Acat2l1 (acetyl-CoA acetyltransferase 2-like 1) - Rat Genome Database

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Gene: Acat2l1 (acetyl-CoA acetyltransferase 2-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Acat2l1
Name: acetyl-CoA acetyltransferase 2-like 1
RGD ID: 1562948
Description: Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be located in cytoplasm; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: acetyl-CoA acetyltransferase, cytosolic-like; LOC102554294; LOC365096; RGD1562948; similar to Ab2-076
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,341,596 - 50,376,961 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl150,359,869 - 50,376,959 (+)EnsemblGRCr8
mRatBN7.2147,803,822 - 47,829,012 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,803,813 - 47,829,151 (+)EnsemblmRatBN7.2
Rnor_6.0148,008,574 - 48,025,730 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,996,521 - 48,026,268 (+)Ensemblrn6Rnor6.0
Rnor_5.0151,726,651 - 51,743,785 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,018,019 - 42,103,632 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera143,612,424 - 43,629,590 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Acat2l1
195 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:102
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000018934
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
AI528772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,829,186 - 47,829,332 (+)MAPPERmRatBN7.2
mRatBN7.24120,706,024 - 120,706,170 (+)MAPPERmRatBN7.2
Rnor_6.0148,025,789 - 48,025,934NCBIRnor6.0
Rnor_6.04120,180,744 - 120,180,889NCBIRnor6.0
Rnor_5.04185,422,198 - 185,422,343UniSTSRnor5.0
RGSC_v3.44122,326,785 - 122,326,930UniSTSRGSC3.4
RGSC_v3.4142,103,668 - 42,103,813UniSTSRGSC3.4
Celera143,629,649 - 43,629,794UniSTS
Celera4109,662,385 - 109,662,530UniSTS
Cytogenetic Map4q34UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map1q12UniSTS
RH94518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,829,061 - 47,829,145 (+)MAPPERmRatBN7.2
Rnor_6.0148,025,664 - 48,025,747NCBIRnor6.0
Rnor_5.0151,726,651 - 51,726,734UniSTSRnor5.0
RGSC_v3.4142,103,543 - 42,103,626UniSTSRGSC3.4
Celera143,629,524 - 43,629,607UniSTS
RH 3.4 Map1537.31UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map1q12UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 16 12 149 241 91 90 64 136 59 21 479 325 9 223 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018934   ⟹   ENSRNOP00000018934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,359,869 - 50,376,959 (+)Ensembl
mRatBN7.2 Ensembl147,812,083 - 47,829,151 (+)Ensembl
Rnor_6.0 Ensembl148,008,683 - 48,025,579 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076951   ⟹   ENSRNOP00000068312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl147,996,521 - 48,026,268 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077707   ⟹   ENSRNOP00000069035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,367,510 - 50,376,959 (+)Ensembl
mRatBN7.2 Ensembl147,803,813 - 47,829,151 (+)Ensembl
RefSeq Acc Id: XM_063276877   ⟹   XP_063132947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,341,596 - 50,376,961 (+)NCBI
RefSeq Acc Id: XM_063276883   ⟹   XP_063132953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,341,596 - 50,376,961 (+)NCBI
RefSeq Acc Id: XM_063276894   ⟹   XP_063132964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,351,608 - 50,376,961 (+)NCBI
RefSeq Acc Id: XM_063276904   ⟹   XP_063132974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,359,842 - 50,376,961 (+)NCBI
RefSeq Acc Id: XM_063276915   ⟹   XP_063132985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,359,869 - 50,376,961 (+)NCBI
Ensembl Acc Id: ENSRNOP00000018934   ⟸   ENSRNOT00000018934
Ensembl Acc Id: ENSRNOP00000068312   ⟸   ENSRNOT00000076951
Ensembl Acc Id: ENSRNOP00000069035   ⟸   ENSRNOT00000077707
RefSeq Acc Id: XP_063132947   ⟸   XM_063276877
- Peptide Label: isoform X1
- UniProtKB: A6KJU9 (UniProtKB/TrEMBL),   A6KP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132953   ⟸   XM_063276883
- Peptide Label: isoform X1
- UniProtKB: A6KJU9 (UniProtKB/TrEMBL),   A6KP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132964   ⟸   XM_063276894
- Peptide Label: isoform X1
- UniProtKB: A6KJU9 (UniProtKB/TrEMBL),   A6KP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132974   ⟸   XM_063276904
- Peptide Label: isoform X1
- UniProtKB: A6KJU9 (UniProtKB/TrEMBL),   A6KP33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132985   ⟸   XM_063276915
- Peptide Label: isoform X2
- UniProtKB: D3ZKB6 (UniProtKB/TrEMBL),   A0A0G2JUB4 (UniProtKB/TrEMBL)
Protein Domains
Thiolase C-terminal   Thiolase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MJY8-F1-model_v2 AlphaFold A0A096MJY8 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562948 AgrOrtholog
BioCyc Gene G2FUF-61586 BioCyc
Ensembl Genes ENSRNOG00000013975 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018934 ENTREZGENE
  ENSRNOT00000018934.8 UniProtKB/TrEMBL
  ENSRNOT00000077707 ENTREZGENE
  ENSRNOT00000077707.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.47.10 UniProtKB/TrEMBL
InterPro Thiolase UniProtKB/TrEMBL
  Thiolase-like UniProtKB/TrEMBL
  Thiolase_AS UniProtKB/TrEMBL
  Thiolase_C UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/TrEMBL
  Thiolase_N UniProtKB/TrEMBL
NCBI Gene 365096 ENTREZGENE
PANTHER ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC UniProtKB/TrEMBL
  ACETYL-COA C-ACYLTRANSFERASE UniProtKB/TrEMBL
Pfam Thiolase_C UniProtKB/TrEMBL
  Thiolase_N UniProtKB/TrEMBL
PhenoGen Acat2l1 PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/TrEMBL
PROSITE THIOLASE_2 UniProtKB/TrEMBL
  THIOLASE_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013975 RatGTEx
Superfamily-SCOP Thiolase-like UniProtKB/TrEMBL
UniProt A0A0G2JUB4 ENTREZGENE, UniProtKB/TrEMBL
  A6KJU9 ENTREZGENE, UniProtKB/TrEMBL
  A6KP33 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKB6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Acat2l1  acetyl-CoA acetyltransferase 2-like 1  LOC102554294  acetyl-CoA acetyltransferase, cytosolic-like  Data merged from RGD:7667309 737654 PROVISIONAL
2015-06-26 Acat2l1  acetyl-CoA acetyltransferase 2-like 1  RGD1562948  similar to Ab2-076  Name and Symbol changed 629549 APPROVED
2013-12-18 LOC102554294  acetyl-CoA acetyltransferase, cytosolic-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1562948  similar to Ab2-076   RGD1562948_predicted  similar to Ab2-076 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562948_predicted  similar to Ab2-076 (predicted)  LOC365096  similar to Ab2-076  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC365096  similar to Ab2-076      Symbol and Name status set to provisional 70820 PROVISIONAL