Nod1 (nucleotide-binding oligomerization domain containing 1) - Rat Genome Database

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Gene: Nod1 (nucleotide-binding oligomerization domain containing 1) Rattus norvegicus
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Symbol: Nod1
Name: nucleotide-binding oligomerization domain containing 1
RGD ID: 1562269
Description: Predicted to enable several functions, including CARD domain binding activity; peptidoglycan binding activity; and protein homodimerization activity. Involved in positive regulation of apoptotic process; positive regulation of interleukin-1 beta production; and positive regulation of tumor necrosis factor production. Predicted to be located in basolateral plasma membrane; cytosol; and phagocytic vesicle. Predicted to be part of canonical inflammasome complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1); PARTICIPATES IN NOD-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC500133; nucleotide-binding oligomerization domain-containing protein 1; RGD1562269; similar to Caspase recruitment domain protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,391,142 - 85,442,281 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl485,391,151 - 85,441,674 (-)EnsemblGRCr8
mRatBN7.2484,060,871 - 84,111,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,060,880 - 84,111,404 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx489,285,035 - 89,334,440 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,060,457 - 85,109,860 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,471,807 - 83,522,335 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,123,965 - 85,175,206 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,123,960 - 85,174,951 (-)Ensemblrn6Rnor6.0
Rnor_5.04149,781,209 - 149,832,175 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4483,398,809 - 83,449,207 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera478,928,394 - 78,978,728 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
cellular response to muramyl dipeptide  (IEA,ISO)
defense response to bacterium  (IBA,IEA,ISO)
defense response to Gram-negative bacterium  (IEA,ISO)
defense response to Gram-positive bacterium  (ISO)
detection of bacterium  (IEA,ISO)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
intracellular signal transduction  (IBA,IEA,ISO)
negative regulation of cellular defense response  (IEA)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (IEA,ISO)
pattern recognition receptor signaling pathway  (IBA,IEA,ISO)
positive regulation of apoptotic process  (IDA)
positive regulation of autophagy  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IBA,IEA,ISO)
positive regulation of cytokine production  (IEA)
positive regulation of dendritic cell antigen processing and presentation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of interleukin-1 beta production  (IMP)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of nitric-oxide synthase activity  (IMP)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of pyroptotic inflammatory response  (IEA)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of tumor necrosis factor production  (IMP,ISO)
positive regulation of xenophagy  (ISO)
regulation of apoptotic process  (IEA)
response to endoplasmic reticulum stress  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nod1, Nod2 and Nalp3 receptors, new potential targets in treatment of allergic rhinitis? Bogefors J, etal., Allergy. 2010 Oct;65(10):1222-6. Epub 2010 Apr 7.
2. Association between exposure to farming, allergies and genetic variation in CARD4/NOD1. Eder W, etal., Allergy. 2006 Sep;61(9):1117-24.
3. NOD1 activation induces cardiac dysfunction and modulates cardiac fibrosis and cardiomyocyte apoptosis. Fernandez-Velasco M, etal., PLoS One. 2012;7(9):e45260. doi: 10.1371/journal.pone.0045260. Epub 2012 Sep 18.
4. The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila. Frutuoso MS, etal., Microbes Infect. 2010 Oct;12(11):819-27. Epub 2010 Jun 2.
5. A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses. Gatheral T, etal., PLoS One. 2012;7(8):e42386. doi: 10.1371/journal.pone.0042386. Epub 2012 Aug 1.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model. Geddes K, etal., Infect Immun. 2010 Dec;78(12):5107-15. Epub 2010 Oct 4.
8. NOD1 variation, immunoglobulin E and asthma. Hysi P, etal., Hum Mol Genet. 2005 Apr 1;14(7):935-41. Epub 2005 Feb 17.
9. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. Opitz B, etal., J Biol Chem. 2004 Aug 27;279(35):36426-32. Epub 2004 Jun 23.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. Shimada K, etal., PLoS Pathog. 2009 Apr;5(4):e1000379. Epub 2009 Apr 10.
14. TNFalpha and IL-1beta are mediated by both TLR4 and Nod1 pathways in the cultured HAPI cells stimulated by LPS. Zheng W, etal., Biochem Biophys Res Commun. 2012 Apr 20;420(4):762-7. doi: 10.1016/j.bbrc.2012.03.068. Epub 2012 Mar 17.
Additional References at PubMed
PMID:10329646   PMID:15653568   PMID:17054981   PMID:17337451   PMID:18186648   PMID:18261938   PMID:19043560   PMID:20008287   PMID:20649597   PMID:20976174   PMID:22033934   PMID:25093298  
PMID:25502289   PMID:27169686   PMID:27747243   PMID:29303910   PMID:31649195   PMID:32888957   PMID:34774740  


