Ak2-ps3 (adenylate kinase 2, pseudogene 3) - Rat Genome Database

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Gene: Ak2-ps3 (adenylate kinase 2, pseudogene 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ak2-ps3 (Ensembl: RGD1562178)
Name: adenylate kinase 2, pseudogene 3 (Ensembl:similar to Adenylate kinase 2)
RGD ID: 1562178
Description: Predicted to enable ATP binding activity and adenylate kinase activity. Predicted to be involved in nucleotide metabolic process and phosphorylation. Predicted to be located in mitochondrial intermembrane space; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; ammonium chloride; paracetamol.
Type: pseudo (Ensembl: protein-coding)
RefSeq Status: INFERRED
Previously known as: adenylate kinase 2 like 1; adenylate kinase 2, mitochondrial-like; Ak2l1; LOC500039; RGD1562178; similar to Adenylate kinase 2
RGD Orthologs
Alliance Genes
More Info homologs ...
Related Functional Gene: Ak2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8445,932,601 - 45,934,227 (+)NCBIGRCr8
mRatBN7.2444,966,606 - 44,967,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl444,966,627 - 44,967,325 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0443,915,327 - 43,916,115 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0444,521,910 - 44,522,713 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,277,200 - 42,277,898 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera440,258,192 - 40,258,995 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ak2-ps3
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:95
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000000134
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000090618   ⟹   ENSRNOP00000080641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl444,966,627 - 44,967,325 (+)Ensembl
Rnor_6.0 Ensembl443,915,333 - 43,916,028 (+)Ensembl
RefSeq Acc Id: XM_039108502   ⟹   XP_038964430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8445,932,601 - 45,934,227 (+)NCBI
mRatBN7.2444,966,606 - 44,967,403 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038964430 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080641
  ENSRNOP00000080641.1
Reference Protein Sequences
RefSeq Acc Id: XP_038964430   ⟸   XM_039108502
- UniProtKB: Q6P7C6 (UniProtKB/Swiss-Prot),   P29410 (UniProtKB/Swiss-Prot),   A0A8I5ZQQ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080641   ⟸   ENSRNOT00000090618
Protein Domains
Adenylate kinase active site lid

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-45587 BioCyc
Ensembl Genes ENSRNOG00000052702 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090618.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro Adenyl_kin_sub UniProtKB/TrEMBL
  Adenylat/UMP-CMP_kin UniProtKB/TrEMBL
  Adenylat_kinase_CS UniProtKB/TrEMBL
  Adenylate_kinase_lid-dom UniProtKB/TrEMBL
  AK2 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 500039 ENTREZGENE
PANTHER ADENYLATE KINASE 2, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR23359 UniProtKB/TrEMBL
Pfam ADK UniProtKB/TrEMBL
  ADK_lid UniProtKB/TrEMBL
PhenoGen Ak2-ps3 PhenoGen
PRINTS ADENYLTKNASE UniProtKB/TrEMBL
PROSITE ADENYLATE_KINASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052702 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5ZQQ9 ENTREZGENE, UniProtKB/TrEMBL
  P29410 ENTREZGENE
  Q6P7C6 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-04-15 Ak2-ps3  adenylate kinase 2, pseudogene 3  Ak2l1  adenylate kinase 2 like 1  Name and Symbol and Type changed (type changed from [protein-coding] to [pseudo]) 629549 APPROVED
2023-09-19 Ak2l1  adenylate kinase 2 like 1  RGD1562178  similar to Adenylate kinase 2  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1562178  similar to Adenylate kinase 2   RGD1562178_predicted  similar to Adenylate kinase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562178_predicted  similar to Adenylate kinase 2 (predicted)  LOC500039  similar to Adenylate kinase 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500039  similar to Adenylate kinase 2      Symbol and Name status set to provisional 70820 PROVISIONAL