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Gene: Lrrc8b (leucine rich repeat containing 8 VRAC subunit B) Rattus norvegicus

Analyze

Symbol:

Lrrc8b

Name:

leucine rich repeat containing 8 VRAC subunit B

RGD ID:

1563429

Description:

Predicted to enable volume-sensitive anion channel activity. Predicted to be involved in aspartate transmembrane transport; cyclic-GMP-AMP transmembrane import across plasma membrane; and monoatomic anion transmembrane transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LRRC8B (leucine rich repeat containing 8 VRAC subunit B); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

leucine rich repeat containing 8 family, member B; leucine-rich repeat-containing protein 8B; LOC305135; RGD1563429; similar to T-cell activation leucine repeat-rich protein; volume-regulated anion channel subunit LRRC8B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	4,655,273 - 4,721,648 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	4,655,273 - 4,721,076 (-)	Ensembl				GRCr8
mRatBN7.2	14	4,350,462 - 4,416,336 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	4,354,508 - 4,416,311 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	4,351,154 - 4,357,759 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	5,651,315 - 5,657,920 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	4,356,038 - 4,362,627 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	5,414,872 - 5,482,004 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	5,418,741 - 5,428,757 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	5,405,589 - 5,471,374 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	5,431,777 - 5,451,584 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	4,516,655 - 4,523,205 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (EXP)

chlorpyrifos (ISO)

chrysene (ISO)

copper(II) sulfate (ISO)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

flutamide (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (EXP,ISO)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP)

nefazodone (EXP)

nickel atom (ISO)

okadaic acid (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

testosterone enanthate (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

tributylstannane (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

tris(2-butoxyethyl) phosphate (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aspartate transmembrane transport (IBA)

cyclic-GMP-AMP transmembrane import across plasma membrane (IBA)

monoatomic anion transmembrane transport (IBA,IEA,ISO)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

transmembrane transport (IEA)

Cellular Component

cytoplasm (IBA,IEA,ISO)

monoatomic ion channel complex (IBA,IEA,ISO)

plasma membrane (IBA,IEA,ISO)

Molecular Function

protein binding (ISO)

volume-sensitive anion channel activity (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:24790029	PMID:28193731

Genomics

Comparative Map Data

Lrrc8b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	4,655,273 - 4,721,648 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	4,655,273 - 4,721,076 (-)	Ensembl				GRCr8
mRatBN7.2	14	4,350,462 - 4,416,336 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	4,354,508 - 4,416,311 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	4,351,154 - 4,357,759 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	5,651,315 - 5,657,920 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	4,356,038 - 4,362,627 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	5,414,872 - 5,482,004 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	5,418,741 - 5,428,757 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	5,405,589 - 5,471,374 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	5,431,777 - 5,451,584 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	4,516,655 - 4,523,205 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

LRRC8B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	89,524,829 - 89,597,861 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	89,524,829 - 89,597,861 (+)	Ensembl			hg38	GRCh38
GRCh37	1	89,990,388 - 90,063,420 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	89,796,860 - 89,831,803 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	88,236,130 - 88,309,141 (+)	NCBI		Celera
Cytogenetic Map	1	p22.2	NCBI
HuRef	1	88,107,692 - 88,180,733 (+)	NCBI		HuRef
CHM1_1	1	90,105,381 - 90,178,402 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	89,368,070 - 89,441,117 (+)	NCBI		T2T-CHM13v2.0

Lrrc8b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	105,563,072 - 105,637,945 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	105,563,641 - 105,637,940 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	105,415,206 - 105,490,079 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	105,415,775 - 105,490,074 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	105,844,794 - 105,915,208 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	105,656,077 - 105,726,491 (+)	NCBI		MGSCv36	mm8
Celera	5	102,532,650 - 102,601,055 (+)	NCBI		Celera
Cytogenetic Map	5	E5	NCBI
cM Map	5	50.68	NCBI