Genomics

Comparative Map Data
Nod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,391,142 - 85,442,281 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl485,391,151 - 85,441,674 (-)EnsemblGRCr8
mRatBN7.2484,060,871 - 84,111,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,060,880 - 84,111,404 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx489,285,035 - 89,334,440 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,060,457 - 85,109,860 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,471,807 - 83,522,335 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,123,965 - 85,175,206 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,123,960 - 85,174,951 (-)Ensemblrn6Rnor6.0
Rnor_5.04149,781,209 - 149,832,175 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4483,398,809 - 83,449,207 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera478,928,394 - 78,978,728 (-)NCBICelera
Cytogenetic Map4q24NCBI
NOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38730,424,527 - 30,478,784 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl730,424,527 - 30,478,789 (-)Ensemblhg38GRCh38
GRCh37730,464,143 - 30,518,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,430,675 - 30,484,790 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34730,237,389 - 30,291,505NCBI
Celera730,453,464 - 30,507,713 (-)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef730,346,423 - 30,400,669 (-)NCBIHuRef
CHM1_1730,464,171 - 30,518,245 (-)NCBICHM1_1
T2T-CHM13v2.0730,562,221 - 30,616,484 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2730,513,913 - 30,568,158 (-)NCBI
Nod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39654,900,927 - 54,949,655 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl654,900,934 - 54,949,597 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38654,923,942 - 54,972,674 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl654,923,949 - 54,972,612 (-)Ensemblmm10GRCm38
MGSCv37654,873,936 - 54,922,606 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36654,853,527 - 54,901,991 (-)NCBIMGSCv36mm8
Celera655,457,493 - 55,496,882 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.22NCBI
Nod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541031,681,077 - 31,725,173 (-)Ensembl
ChiLan1.0NW_00495541031,681,191 - 31,725,173 (-)NCBIChiLan1.0ChiLan1.0
NOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2635,258,093 - 35,306,265 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1783,582,820 - 83,631,444 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0731,060,245 - 31,109,012 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1731,182,275 - 31,230,388 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,182,275 - 31,208,742 (-)EnsemblpanPan2panpan1.1
NOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,162,671 - 43,226,948 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,163,571 - 43,227,103 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1442,595,450 - 42,659,740 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01443,105,467 - 43,168,383 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1443,105,475 - 43,194,265 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11443,221,377 - 43,284,335 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01442,900,527 - 42,960,255 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01443,258,705 - 43,321,637 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511887,505,623 - 87,556,280 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364786,715,245 - 6,768,372 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364786,717,354 - 6,768,293 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,432,050 - 42,512,264 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11842,464,667 - 42,509,135 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,989,047 - 47,012,192 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,907,628 - 27,957,621 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2127,926,710 - 27,957,619 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604276,740,001 - 76,789,440 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624739285,689 - 341,956 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624739285,791 - 339,752 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nod1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1686,096,462 - 86,144,017 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nod1
453 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:99
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000014324
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48279077797183061Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014324   ⟹   ENSRNOP00000014324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl485,391,151 - 85,441,674 (-)Ensembl
mRatBN7.2 Ensembl484,060,880 - 84,111,404 (-)Ensembl
Rnor_6.0 Ensembl485,123,974 - 85,174,931 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088085   ⟹   ENSRNOP00000074999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl485,123,960 - 85,174,951 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137448   ⟹   ENSRNOP00000112111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl485,396,843 - 85,441,674 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171288   ⟹   ENSRNOP00000100453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl485,391,151 - 85,441,674 (-)Ensembl
RefSeq Acc Id: NM_001109236   ⟹   NP_001102706
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,391,142 - 85,441,674 (-)NCBI
mRatBN7.2484,060,871 - 84,111,404 (-)NCBI
Rnor_6.0485,123,965 - 85,174,931 (-)NCBI
Rnor_5.04149,781,209 - 149,832,175 (-)NCBI
RGSC_v3.4483,398,809 - 83,449,207 (-)RGD
Celera478,928,394 - 78,978,728 (-)RGD
Sequence:
RefSeq Acc Id: XR_005503297
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,400,348 - 85,442,281 (-)NCBI
mRatBN7.2484,070,077 - 84,111,668 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102706 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88106 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014324
  ENSRNOP00000014324.4
  ENSRNOP00000100453.1
  ENSRNOP00000112111.1
RefSeq Acc Id: NP_001102706   ⟸   NM_001109236
- UniProtKB: D4ADT7 (UniProtKB/TrEMBL),   A6K0W2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014324   ⟸   ENSRNOT00000014324
Ensembl Acc Id: ENSRNOP00000074999   ⟸   ENSRNOT00000088085
Ensembl Acc Id: ENSRNOP00000112111   ⟸   ENSRNOT00000137448
Ensembl Acc Id: ENSRNOP00000100453   ⟸   ENSRNOT00000171288
Protein Domains
CARD   NACHT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADT7-F1-model_v2 AlphaFold D4ADT7 1-953 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693070
Promoter ID:EPDNEW_R3594
Type:multiple initiation site
Name:Nod1_1
Description:nucleotide-binding oligomerization domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0485,174,948 - 85,175,008EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562269 AgrOrtholog
BioCyc Gene G2FUF-44750 BioCyc
Ensembl Genes ENSRNOG00000010629 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014324 ENTREZGENE
  ENSRNOT00000014324.8 UniProtKB/TrEMBL
  ENSRNOT00000137448.1 UniProtKB/TrEMBL
  ENSRNOT00000171288.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  NLR UniProtKB/TrEMBL
  NLRC_HD2 UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:500133 UniProtKB/TrEMBL
NCBI Gene 500133 ENTREZGENE
PANTHER NACHT, LRR AND CARD DOMAINS-CONTAINING UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
PhenoGen Nod1 PhenoGen
PROSITE CARD UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010629 RatGTEx
SMART LRR_RI UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
UniProt A0ABK0L892_RAT UniProtKB/TrEMBL
  A0ABK0M2K6_RAT UniProtKB/TrEMBL
  A6K0W2 ENTREZGENE, UniProtKB/TrEMBL
  D4ADT7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Nod1  nucleotide-binding oligomerization domain containing 1  RGD1562269_predicted  similar to Caspase recruitment domain protein 4 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562269_predicted  similar to Caspase recruitment domain protein 4 (predicted)  LOC500133  similar to Caspase recruitment domain protein 4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500133  similar to Caspase recruitment domain protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL