Klhl15 (kelch-like family member 15) - Rat Genome Database

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Gene: Klhl15 (kelch-like family member 15) Rattus norvegicus
Analyze
Symbol: Klhl15
Name: kelch-like family member 15
RGD ID: 1563101
Description: Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination and nuclear protein quality control by the ubiquitin-proteasome system. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 103. Orthologous to human KLHL15 (kelch like family member 15); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kelch-like 15; kelch-like 15 (Drosophila); kelch-like protein 15; LOC314111; MGC189229; RGD1563101; similar to Kelch-like 15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X62,987,762 - 63,043,980 (+)NCBIGRCr8
mRatBN7.2X58,994,726 - 59,050,207 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX58,995,461 - 59,046,069 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX60,434,029 - 60,484,320 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X63,935,152 - 63,985,443 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X61,486,233 - 61,536,524 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X63,342,277 - 63,390,915 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX63,343,546 - 63,389,989 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X63,938,247 - 63,988,155 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X81,629,200 - 81,679,937 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX59,429,136 - 59,478,975 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:27561354  


Genomics

Comparative Map Data
Klhl15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X62,987,762 - 63,043,980 (+)NCBIGRCr8
mRatBN7.2X58,994,726 - 59,050,207 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX58,995,461 - 59,046,069 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX60,434,029 - 60,484,320 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X63,935,152 - 63,985,443 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X61,486,233 - 61,536,524 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X63,342,277 - 63,390,915 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX63,343,546 - 63,389,989 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X63,938,247 - 63,988,155 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X81,629,200 - 81,679,937 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX59,429,136 - 59,478,975 (+)NCBICelera
Cytogenetic MapXq22NCBI
KLHL15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X23,983,720 - 24,027,186 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX23,983,716 - 24,027,186 (-)EnsemblGRCh38hg38GRCh38
GRCh37X24,001,837 - 24,045,303 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X23,915,884 - 23,955,224 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX28,123,598 - 28,167,503 (-)NCBICelera
Cytogenetic MapXp22.11NCBI
HuRefX21,746,167 - 21,788,942 (-)NCBIHuRef
CHM1_1X24,033,076 - 24,076,523 (-)NCBICHM1_1
T2T-CHM13v2.0X23,568,140 - 23,611,609 (-)NCBIT2T-CHM13v2.0
Klhl15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X93,275,884 - 93,321,330 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX93,278,205 - 93,321,330 (+)EnsemblGRCm39 Ensembl
GRCm38X94,232,278 - 94,277,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX94,234,599 - 94,277,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X91,480,269 - 91,518,854 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X90,487,649 - 90,526,234 (+)NCBIMGSCv36mm8
CeleraX81,157,596 - 81,195,565 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX41.53NCBI
Klhl15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555094,375,240 - 4,439,287 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555094,377,975 - 4,439,287 (-)NCBIChiLan1.0ChiLan1.0
KLHL15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X25,784,838 - 25,830,079 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X25,788,223 - 25,833,461 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X16,583,117 - 16,625,029 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X23,956,827 - 23,997,742 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX23,956,827 - 23,997,742 (-)Ensemblpanpan1.1panPan2
KLHL15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X19,617,629 - 19,651,076 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX19,618,569 - 19,650,728 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X19,573,214 - 19,606,694 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX19,574,030 - 19,606,676 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X19,612,048 - 19,645,468 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X19,645,464 - 19,678,906 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X19,701,687 - 19,735,087 (-)NCBIUU_Cfam_GSD_1.0
