Ap4e1 (adaptor related protein complex 4 subunit epsilon 1)

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Gene: Ap4e1 (adaptor related protein complex 4 subunit epsilon 1) Rattus norvegicus

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Symbol:

Ap4e1

Name:

adaptor related protein complex 4 subunit epsilon 1

RGD ID:

1562199

Description:

Predicted to enable cargo adaptor activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus. Predicted to be part of AP-4 adaptor complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 51 and stuttering. Orthologous to human AP4E1 (adaptor related protein complex 4 subunit epsilon 1); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; gentamycin.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adaptor-related protein complex 4, epsilon 1 subunit; adaptor-related protein complex AP-4, epsilon 1; AP-4 complex subunit epsilon-1; LOC311404; RGD1562199; similar to Adapter-related protein complex 4 epsilon 1 subunit (Epsilon subunit of AP-4); similar to Adapter-related protein complex 4 epsilon 1 subunit (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	134,726,338 - 134,792,820 (+)	NCBI		GRCr8
mRatBN7.2	3	114,272,997 - 114,339,484 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	114,272,956 - 114,336,752 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	118,164,967 - 118,228,802 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	126,760,516 - 126,824,351 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	124,420,900 - 124,484,727 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	119,484,714 - 119,548,491 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	119,484,677 - 119,548,621 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	126,010,551 - 126,074,949 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	114,550,205 - 114,615,150 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	113,113,130 - 113,177,269 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

congenital disorder of glycosylation Ig (ISO)

Developmental Disease (ISO)

Familial Persistent Stuttering 1 (ISO)

genetic disease (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 51 (ISO)

intellectual disability (ISO)

Nervous System Malformations (ISO)

neuropathy (ISO)

paraplegia (ISO)

peripheral nervous system disease (ISO)

stuttering (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

caffeine (ISO)

cannabidiol (ISO)

chlorpyrifos (ISO)

choline (ISO)

coumarin (ISO)

cyclosporin A (ISO)

doxorubicin (ISO)

folic acid (ISO)

gentamycin (EXP)

glyphosate (EXP)

hydrogen peroxide (ISO)

L-methionine (ISO)

lead(0) (ISO)

methyl methanesulfonate (ISO)

paracetamol (ISO)

PCB138 (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular protein transport (IEA)

vesicle-mediated transport (IEA)

Cellular Component

AP-4 adaptor complex (IBA,ISO)

Golgi apparatus (IEA)

Molecular Function

cargo adaptor activity (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10066790

Genomics

Comparative Map Data

Ap4e1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	134,726,338 - 134,792,820 (+)	NCBI		GRCr8
mRatBN7.2	3	114,272,997 - 114,339,484 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	114,272,956 - 114,336,752 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	118,164,967 - 118,228,802 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	126,760,516 - 126,824,351 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	124,420,900 - 124,484,727 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	119,484,714 - 119,548,491 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	119,484,677 - 119,548,621 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	126,010,551 - 126,074,949 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	114,550,205 - 114,615,150 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	113,113,130 - 113,177,269 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

AP4E1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	50,907,492 - 51,005,895 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	50,908,672 - 51,005,895 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	51,200,880 - 51,298,092 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	48,988,238 - 49,085,389 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	48,988,237 - 49,082,859	NCBI
Celera	15	28,093,991 - 28,191,516 (+)	NCBI		Celera
Cytogenetic Map	15	q21.2	NCBI
HuRef	15	28,030,752 - 28,128,080 (+)	NCBI		HuRef
CHM1_1	15	51,319,007 - 51,416,201 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	48,714,133 - 48,813,558 (+)	NCBI		T2T-CHM13v2.0

Ap4e1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	126,850,600 - 126,911,734 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	126,850,637 - 126,909,829 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	127,008,679 - 127,069,814 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	127,008,717 - 127,067,909 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	126,834,447 - 126,895,550 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	126,700,152 - 126,761,255 (+)	NCBI		MGSCv36	mm8
Celera	2	128,232,201 - 128,296,951 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	61.76	NCBI

