Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | affects expression | ISO | Etl4 (Mus musculus) | 6480464 | ethylene dichloride affects the expression of ETL4 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | ISO | Etl4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of ETL4 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Etl4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ETL4 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of ETL4 mRNA | CTD | PMID:26496021 | 17beta-hydroxy-5alpha-androstan-3-one | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of KIAA1217 mRNA] | CTD | PMID:17624924 | 17beta-hydroxy-5alpha-androstan-3-one | decreases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Dihydrotestosterone results in decreased expression of KIAA1217 mRNA | CTD | PMID:17624924 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ETL4 mRNA | CTD | PMID:34747641 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 2-hydroxypropanoic acid | decreases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of KIAA1217 mRNA | CTD | PMID:30851411 | 4,4'-sulfonyldiphenol | increases expression | ISO | Etl4 (Mus musculus) | 6480464 | bisphenol S results in increased expression of ETL4 mRNA | CTD | PMID:30951980 | 4-hydroxyphenyl retinamide | increases expression | ISO | Etl4 (Mus musculus) | 6480464 | Fenretinide results in increased expression of KIAA1217 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of ETL4 mRNA | CTD | PMID:24780913 and PMID:30047161 | aflatoxin B1 | increases methylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of KIAA1217 gene | CTD | PMID:27153756 | aflatoxin B1 | affects methylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the methylation of KIAA1217 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | affects methylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | aflatoxin B2 affects the methylation of KIAA1217 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of KIAA1217 mRNA | CTD | PMID:21934132 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of ETL4 mRNA | CTD | PMID:30047161 | aristolochic acid A | increases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of KIAA1217 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to KIAA1217 mRNA] and arsenite promotes the reaction [G3BP1 protein binds to KIAA1217 protein] | CTD | PMID:32406909 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of ETL4 gene | CTD | PMID:28931070 and PMID:35440735 | benzo[a]pyrene | decreases expression | ISO | Etl4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of ETL4 mRNA | CTD | PMID:21569818 | benzo[a]pyrene | affects methylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KIAA1217 5' UTR more ... | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | decreases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of KIAA1217 mRNA | CTD | PMID:26238291 | benzo[e]pyrene | increases methylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of KIAA1217 intron | CTD | PMID:30157460 | bicalutamide | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of KIAA1217 mRNA] | CTD | PMID:17624924 | bisphenol A | increases expression | ISO | Etl4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of ETL4 mRNA | CTD | PMID:21932408 and PMID:30951980 | bisphenol A | increases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of KIAA1217 mRNA | CTD | PMID:36232920 | bisphenol A | affects methylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of KIAA1217 gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of KIAA1217 gene | CTD | PMID:31601247 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of KIAA1217 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of ETL4 mRNA | CTD | PMID:26496021 | bisphenol F | increases expression | ISO | Etl4 (Mus musculus) | 6480464 | bisphenol F results in increased expression of ETL4 mRNA | CTD | PMID:30951980 | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of ETL4 protein | CTD | PMID:28903499 | buta-1,3-diene | decreases expression | ISO | Etl4 (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of ETL4 mRNA | CTD | PMID:29038090 | cadmium atom | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KIAA1217 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KIAA1217 mRNA | CTD | PMID:35301059 | caffeine | affects phosphorylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of KIAA1217 protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | ISO | Etl4 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | chromium(6+) | affects expression | ISO | Etl4 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of ETL4 mRNA | CTD | PMID:28472532 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of ETL4 mRNA | CTD | PMID:24386269 | coumarin | decreases phosphorylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of KIAA1217 protein | CTD | PMID:35688186 | dibutyl phthalate | increases expression | ISO | Etl4 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of ETL4 mRNA | CTD | PMID:21266533 | dicrotophos | increases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of KIAA1217 mRNA | CTD | PMID:28302478 | dioxygen | multiple interactions | ISO | Etl4 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ETL4 mRNA | CTD | PMID:30529165 | dorsomorphin | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of KIAA1217 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of ETL4 mRNA | CTD | PMID:29391264 | entinostat | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA | CTD | PMID:27188386 | ethanol | affects splicing | ISO | Etl4 (Mus musculus) | 6480464 | Ethanol affects the splicing of ETL4 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Etl4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ETL4 mRNA | CTD | PMID:22206623 | folic acid | decreases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of KIAA1217 mRNA | CTD | PMID:21867686 | folic acid | decreases expression | ISO | Etl4 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of ETL4 mRNA | CTD | PMID:25629700 | FR900359 | affects phosphorylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of KIAA1217 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of KIAA1217 gene | CTD | PMID:31601247 | genistein | affects expression | ISO | Etl4 (Mus musculus) | 6480464 | Genistein affects the expression of ETL4 mRNA | CTD | PMID:32186404 | glyphosate | affects methylation | EXP | | 6480464 | Glyphosate affects the methylation of ETL4 gene | CTD | PMID:35440735 | hydralazine | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of KIAA1217 mRNA | CTD | PMID:17183730 | maneb | multiple interactions | ISO | Etl4 (Mus musculus) | 6480464 | [Paraquat co-treated with Maneb] affects the expression of ETL4 mRNA | CTD | PMID:22563483 | mercury dibromide | increases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of KIAA1217 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA | CTD | PMID:27188386 | methamphetamine | increases expression | ISO | Etl4 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of ETL4 mRNA | CTD | PMID:26307267 | methapyrilene | increases methylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of KIAA1217 intron | CTD | PMID:30157460 | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of ETL4 mRNA | CTD | PMID:30467583 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of ETL4 mRNA | CTD | PMID:30047161 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of ETL4 gene | CTD | PMID:35440735 | nickel sulfate | decreases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | nickel sulfate results in decreased expression of KIAA1217 mRNA | CTD | PMID:22714537 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of ETL4 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | Etl4 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of ETL4 mRNA | CTD | PMID:27106289 | paraquat | multiple interactions | ISO | Etl4 (Mus musculus) | 6480464 | [Paraquat co-treated with Maneb] affects the expression of ETL4 mRNA | CTD | PMID:22563483 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of ETL4 mRNA | CTD | PMID:32680482 | paraquat | increases expression | ISO | Etl4 (Mus musculus) | 6480464 | Paraquat results in increased expression of ETL4 mRNA | CTD | PMID:22563483 | phenylmercury acetate | increases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of KIAA1217 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA | CTD | PMID:27188386 | potassium chromate | decreases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of KIAA1217 mRNA | CTD | PMID:22714537 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | Etl4 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of ETL4 mRNA | CTD | PMID:28903501 | progesterone | increases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Progesterone results in increased expression of KIAA1217 mRNA | CTD | PMID:20864642 | pyridaben | increases expression | ISO | Etl4 (Mus musculus) | 6480464 | pyridaben results in increased expression of ETL4 mRNA | CTD | PMID:22563483 | quercetin | increases phosphorylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | Quercetin results in increased phosphorylation of KIAA1217 protein | CTD | PMID:35688186 | rac-lactic acid | decreases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of KIAA1217 mRNA | CTD | PMID:30851411 | SB 431542 | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silver atom | decreases expression | ISO | Etl4 (Mus musculus) | 6480464 | Silver results in decreased expression of ETL4 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | Etl4 (Mus musculus) | 6480464 | Silver results in decreased expression of ETL4 mRNA | CTD | PMID:27131904 | sodium arsenate | increases expression | ISO | Etl4 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of ETL4 mRNA | CTD | PMID:21795629 | sodium dichromate | affects expression | EXP | | 6480464 | sodium bichromate affects the expression of ETL4 mRNA | CTD | PMID:22110744 | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of ETL4 mRNA | CTD | PMID:30047161 | sunitinib | increases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of KIAA1217 mRNA | CTD | PMID:31533062 | temozolomide | decreases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of KIAA1217 mRNA | CTD | PMID:31758290 | testosterone | increases expression | ISO | Etl4 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of ETL4 mRNA | CTD | PMID:33848595 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of ETL4 mRNA | CTD | PMID:34492290 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of ETL4 mRNA | CTD | PMID:25729387 | trichostatin A | increases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of KIAA1217 mRNA | CTD | PMID:24935251 | triclosan | increases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Triclosan results in increased expression of KIAA1217 mRNA | CTD | PMID:30510588 | valproic acid | multiple interactions | ISO | KIAA1217 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of KIAA1217 mRNA | CTD | PMID:17183730 | valproic acid | increases expression | ISO | KIAA1217 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of KIAA1217 mRNA | CTD | PMID:23179753 | valproic acid | decreases methylation | ISO | KIAA1217 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of KIAA1217 gene | CTD | PMID:29154799 | vinclozolin | decreases methylation | EXP | | 6480464 | vinclozolin results in decreased methylation of ETL4 gene | CTD | PMID:31682807 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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