Klhl15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X12,562,053 - 12,605,647 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936624552,177 - 591,578 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936624552,220 - 593,546 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX20,091,904 - 20,129,561 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X20,088,208 - 20,130,452 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X21,516,308 - 21,553,794 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X22,497,481 - 22,499,997 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX22,460,041 - 22,497,773 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
ChlSab1.1 EnsemblX22,460,041 - 22,497,773 (-)NCBIChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605624,330,864 - 24,379,115 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624897357,551 - 406,561 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624897361,663 - 429,401 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klhl15
133 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:41
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000008558
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X5704214165612192Rat

Markers in Region
DXRat90  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.1X81,702,501 - 81,702,819RGD
CeleraX59,429,328 - 59,429,519UniSTS
SHRSP x BN MapX17.21UniSTS
SHRSP x BN MapX17.21RGD
Cytogenetic MapXq31UniSTS
AU049895  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X59,001,096 - 59,001,386 (+)MAPPERmRatBN7.2
Rnor_6.0X63,348,852 - 63,349,139NCBIRnor6.0
Rnor_5.0X63,944,078 - 63,944,365UniSTSRnor5.0
RGSC_v3.4X81,634,136 - 81,634,423UniSTSRGSC3.4
CeleraX59,434,542 - 59,434,829UniSTS
Cytogenetic MapXq31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 14 15 7 3 17 8
Low 3 42 43 41 4 41 8 10 67 32 24 3 8
Below cutoff 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC168930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000008558   ⟹   ENSRNOP00000008558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX58,995,666 - 59,046,069 (+)Ensembl
Rnor_6.0 EnsemblX63,343,751 - 63,389,989 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076315   ⟹   ENSRNOP00000068100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX58,995,461 - 59,010,630 (+)Ensembl
Rnor_6.0 EnsemblX63,343,546 - 63,358,383 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076530   ⟹   ENSRNOP00000068396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX63,343,724 - 63,389,972 (+)Ensembl
RefSeq Acc Id: NM_001108021   ⟹   NP_001101491
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,989,439 - 63,039,842 (+)NCBI
mRatBN7.2X58,995,666 - 59,046,069 (+)NCBI
Rnor_6.0X63,343,751 - 63,389,989 (+)NCBI
Rnor_5.0X63,938,247 - 63,988,155 (+)NCBI
RGSC_v3.4X81,629,200 - 81,679,937 (+)RGD
CeleraX59,429,136 - 59,478,975 (+)RGD
Sequence:
RefSeq Acc Id: XM_017602041   ⟹   XP_017457530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,861 - 63,043,980 (+)NCBI
mRatBN7.2X58,995,224 - 59,050,207 (+)NCBI
Rnor_6.0X63,343,339 - 63,390,915 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602042   ⟹   XP_017457531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,987,762 - 63,043,980 (+)NCBI
mRatBN7.2X58,994,726 - 59,050,207 (+)NCBI
Rnor_6.0X63,342,995 - 63,390,915 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099705   ⟹   XP_038955633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,861 - 63,043,980 (+)NCBI
mRatBN7.2X58,995,780 - 59,050,207 (+)NCBI
RefSeq Acc Id: XM_039099706   ⟹   XP_038955634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,860 - 63,043,980 (+)NCBI
mRatBN7.2X58,995,780 - 59,050,207 (+)NCBI
RefSeq Acc Id: XM_063279992   ⟹   XP_063136062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,862 - 63,043,980 (+)NCBI
RefSeq Acc Id: XM_063279993   ⟹   XP_063136063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,861 - 63,043,980 (+)NCBI
RefSeq Acc Id: XM_063279994   ⟹   XP_063136064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,860 - 63,043,980 (+)NCBI
RefSeq Acc Id: XM_063279995   ⟹   XP_063136065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,987,762 - 63,043,980 (+)NCBI
RefSeq Acc Id: XM_063279996   ⟹   XP_063136066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,861 - 63,043,980 (+)NCBI
RefSeq Acc Id: XM_063279997   ⟹   XP_063136067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,860 - 63,043,980 (+)NCBI
RefSeq Acc Id: XM_063279998   ⟹   XP_063136068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,860 - 63,043,980 (+)NCBI
RefSeq Acc Id: XM_063279999   ⟹   XP_063136069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,289 - 63,043,980 (+)NCBI
