Trat1 (T cell receptor associated transmembrane adaptor 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Trat1 (T cell receptor associated transmembrane adaptor 1) Rattus norvegicus
Analyze
Symbol: Trat1
Name: T cell receptor associated transmembrane adaptor 1
RGD ID: 1563011
Description: Predicted to be involved in negative regulation of receptor recycling and positive regulation of T cell receptor signaling pathway. Predicted to act upstream of or within negative regulation of transport and positive regulation of calcium-mediated signaling. Predicted to be located in centriolar satellite; mitotic spindle; and plasma membrane. Predicted to be part of T cell receptor complex. Orthologous to human TRAT1 (T cell receptor associated transmembrane adaptor 1); INTERACTS WITH alpha-Zearalanol; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC125004; similar to T cell receptor interacting molecule
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,498,742 - 65,540,823 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1165,498,742 - 65,542,381 (+)EnsemblGRCr8
mRatBN7.21152,035,750 - 52,077,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,035,750 - 52,077,805 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1160,798,860 - 60,840,951 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,460,643 - 53,502,744 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01152,565,480 - 52,607,541 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01154,619,169 - 54,661,284 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,619,129 - 54,662,353 (+)Ensemblrn6Rnor6.0
Rnor_5.01157,780,653 - 57,820,982 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41153,279,300 - 53,321,892 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,634,708 - 51,676,239 (+)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11390434  


Genomics

Comparative Map Data
Trat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,498,742 - 65,540,823 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1165,498,742 - 65,542,381 (+)EnsemblGRCr8
mRatBN7.21152,035,750 - 52,077,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,035,750 - 52,077,805 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1160,798,860 - 60,840,951 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,460,643 - 53,502,744 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01152,565,480 - 52,607,541 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01154,619,169 - 54,661,284 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,619,129 - 54,662,353 (+)Ensemblrn6Rnor6.0
Rnor_5.01157,780,653 - 57,820,982 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41153,279,300 - 53,321,892 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,634,708 - 51,676,239 (+)NCBICelera
Cytogenetic Map11q21NCBI
TRAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383108,822,786 - 108,855,005 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3108,822,770 - 108,855,005 (+)Ensemblhg38GRCh38
GRCh373108,541,633 - 108,573,852 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363110,024,321 - 110,056,404 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343110,024,320 - 110,056,404NCBI
Celera3106,939,375 - 106,971,458 (+)NCBICelera
Cytogenetic Map3q13.13NCBI
HuRef3105,915,273 - 105,947,371 (+)NCBIHuRef
CHM1_13108,505,620 - 108,537,674 (+)NCBICHM1_1
T2T-CHM13v2.03111,543,021 - 111,575,233 (+)NCBIT2T-CHM13v2.0
Trat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391648,551,137 - 48,630,883 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1648,551,137 - 48,592,384 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl1648,595,767 - 48,637,156 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381648,730,774 - 48,810,547 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1648,730,774 - 48,772,021 (-)Ensemblmm10GRCm38
MGSCv371648,734,803 - 48,772,069 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361648,651,536 - 48,691,761 (-)NCBIMGSCv36mm8
Celera1649,095,445 - 49,132,938 (-)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1630.75NCBI
LOC102018114
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554279,665,456 - 9,699,788 (+)Ensembl
ChiLan1.0NW_0049554279,665,479 - 9,700,305 (+)NCBIChiLan1.0ChiLan1.0
LOC100990994
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22106,800,505 - 106,833,301 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13106,805,284 - 106,838,080 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03105,948,998 - 105,981,111 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13112,879,399 - 112,911,668 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3112,879,355 - 112,911,668 (+)EnsemblpanPan2panpan1.1
TRAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13314,033,597 - 14,068,309 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3314,033,657 - 14,067,974 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3314,139,060 - 14,175,773 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03314,199,408 - 14,237,150 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3314,199,468 - 14,235,554 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13314,068,627 - 14,103,302 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03314,135,794 - 14,173,516 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03314,547,404 - 14,584,144 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101972231
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602140,353,838 - 140,386,098 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366452,464,548 - 2,491,016 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366452,459,524 - 2,491,016 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13150,629,944 - 150,666,598 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113150,629,942 - 150,666,842 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213159,760,124 - 159,796,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12271,939,447 - 71,972,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2271,939,207 - 71,972,172 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604194,493,792 - 94,526,013 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101706523
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473140,280,884 - 40,306,653 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473140,281,086 - 40,319,254 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116898310
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1433,247,034 - 33,263,682 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Trat1
317 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:344
Count of miRNA genes:203
Interacting mature miRNAs:235
Transcripts:ENSRNOT00000059924
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
RH130838  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81165,540,545 - 65,540,763 (+)Marker Load Pipeline
mRatBN7.21152,077,527 - 52,077,745 (+)MAPPERmRatBN7.2
Rnor_6.01154,661,007 - 54,661,224NCBIRnor6.0
Rnor_5.01157,820,705 - 57,820,922UniSTSRnor5.0
RGSC_v3.41153,321,615 - 53,321,832UniSTSRGSC3.4
Celera1151,675,962 - 51,676,179UniSTS
Cytogenetic Map11q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
14 7 27 54 52 52 22 92 22 6 232 137 6 31 53 55 30

Sequence


Ensembl Acc Id: ENSRNOT00000059924   ⟹   ENSRNOP00000056668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,498,764 - 65,541,637 (+)Ensembl
mRatBN7.2 Ensembl1152,035,750 - 52,077,805 (+)Ensembl
Rnor_6.0 Ensembl1154,619,129 - 54,662,353 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000130061   ⟹   ENSRNOP00000101516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,498,742 - 65,542,381 (+)Ensembl
RefSeq Acc Id: NM_001037981   ⟹   NP_001033070
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,498,742 - 65,540,823 (+)NCBI
mRatBN7.21152,035,750 - 52,077,805 (+)NCBI
Rnor_6.01154,619,169 - 54,661,284 (+)NCBI
Rnor_5.01157,780,653 - 57,820,982 (+)NCBI
RGSC_v3.41153,279,300 - 53,321,892 (+)RGD
Celera1151,634,708 - 51,676,239 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001033070 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI11082 (Get FASTA)   NCBI Sequence Viewer  
  EDM11111 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056668
  ENSRNOP00000056668.2
  ENSRNOP00000101516.1
RefSeq Acc Id: NP_001033070   ⟸   NM_001037981
- UniProtKB: F7F6T0 (UniProtKB/TrEMBL),   A6IQV8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056668   ⟸   ENSRNOT00000059924
Ensembl Acc Id: ENSRNOP00000101516   ⟸   ENSRNOT00000130061

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F6T0-F1-model_v2 AlphaFold F7F6T0 1-186 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563011 AgrOrtholog
BioCyc Gene G2FUF-21420 BioCyc
Ensembl Genes ENSRNOG00000029564 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059924 ENTREZGENE
  ENSRNOT00000059924.4 UniProtKB/TrEMBL
  ENSRNOT00000130061.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7384735 IMAGE-MGC_LOAD
InterPro T-cell_rcpt-assoc_TM_adapter-1 UniProtKB/TrEMBL
KEGG Report rno:498075 UniProtKB/TrEMBL
MGC_CLONE MGC:125004 IMAGE-MGC_LOAD
NCBI Gene 498075 ENTREZGENE
PANTHER PTHR15951 UniProtKB/TrEMBL
  T-CELL RECEPTOR-ASSOCIATED TRANSMEMBRANE ADAPTER 1 UniProtKB/TrEMBL
Pfam SIT UniProtKB/TrEMBL
PhenoGen Trat1 PhenoGen
RatGTEx ENSRNOG00000029564 RatGTEx
UniProt A0ABK0LI62_RAT UniProtKB/TrEMBL
  A6IQV8 ENTREZGENE, UniProtKB/TrEMBL
  F7F6T0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Trat1  T cell receptor associated transmembrane adaptor 1  MGC125004  similar to T cell receptor interacting molecule  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 MGC125004  similar to T cell receptor interacting molecule      Symbol and Name status set to provisional 70820 PROVISIONAL