Ap4e1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955409	3,476,527 - 3,532,683 (-)	NCBI	ChiLan1.0	ChiLan1.0

AP4E1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	40,154,942 - 40,252,467 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	44,335,335 - 44,439,393 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	29,857,818 - 29,957,158 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	48,195,475 - 48,292,133 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	48,195,581 - 48,288,895 (+)	Ensembl	panpan1.1		panPan2

AP4E1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	16,745,567 - 16,800,662 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	16,745,620 - 16,797,704 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	16,671,629 - 16,726,720 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	16,890,099 - 16,945,193 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	16,879,004 - 16,945,179 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	16,812,394 - 16,867,478 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	16,929,887 - 16,984,952 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	17,036,542 - 17,091,637 (+)	NCBI		UU_Cfam_GSD_1.0

Ap4e1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	95,008,953 - 95,071,552 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	12,857,323 - 12,916,718 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	12,857,259 - 12,919,615 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AP4E1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	120,880,456 - 120,946,031 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	120,880,460 - 120,946,045 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	134,278,410 - 134,343,745 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AP4E1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	32,358,432 - 32,447,207 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	32,357,199 - 32,446,274 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	108,710,522 - 108,835,633 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ap4e1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	9,298,016 - 9,348,284 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	9,295,151 - 9,348,394 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ap4e1
466 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	6
Count of miRNA genes:	4
Interacting mature miRNAs:	6
Transcripts:	ENSRNOT00000037390
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	102200529	115665732	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	96127817	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	84091273	129091273	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	80800231	114297550	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	112287552	135181505	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat

Markers in Region

D3Mit12

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	114,297,399 - 114,297,550 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	119,509,110 - 119,509,260	NCBI	Rnor6.0
Rnor_5.0	3	126,034,947 - 126,035,097	UniSTS	Rnor5.0
RGSC_v3.4	3	114,574,601 - 114,574,752	RGD	RGSC3.4
RGSC_v3.4	3	114,574,602 - 114,574,752	UniSTS	RGSC3.4
RGSC_v3.1	3	114,480,095 - 114,480,482	RGD
Celera	3	113,137,443 - 113,137,593	UniSTS
RH 2.0 Map	3	660.6	RGD
SHRSP x BN Map	3	54.0299	RGD
Cytogenetic Map	3	q36	UniSTS

RH132863

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	114,337,044 - 114,337,236 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	119,548,771 - 119,548,962	NCBI	Rnor6.0
Rnor_5.0	3	126,074,613 - 126,074,804	UniSTS	Rnor5.0
RGSC_v3.4	3	114,615,443 - 114,615,634	UniSTS	RGSC3.4
Celera	3	113,177,562 - 113,177,753	UniSTS
RH 3.4 Map	3	997.8	UniSTS
Cytogenetic Map	3	q36	UniSTS

BE101110

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	114,281,049 - 114,281,231 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	119,492,764 - 119,492,945	NCBI	Rnor6.0
Rnor_5.0	3	126,018,601 - 126,018,782	UniSTS	Rnor5.0
RGSC_v3.4	3	114,558,255 - 114,558,436	UniSTS	RGSC3.4
Celera	3	113,121,096 - 113,121,277	UniSTS
RH 3.4 Map	3	996.8	UniSTS
Cytogenetic Map	3	q36	UniSTS

RH141233

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	101,712,146 - 101,712,334 (+)	MAPPER	mRatBN7.2
mRatBN7.2	3	114,288,448 - 114,288,636 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	119,500,161 - 119,500,348	NCBI	Rnor6.0
Rnor_6.0	2	104,039,514 - 104,039,701	NCBI	Rnor6.0
Rnor_5.0	3	126,025,998 - 126,026,185	UniSTS	Rnor5.0
Rnor_5.0	2	123,761,527 - 123,761,714	UniSTS	Rnor5.0
RGSC_v3.4	3	114,565,653 - 114,565,840	UniSTS	RGSC3.4
RGSC_v3.4	2	104,333,613 - 104,333,800	UniSTS	RGSC3.4
Celera	2	97,106,105 - 97,106,292	UniSTS
Celera	3	113,128,494 - 113,128,681	UniSTS
Cytogenetic Map	3	q36	UniSTS
Cytogenetic Map	2	q24	UniSTS

AU049137

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	114,294,217 - 114,294,356 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	119,505,928 - 119,506,066	NCBI	Rnor6.0
Rnor_5.0	3	126,031,765 - 126,031,903	UniSTS	Rnor5.0
RGSC_v3.4	3	114,571,420 - 114,571,558	UniSTS	RGSC3.4
Celera	3	113,134,261 - 113,134,399	UniSTS
Cytogenetic Map	3	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000037390 ⟹ ENSRNOP00000037349

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	114,272,956 - 114,336,752 (+)	Ensembl
Rnor_6.0 Ensembl	3	119,484,677 - 119,548,621 (+)	Ensembl

RefSeq Acc Id:

NM_001191742 ⟹ NP_001178671

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	134,726,338 - 134,790,088 (+)	NCBI
mRatBN7.2	3	114,272,997 - 114,336,752 (+)	NCBI
Rnor_6.0	3	119,484,714 - 119,548,478 (+)	NCBI
Rnor_5.0	3	126,010,551 - 126,074,949 (+)	NCBI
Celera	3	113,113,130 - 113,177,269 (+)	NCBI

Sequence:

show sequence

ATGAGCGACATGGTGGAGAGGACGCTGACCGCACTGCCGGGGCTCTTCTTGCAGAACCAGCTGG
GAGGGCCTGCGGCCTCCAGAGCACCCTTCTTCTCCAGGCTGGGCGGCCTCATCCGTGGCGTCAC
TGCGCTCTCATCCAAGCACGAAGAAGAGAAGTTAATCCAGCAGGAACTGAGTAGTCTGAAGGCG
ACTGTTTCTGCTCCTACTACAACACTGAAAATGATGAAGGAATGTATGGTGAGACTTATATACT
GTGAGATGCTTGGATACGATGCTTCTTTTGGTTATATACATGCAATCAAGTTGGCCCAACAAGG
AAACCTCTTAGAAAAAAGAGTGGGTTATTTGGCTGTTTCTCTGTTTCTACATGAAAGTCATGAA
CTTTTGCTTCTCCTTGTGAATACAGTGGTAAAGGACCTGCAGAGCACTAATCTGGTAGAAGTGT
GTATGGCACTCACTGTCGTCAGCCAGATTTTCCCTCGAGAAATGATTCCAGCTGTCCTTCCACT
AATAGAAGAGAAACTCCAACATTCTAAGGAGATTATACGAAGAAAAGCAGTTCTGGCATTATAC
AAATTTTATCTCATTGCCCCTAATCAAGTACAGCATATCCATACTAAGTTTCGGAAAGCACTCT
GTGACAGAGATGTTGGGGTCATGGCTGCCTCTTTGCATATATACCTTAGGATGATTAAGGAAAA
TTCTTCTGGATATAAAGACTTGACTGAGAGTTTTGTAACAATTTTAAAGCAGGTGGTGGGGGGA
AAGCTCCCTGTAGAGTTCAGTTACCACAGTGTGCCAGCGCCATGGTTACAGATTCAGCTCTTGA
GAATACTGGGACTGCTGGGAAAAGACGATGAAAGGACAAGTGAACTAATGTATGATGTTCTTGA
TGAATCCTTACGAAGAGCCGAGTTAAATCACAATGTCACTTACGCTATTCTGTTTGAGTGTGTA
CACACAATCTATTCTATTTATCCTAAATCAGAATTACTTGAGAAGGCTGCCAAGTGCATTGGAA
AATTTGTTCTGTCACCTAAAATAAACCTCAAATATTTAGGACTGAAGGCTCTTACCTATGTTAT
CCAGCAGGATCCTTCTCTGGCTCTTCAACACCAGATAACCATAATTGAATGCCTAGACCACCCT
GATCCCATTATTAAAAGAGAGACTCTGGAACTTCTTTACAGAATTACAAATGCACAGAATGTAG
TAGTTATTGTACAGAAAATGCTTGAATATTTACATCAGAGCAAAGAAGAGTACATCATCATCAA
