Gstt3 (glutathione S-transferase, theta 3) - Rat Genome Database

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Pathways
Gene: Gstt3 (glutathione S-transferase, theta 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gstt3
Name: glutathione S-transferase, theta 3
RGD ID: 1562732
Description: Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm; INTERACTS WITH 1-benzylpiperazine; 17beta-estradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC499422; RGD1562732; similar to Glutathione S-transferase, theta 3
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,873,618 - 12,881,974 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2012,874,374 - 12,881,973 (+)EnsemblGRCr8
mRatBN7.22012,875,184 - 12,882,540 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,874,854 - 12,882,599 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2013,581,761 - 13,589,116 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,942,702 - 12,950,057 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,414,801 - 13,422,307 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,817,795 - 13,825,475 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,817,795 - 13,825,475 (+)Ensemblrn6Rnor6.0
Rnor_5.02016,007,776 - 16,015,160 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42013,595,934 - 13,603,087 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2014,366,551 - 14,374,191 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19800905  


Genomics

Variants

.
Variants in Gstt3
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:70
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000036518
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH133843  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02013,823,677 - 13,824,643NCBIRnor6.0
Cytogenetic Map20p12UniSTS
RH128155  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22012,882,322 - 12,882,515 (+)MAPPERmRatBN7.2
Rnor_6.02013,825,260 - 13,825,452NCBIRnor6.0
Rnor_5.02016,014,945 - 16,015,137UniSTSRnor5.0
RGSC_v3.42013,595,957 - 13,596,149UniSTSRGSC3.4
Celera2014,373,976 - 14,374,168UniSTS
Cytogenetic Map20p12UniSTS
RH130749  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22012,873,378 - 12,873,564 (+)MAPPERmRatBN7.2
Rnor_6.02013,816,320 - 13,816,505NCBIRnor6.0
Rnor_5.02016,006,301 - 16,006,486UniSTSRnor5.0
RGSC_v3.42013,604,377 - 13,604,562UniSTSRGSC3.4
Celera2014,365,076 - 14,365,261UniSTS
RH 3.4 Map20154.86UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 68 59 6 332 168 11 139 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000036518   ⟹   ENSRNOP00000055038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,874,854 - 12,882,538 (+)Ensembl
Rnor_6.0 Ensembl2013,817,795 - 13,825,475 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098201   ⟹   ENSRNOP00000078933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,874,618 - 12,881,065 (+)Ensembl
mRatBN7.2 Ensembl2012,874,854 - 12,882,599 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109740   ⟹   ENSRNOP00000086329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,874,625 - 12,881,973 (+)Ensembl
mRatBN7.2 Ensembl2012,876,581 - 12,882,599 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114782   ⟹   ENSRNOP00000094988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,874,374 - 12,881,225 (+)Ensembl
mRatBN7.2 Ensembl2012,874,854 - 12,881,631 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133964   ⟹   ENSRNOP00000106346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,876,178 - 12,881,225 (+)Ensembl
RefSeq Acc Id: NM_001399042   ⟹   NP_001385971
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,874,618 - 12,881,974 (+)NCBI
mRatBN7.22012,875,184 - 12,882,540 (+)NCBI
RefSeq Acc Id: XM_063279466   ⟹   XP_063135536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,876,132 - 12,881,974 (+)NCBI
RefSeq Acc Id: XM_063279467   ⟹   XP_063135537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,873,618 - 12,881,974 (+)NCBI
Ensembl Acc Id: ENSRNOP00000055038   ⟸   ENSRNOT00000036518
Ensembl Acc Id: ENSRNOP00000086329   ⟸   ENSRNOT00000109740
Ensembl Acc Id: ENSRNOP00000078933   ⟸   ENSRNOT00000098201
Ensembl Acc Id: ENSRNOP00000094988   ⟸   ENSRNOT00000114782
RefSeq Acc Id: NP_001385971   ⟸   NM_001399042
- UniProtKB: A0A8I5ZLR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135537   ⟸   XM_063279467
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135536   ⟸   XM_063279466
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000106346   ⟸   ENSRNOT00000133964

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8I7-F1-model_v2 AlphaFold D3Z8I7 1-210 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562732 AgrOrtholog
BioCyc Gene G2FUF-4158 BioCyc
Ensembl Genes ENSRNOG00000001242 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000098201.2 UniProtKB/TrEMBL
  ENSRNOT00000109740.2 UniProtKB/TrEMBL
  ENSRNOT00000114782 ENTREZGENE
  ENSRNOT00000114782.2 UniProtKB/TrEMBL
  ENSRNOT00000133964.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C-like UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  GST_C UniProtKB/TrEMBL
  GST_C_Theta UniProtKB/TrEMBL
  GST_N_Theta UniProtKB/TrEMBL
  GST_Theta UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene 499422 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE THETA-3 UniProtKB/TrEMBL
  PTHR43917 UniProtKB/TrEMBL
Pfam GST_C UniProtKB/TrEMBL
  GST_N UniProtKB/TrEMBL
PhenoGen Gstt3 PhenoGen
PROSITE GST_CTER UniProtKB/TrEMBL
  GST_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001242 RatGTEx
Superfamily-SCOP GST_C_like UniProtKB/TrEMBL
  Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A0A8I5ZLR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5Y5_RAT UniProtKB/TrEMBL
  A0A8I6GKZ0_RAT UniProtKB/TrEMBL
  A0ABK0LP64_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Gstt3  glutathione S-transferase, theta 3  RGD1562732_predicted  similar to Glutathione S-transferase, theta 3 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562732_predicted  similar to Glutathione S-transferase, theta 3 (predicted)  LOC499422  similar to Glutathione S-transferase, theta 3  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499422  similar to Glutathione S-transferase, theta 3      Symbol and Name status set to provisional 70820 PROVISIONAL