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Gene: Ppef1 (protein phosphatase with EF-hand domain 1) Rattus norvegicus

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Symbol:

Ppef1

Name:

protein phosphatase with EF-hand domain 1

RGD ID:

1562772

Description:

Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in detection of stimulus involved in sensory perception. Predicted to be active in cytosol and nucleus. Orthologous to human PPEF1 (protein phosphatase with EF-hand domain 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; atrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC317498; MGC125115; PPEF-1; protein phosphatase with EF hand calcium-binding domain 1; protein phosphatase, EF-hand calcium binding domain 1; serine/threonine-protein phosphatase with EF-hands 1; serine/threonine-protein phosphatase with EF-hands 1-like; similar to Serine/threonine protein phosphatase with EF-hands-1 (PPEF-1) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine protein phosphatase 7) (PP7)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	37,803,204 - 37,960,378 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	37,830,055 - 37,960,375 (+)	Ensembl				GRCr8
mRatBN7.2	X	33,994,503 - 34,151,704 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	34,021,350 - 34,151,701 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	35,194,826 - 35,309,125 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	38,656,656 - 38,770,959 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	36,331,981 - 36,446,278 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	35,822,687 - 35,947,690 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	35,869,538 - 35,947,282 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	36,142,176 - 36,270,449 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	55,347,219 - 55,436,212 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	34,715,653 - 34,830,012 (+)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Bufotalin (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

dibromine (EXP)

endosulfan (EXP)

entinostat (ISO)

epoxiconazole (ISO)

ethylparaben (ISO)

genistein (ISO)

gentamycin (EXP)

lead diacetate (EXP)

Licochalcone B (ISO)

okadaic acid (ISO)

paracetamol (EXP)

permethrin (ISO)

propanal (ISO)

thapsigargin (ISO)

trichloroethene (EXP)

triptonide (ISO)

tunicamycin (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of stimulus involved in sensory perception (IEA)

Cellular Component

cytosol (IBA)

nucleus (IBA)

Molecular Function

calcium ion binding (IEA)

hydrolase activity (IEA)

iron ion binding (IEA)

manganese ion binding (IEA)

metal ion binding (IEA)

phosphoprotein phosphatase activity (IEA)

protein binding (ISO)

protein serine/threonine phosphatase activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data

Ppef1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	37,803,204 - 37,960,378 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	37,830,055 - 37,960,375 (+)	Ensembl				GRCr8
mRatBN7.2	X	33,994,503 - 34,151,704 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	34,021,350 - 34,151,701 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	35,194,826 - 35,309,125 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	38,656,656 - 38,770,959 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	36,331,981 - 36,446,278 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	35,822,687 - 35,947,690 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	35,869,538 - 35,947,282 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	36,142,176 - 36,270,449 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	55,347,219 - 55,436,212 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	34,715,653 - 34,830,012 (+)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

PPEF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	18,675,067 - 18,827,917 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	18,675,909 - 18,827,921 (+)	Ensembl			hg38	GRCh38
GRCh37	X	18,693,187 - 18,846,035 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	18,618,966 - 18,755,956 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	X	22,829,137 - 22,966,124 (+)	NCBI		Celera
Cytogenetic Map	X	p22.13	NCBI
HuRef	X	16,462,688 - 16,598,790 (+)	NCBI		HuRef
CHM1_1	X	18,740,148 - 18,877,076 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	18,257,672 - 18,410,535 (+)	NCBI		T2T-CHM13v2.0

Ppef1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	159,404,997 - 159,534,286 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	159,406,090 - 159,518,761 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	160,622,419 - 160,751,290 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	160,623,094 - 160,735,765 (-)	Ensembl			mm10	GRCm38
MGSCv37	X	157,061,026 - 157,157,904 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	155,967,609 - 156,038,528 (-)	NCBI		MGSCv36	mm8
Celera	X	143,864,055 - 143,960,973 (-)	NCBI		Celera
Cytogenetic Map	X	F4	NCBI
cM Map	X	73.95	NCBI

Ppef1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955586	597,164 - 760,136 (-)	Ensembl
ChiLan1.0	NW_004955586	597,620 - 761,433 (-)	NCBI	ChiLan1.0	ChiLan1.0