CTTAGTCGGCAAAATAGCTGAATTGGCTGAGAAATATGCTCCTGACAACGTGTGGTTCATTCAG
ACGATGAATGCTGTGTTTTCAGTGGGAGGAGATGTAATGCACCCAGACATTCTCAGTAACTTTC
TGAGACTGCTAGCAGAAGGTTTTGATGATGAAACAGAAGATCAACAGTTAAGACTCTATGCAGT
TCAGTCTTACCTCACCTTACTAGACATGGAAAACACTTTCTATCCACAGAGATTTCTTCAAGTT
ATGAGTTGGGTATTAGGAGAGTATTCCTACCTCTTAGATAGAGAAAGCCCCGAGGCAGTTATGA
CCAGGCTCTACAAGTTACTGAGGAGTGACTCCATTTCTTCAGAAACGAAAGCATGGTTGTTTGC
TGCAGTAACCAAGTTAACACCTCAAGCTCATTCTTCTCCCATAGTTGAGAACTTAATCCAAGAA
TTCACTGTATCCTTGAATACTTGTCTGAGACAACATGCATTTGAATTGAAACATCTACATGAAA
ATGAAGAGCTTATGAAGAGCTTGCTTCAGAGTGCTCAGAATTGTGACGACATCATGGCAGATGC
TTCTTTATCTTTTCTGGATGGTTTTGTGGCTGAAGGACTCAGTCAGGGAGCAGCACCTTATAAG
CCCCGTCACCAGCGCCAAGAGGAGCAGCTCTCTCAGGAAAAAGTTCTCAATTTTGAACCATATG
GACTATCATTTTCTTCATCTGGCTTCACTGGACGACAGTCTCCTGCTGGCGTTTCTCTGGGCTC
AGATATATCTGGAAACAGTGCTGAAACAGGGCTGAAAGAGGCAGGTAGCCTGAAGATGGACGGC
ATAAAGAAATTATGGGGTAAAGAAGGTTATCTCCCCAAGAAGGAGAGTGGAGCTGCTGATAAAC
TGGAAGCCGCACATGCTCCTGCAGAGAGTGCAATGATGGAGAATGTAGACCAAGCCATGACTAG
GAAGGACCAAGCTCAAGGCCACACCCCTTCTACAGAGGAGAAAGAAAAGCAGCTGTTGGCATCA
TCGCTGTTTGTTGGGCTAGGACCAGAAAATACGATCAATTTGTTGGGAAAAGCAGATGTTGTGT
CTTACAAGTTCAGGAGGAAGTCAAAACCCAAGGTAGCCCAAAGTGACAAGATGCCCAGCGCTCA
TGCCGCTCCCTCCTCCACCCTTAGCCCTGTGTCCGATGTGGCTGGGGGGGATGAGGACAGTCTG
AGCGCTGCGGATAGAGGAGACGGGGAGCTTGGTTCAGAGCTGTTGGGTTCTGAGTCTGTCTTGG
AGCTGCCCTCAGTTGAAAACCTCTCGAGTGTCAGCTTGCCCGTGTCTTCTTTGTTTGCGGGTAA
CGACATGGAAGTATTTCATCCCCCTTCATCCTCTGCAACTTCAGCCGTCAAGGAAGTCAGTTTG
GCTGCTCTGTTGGAAGAAACTCCTGAATGCAGGCGTTCAGCTCTCGTGGAAATCTGTAGTAATG
AAACTGTGGCTGTGTCTTCTTACAAAGTCTGGAAGGATGAGTGTTTATTGCTGGTGTGCTCAGT
CACTAGTAAGACTGATTCAGAGTTCACAGATGCTCAATTAGAAATTTTTCCTTTGGAAAATTTC
AAGATCATTGAGCAGCCTGGATGTCCTTCACCTGTGATGGAAGCAGAAAGCACCAAATCCTTCC
AATATGGCGTGCAGATGGAAAGCCCTTGTGTAGAGGGGACTCTCTCTGGTTTTATAAAGTATCA
AATGATGGATACACATCCTGTTCAACTGGAATTTTCCATGAACTTATCACTACTAGATTTTATT
AGGCCATTAAAGATCTCAACTGAAGACTTTGGCAAACTCTGGTTGTCTTTTGCAAATGATGTGA
AGCAAAATATAAAAATATCAGAGCCTCGAGTTGCACTGGCTTCTGTCCTGACAGAGCTGCAGCA
GAAACTCAGACTTTGCGTGGTTGACGTCATAGGCAGTGAAGGTCTGCTGGCCTGTAAGCTGCTT
CCGTCCACCCCCTGTATCCTGCACTGCCGAGTACACGCTGACGTGGTAGCCCTGTGGTTCCGAT
CCTCTAGCTCTGTTCTTTCAGACTGTTTATCTTGTCACTGTCAGAAAGTGATGCAGACATCCTA
GCAAAGTTCTGTTAAGTTTTACTTTTTTCACATAAATGGTTTACATTTACAACCTT

