Ldhal1 (lactate dehydrogenase A like 1) - Rat Genome Database

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Gene: Ldhal1 (lactate dehydrogenase A like 1) Rattus norvegicus
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Symbol: Ldhal1 (Ensembl: RGD1562690)
Name: lactate dehydrogenase A like 1 (Ensembl:similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M))
RGD ID: 1562690
Description: ENCODES a protein that exhibits catalytic activity (inferred); L-lactate dehydrogenase (NAD+) activity (inferred); NAD binding (inferred); INVOLVED IN carboxylic acid metabolic process (inferred); lactate metabolic process (inferred); NAD+ metabolic process (inferred); PARTICIPATES IN cysteine and methionine metabolic pathway; gluconeogenesis pathway; glycolysis pathway; FOUND IN cytoplasm (inferred); INTERACTS WITH (+)-taxifolin; 4,4'-diaminodiphenylmethane; bleomycin A2
Type: protein-coding (Ensembl: processed_pseudogene)
RefSeq Status: MODEL
Previously known as: L-lactate dehydrogenase A chain-like; LOC500965; RGD1562690; similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M)
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8838,621,351 - 38,622,975 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2830,363,220 - 30,364,836 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.0833,075,109 - 33,076,725 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl833,075,211 - 33,076,206 (+)Ensemblrn6Rnor6.0
Rnor_5.0833,096,206 - 33,097,823 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4831,685,666 - 31,686,664 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera831,821,342 - 31,822,963 (+)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18358626   PMID:19464385  


Genomics

Variants

.
Variants in Ldhal1
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:67
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000012585
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 63 151 78 79 58 81 58 6 327 170 11 137 75 86 21 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl833,075,211 - 33,076,206 (+)Ensembl
RefSeq Acc Id: XM_039082293   ⟹   XP_038938221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,621,351 - 38,622,975 (+)NCBI
mRatBN7.2830,363,220 - 30,364,836 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038938221 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095297.1
  ENSRNOP00000109183.1
RefSeq Acc Id: XP_038938221   ⟸   XM_039082293
- UniProtKB: A0A8I6AMT0 (UniProtKB/TrEMBL)
Protein Domains
Lactate/malate dehydrogenase C-terminal   Lactate/malate dehydrogenase N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-31244 BioCyc
BioCyc Pathway PWY-5031 [L-histidine degradation V] BioCyc
BioCyc Pathway Image PWY-5031 BioCyc
Ensembl Genes ENSRNOG00000009373 Ensembl
  ENSRNOG00000013009 UniProtKB/TrEMBL
  ENSRNOG00000075838 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000107981.2 UniProtKB/TrEMBL
  ENSRNOT00000166608.1 UniProtKB/TrEMBL
Gene3D-CATH Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro L-lactate/malate_DH UniProtKB/TrEMBL
  L-lactate_DH UniProtKB/TrEMBL
  L-lactate_DH_AS UniProtKB/TrEMBL
  Lactate/malate_DH_C UniProtKB/TrEMBL
  Lactate/malate_DH_N UniProtKB/TrEMBL
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
NCBI Gene 500965 ENTREZGENE
PANTHER L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) UniProtKB/TrEMBL
  L-LACTATE DEHYDROGENASE A CHAIN UniProtKB/TrEMBL
Pfam Ldh_1_C UniProtKB/TrEMBL
  Ldh_1_N UniProtKB/TrEMBL
PhenoGen Ldhal1 PhenoGen
PIRSF Lac_mal_DH UniProtKB/TrEMBL
PRINTS LLDHDRGNASE UniProtKB/TrEMBL
PROSITE L_LDH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009373 RatGTEx
  ENSRNOG00000013009 RatGTEx
  ENSRNOG00000075838 RatGTEx
Superfamily-SCOP LDH C-terminal domain-like UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-fold domains UniProtKB/TrEMBL
UniProt A0A8I6AMT0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LEI3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Ldhal1  lactate dehydrogenase A like 1  RGD1562690  similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M)  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1562690  similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M)   RGD1562690_predicted  similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562690_predicted  similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M) (predicted)  LOC500965  similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500965  similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M)      Symbol and Name status set to provisional 70820 PROVISIONAL