Tmem196 (transmembrane protein 196) - Rat Genome Database

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Pathways
Gene: Tmem196 (transmembrane protein 196) Rattus norvegicus
Analyze
Symbol: Tmem196
Name: transmembrane protein 196
RGD ID: 1562527
Description: Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth; and negative regulation of cell migration. Predicted to be located in cytoplasm. Orthologous to human TMEM196 (transmembrane protein 196); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC500750; MGC109451; RGD1562527
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86147,039,315 - 147,102,464 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6147,039,533 - 147,102,462 (+)EnsemblGRCr8
mRatBN7.26140,895,556 - 140,959,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6140,896,576 - 140,957,435 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6144,339,111 - 144,405,642 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06140,956,580 - 141,023,106 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06141,523,748 - 141,590,267 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06147,874,536 - 147,940,231 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6147,876,237 - 147,940,226 (+)Ensemblrn6Rnor6.0
Rnor_5.06156,783,475 - 156,849,159 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46147,554,825 - 147,617,422 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6138,527,200 - 138,588,046 (+)NCBICelera
Cytogenetic Map6q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:26056045  


Genomics

Comparative Map Data
Tmem196
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86147,039,315 - 147,102,464 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6147,039,533 - 147,102,462 (+)EnsemblGRCr8
mRatBN7.26140,895,556 - 140,959,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6140,896,576 - 140,957,435 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6144,339,111 - 144,405,642 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06140,956,580 - 141,023,106 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06141,523,748 - 141,590,267 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06147,874,536 - 147,940,231 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6147,876,237 - 147,940,226 (+)Ensemblrn6Rnor6.0
Rnor_5.06156,783,475 - 156,849,159 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46147,554,825 - 147,617,422 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6138,527,200 - 138,588,046 (+)NCBICelera
Cytogenetic Map6q33NCBI
TMEM196
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38719,719,315 - 19,773,617 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl719,719,315 - 19,773,617 (-)Ensemblhg38GRCh38
GRCh37719,758,938 - 19,813,240 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36719,725,463 - 19,779,541 (-)NCBIBuild 36Build 36hg18NCBI36
Celera719,743,241 - 19,796,711 (-)NCBICelera
Cytogenetic Map7p21.1NCBI
HuRef719,648,094 - 19,701,563 (-)NCBIHuRef
CHM1_1719,759,739 - 19,813,222 (-)NCBICHM1_1
T2T-CHM13v2.0719,853,775 - 19,908,049 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2719,810,345 - 19,863,812 (-)NCBI
Tmem196
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912119,909,422 - 119,984,981 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12119,909,557 - 119,984,981 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812119,946,127 - 120,021,242 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12119,945,822 - 120,021,246 (+)Ensemblmm10GRCm38
MGSCv3712121,184,435 - 121,257,179 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612114,169,373 - 114,240,928 (+)NCBIMGSCv36mm8
MGSCv3612120,389,878 - 120,462,915 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1263.86NCBI
Tmem196
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541022,455,130 - 22,509,507 (-)Ensembl
ChiLan1.0NW_00495541022,455,130 - 22,509,507 (-)NCBIChiLan1.0ChiLan1.0
TMEM196
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2624,572,356 - 24,626,552 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1772,897,081 - 72,951,261 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0720,393,673 - 20,447,857 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1719,713,634 - 19,767,598 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl719,712,988 - 19,767,598 (-)EnsemblpanPan2panpan1.1
TMEM196
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11433,881,098 - 33,930,362 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1433,881,166 - 33,975,284 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1433,415,239 - 33,466,878 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01433,800,027 - 33,851,710 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1433,800,038 - 33,851,598 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11433,909,793 - 33,972,666 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01433,617,744 - 33,669,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01433,928,443 - 33,980,096 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem196
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511878,091,086 - 78,152,135 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365465,766,808 - 5,826,012 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365465,766,175 - 5,827,925 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM196
