Defb44 (defensin beta 44) - Rat Genome Database

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Gene: Defb44 (defensin beta 44) Rattus norvegicus
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Symbol: Defb44
Name: defensin beta 44
RGD ID: 1562179
Description: Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in antifungal innate immune response and defense response to bacterium. Orthologous to human DEFB136 (defensin beta 136); INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-defensin 136; beta-defensin 44
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,487,871 - 41,489,562 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1541,487,871 - 41,489,562 (+)EnsemblGRCr8
mRatBN7.21537,311,888 - 37,313,579 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,312,308 - 37,313,370 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1539,177,406 - 39,178,476 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,328,216 - 40,329,286 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,772,943 - 38,774,005 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,235,942 - 46,237,658 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,236,410 - 46,237,472 (+)Ensemblrn6Rnor6.0
Rnor_5.01550,002,354 - 50,003,416 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41542,326,577 - 42,327,639 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1536,998,370 - 36,999,432 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16033865  


Genomics

Comparative Map Data
Defb44
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,487,871 - 41,489,562 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1541,487,871 - 41,489,562 (+)EnsemblGRCr8
mRatBN7.21537,311,888 - 37,313,579 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,312,308 - 37,313,370 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1539,177,406 - 39,178,476 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,328,216 - 40,329,286 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,772,943 - 38,774,005 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,235,942 - 46,237,658 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,236,410 - 46,237,472 (+)Ensemblrn6Rnor6.0
Rnor_5.01550,002,354 - 50,003,416 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41542,326,577 - 42,327,639 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1536,998,370 - 36,999,432 (+)NCBICelera
Cytogenetic Map15p12NCBI
DEFB136
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38811,973,937 - 11,974,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl811,973,937 - 11,974,599 (-)Ensemblhg38GRCh38
GRCh37811,831,446 - 11,832,108 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,868,855 - 11,869,517 (-)NCBIBuild 36Build 36hg18NCBI36
Celera810,960,843 - 10,961,505 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef810,762,186 - 10,762,848 (-)NCBIHuRef
CHM1_1812,272,852 - 12,273,514 (-)NCBICHM1_1
T2T-CHM13v2.087,765,666 - 7,766,328 (+)NCBIT2T-CHM13v2.0
Defb42
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391463,284,445 - 63,286,052 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1463,284,440 - 63,295,598 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381463,046,991 - 63,048,606 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,046,991 - 63,058,149 (+)Ensemblmm10GRCm38
MGSCv371463,665,828 - 63,667,443 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361462,001,101 - 62,002,710 (+)NCBIMGSCv36mm8
Celera1460,807,590 - 60,809,205 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.24NCBI
Defb136
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540353,167,242 - 53,170,281 (-)Ensembl
ChiLan1.0NW_00495540353,168,733 - 53,170,177 (-)NCBIChiLan1.0ChiLan1.0
DEFB136
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2728,438,953 - 28,472,857 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan184,466,728 - 4,471,201 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v087,224,285 - 7,226,508 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DEFB136
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12525,963,192 - 25,964,008 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2525,963,286 - 25,963,991 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2526,620,230 - 26,621,046 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02526,118,472 - 26,119,288 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2526,118,566 - 26,119,271 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12526,062,865 - 26,063,681 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02525,967,871 - 25,968,687 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02526,119,075 - 26,119,891 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
DEFB136
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1415,109,002 - 15,110,878 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11415,109,961 - 15,110,778 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DEFB136
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605235,271,150 - 35,272,270 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Defb136
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475825,439,976 - 25,440,556 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475825,439,976 - 25,440,556 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Defb136
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11261,315,623 - 61,316,667 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Defb44
5 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:27
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000059209
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

appendage
endoderm
mesenchyme
renal system
reproductive system
respiratory system
1 1 2 1 3 1

Sequence


Ensembl Acc Id: ENSRNOT00000059209   ⟹   ENSRNOP00000055979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1541,487,871 - 41,489,562 (+)Ensembl
mRatBN7.2 Ensembl1537,312,308 - 37,313,370 (+)Ensembl
Rnor_6.0 Ensembl1546,236,410 - 46,237,472 (+)Ensembl
RefSeq Acc Id: NM_001037529   ⟹   NP_001032618
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81541,487,871 - 41,489,562 (+)NCBI
mRatBN7.21537,311,888 - 37,313,579 (+)NCBI
Rnor_6.01546,236,410 - 46,237,472 (+)NCBI
Rnor_5.01550,002,354 - 50,003,416 (+)NCBI
RGSC_v3.41542,326,577 - 42,327,639 (+)RGD
Celera1536,998,370 - 36,999,432 (+)RGD
Sequence:
RefSeq Acc Id: NM_001412579   ⟹   NP_001399508
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81541,487,871 - 41,489,562 (+)NCBI
mRatBN7.21537,311,888 - 37,313,579 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001032618 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399508 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT51910 (Get FASTA)   NCBI Sequence Viewer  
  EDL85310 (Get FASTA)   NCBI Sequence Viewer  
  EDL85311 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055979.2
RefSeq Acc Id: NP_001032618   ⟸   NM_001037529
- Peptide Label: precursor
- UniProtKB: Q32ZF2 (UniProtKB/TrEMBL),   A6K6F1 (UniProtKB/TrEMBL),   F6SY76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055979   ⟸   ENSRNOT00000059209
RefSeq Acc Id: NP_001399508   ⟸   NM_001412579
- Peptide Label: precursor
- UniProtKB: Q32ZF2 (UniProtKB/TrEMBL),   A6K6F1 (UniProtKB/TrEMBL),   F6SY76 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32ZF2-F1-model_v2 AlphaFold Q32ZF2 1-75 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562179 AgrOrtholog
BioCyc Gene G2FUF-13439 BioCyc
Ensembl Genes ENSRNOG00000038757 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059209.3 UniProtKB/TrEMBL
InterPro DEFB136/42 UniProtKB/TrEMBL
KEGG Report rno:641652 UniProtKB/TrEMBL
NCBI Gene 641652 ENTREZGENE
PANTHER BETA-DEFENSIN 136 UniProtKB/TrEMBL
  PTHR39413 UniProtKB/TrEMBL
Pfam DEFB136 UniProtKB/TrEMBL
PhenoGen Defb44 PhenoGen
RatGTEx ENSRNOG00000038757 RatGTEx
UniProt A0ABZ3NNG0_RAT UniProtKB/TrEMBL
  A6K6F0_RAT UniProtKB/TrEMBL
  A6K6F1 ENTREZGENE, UniProtKB/TrEMBL
  F6SY76 ENTREZGENE, UniProtKB/TrEMBL
  Q32ZF2 ENTREZGENE
UniProt Secondary Q32ZF2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-11-07 Defb44  defensin beta 44    beta-defensin 44  Name updated 1299863 APPROVED
2006-02-09 Defb44  beta-defensin 44      Symbol and Name status set to provisional 70820 PROVISIONAL