Il36g (interleukin 36, gamma) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Il36g (interleukin 36, gamma) Rattus norvegicus
Analyze
Symbol: Il36g
Name: interleukin 36, gamma
RGD ID: 1563019
Description: Predicted to enable cytokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; cytokine-mediated signaling pathway; and inflammatory response. Predicted to act upstream of or within negative regulation of myoblast differentiation; negative regulation of myoblast fusion; and positive regulation of interleukin-6 production. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human IL36G (interleukin 36 gamma); INTERACTS WITH bisphenol A; paracetamol; sodium fluoride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Il1f9; interleukin 1 family, member 9; interleukin-1 family member 9; interleukin-36 gamma; LOC499744; RGD1563019; similar to IL-1F9
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,346,675 - 27,352,839 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl327,346,670 - 27,352,834 (+)EnsemblGRCr8
mRatBN7.236,948,323 - 6,954,485 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl36,948,297 - 6,954,480 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx310,042,438 - 10,048,603 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,628,663 - 18,634,828 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0316,818,475 - 16,824,640 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,285,658 - 1,291,836 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,285,664 - 1,291,865 (+)Ensemblrn6Rnor6.0
Rnor_5.031,278,763 - 1,284,915 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.432,432,285 - 2,438,437 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera31,785,790 - 1,791,942 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
cytokine activity  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21860022   PMID:23844157  


Genomics

Comparative Map Data
Il36g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,346,675 - 27,352,839 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl327,346,670 - 27,352,834 (+)EnsemblGRCr8
mRatBN7.236,948,323 - 6,954,485 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl36,948,297 - 6,954,480 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx310,042,438 - 10,048,603 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,628,663 - 18,634,828 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0316,818,475 - 16,824,640 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,285,658 - 1,291,836 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,285,664 - 1,291,865 (+)Ensemblrn6Rnor6.0
Rnor_5.031,278,763 - 1,284,915 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.432,432,285 - 2,438,437 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera31,785,790 - 1,791,942 (+)NCBICelera
Cytogenetic Map3p13NCBI
IL36G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382112,978,006 - 112,985,658 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2112,973,203 - 112,985,658 (+)Ensemblhg38GRCh38
GRCh372113,735,583 - 113,743,235 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,452,077 - 113,459,698 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342113,451,836 - 113,459,458NCBI
Celera2107,120,767 - 107,128,388 (+)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,190,145 - 106,197,806 (+)NCBIHuRef
CHM1_12113,739,752 - 113,747,405 (+)NCBICHM1_1
T2T-CHM13v2.02113,404,536 - 113,412,188 (+)NCBIT2T-CHM13v2.0
Il36g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,076,488 - 24,083,579 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,076,488 - 24,083,580 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38224,186,476 - 24,193,567 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,186,476 - 24,193,568 (+)Ensemblmm10GRCm38
MGSCv37224,041,996 - 24,049,087 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36224,009,168 - 24,014,841 (+)NCBIMGSCv36mm8
Celera223,911,774 - 23,936,073 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.24NCBI
IL36G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21215,168,900 - 15,360,996 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A15,171,664 - 15,362,358 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A89,080,711 - 89,293,626 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A113,781,781 - 113,965,660 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A113,953,169 - 113,965,648 (+)EnsemblpanPan2panpan1.1
PanPan1.1 Ensembl2A113,985,464 - 113,988,046 (+)EnsemblpanPan2panpan1.1
IL36G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,100,557 - 37,148,402 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,144,309 - 37,149,400 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1736,913,566 - 36,918,410 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01737,920,415 - 37,925,259 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1737,752,862 - 37,926,257 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11737,055,847 - 37,060,691 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01737,112,332 - 37,117,178 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01737,326,118 - 37,330,966 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il36g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,460,389 - 82,466,760 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367831,354,955 - 1,360,519 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367831,355,562 - 1,359,524 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL36G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11415,997,954 - 16,007,394 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1416,000,301 - 16,006,810 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660803,673,689 - 3,681,391 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il36g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474913,019,657 - 13,025,590 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474913,016,497 - 13,026,271 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Il36g
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:69
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000007512
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
11 1 6 15 28 36 11 18 11 6 52 29 6 29 25

Sequence


Ensembl Acc Id: ENSRNOT00000007512   ⟹   ENSRNOP00000007512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl327,346,670 - 27,352,834 (+)Ensembl
mRatBN7.2 Ensembl36,948,297 - 6,954,480 (+)Ensembl
Rnor_6.0 Ensembl31,285,664 - 1,291,865 (+)Ensembl
RefSeq Acc Id: NM_001113790   ⟹   NP_001107262
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,346,687 - 27,352,839 (+)NCBI
mRatBN7.236,948,323 - 6,954,485 (+)NCBI
Rnor_6.031,285,684 - 1,291,836 (+)NCBI
Rnor_5.031,278,763 - 1,284,915 (+)NCBI
RGSC_v3.432,432,285 - 2,438,437 (+)RGD
Celera31,785,790 - 1,791,942 (+)RGD
Sequence:
RefSeq Acc Id: XM_063284336   ⟹   XP_063140406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,346,675 - 27,352,839 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001107262 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140406 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58612 (Get FASTA)   NCBI Sequence Viewer  
  EDL93671 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007512
  ENSRNOP00000007512.7
RefSeq Acc Id: NP_001107262   ⟸   NM_001113790
- UniProtKB: B0BMY4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007512   ⟸   ENSRNOT00000007512
RefSeq Acc Id: XP_063140406   ⟸   XM_063284336
- Peptide Label: isoform X1
- UniProtKB: A6JSX6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FNC4-F1-model_v2 AlphaFold F7FNC4 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691847
Promoter ID:EPDNEW_R2372
Type:single initiation site
Name:Il36g_1
Description:interleukin 36, gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.031,285,672 - 1,285,732EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563019 AgrOrtholog
BioCyc Gene G2FUF-50513 BioCyc
Ensembl Genes ENSRNOG00000005701 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007512 ENTREZGENE
  ENSRNOT00000007512.8 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7384725 IMAGE-MGC_LOAD
InterPro Cytokine_IL1-like UniProtKB/TrEMBL
  Interleukin_1 UniProtKB/TrEMBL
KEGG Report rno:499744 UniProtKB/TrEMBL
MGC_CLONE MGC:187491 IMAGE-MGC_LOAD
NCBI Gene 499744 ENTREZGENE
PANTHER INTERLEUKIN-36 GAMMA UniProtKB/TrEMBL
  PTHR10078 UniProtKB/TrEMBL
Pfam IL1 UniProtKB/TrEMBL
PhenoGen Il36g PhenoGen
RatGTEx ENSRNOG00000005701 RatGTEx
SMART IL1 UniProtKB/TrEMBL
Superfamily-SCOP Cytok_IL1_like UniProtKB/TrEMBL
UniProt A6JSX6 ENTREZGENE, UniProtKB/TrEMBL
  B0BMY4 ENTREZGENE, UniProtKB/TrEMBL
  F7FNC4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Il36g  interleukin 36, gamma  Il1f9  interleukin 1 family, member 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Il1f9  interleukin 1 family, member 9  RGD1563019_predicted  similar to IL-1F9 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563019_predicted  similar to IL-1F9 (predicted)  LOC499744  similar to IL-1F9  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499744  similar to IL-1F9      Symbol and Name status set to provisional 70820 PROVISIONAL