RefSeq Acc Id: XM_063280000   ⟹   XP_063136070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,987,762 - 63,043,980 (+)NCBI
RefSeq Acc Id: XM_063280001   ⟹   XP_063136071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,862 - 63,043,980 (+)NCBI
RefSeq Acc Id: XM_063280002   ⟹   XP_063136072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X63,011,108 - 63,043,980 (+)NCBI
RefSeq Acc Id: XM_063280003   ⟹   XP_063136073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,841 - 63,009,806 (+)NCBI
RefSeq Acc Id: XM_063280004   ⟹   XP_063136074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,988,857 - 63,011,226 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001101491   ⟸   NM_001108021
- UniProtKB: D3ZA50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457531   ⟸   XM_017602042
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457530   ⟸   XM_017602041
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008558   ⟸   ENSRNOT00000008558
RefSeq Acc Id: ENSRNOP00000068100   ⟸   ENSRNOT00000076315
RefSeq Acc Id: ENSRNOP00000068396   ⟸   ENSRNOT00000076530
RefSeq Acc Id: XP_038955633   ⟸   XM_039099705
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038955634   ⟸   XM_039099706
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136070   ⟸   XM_063280000
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136065   ⟸   XM_063279995
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136069   ⟸   XM_063279999
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136073   ⟸   XM_063280003
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063136074   ⟸   XM_063280004
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063136064   ⟸   XM_063279994
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136067   ⟸   XM_063279997
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136068   ⟸   XM_063279998
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136066   ⟸   XM_063279996
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136063   ⟸   XM_063279993
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136071   ⟸   XM_063280001
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063136062   ⟸   XM_063279992
- Peptide Label: isoform X1
- UniProtKB: D3ZA50 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136072   ⟸   XM_063280002
- Peptide Label: isoform X3
Protein Domains
BACK   BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZA50-F1-model_v2 AlphaFold D3ZA50 1-604 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563101 AgrOrtholog
BioCyc Gene G2FUF-2243 BioCyc
Ensembl Genes ENSRNOG00000006515 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055030932 UniProtKB/Swiss-Prot
  ENSRNOG00060015638 UniProtKB/Swiss-Prot
  ENSRNOG00065010123 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008558 ENTREZGENE
  ENSRNOT00000008558.6 UniProtKB/Swiss-Prot
  ENSRNOT00000076315.3 UniProtKB/TrEMBL
  ENSRNOT00055053662 UniProtKB/Swiss-Prot
  ENSRNOT00060026785 UniProtKB/Swiss-Prot
  ENSRNOT00065016307 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.420 UniProtKB/Swiss-Prot
  2.120.10.80 UniProtKB/Swiss-Prot
InterPro BACK UniProtKB/Swiss-Prot
  BTB-kelch_protein UniProtKB/Swiss-Prot
  BTB/POZ_dom UniProtKB/Swiss-Prot
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
  KLHL15 UniProtKB/Swiss-Prot
  KLHL15_BACK UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:314111 UniProtKB/Swiss-Prot
NCBI Gene 314111 ENTREZGENE
PANTHER LD33804P UniProtKB/Swiss-Prot
  PTHR45632:SF12 UniProtKB/Swiss-Prot
Pfam BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
  Kelch_6 UniProtKB/Swiss-Prot
PhenoGen Klhl15 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot
PROSITE BTB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006515 RatGTEx
  ENSRNOG00055030932 RatGTEx
  ENSRNOG00060015638 RatGTEx
  ENSRNOG00065010123 RatGTEx
SMART BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot
  SSF54695 UniProtKB/Swiss-Prot
UniProt A0A096MJE5_RAT UniProtKB/TrEMBL
  D3ZA50 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-06 Klhl15  kelch-like family member 15  Klhl15  kelch-like 15 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Klhl15  kelch-like 15 (Drosophila)   Klhl15_predicted  kelch-like 15 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Klhl15_predicted  kelch-like 15 (Drosophila) (predicted)  RGD1563101_predicted  similar to Kelch-like 15 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1563101_predicted  similar to Kelch-like 15 (predicted)  LOC314111  similar to Kelch-like 15  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC314111  similar to Kelch-like 15      Symbol and Name status set to provisional 70820 PROVISIONAL