455,417 - 5,456,856 (+)Ensemblhg38GRCh38
GRCh37195,455,428 - 5,456,867 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36195,406,426 - 5,407,867 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34195,406,441 - 5,407,866NCBI
Celera195,392,967 - 5,394,408 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef195,216,538 - 5,217,979 (+)NCBIHuRef
CHM1_1195,455,266 - 5,456,707 (+)NCBICHM1_1
T2T-CHM13v2.0195,442,067 - 5,443,506 (+)NCBIT2T-CHM13v2.0
Znrf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,818,248 - 56,819,483 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,818,248 - 56,819,431 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381756,511,248 - 56,512,483 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,511,248 - 56,512,431 (-)Ensemblmm10GRCm38
MGSCv371756,650,671 - 56,651,906 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,144,956 - 56,146,126 (-)NCBIMGSCv36mm8
Celera1760,856,819 - 60,858,054 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.37NCBI
Znrf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,854,438 - 3,855,471 (+)Ensembl
ChiLan1.0NW_0049554953,854,178 - 3,855,556 (+)NCBIChiLan1.0ChiLan1.0
ZNRF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2209,853,056 - 9,854,719 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,079,279 - 9,080,940 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0194,474,001 - 4,475,435 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,411,760 - 5,413,198 (+)NCBIPanPan1.1PanPan1.1panPan2
ZNRF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,498,150 - 54,499,662 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,493,227 - 54,499,675 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2054,224,636 - 54,226,343 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02055,154,135 - 55,155,943 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2055,154,487 - 55,155,578 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,215,840 - 54,217,666 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02054,696,650 - 54,698,349 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,894,086 - 54,895,895 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Znrf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,690,901 - 214,692,096 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,142,736 - 3,143,793 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,142,687 - 3,143,793 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNRF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl273,481,337 - 73,486,347 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1273,484,904 - 73,486,349 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,178,754 - 74,180,546 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNRF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,127,332 - 5,129,463 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,127,865 - 5,129,154 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660812,988,589 - 2,990,026 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znrf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248284,633,434 - 4,635,366 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Znrf4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1487,895,825 - 87,897,006 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:100
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000075408
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 9 29 110 44 39 18 33 18 5 151 80 2 93 35 71 21 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000075408   ⟹   ENSRNOP00000066001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,440,445 - 1,441,689 (-)Ensembl
mRatBN7.2 Ensembl91,353,306 - 1,354,584 (-)Ensembl
Rnor_6.0 Ensembl910,535,340 - 10,536,528 (+)Ensembl
RefSeq Acc Id: NM_001024878   ⟹   NP_001020049
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,440,444 - 1,441,632 (-)NCBI
mRatBN7.291,353,308 - 1,354,496 (-)NCBI
Rnor_6.0910,535,340 - 10,536,528 (+)NCBI
Rnor_5.099,530,159 - 9,531,347 (+)NCBI
Celera97,158,413 - 7,159,601 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020049 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98025 (Get FASTA)   NCBI Sequence Viewer  
  EDL83632 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066001
  ENSRNOP00000066001.1
RefSeq Acc Id: NP_001020049   ⟸   NM_001024878
- Peptide Label: precursor
- UniProtKB: Q4V7C2 (UniProtKB/TrEMBL),   M0R940 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066001   ⟸   ENSRNOT00000075408
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V7C2-F1-model_v2 AlphaFold Q4V7C2 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696458
Promoter ID:EPDNEW_R6983
Type:initiation region
Name:Znrf4_1
Description:zinc and ring finger 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,535,283 - 10,535,343EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563631 AgrOrtholog
BioCyc Gene G2FUF-28530 BioCyc
Ensembl Genes ENSRNOG00000048875 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075408 ENTREZGENE
  ENSRNOT00000075408.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7455918 IMAGE-MGC_LOAD
InterPro E3_ligase_sorting_rcpt UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:301127 UniProtKB/TrEMBL
MGC_CLONE MGC:116178 IMAGE-MGC_LOAD
NCBI Gene 301127 ENTREZGENE
PANTHER OS02G0798600 PROTEIN UniProtKB/TrEMBL
  RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED UniProtKB/TrEMBL
Pfam zf-RING_2 UniProtKB/TrEMBL
PhenoGen Znrf4 PhenoGen
PROSITE ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048875 RatGTEx
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt M0R940 ENTREZGENE, UniProtKB/TrEMBL
  Q4V7C2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Znrf4  zinc and ring finger 4      Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Znrf4  zinc and ring finger 4      Symbol and Name status set to provisional 70820 PROVISIONAL