Lrrc8b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	4,585,902 - 4,612,001 (-)	Ensembl
ChiLan1.0	NW_004955423	4,585,902 - 4,612,008 (-)	NCBI	ChiLan1.0	ChiLan1.0

LRRC8B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	137,422,804 - 137,436,741 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	136,577,590 - 136,592,583 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	92,192,657 - 92,264,437 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	90,943,166 - 91,014,796 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	90,969,241 - 91,014,796 (+)	Ensembl			panPan2	panpan1.1

LRRC8B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	59,012,558 - 59,061,302 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	59,020,685 - 59,038,934 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	61,702,505 - 61,806,830 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	59,517,857 - 59,608,536 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	59,524,003 - 59,550,202 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	59,091,382 - 59,176,096 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	59,031,385 - 59,129,232 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	59,511,547 - 59,615,645 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LRRC8B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	127,071,057 - 127,081,071 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	127,067,794 - 127,136,616 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	139,109,341 - 139,177,415 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103224467
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	43,879,732 - 43,947,761 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	43,881,450 - 43,905,691 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	73,985,861 - 74,057,137 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrc8b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	8,138,457 - 8,151,186 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624742	8,135,953 - 8,209,729 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lrrc8b
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	15,149,601 - 15,214,447 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lrrc8b
703 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	32
Count of miRNA genes:	31
Interacting mature miRNAs:	32
Transcripts:	ENSRNOT00000002897
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3957878	21572472	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3957878	24886169	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3957878	18558812	Rat
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	40068101	Rat
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	40068101	Rat
724541	Niddm53	Non-insulin dependent diabetes mellitus QTL 53		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	3957878	9393298	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3957878	31121464	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	11334906	Rat
71117	Niddm17	Non-insulin dependent diabetes mellitus QTL 17	2.35		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	17877928	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1	31893212	Rat

Markers in Region

BF418432

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	4,352,650 - 4,352,788 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	5,417,061 - 5,417,198	NCBI	Rnor6.0
Rnor_5.0	14	5,407,778 - 5,407,915	UniSTS	Rnor5.0
RGSC_v3.4	14	5,431,360 - 5,431,497	UniSTS	RGSC3.4
Celera	14	4,514,829 - 4,514,966	UniSTS
RH 3.4 Map	14	84.6	UniSTS
Cytogenetic Map	14	p22	UniSTS

BF401702

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	4,398,189 - 4,398,346 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	5,462,650 - 5,462,806	NCBI	Rnor6.0
Rnor_5.0	14	5,453,367 - 5,453,523	UniSTS	Rnor5.0
RGSC_v3.4	14	5,476,899 - 5,477,055	UniSTS	RGSC3.4
Celera	14	4,559,999 - 4,560,155	UniSTS
RH 3.4 Map	14	126.6	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH139589

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	4,658,096 - 4,658,314 (+)	Marker Load Pipeline
mRatBN7.2	14	4,353,285 - 4,353,503 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	5,417,696 - 5,417,913	NCBI	Rnor6.0
Rnor_5.0	14	5,408,413 - 5,408,630	UniSTS	Rnor5.0
RGSC_v3.4	14	5,431,995 - 5,432,212	UniSTS	RGSC3.4
Celera	14	4,515,464 - 4,515,681	UniSTS
RH 3.4 Map	14	83.7	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH140442

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	4,658,064 - 4,658,314 (+)	Marker Load Pipeline
mRatBN7.2	14	4,353,253 - 4,353,503 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	5,417,664 - 5,417,913	NCBI	Rnor6.0
Rnor_5.0	14	5,408,381 - 5,408,630	UniSTS	Rnor5.0
RGSC_v3.4	14	5,431,963 - 5,432,212	UniSTS	RGSC3.4
Celera	14	4,515,432 - 4,515,681	UniSTS
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063273044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001841018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001841019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002897 ⟹ ENSRNOP00000002897

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	4,655,273 - 4,721,076 (-)	Ensembl
mRatBN7.2 Ensembl	14	4,354,508 - 4,416,311 (-)	Ensembl
Rnor_6.0 Ensembl	14	5,418,741 - 5,428,757 (-)	Ensembl

RefSeq Acc Id:

NM_001107204 ⟹ NP_001100674

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	4,655,273 - 4,721,076 (-)	NCBI
mRatBN7.2	14	4,350,462 - 4,416,271 (-)	NCBI
Rnor_6.0	14	5,418,940 - 5,425,490 (-)	NCBI
Rnor_5.0	14	5,405,589 - 5,471,374 (-)	NCBI
RGSC_v3.4	14	5,431,777 - 5,451,584 (-)	RGD
Celera	14	4,516,655 - 4,523,205 (-)	NCBI

Sequence:

show sequence

ATGATTACACTAACAGAGTTGAAATGCTTAGCGGATGCCCAGTCATCCTACCACATACTGAAGC
CGTGGTGGGACGTCTTCTGGTATTACCTCACCCTCATCATGCTGTTGGTGGCTGTGCTGGCCGG
AGCCCTGCAGCTTACGCAGAGCAGGGTTCTGTGCTGTCTTCCCTGCAAGGTGGAATTTGACAAT
CACTGCGCTGTGCCTTGGGACCTCCTGAAAGCCAGTGAGAACACGTCTTCTAACTCAGGCCTGC
CACTCCCGCTGCCGCTCCGGATCCAGAACGACCTCCACCGACAGCAGTACTCCTACATCGACGC
CGTCTGCTACGAGAAACAGCTCCATTGGTTCGCTAAGTTTTTCCCCTATCTGGTGCTTCTGCAC
ACTCTAATCTTTGCAGCCTGCAGCAACTTCTGGCTTCACTACCCCAGCACCAGCTCCAGGCTGG
AGCACTTTGTGTCCATCCTCCACAAGTGCTTCGATTCTCCATGGACCACTCGCGCCCTGTCAGA
GACAGTGGCCGAACAGTCAGTGAGGCCCCTGAAACTCTCCAAGTCCAAAACCTTGCTCTCAACC
TCAGGGGGCTCTGCCGACATCGACGCCAGCAAGCAGTCATTGCCCTACCCACAGCCAGGCTTGG
AGTCACCTGGCATAGAAAGCCCAACTTCTAGCGTCCTGGACAAGAAGGAGGGTGAACAAGCCAA
AGCCATCTTCGAAAAAGTGAAGAGGTTTCGCCTGCATGTGGAGCAGAGGGACATCATCTACCGG
GTGTACCTGAAGCAGATAATCGTCAAAGTCATTCTGTTTGTTCTCATTATAACTTACGTCCCGT
ATTTTCTCAGCTACATAACTCTGGAAATCGACTGCTCGATCGACGTGCAGGCATTCACAGGCTA
TAAGCGCTACCAGTGCGTCTACTCCTTGGCAGAGATCTTTAAGGTGTTGGCTTCATTTTATGTC
ATTTTGGTGATGCTTTATGGTCTCACGTCGTCCTATAGCCTGTGGTGGATGTTGAGGAGTTCCT
TGAAGCAGTACTCCTTTGAGGCTCTCAGAGAGAAAAGCAACTACAGCGATATCCCTGATGTCAA
GAACGACTTCGCCTTCATCCTCCATCTGGCCGACCAGTACGACCCCCTGTACTCCAAGCGCTTC
TCCATCTTCCTGTCGGAGGTCAGTGAGAACAAACTGAAGCAGATCAACCTCAACAACGAGTGGA
CCGTGGAGAAACTGAAGAGCAAGCTTGTGAAAAACTCCCAGGACAAGGTCGAGCTGCATCTCTT
CATGCTCAACGGTCTTCCAGATAACGTCTTCGAGTTAACAGACATGGAAGTGCTGAGCCTGGAG
CTCATCCCCGAGGTCAAGCTGCCCGCCGCCGCCTCTCAGCTTGTCAACCTCAGGGAGCTCCGTG
TGTACCACTCGTCCTTGGTGGTCGACCATCCCGCCCTGGCCTTTCTTGAGGAGAACTTAAAAAT
CCTCCGCCTGAAATTTACCGAGATGGGAAAGATCCCACGCTGGGTGTTCCACCTGAAGAACCTC
AAGGAACTGTACCTGTCAGGCTGTGTCCTCCCGGAGCAGCTGAGCTCCATGCAGCCGGAGGGCT
TCCAGGATCTGAAGAACCTGAGGACCCTCTACTTGAAGAGCAGCCTGTCCCGGATCCCTCAGGT
GGTGACAGACCTGCTGCCCTCCCTGCAGAAGCTGTCCCTCGATAACGAGGGGAGCAAACTGGTC
GTGCTGAACAACCTGAAGAAGATGGTCAATCTGAAAAGCCTGGAGCTCCTCAGCTGCGACCTGG
AGCGCATCCCCCACTCCATTTTCAGCCTGAACAACCTGCACGAGTTGGACCTGAAGGAAAACAA
CCTCAAGACGGTGGAGGAGATCATCAGCTTCCAGCATCTCCCGAGCCTCTCCTGCCTGAAGCTC
TGGCACAATAACATCGCTTACATCCCCGCACAGATCGGAGCGCTGTCCAACCTGGAGCAACTCT
ACCTGGGTCACAACAACATCGAGAGCCTGCCCTTGCAGCTTTTTCTATGCACCAAACTACACTA
CTTGGATCTAAGCTATAACCATCTGACCTTCATTCCCGAGGAAATCCAGTACCTGACCAACCTG
CAGTACTTCGCCGTGACCAACAATAACATCGAGATGCTACCAGACGGGCTGTTCCAGTGCAAGA
AACTTCAGTGTCTACTCTTGGGAAGAAACAGCCTAACAGATTTGTCCCCTCTGGTTGGGGAGCT
GTCAAACCTCACCCACCTGGAACTCATTGGCAACTACCTAGAGACACTGCCTGTGGAGCTGGAA
GGGTGTCAGTCCCTGAAACGGAGCTGTCTGATTGTGGAGGACAGCTTGCTTAATTCTCTTCCGC
TTCCTGTGACGGAGCGTTTGCAGACTTGCTTAGATAAATGTTAA