hide sequence

RefSeq Acc Id:

XM_039104990 ⟹ XP_038960918

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	134,755,722 - 134,792,820 (+)	NCBI
mRatBN7.2	3	114,302,388 - 114,339,484 (+)	NCBI

RefSeq Acc Id:

XM_063283751 ⟹ XP_063139821

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	134,733,301 - 134,792,820 (+)	NCBI

RefSeq Acc Id:

XM_063283752 ⟹ XP_063139822

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	134,757,240 - 134,792,820 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178671	(Get FASTA)	NCBI Sequence Viewer
	XP_038960918	(Get FASTA)	NCBI Sequence Viewer
	XP_063139821	(Get FASTA)	NCBI Sequence Viewer
	XP_063139822	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL80098	(Get FASTA)	NCBI Sequence Viewer
	EDL80099	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000037349.5

RefSeq Acc Id:

NP_001178671 ⟸ NM_001191742

- UniProtKB:

D3ZX21 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSDMVERTLTALPGLFLQNQLGGPAASRAPFFSRLGGLIRGVTALSSKHEEEKLIQQELSSLKA
TVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHE
LLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPREMIPAVLPLIEEKLQHSKEIIRRKAVLALY
KFYLIAPNQVQHIHTKFRKALCDRDVGVMAASLHIYLRMIKENSSGYKDLTESFVTILKQVVGG
KLPVEFSYHSVPAPWLQIQLLRILGLLGKDDERTSELMYDVLDESLRRAELNHNVTYAILFECV
HTIYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPSLALQHQITIIECLDHP
DPIIKRETLELLYRITNAQNVVVIVQKMLEYLHQSKEEYIIINLVGKIAELAEKYAPDNVWFIQ
TMNAVFSVGGDVMHPDILSNFLRLLAEGFDDETEDQQLRLYAVQSYLTLLDMENTFYPQRFLQV
MSWVLGEYSYLLDRESPEAVMTRLYKLLRSDSISSETKAWLFAAVTKLTPQAHSSPIVENLIQE
FTVSLNTCLRQHAFELKHLHENEELMKSLLQSAQNCDDIMADASLSFLDGFVAEGLSQGAAPYK
PRHQRQEEQLSQEKVLNFEPYGLSFSSSGFTGRQSPAGVSLGSDISGNSAETGLKEAGSLKMDG
IKKLWGKEGYLPKKESGAADKLEAAHAPAESAMMENVDQAMTRKDQAQGHTPSTEEKEKQLLAS
SLFVGLGPENTINLLGKADVVSYKFRRKSKPKVAQSDKMPSAHAAPSSTLSPVSDVAGGDEDSL
SAADRGDGELGSELLGSESVLELPSVENLSSVSLPVSSLFAGNDMEVFHPPSSSATSAVKEVSL
AALLEETPECRRSALVEICSNETVAVSSYKVWKDECLLLVCSVTSKTDSEFTDAQLEIFPLENF
KIIEQPGCPSPVMEAESTKSFQYGVQMESPCVEGTLSGFIKYQMMDTHPVQLEFSMNLSLLDFI
RPLKISTEDFGKLWLSFANDVKQNIKISEPRVALASVLTELQQKLRLCVVDVIGSEGLLACKLL
PSTPCILHCRVHADVVALWFRSSSSVLSDCLSCHCQKVMQTS

hide sequence

Ensembl Acc Id:

ENSRNOP00000037349 ⟸ ENSRNOT00000037390

RefSeq Acc Id:	XP_038960918 ⟸ XM_039104990
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063139821 ⟸ XM_063283751
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063139822 ⟸ XM_063283752
- Peptide Label:	isoform X2

Protein Domains

AP-4 complex subunit epsilon-1 C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZX21-F1-model_v2	AlphaFold	D3ZX21	1-1130	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692394

Promoter ID:

EPDNEW_R2919

Type:

multiple initiation site

Name:

Ap4e1_1

Description:

adaptor-related protein complex 4, epsilon 1 subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	119,484,694 - 119,484,754	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562199	AgrOrtholog
BioCyc Gene	G2FUF-48013	BioCyc
Ensembl Genes	ENSRNOG00000022938	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037390.7	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/TrEMBL
InterPro	Adaptor_Complx_Large_Subunit	UniProtKB/TrEMBL
	AP4_complex_esu	UniProtKB/TrEMBL
	AP4E1_C	UniProtKB/TrEMBL
	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	Clathrin/coatomer_adapt-like_N	UniProtKB/TrEMBL
KEGG Report	rno:311404	UniProtKB/TrEMBL
NCBI Gene	311404	ENTREZGENE
PANTHER	ADAPTIN, ALPHA/GAMMA/EPSILON	UniProtKB/TrEMBL
	AP-4 COMPLEX SUBUNIT EPSILON-1	UniProtKB/TrEMBL
Pfam	Adaptin_N	UniProtKB/TrEMBL
	AP4E_app_platf	UniProtKB/TrEMBL
PhenoGen	Ap4e1	PhenoGen
PIRSF	AP4_complex_epsilon	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000022938	RatGTEx
SMART	AP4E_app_platf	UniProtKB/TrEMBL
Superfamily-SCOP	ARM-type_fold	UniProtKB/TrEMBL
UniProt	D3ZX21	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-03	Ap4e1	adaptor related protein complex 4 subunit epsilon 1	Ap4e1	adaptor-related protein complex 4, epsilon 1 subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Ap4e1	adaptor-related protein complex 4, epsilon 1 subunit	Ap4e1	adaptor-related protein complex AP-4, epsilon 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-29	Ap4e1	adaptor-related protein complex AP-4, epsilon 1	RGD1562199_predicted	similar to Adapter-related protein complex 4 epsilon 1 subunit (Epsilon subunit of AP-4) (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-10	RGD1562199_predicted	similar to Adapter-related protein complex 4 epsilon 1 subunit (Epsilon subunit of AP-4) (predicted)		similar to Adapter-related protein complex 4 epsilon 1 subunit (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit) (predicted)	Name updated	1299863	APPROVED
2006-03-07	RGD1562199_predicted	similar to Adapter-related protein complex 4 epsilon 1 subunit (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit) (predicted)	LOC311404	similar to Adapter-related protein complex 4 epsilon 1 subunit (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit)	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC311404	similar to Adapter-related protein complex 4 epsilon 1 subunit (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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