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl988,798,831 - 88,858,006 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1988,798,095 - 88,858,270 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2998,050,988 - 98,062,599 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM196
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12138,424,266 - 38,478,725 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604266,086,677 - 66,140,209 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem196
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473910,815,083 - 10,878,588 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473910,814,724 - 10,878,468 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem196
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17116,266,103 - 116,335,175 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:365
Count of miRNA genes:214
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000056649
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 64 145 55 54 23 24 23 6 224 121 11 124 62 87 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000056649   ⟹   ENSRNOP00000053487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6147,039,533 - 147,102,462 (+)Ensembl
mRatBN7.2 Ensembl6140,896,576 - 140,957,435 (+)Ensembl
Rnor_6.0 Ensembl6147,876,237 - 147,938,165 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080090   ⟹   ENSRNOP00000071122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6147,876,557 - 147,940,226 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000161658   ⟹   ENSRNOP00000107128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6147,039,545 - 147,102,462 (+)Ensembl
RefSeq Acc Id: NM_001044269   ⟹   NP_001037734
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86147,039,841 - 147,102,464 (+)NCBI
mRatBN7.26140,896,876 - 140,959,501 (+)NCBI
Rnor_6.06147,876,237 - 147,938,168 (+)NCBI
Rnor_5.06156,783,475 - 156,849,159 (+)NCBI
RGSC_v3.46147,554,825 - 147,617,422 (+)RGD
Celera6138,527,200 - 138,588,046 (+)RGD
Sequence:
RefSeq Acc Id: NM_001399754   ⟹   NP_001386683
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86147,039,841 - 147,102,464 (+)NCBI
mRatBN7.26140,896,876 - 140,959,501 (+)NCBI
RefSeq Acc Id: NM_001414975   ⟹   NP_001401904
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86147,039,841 - 147,102,464 (+)NCBI
mRatBN7.26140,896,876 - 140,959,501 (+)NCBI
RefSeq Acc Id: XM_006240702   ⟹   XP_006240764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86147,039,315 - 147,102,464 (+)NCBI
mRatBN7.26140,896,340 - 140,959,501 (+)NCBI
Rnor_6.06147,874,536 - 147,938,810 (+)NCBI
Rnor_5.06156,783,475 - 156,849,159 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594310   ⟹   XP_017449799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86147,039,315 - 147,102,464 (+)NCBI
mRatBN7.26140,895,556 - 140,959,501 (+)NCBI
Rnor_6.06147,874,536 - 147,938,810 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594311   ⟹   XP_017449800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86147,039,315 - 147,102,464 (+)NCBI
mRatBN7.26140,895,559 - 140,959,501 (+)NCBI
Rnor_6.06147,874,536 - 147,938,810 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001037734   ⟸   NM_001044269
- Peptide Label: isoform 2
- UniProtKB: Q5EB63 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240764   ⟸   XM_006240702
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QSV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449799   ⟸   XM_017594310
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017449800   ⟸   XM_017594311
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000071122   ⟸   ENSRNOT00000080090
Ensembl Acc Id: ENSRNOP00000053487   ⟸   ENSRNOT00000056649
RefSeq Acc Id: NP_001386683   ⟸   NM_001399754
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001401904   ⟸   NM_001414975
- Peptide Label: isoform 3
Ensembl Acc Id: ENSRNOP00000107128   ⟸   ENSRNOT00000161658

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5EB63-F1-model_v2 AlphaFold Q5EB63 1-176 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562527 AgrOrtholog
BioCyc Gene G2FUF-35445 BioCyc
Ensembl Genes ENSRNOG00000037435 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000056649 ENTREZGENE
  ENSRNOT00000161658 ENTREZGENE
IMAGE_CLONE IMAGE:7320460 IMAGE-MGC_LOAD
InterPro TMEM196 UniProtKB/Swiss-Prot
KEGG Report rno:500750 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109451 IMAGE-MGC_LOAD
NCBI Gene 500750 ENTREZGENE
PANTHER PTHR28681 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 196 UniProtKB/Swiss-Prot
PhenoGen Tmem196 PhenoGen
RatGTEx ENSRNOG00000037435 RatGTEx
UniProt A0A8L2QSV5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LR24_RAT UniProtKB/TrEMBL
  Q5EB63 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Tmem196  transmembrane protein 196  RGD1562527_predicted  RGD1562527 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562527_predicted  RGD1562527 (predicted)  LOC500750  LOC500750  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500750  LOC500750      Symbol and Name status set to provisional 70820 PROVISIONAL