Defb21 (defensin beta 21) - Rat Genome Database

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Pathways
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Gene: Defb21 (defensin beta 21) Rattus norvegicus
Analyze
Symbol: Defb21
Name: defensin beta 21
RGD ID: 1562393
Description: Predicted to enable lipopolysaccharide binding activity and membrane destabilizing activity. Predicted to be involved in several processes, including defense response to other organism; killing of cells of another organism; and negative regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in extracellular region. Orthologous to human DEFB118 (defensin beta 118); INTERACTS WITH bisphenol A; lipopolysaccharide; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-defensin 118; beta-defensin 21
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,503,090 - 161,504,507 (+)NCBIGRCr8
mRatBN7.23141,042,810 - 141,044,228 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,042,810 - 141,044,184 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3144,947,797 - 144,949,111 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,531,633 - 153,532,947 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,271,990 - 151,273,300 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,047,638 - 148,048,952 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,047,638 - 148,048,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,453,217 - 154,455,520 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43142,910,151 - 142,911,465 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3139,793,810 - 139,795,124 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15033915   PMID:16033865   PMID:16457734  


Genomics

Comparative Map Data
Defb21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,503,090 - 161,504,507 (+)NCBIGRCr8
mRatBN7.23141,042,810 - 141,044,228 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,042,810 - 141,044,184 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3144,947,797 - 144,949,111 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,531,633 - 153,532,947 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,271,990 - 151,273,300 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,047,638 - 148,048,952 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,047,638 - 148,048,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,453,217 - 154,455,520 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43142,910,151 - 142,911,465 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3139,793,810 - 139,795,124 (+)NCBICelera
Cytogenetic Map3q41NCBI
DEFB118
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,368,601 - 31,373,923 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2031,368,601 - 31,373,923 (+)EnsemblGRCh38hg38GRCh38
GRCh372029,956,404 - 29,961,726 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,420,089 - 29,424,825 (+)NCBINCBI36Build 36hg18NCBI36
Build 342029,420,088 - 29,424,825NCBI
Celera2026,712,675 - 26,717,411 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2026,745,178 - 26,750,482 (+)NCBIHuRef
CHM1_12029,860,364 - 29,865,668 (+)NCBICHM1_1
T2T-CHM13v2.02033,092,784 - 33,098,107 (+)NCBIT2T-CHM13v2.0
Defb21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,414,663 - 152,416,864 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,414,664 - 152,416,864 (+)EnsemblGRCm39 Ensembl
GRCm382152,572,743 - 152,574,944 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,572,744 - 152,574,944 (+)EnsemblGRCm38mm10GRCm38
MGSCv372152,398,480 - 152,400,679 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,264,185 - 152,266,384 (+)NCBIMGSCv36mm8
Celera2158,385,696 - 158,387,895 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.31NCBI
Defb118
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542229,554,310 - 29,560,660 (-)NCBIChiLan1.0ChiLan1.0
DEFB118
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,063,232 - 37,070,346 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12037,056,329 - 37,063,443 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02027,659,911 - 27,666,555 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12028,296,644 - 28,301,392 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2028,296,644 - 28,301,392 (+)Ensemblpanpan1.1panPan2
DEFB118
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12420,894,219 - 20,900,503 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2420,893,663 - 20,900,618 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,542,462 - 20,548,755 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,581,391 - 21,587,689 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,581,268 - 21,587,804 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12420,859,714 - 20,866,012 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02420,964,652 - 20,970,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,395,297 - 21,401,413 (+)NCBIUU_Cfam_GSD_1.0
LOC100621695
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11735,167,885 - 35,173,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21739,889,039 - 39,895,434 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DEFB118
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1235,788,326 - 35,794,780 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl235,788,670 - 35,794,043 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605091,163,769 - 91,169,577 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Defb21
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:53
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000031613
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system
High
Medium
Low 9 2 6
Below cutoff 2 2 2 2 1 4 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031613   ⟹   ENSRNOP00000037945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3141,042,810 - 141,044,184 (+)Ensembl
Rnor_6.0 Ensembl3148,047,638 - 148,048,952 (+)Ensembl
RefSeq Acc Id: NM_001037512   ⟹   NP_001032601
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,503,090 - 161,504,507 (+)NCBI
mRatBN7.23141,042,810 - 141,044,228 (+)NCBI
Rnor_6.03148,047,638 - 148,048,952 (+)NCBI
Rnor_5.03154,453,217 - 154,455,520 (+)NCBI
RGSC_v3.43142,910,151 - 142,911,465 (+)RGD
Celera3139,793,810 - 139,795,124 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001032601 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT51891 (Get FASTA)   NCBI Sequence Viewer  
  AAU04551 (Get FASTA)   NCBI Sequence Viewer  
  EDL86063 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037945
  ENSRNOP00000037945.3
Reference Protein Sequences
RefSeq Acc Id: NP_001032601   ⟸   NM_001037512
- Peptide Label: precursor
- UniProtKB: Q32ZH1 (UniProtKB/TrEMBL),   F7EYR7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000037945   ⟸   ENSRNOT00000031613
Protein Domains
Beta-defensin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32ZH1-F1-model_v2 AlphaFold Q32ZH1 1-83 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692544
Promoter ID:EPDNEW_R3068
Type:single initiation site
Name:Defb21_1
Description:defensin beta 21
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03148,047,591 - 148,047,651EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562393 AgrOrtholog
BioCyc Gene G2FUF-47262 BioCyc
Ensembl Genes ENSRNOG00000023154 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031613 ENTREZGENE
  ENSRNOT00000031613.5 UniProtKB/TrEMBL
InterPro Beta_defensin UniProtKB/TrEMBL
KEGG Report rno:641636 UniProtKB/TrEMBL
NCBI Gene 641636 ENTREZGENE
PANTHER BETA-DEFENSIN 118 UniProtKB/TrEMBL
  BETA-DEFENSIN 123-RELATED UniProtKB/TrEMBL
Pfam Defensin_beta_2 UniProtKB/TrEMBL
PhenoGen Defb21 PhenoGen
RatGTEx ENSRNOG00000023154 RatGTEx
UniProt F7EYR7 ENTREZGENE, UniProtKB/TrEMBL
  Q32ZH1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-11-07 Defb21  defensin beta 21    beta-defensin 21  Name updated 1299863 APPROVED
2006-02-09 Defb21  beta-defensin 21      Symbol and Name status set to provisional 70820 PROVISIONAL