PPEF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	20,471,844 - 20,625,418 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	20,475,230 - 20,628,811 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	11,311,905 - 11,448,676 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	18,675,714 - 18,812,412 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	18,675,714 - 18,812,412 (+)	Ensembl			panPan2	panpan1.1

PPEF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	14,752,768 - 14,876,297 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	14,760,452 - 14,875,997 (+)	Ensembl			canFam3	CanFam3.1
ROS_Cfam_1.0	X	14,719,061 - 14,842,205 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	14,726,879 - 14,841,905 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	14,779,855 - 14,902,913 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	14,773,051 - 14,900,714 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	14,836,884 - 14,960,026 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ppef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	7,827,299 - 7,954,506 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936844	318,367 - 445,183 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936844	316,889 - 444,043 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPEF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	15,138,350 - 15,251,228 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	X	15,111,230 - 15,251,415 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	16,319,828 - 16,459,831 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPEF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	17,130,694 - 17,265,097 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	17,175,007 - 17,264,701 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666056	19,024,759 - 19,157,194 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppef1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	3,537,840 - 3,666,725 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624829	3,520,439 - 3,666,568 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ppef1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	X	31,976,598 - 32,070,877 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ppef1
602 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	191
Count of miRNA genes:	145
Interacting mature miRNAs:	162
Transcripts:	ENSRNOT00000058947
Prediction methods:	Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	24470360	44931007	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	4001493	44939387	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	24470360	45082063	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1970440	46970440	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	8111486	53111486	Rat

Markers in Region

DXRat125

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	34,150,505 - 34,150,752 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	35,946,493 - 35,946,740	NCBI	Rnor6.0
Rnor_5.0	X	36,269,252 - 36,269,499	UniSTS	Rnor5.0
Celera	X	34,828,813 - 34,829,060	UniSTS
SHRSP x BN Map	X	13.77	RGD
SHRSP x BN Map	X	13.77	UniSTS
Cytogenetic Map	X	q21	UniSTS

DXGot173

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	X	37,959,198 - 37,959,426 (+)	Marker Load Pipeline
mRatBN7.2	X	34,150,525 - 34,150,752 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	35,946,513 - 35,946,740	NCBI	Rnor6.0
Rnor_5.0	X	36,269,272 - 36,269,499	UniSTS	Rnor5.0
Celera	X	34,828,833 - 34,829,060	UniSTS
Cytogenetic Map	X	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	8	60	152	71	71	40	85	40	6	304	172	10	132	72	87	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001034935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001434223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001434224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001434225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099837	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC104696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000058947 ⟹ ENSRNOP00000055729

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	37,830,061 - 37,960,375 (+)	Ensembl
mRatBN7.2 Ensembl	X	34,035,279 - 34,151,701 (+)	Ensembl
Rnor_6.0 Ensembl	X	35,869,538 - 35,947,282 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094755 ⟹ ENSRNOP00000095819

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	37,830,055 - 37,960,375 (+)	Ensembl
mRatBN7.2 Ensembl	X	34,021,350 - 34,151,701 (+)	Ensembl

RefSeq Acc Id:

NM_001034935 ⟹ NP_001030107

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	37,843,965 - 37,960,378 (+)	NCBI
mRatBN7.2	X	34,035,279 - 34,151,704 (+)	NCBI
Rnor_6.0	X	35,822,687 - 35,947,690 (+)	NCBI
Rnor_5.0	X	36,142,176 - 36,270,449 (+)	NCBI
Celera	X	34,715,653 - 34,830,012 (+)	RGD

Sequence:

show sequence

CTGCACTGGCCGAGCAGAAGGCACAGTATCTATGGACTGAAGGGAATCGGTTGAGTGGCTTCTT
GAAGCACAAAGGGAGGGAATTCACACTCTCACTGAGAACCAGAAGTTGAATTTGTCAGCATATA
TGCTTTAGAAGCCATGGGCTGTGGCAGTTCTTCAAAAAAAGGCAAGAAATCTGAGAAAGTGGTG
AGAGCTGCATTAATCATCCAAAATTGGTACCGACGGTACAGAGCTCGACTGAGCGCCAGACAAC
ATTATGCCCTCGCCATCTTCCAGTCTATCGAATATGCTGACGAGCAAGGCCAGATGCAGCTATC
CAGCTTCTTTTCTTTCATGTTGGAAAACTATACAAACACACACAAGGAAGATTCAGCATTAGTA
AGTCGACTTTTTGAAAACACCAGGCTCGAAAGCAAGGACAGAGAGGAATACGTGGGATTGATAG
ATGTGCCTGACTCCTATGACGGTCCTCGTCTGCAGTTTCCTCTCACGTTTACTGACATCAATTT
ACTTCTTCAGGCCTTCAAGCAACAGCAGACACTTCATGCTCACTATGTCTTAGAGGTGCTATTT
GAAGCCAGGAAAATCCTGAAGCAGATGCCGAATTTCACTCGCATACAAACCTTTCCCGCCAAAG
AAATAACAATCTGTGGTGATTTGCATGGGAAACTGGATGATCTTATGTTAATTTTCTATAAGAA
TGGCCTGCCTTCAGAGAAGAATCCATATGTGTTTAATGGTGATTTTGTAGATCGAGGAAACAAT
TCCATGGAGATCCTAATGATCCTGCTTGTTAGTTTTCTTGTCTACCCCACTGACCTGCACCTCA
ATAGAGGGAACCATGAAGACTTTATGATGAACCTGAGGTATGGCTTCACAAAAGAAATCTTACA
GAAATACAAGCTACATGGGAAAAAAATCTTACAAGTCTTGGAAGAACTCTATACCTGGCTCCCA
ATTGGTACAATTATTGACAATGAAATCCTGGTCATACATGGTGGGATATCAGAATCCACGGACT
TGAATATACTCCAGCAACTACAGAGAAATAAAATGAAGTCTGTGTTAATGCCACCAATGTCAAC
AAATCAGGAATGTAACATAAAGAAAAATAAAGCAGGGCCGAGCGAACAGTCTGCTTCTGAACAG
TTGACAAAGCTGGAATGGGAACAGATTATTGACCTTCTGTGGAGTGACCCCAGAGGCAAAAAAG
GCTGTTATCCAAACACAAGCCGAGGAGGCGGCTGCTATTTTGGACCAGATGTTACCTCTAAGGT
TCTTAATAAAAACCAGTTGAAGATGGTCATTCGGTCTCATGAGTGTAAACCTGATGGGTATGAA
ATCTGTCATGATGGAAAGGTCATTACTGTATTTTCTGCTTCTAATTATTATGAAGAAGGCAGCA
ACCGAGGAGCTTACATCAGACTAAGTTATGGTACATCTCCACAATTTTTCCAGTACCAAGTGAC
TAGTACATCATGCCTGAACCCTCTTTACCAAAGGGTGAATGCTATGGAATTCAGTGCCTTCAGG
ATACTAAAGGAAAGAATGATTGCAAGAAAAACTGACCTTATCAATGCTTTTGAGCTCCGAGATC
ACAGTAGGACAGGAAAGATTTCATTGGCCCAGTGGGCTTTTTCTATGGAGAGCATTTTGGGGCT
GAACTTACCGTGGAGATCTCTGAGTTCGCATCTGGTAAGCACTGACTCCAGCGGAAGCGTCGAC
TACATGTCCAGCTTTGATGACATCCACATTGAGAAGCCGATGAAAGATATGAAGTCTGATCTCA
TTGAAACTATGTACAGATACCGATCTGACCTGAAAATCATATTTAATATCATCGACACCGATCA
GTCAGGTCTGATCTCCATGGATGAATTCCGGACCATGTGGAAACTTTTCAATGCTCATTACAAA
GTTCATATTGATGATTCCCAAATTGATGAGCTTGCCAGCACAATGGACTCCAACAAAGATGGCA
ACATAGACTTTAACGAGTTTTTAAGGGCTTTCTATGTAGTCCATAAATACGAGACGCCAGAGAG
CCCTTTGAACAAATGAGAGAGCTTAGCATGAACAAAACCTTCTCCCAGCCCCCTTGAAAACAGC
TGACCTCAACTCTCGGCCTTAACAAGAGCCCTTGAAACTCATAGTAGTAGAGAAAAGTAGATCC
TAATTCGCACCATAAGTAGATGCACAGTGTGAGTGTTGGCAGGCTTTAGCGAACTGCTATTGGT
AAGACTATGTTAAATATCAGTTGATGAGATTCACTTCCATTGCCAGTGATAAACTGGGTTTGAG
CCTGGGGCTGGTCTCAGATGACACCTAACCATGAGACCAGAGAAATTTAGAAGCATATTCAAAG
GAACCCAGAGAGCAGGAAGAGAAATCAATAGGTGTAATATCTGTGAGTGACTGAGGATGAGGTG
AATACTAAACTATTGTTGAAATAAAGTATTTCCATCATCAAAAAAAAAAAAAAAAAAAAAAAAA
A