hide sequence

RefSeq Acc Id:

XM_039091812 ⟹ XP_038947740

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	4,659,138 - 4,691,866 (-)	NCBI
mRatBN7.2	14	4,350,462 - 4,385,233 (-)	NCBI

RefSeq Acc Id:

XM_039091813 ⟹ XP_038947741

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	4,659,138 - 4,691,866 (-)	NCBI
mRatBN7.2	14	4,350,462 - 4,385,233 (-)	NCBI

RefSeq Acc Id:

XM_039091814 ⟹ XP_038947742

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	4,659,138 - 4,691,866 (-)	NCBI
mRatBN7.2	14	4,350,462 - 4,385,233 (-)	NCBI

RefSeq Acc Id:

XM_039091815 ⟹ XP_038947743

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	4,659,138 - 4,691,866 (-)	NCBI
mRatBN7.2	14	4,350,462 - 4,385,233 (-)	NCBI

RefSeq Acc Id:

XM_063273044 ⟹ XP_063129114

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	4,659,138 - 4,721,648 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100674	(Get FASTA)	NCBI Sequence Viewer
	XP_038947740	(Get FASTA)	NCBI Sequence Viewer
	XP_038947741	(Get FASTA)	NCBI Sequence Viewer
	XP_038947742	(Get FASTA)	NCBI Sequence Viewer
	XP_038947743	(Get FASTA)	NCBI Sequence Viewer
	XP_063129114	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL99474	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002897
	ENSRNOP00000002897.4

RefSeq Acc Id:

NP_001100674 ⟸ NM_001107204

- UniProtKB:

D4A758 (UniProtKB/TrEMBL), A6K5Q4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MITLTELKCLADAQSSYHILKPWWDVFWYYLTLIMLLVAVLAGALQLTQSRVLCCLPCKVEFDN
HCAVPWDLLKASENTSSNSGLPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLH
TLIFAACSNFWLHYPSTSSRLEHFVSILHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLLST
SGGSADIDASKQSLPYPQPGLESPGIESPTSSVLDKKEGEQAKAIFEKVKRFRLHVEQRDIIYR
VYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLAEIFKVLASFYV
ILVMLYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRF
SIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNSQDKVELHLFMLNGLPDNVFELTDMEVLSLE
LIPEVKLPAAASQLVNLRELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNL
KELYLSGCVLPEQLSSMQPEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLV
VLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEIISFQHLPSLSCLKL
WHNNIAYIPAQIGALSNLEQLYLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNL
QYFAVTNNNIEMLPDGLFQCKKLQCLLLGRNSLTDLSPLVGELSNLTHLELIGNYLETLPVELE
GCQSLKRSCLIVEDSLLNSLPLPVTERLQTCLDKC

hide sequence

Ensembl Acc Id:

ENSRNOP00000002897 ⟸ ENSRNOT00000002897

RefSeq Acc Id:	XP_038947743 ⟸ XM_039091815
- Peptide Label:	isoform X1
- UniProtKB:	D4A758 (UniProtKB/TrEMBL), A6K5Q4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947741 ⟸ XM_039091813
- Peptide Label:	isoform X1
- UniProtKB:	D4A758 (UniProtKB/TrEMBL), A6K5Q4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947740 ⟸ XM_039091812
- Peptide Label:	isoform X1
- UniProtKB:	D4A758 (UniProtKB/TrEMBL), A6K5Q4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947742 ⟸ XM_039091814
- Peptide Label:	isoform X1
- UniProtKB:	D4A758 (UniProtKB/TrEMBL), A6K5Q4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063129114 ⟸ XM_063273044
- Peptide Label:	isoform X1
- UniProtKB:	A6K5Q4 (UniProtKB/TrEMBL), D4A758 (UniProtKB/TrEMBL)

Protein Domains

LRRC8 pannexin-like TM region

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A758-F1-model_v2	AlphaFold	D4A758	1-803	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563429	AgrOrtholog
BioCyc Gene	G2FUF-16548	BioCyc
Ensembl Genes	ENSRNOG00000002129	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002897	ENTREZGENE
	ENSRNOT00000002897.8	UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/TrEMBL
InterPro	L_dom-like	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	LRR-cont_prot_8_DUF3733	UniProtKB/TrEMBL
	LRR-RLK	UniProtKB/TrEMBL
	LRR_5	UniProtKB/TrEMBL
KEGG Report	rno:305135	UniProtKB/TrEMBL
NCBI Gene	305135	ENTREZGENE
PANTHER	LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN FASCIATED EAR2	UniProtKB/TrEMBL
	RECEPTOR KINASE-LIKE PROTEIN XA21	UniProtKB/TrEMBL
Pfam	DUF3733	UniProtKB/TrEMBL
	LRR_5	UniProtKB/TrEMBL
	LRR_8	UniProtKB/TrEMBL
PhenoGen	Lrrc8b	PhenoGen
PROSITE	LRR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002129	RatGTEx
SMART	LRR_TYP	UniProtKB/TrEMBL
Superfamily-SCOP	RNI-like	UniProtKB/TrEMBL
UniProt	A6K5Q4	ENTREZGENE, UniProtKB/TrEMBL
	D4A758	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-16	Lrrc8b	leucine rich repeat containing 8 VRAC subunit B	Lrrc8b	leucine rich repeat containing 8 family, member B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Lrrc8b	leucine rich repeat containing 8 family, member B	RGD1563429_predicted	similar to T-cell activation leucine repeat-rich protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1563429_predicted	similar to T-cell activation leucine repeat-rich protein (predicted)	LOC305135	similar to T-cell activation leucine repeat-rich protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC305135	similar to T-cell activation leucine repeat-rich protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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