Spatc1l (spermatogenesis and centriole associated 1-like) - Rat Genome Database

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Gene: Spatc1l (spermatogenesis and centriole associated 1-like) Rattus norvegicus
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Symbol: Spatc1l
Name: spermatogenesis and centriole associated 1-like
RGD ID: 1562578
Description: Predicted to enable identical protein binding activity and protein kinase A regulatory subunit binding activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within actin polymerization or depolymerization; positive regulation of cAMP-dependent protein kinase activity; and positive regulation of cAMP/PKA signal transduction. Predicted to be active in centrosome and sperm head-tail coupling apparatus. Orthologous to human SPATC1L (spermatogenesis and centriole associated 1 like); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC499418; LOC108348157; LOC499418; similar to Putative protein C21orf56 homolog; speriolin-like protein; uncharacterized protein LOC499418
RGD Orthologs
Human
Mouse
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,073,542 - 12,082,866 (-)NCBIGRCr8
mRatBN7.22012,074,040 - 12,083,873 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,074,047 - 12,083,301 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2012,770,347 - 12,779,565 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,131,269 - 12,140,487 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02012,603,047 - 12,612,265 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02012,825,789 - 12,835,007 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,164,628 - 13,173,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2012,825,775 - 12,835,044 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,318,495 - 15,327,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02014,983,177 - 14,990,480 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42012,488,956 - 12,498,060 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2013,572,304 - 13,581,438 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:30026308  


Genomics

Comparative Map Data
Spatc1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,073,542 - 12,082,866 (-)NCBIGRCr8
mRatBN7.22012,074,040 - 12,083,873 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,074,047 - 12,083,301 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2012,770,347 - 12,779,565 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,131,269 - 12,140,487 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02012,603,047 - 12,612,265 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02012,825,789 - 12,835,007 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,164,628 - 13,173,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2012,825,775 - 12,835,044 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,318,495 - 15,327,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02014,983,177 - 14,990,480 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42012,488,956 - 12,498,060 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2013,572,304 - 13,581,438 (-)NCBICelera
Cytogenetic Map20p12NCBI
SPATC1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382146,161,160 - 46,184,459 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2146,161,148 - 46,184,476 (-)EnsemblGRCh38hg38GRCh38
GRCh372147,581,074 - 47,604,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362146,405,498 - 46,428,729 (-)NCBINCBI36Build 36hg18NCBI36
Build 342146,405,497 - 46,428,729NCBI
Celera2132,693,446 - 32,716,761 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2132,963,847 - 32,985,837 (-)NCBIHuRef
CHM1_12147,141,961 - 47,163,904 (-)NCBICHM1_1
T2T-CHM13v2.02144,540,975 - 44,566,185 (-)NCBIT2T-CHM13v2.0
Spatc1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391076,394,180 - 76,406,035 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1076,398,106 - 76,406,035 (+)EnsemblGRCm39 Ensembl
GRCm381076,561,993 - 76,570,201 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1076,562,272 - 76,570,201 (+)EnsemblGRCm38mm10GRCm38
MGSCv371076,025,017 - 76,032,945 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361076,005,988 - 76,013,916 (+)NCBIMGSCv36mm8
Celera1077,606,787 - 77,614,715 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.2NCBI
SPATC1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.213218,494,437 - 218,512,240 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103220344
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,781,950 - 89,805,927 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl289,782,182 - 89,803,593 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605418,164,576 - 18,188,041 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spatc1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474531,292,684 - 31,302,306 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474531,290,119 - 31,302,261 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spatc1l
99 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 12 61 61 53 29 12 29 12 98 48 37 9 52 24

Sequence


Ensembl Acc Id: ENSRNOT00000001704   ⟹   ENSRNOP00000001704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2013,164,628 - 13,173,774 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074268   ⟹   ENSRNOP00000065946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2012,825,775 - 12,835,044 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102485   ⟹   ENSRNOP00000077795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,074,047 - 12,083,301 (-)Ensembl
RefSeq Acc Id: NM_001024296   ⟹   NP_001019467
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,073,542 - 12,082,760 (-)NCBI
mRatBN7.22012,074,040 - 12,083,261 (-)NCBI
Rnor_6.02012,825,789 - 12,835,007 (-)NCBI
Rnor_5.02015,318,495 - 15,327,599 (-)NCBI
RGSC_v3.42012,488,956 - 12,498,060 (-)RGD
Celera2013,572,304 - 13,581,438 (-)RGD
Sequence:
RefSeq Acc Id: XM_063279459   ⟹   XP_063135529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,074,483 - 12,082,866 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001019467 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135529 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79291 (Get FASTA)   NCBI Sequence Viewer  
  EDL97140 (Get FASTA)   NCBI Sequence Viewer  
  EDL97141 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077795.1
RefSeq Acc Id: NP_001019467   ⟸   NM_001024296
- UniProtKB: Q68FV7 (UniProtKB/TrEMBL),   M0R8Y9 (UniProtKB/TrEMBL),   A0A8I5Y6R1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065946   ⟸   ENSRNOT00000074268
Ensembl Acc Id: ENSRNOP00000001704   ⟸   ENSRNOT00000001704
Ensembl Acc Id: ENSRNOP00000077795   ⟸   ENSRNOT00000102485
RefSeq Acc Id: XP_063135529   ⟸   XM_063279459
- Peptide Label: isoform X1
- UniProtKB: A6JKC5 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FV7-F1-model_v2 AlphaFold Q68FV7 1-342 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701515
Promoter ID:EPDNEW_R12039
Type:multiple initiation site
Name:Spatc1l_1
Description:spermatogenesis and centriole associated 1-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02012,835,020 - 12,835,080EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562578 AgrOrtholog
BioCyc Gene G2FUF-4192 BioCyc
Ensembl Genes ENSRNOG00000001262 Ensembl
  ENSRNOG00000045929 Ensembl
  ENSRNOG00000070409 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000102485.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134390 IMAGE-MGC_LOAD
InterPro SPATC1 UniProtKB/TrEMBL
  Speriolin_C UniProtKB/TrEMBL
  Speriolin_N UniProtKB/TrEMBL
KEGG Report rno:499418 UniProtKB/TrEMBL
MGC_CLONE MGC:94423 IMAGE-MGC_LOAD
NCBI Gene 499418 ENTREZGENE
PANTHER PTHR22192 UniProtKB/TrEMBL
  SPERIOLIN-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Speriolin_C UniProtKB/TrEMBL
  Speriolin_N UniProtKB/TrEMBL
PhenoGen Spatc1l PhenoGen
RatGTEx ENSRNOG00000001262 RatGTEx
  ENSRNOG00000045929 RatGTEx
  ENSRNOG00000070409 RatGTEx
UniProt A0A8I5Y6R1 ENTREZGENE, UniProtKB/TrEMBL
  A6JKC5 ENTREZGENE, UniProtKB/TrEMBL
  M0R8Y9 ENTREZGENE
  Q68FV7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary M0R8Y9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Spatc1l  spermatogenesis and centriole associated 1-like  LOC108348157  speriolin-like protein  Data merged from RGD:11505374 737654 PROVISIONAL
2016-08-02 LOC108348157  speriolin-like protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-11-19 Spatc1l  spermatogenesis and centriole associated 1-like  LOC499418  similar to Putative protein C21orf56 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC499418  similar to Putative protein C21orf56 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL