Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sema4c | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Sema4c (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in increased expression of SEMA4C mRNA | CTD | PMID:22206623 | Sema4c | Rat | 1-chloro-2,4-dinitrobenzene | increases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | Dinitrochlorobenzene results in increased expression of SEMA4C mRNA | CTD | PMID:16314067 | Sema4c | Rat | 17beta-estradiol | increases expression | ISO | Sema4c (Mus musculus) | 6480464 | Estradiol results in increased expression of SEMA4C mRNA | CTD | PMID:39298647 | Sema4c | Rat | 2-butoxyethanol | increases expression | ISO | Sema4c (Mus musculus) | 6480464 | n-butoxyethanol results in increased expression of SEMA4C mRNA | CTD | PMID:19812364 | Sema4c | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Sema4c (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of SEMA4C exon | CTD | PMID:33297965 | Sema4c | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Sema4c (Mus musculus) | 6480464 | Fenretinide results in increased expression of SEMA4C mRNA | CTD | PMID:28973697 | Sema4c | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SEMA4C mRNA | CTD | PMID:31881176 | Sema4c | Rat | aflatoxin B1 | increases methylation | ISO | SEMA4C (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SEMA4C 5' UTR | CTD | PMID:30157460 | Sema4c | Rat | arsane | affects methylation | ISO | SEMA4C (Homo sapiens) | 6480464 | Arsenic affects the methylation of SEMA4C gene | CTD | PMID:25304211 | Sema4c | Rat | arsane | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Sema4c | Rat | arsenic atom | affects methylation | ISO | SEMA4C (Homo sapiens) | 6480464 | Arsenic affects the methylation of SEMA4C gene | CTD | PMID:25304211 | Sema4c | Rat | arsenic atom | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Sema4c | Rat | arsenite(3-) | increases expression | ISO | Sema4c (Mus musculus) | 6480464 | arsenite results in increased expression of SEMA4C mRNA | CTD | PMID:33053406 | Sema4c | Rat | arsenite(3-) | increases methylation | ISO | SEMA4C (Homo sapiens) | 6480464 | arsenite results in increased methylation of SEMA4C promoter | CTD | PMID:23974009 | Sema4c | Rat | benzo[a]pyrene | increases methylation | ISO | SEMA4C (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SEMA4C promoter | CTD | PMID:27901495 | Sema4c | Rat | benzo[a]pyrene | affects methylation | ISO | SEMA4C (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SEMA4C 5' UTR | CTD | PMID:27901495 | Sema4c | Rat | beta-lapachone | decreases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of SEMA4C mRNA | CTD | PMID:38218311 | Sema4c | Rat | bisphenol A | decreases expression | ISO | Sema4c (Mus musculus) | 6480464 | bisphenol A results in decreased expression of SEMA4C mRNA | CTD | PMID:25594700 | Sema4c | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SEMA4C mRNA | CTD | PMID:30816183|PMID:32528016|PMID:34947998 | Sema4c | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of SEMA4C gene | CTD | PMID:28505145 | Sema4c | Rat | butanal | decreases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of SEMA4C mRNA | CTD | PMID:26079696 | Sema4c | Rat | carbon nanotube | decreases expression | ISO | Sema4c (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of SEMA4C mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | Sema4c | Rat | cefaloridine | decreases expression | EXP | | 6480464 | Cephaloridine results in decreased expression of SEMA4C mRNA | CTD | PMID:18500788 | Sema4c | Rat | CGP 52608 | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SEMA4C gene] | CTD | PMID:28238834 | Sema4c | Rat | chlorpyrifos | decreases expression | ISO | Sema4c (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SEMA4C mRNA | CTD | PMID:37019170 | Sema4c | Rat | cisplatin | increases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | Cisplatin results in increased expression of SEMA4C mRNA | CTD | PMID:27594783 | Sema4c | Rat | cocaine | increases expression | EXP | | 6480464 | Cocaine results in increased expression of SEMA4C mRNA | CTD | PMID:15691709 | Sema4c | Rat | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of SEMA4C mRNA | CTD | PMID:26033743 | Sema4c | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of SEMA4C mRNA | CTD | PMID:26033743 | Sema4c | Rat | cyclosporin A | increases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SEMA4C mRNA | CTD | PMID:25562108 | Sema4c | Rat | diazinon | increases methylation | ISO | SEMA4C (Homo sapiens) | 6480464 | Diazinon results in increased methylation of SEMA4C gene | CTD | PMID:22964155 | Sema4c | Rat | Dibutyl phosphate | affects expression | ISO | SEMA4C (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of SEMA4C mRNA | CTD | PMID:37042841 | Sema4c | Rat | dibutyl phthalate | decreases expression | ISO | Sema4c (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of SEMA4C mRNA | CTD | PMID:17361019|PMID:21266533 | Sema4c | Rat | dorsomorphin | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Sema4c | Rat | doxorubicin | decreases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SEMA4C mRNA | CTD | PMID:29803840 | Sema4c | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of SEMA4C mRNA | CTD | PMID:29391264 | Sema4c | Rat | FR900359 | affects phosphorylation | ISO | SEMA4C (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of SEMA4C protein | CTD | PMID:37730182 | Sema4c | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of SEMA4C mRNA | CTD | PMID:33387578 | Sema4c | Rat | lipopolysaccharide | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of SEMA4C mRNA; [S-(1,2-dichlorovinyl)cysteine more ... | CTD | PMID:35811015 | Sema4c | Rat | manganese atom | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Sema4c | Rat | manganese(0) | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Sema4c | Rat | manganese(II) chloride | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Sema4c | Rat | nickel sulfate | increases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of SEMA4C mRNA | CTD | PMID:16314067 | Sema4c | Rat | okadaic acid | decreases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | Okadaic Acid results in decreased expression of SEMA4C mRNA | CTD | PMID:38832940 | Sema4c | Rat | ozone | increases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | Ozone results in increased expression of SEMA4C mRNA | CTD | PMID:23033980 | Sema4c | Rat | ozone | multiple interactions | ISO | Sema4c (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... | CTD | PMID:34911549 | Sema4c | Rat | paracetamol | affects expression | ISO | Sema4c (Mus musculus) | 6480464 | Acetaminophen affects the expression of SEMA4C mRNA | CTD | PMID:17562736 | Sema4c | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SEMA4C mRNA | CTD | PMID:33387578 | Sema4c | Rat | paracetamol | decreases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of SEMA4C mRNA | CTD | PMID:29067470 | Sema4c | Rat | phenylmercury acetate | decreases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of SEMA4C mRNA | CTD | PMID:26272509 | Sema4c | Rat | phenylmercury acetate | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Sema4c | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of SEMA4C mRNA; [S-(1,2-dichlorovinyl)cysteine more ... | CTD | PMID:35811015 | Sema4c | Rat | SB 431542 | increases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SEMA4C protein | CTD | PMID:25670856 | Sema4c | Rat | SB 431542 | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Sema4c | Rat | sodium arsenite | multiple interactions | ISO | SEMA4C (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Sema4c | Rat | succimer | multiple interactions | ISO | Sema4c (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of SEMA4C mRNA | CTD | PMID:21641980 | Sema4c | Rat | tetrachloromethane | affects expression | ISO | Sema4c (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of SEMA4C mRNA | CTD | PMID:17484886 | Sema4c | Rat | titanium dioxide | increases methylation | ISO | Sema4c (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of SEMA4C gene | CTD | PMID:35295148 | Sema4c | Rat | titanium dioxide | decreases methylation | ISO | Sema4c (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of SEMA4C gene; titanium dioxide results in decreased methylation more ... | CTD | PMID:35295148 | Sema4c | Rat | triclosan | increases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | Triclosan results in increased expression of SEMA4C mRNA | CTD | PMID:30510588 | Sema4c | Rat | valproic acid | increases methylation | ISO | SEMA4C (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SEMA4C gene | CTD | PMID:29154799 | Sema4c | Rat | valproic acid | decreases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SEMA4C mRNA | CTD | PMID:23179753|PMID:27188386|PMID:28001369 | Sema4c | Rat | valproic acid | affects expression | ISO | SEMA4C (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SEMA4C mRNA | CTD | PMID:25979313 | Sema4c | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of SEMA4C mRNA | CTD | PMID:23034163 | Sema4c | Rat | vorinostat | decreases expression | ISO | SEMA4C (Homo sapiens) | 6480464 | vorinostat results in decreased expression of SEMA4C mRNA | CTD | PMID:27188386 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