hide sequence

RefSeq Acc Id:

XM_039099837 ⟹ XP_038955765

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	37,830,033 - 37,960,378 (+)	NCBI
mRatBN7.2	X	34,021,355 - 34,151,704 (+)	NCBI

RefSeq Acc Id:

XM_039099839 ⟹ XP_038955767

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	37,830,043 - 37,960,378 (+)	NCBI
mRatBN7.2	X	34,021,355 - 34,151,704 (+)	NCBI

RefSeq Acc Id:

XM_039099840 ⟹ XP_038955768

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	37,830,033 - 37,960,378 (+)	NCBI
mRatBN7.2	X	34,021,356 - 34,151,704 (+)	NCBI

RefSeq Acc Id:

XM_063280083 ⟹ XP_063136153

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	37,803,204 - 37,960,378 (+)	NCBI

RefSeq Acc Id:

XM_063280084 ⟹ XP_063136154

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	37,830,043 - 37,960,378 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001030107	(Get FASTA)	NCBI Sequence Viewer
	NP_001421152	(Get FASTA)	NCBI Sequence Viewer
	NP_001421153	(Get FASTA)	NCBI Sequence Viewer
	NP_001421154	(Get FASTA)	NCBI Sequence Viewer
	XP_038955765	(Get FASTA)	NCBI Sequence Viewer
	XP_038955767	(Get FASTA)	NCBI Sequence Viewer
	XP_038955768	(Get FASTA)	NCBI Sequence Viewer
	XP_063136153	(Get FASTA)	NCBI Sequence Viewer
	XP_063136154	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI04697	(Get FASTA)	NCBI Sequence Viewer
	EDL96154	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000055729
	ENSRNOP00000055729.5
	ENSRNOP00000095819
GenBank Protein	Q3SWT6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001030107 ⟸ NM_001034935

- UniProtKB:

Q3SWT6 (UniProtKB/Swiss-Prot), F1LNH9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGCGSSSKKGKKSEKVVRAALIIQNWYRRYRARLSARQHYALAIFQSIEYADEQGQMQLSSFFS
FMLENYTNTHKEDSALVSRLFENTRLESKDREEYVGLIDVPDSYDGPRLQFPLTFTDINLLLQA
FKQQQTLHAHYVLEVLFEARKILKQMPNFTRIQTFPAKEITICGDLHGKLDDLMLIFYKNGLPS
EKNPYVFNGDFVDRGNNSMEILMILLVSFLVYPTDLHLNRGNHEDFMMNLRYGFTKEILQKYKL
HGKKILQVLEELYTWLPIGTIIDNEILVIHGGISESTDLNILQQLQRNKMKSVLMPPMSTNQEC
NIKKNKAGPSEQSASEQLTKLEWEQIIDLLWSDPRGKKGCYPNTSRGGGCYFGPDVTSKVLNKN
QLKMVIRSHECKPDGYEICHDGKVITVFSASNYYEEGSNRGAYIRLSYGTSPQFFQYQVTSTSC
LNPLYQRVNAMEFSAFRILKERMIARKTDLINAFELRDHSRTGKISLAQWAFSMESILGLNLPW
RSLSSHLVSTDSSGSVDYMSSFDDIHIEKPMKDMKSDLIETMYRYRSDLKIIFNIIDTDQSGLI
SMDEFRTMWKLFNAHYKVHIDDSQIDELASTMDSNKDGNIDFNEFLRAFYVVHKYETPESPLNK

hide sequence

Ensembl Acc Id:

ENSRNOP00000055729 ⟸ ENSRNOT00000058947

RefSeq Acc Id:	XP_038955765 ⟸ XM_039099837
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038955767 ⟸ XM_039099839
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038955768 ⟸ XM_039099840
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000095819 ⟸ ENSRNOT00000094755

RefSeq Acc Id:	XP_063136153 ⟸ XM_063280083
- Peptide Label:	isoform X2
- UniProtKB:	Q3SWT6 (UniProtKB/Swiss-Prot), F1LNH9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136154 ⟸ XM_063280084
- Peptide Label:	isoform X2

Protein Domains

EF-hand IQ

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q3SWT6-F1-model_v2	AlphaFold	Q3SWT6	1-640	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562772	AgrOrtholog
BioCyc Gene	G2FUF-2507	BioCyc
Ensembl Genes	ENSRNOG00000027331	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000058947	ENTREZGENE
	ENSRNOT00000058947.5	UniProtKB/Swiss-Prot
	ENSRNOT00000094755	ENTREZGENE
Gene3D-CATH	3.60.21.10	UniProtKB/Swiss-Prot
	EF-hand	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7112183	IMAGE-MGC_LOAD
InterPro	Calcineurin-like_PHP_ApaH	UniProtKB/Swiss-Prot
	EF-hand-dom_pair	UniProtKB/Swiss-Prot
	EF_Hand_1_Ca_BS	UniProtKB/Swiss-Prot
	EF_hand_dom	UniProtKB/Swiss-Prot
	Metallo-depent_PP-like	UniProtKB/Swiss-Prot
	PPP_dom	UniProtKB/Swiss-Prot
	PPP_phosphatase	UniProtKB/Swiss-Prot
	Ser/Thr-Pase_EF-hand_contain	UniProtKB/Swiss-Prot
	Ser/Thr-sp_prot-phosphatase	UniProtKB/Swiss-Prot
KEGG Report	rno:317498	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:125115	IMAGE-MGC_LOAD
NCBI Gene	317498	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED	UniProtKB/Swiss-Prot
	SERINE/THREONINE-PROTEIN PHOSPHATASE WITH EF-HANDS 1	UniProtKB/Swiss-Prot
Pfam	EF-hand_7	UniProtKB/Swiss-Prot
	Metallophos	UniProtKB/Swiss-Prot
	PPP5	UniProtKB/Swiss-Prot
PhenoGen	Ppef1	PhenoGen
PIRSF	PPEF	UniProtKB/Swiss-Prot
PRINTS	STPHPHTASE	UniProtKB/Swiss-Prot
PROSITE	EF_HAND_1	UniProtKB/Swiss-Prot
	EF_HAND_2	UniProtKB/Swiss-Prot
	SER_THR_PHOSPHATASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000027331	RatGTEx
SMART	EFh	UniProtKB/Swiss-Prot
	PP2Ac	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47473	UniProtKB/Swiss-Prot
	SSF56300	UniProtKB/Swiss-Prot
UniProt	A0A8I6B3D3	ENTREZGENE, UniProtKB/TrEMBL
	A6IPK9_RAT	UniProtKB/TrEMBL
	F1LNH9	ENTREZGENE, UniProtKB/TrEMBL
	PPE1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-01	Ppef1	protein phosphatase with EF-hand domain 1	Ppef1	protein phosphatase, EF-hand calcium binding domain 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-05-24	Ppef1	protein phosphatase, EF-hand calcium binding domain 1	LOC100363004	serine/threonine-protein phosphatase with EF-hands 1-like	Data merged from RGD:2323591	1643240	APPROVED
2010-05-06	LOC100363004	serine/threonine-protein phosphatase with EF-hands 1-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-09-24	Ppef1	protein phosphatase, EF-hand calcium binding domain 1	Ppef1	protein phosphatase with EF hand calcium-binding domain 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Ppef1	protein phosphatase with EF hand calcium-binding domain 1	LOC317498	similar to Serine/threonine protein phosphatase with EF-hands-1 (PPEF-1) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine protein phosphatase 7) (PP7)	Symbol and Name updated	1299863	APPROVED
2006-02-09	LOC317498	similar to Serine/threonine protein phosphatase with EF-hands-1 (PPEF-1) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine protein phosphatase 7) (PP7)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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