Lonrf2 (LON peptidase N-terminal domain and ring finger 2) - Rat Genome Database

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Gene: Lonrf2 (LON peptidase N-terminal domain and ring finger 2) Rattus norvegicus
Analyze
Symbol: Lonrf2
Name: LON peptidase N-terminal domain and ring finger 2
RGD ID: 1562137
Description: Predicted to enable misfolded protein binding activity; ribonucleoprotein complex binding activity; and ubiquitin protein ligase activity. Predicted to act upstream of or within several processes, including motor behavior; neuron differentiation; and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be located in cytoplasm. Orthologous to human LONRF2 (LON peptidase N-terminal domain and ring finger 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC301361; LON peptidase N-terminal domain and RING finger protein 2; RGD1562137; similar to FLJ45273 protein
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8948,524,962 - 48,566,353 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl948,530,549 - 48,570,807 (-)EnsemblGRCr8
mRatBN7.2941,033,125 - 41,070,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,034,628 - 41,070,649 (-)EnsemblmRatBN7.2
Rnor_6.0945,468,001 - 45,506,448 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl945,466,688 - 45,505,767 (-)Ensemblrn6Rnor6.0
Rnor_5.0945,161,417 - 45,200,151 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4937,793,985 - 37,829,456 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera938,783,004 - 38,821,241 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Lonrf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8948,524,962 - 48,566,353 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl948,530,549 - 48,570,807 (-)EnsemblGRCr8
mRatBN7.2941,033,125 - 41,070,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,034,628 - 41,070,649 (-)EnsemblmRatBN7.2
Rnor_6.0945,468,001 - 45,506,448 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl945,466,688 - 45,505,767 (-)Ensemblrn6Rnor6.0
Rnor_5.0945,161,417 - 45,200,151 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4937,793,985 - 37,829,456 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera938,783,004 - 38,821,241 (-)NCBICelera
Cytogenetic Map9q22NCBI
LONRF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382100,271,875 - 100,322,501 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2100,271,875 - 100,322,501 (-)Ensemblhg38GRCh38
GRCh372100,888,337 - 100,938,963 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362100,256,185 - 100,305,627 (-)NCBIBuild 36Build 36hg18NCBI36
Celera295,094,286 - 95,143,712 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef294,654,510 - 94,703,915 (-)NCBIHuRef
CHM1_12100,894,158 - 100,943,545 (-)NCBICHM1_1
T2T-CHM13v2.02100,730,785 - 100,781,377 (-)NCBIT2T-CHM13v2.0
Lonrf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39138,832,750 - 38,875,768 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl138,832,726 - 38,875,792 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38138,793,669 - 38,836,687 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl138,793,645 - 38,836,711 (-)Ensemblmm10GRCm38
MGSCv37138,851,354 - 38,878,060 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36138,739,055 - 38,765,761 (-)NCBIMGSCv36mm8
Celera138,580,489 - 38,606,584 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map117.17NCBI
LONRF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21227,903,086 - 27,952,756 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A27,905,854 - 27,955,517 (+)NCBINHGRI_mPanPan1
PanPan1.12A101,255,118 - 101,303,103 (-)NCBIPanPan1.1PanPan1.1panPan2
LONRF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11042,378,459 - 42,412,871 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1042,378,475 - 42,410,076 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1042,301,779 - 42,334,721 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01043,246,934 - 43,279,880 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1043,246,934 - 43,279,340 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11042,967,873 - 43,000,816 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01043,241,595 - 43,274,524 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01043,431,190 - 43,464,138 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lonrf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629285,944,309 - 85,984,539 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936661584,942 - 622,823 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936661584,948 - 623,507 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LONRF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl353,941,485 - 53,981,662 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1353,941,583 - 53,982,630 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2356,528,053 - 56,565,809 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LONRF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1144,014,773 - 4,055,193 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041171,630,965 - 171,672,349 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lonrf2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14115,006,049 - 115,042,749 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lonrf2
382 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:83
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000033964
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 67 157 78 77 46 27 46 6 264 127 11 136 73 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000033964   ⟹   ENSRNOP00000037315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl948,530,549 - 48,566,268 (-)Ensembl
mRatBN7.2 Ensembl941,034,628 - 41,070,649 (-)Ensembl
Rnor_6.0 Ensembl945,466,688 - 45,505,767 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171356   ⟹   ENSRNOP00000109868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl948,530,549 - 48,570,807 (-)Ensembl
RefSeq Acc Id: XM_006244869   ⟹   XP_006244931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8948,524,962 - 48,566,353 (-)NCBI
mRatBN7.2941,033,125 - 41,070,551 (-)NCBI
Rnor_6.0945,468,001 - 45,506,448 (-)NCBI
Rnor_5.0945,161,417 - 45,200,151 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006244931 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99208 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037315
  ENSRNOP00000037315.5
  ENSRNOP00000109868.1
RefSeq Acc Id: XP_006244931   ⟸   XM_006244869
- UniProtKB: D3ZX48 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037315   ⟸   ENSRNOT00000033964
Ensembl Acc Id: ENSRNOP00000109868   ⟸   ENSRNOT00000171356
Protein Domains
Lon N-terminal   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZX48-F1-model_v2 AlphaFold D3ZX48 1-535 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562137 AgrOrtholog
BioCyc Gene G2FUF-27766 BioCyc
Ensembl Genes ENSRNOG00000023312 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033964 ENTREZGENE
  ENSRNOT00000033964.6 UniProtKB/TrEMBL
  ENSRNOT00000171356.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  2.30.130.40 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro Lon_prtase_N_sf UniProtKB/TrEMBL
  Lon_substr-bd UniProtKB/TrEMBL
  PUA-like_sf UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:301361 UniProtKB/TrEMBL
NCBI Gene 301361 ENTREZGENE
PANTHER LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 2 UniProtKB/TrEMBL
  RING FINGER PROTEIN 127 UniProtKB/TrEMBL
Pfam LON_substr_bdg UniProtKB/TrEMBL
  TPR_16 UniProtKB/TrEMBL
  TPR_19 UniProtKB/TrEMBL
  zf-C3HC4_2 UniProtKB/TrEMBL
PhenoGen Lonrf2 PhenoGen
PROSITE LON_N UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023312 RatGTEx
SMART LON UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
  SSF88697 UniProtKB/TrEMBL
UniProt A0ABK0LUH2_RAT UniProtKB/TrEMBL
  D3ZX48 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Lonrf2  LON peptidase N-terminal domain and ring finger 2   Lonrf2_predicted  LON peptidase N-terminal domain and ring finger 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Lonrf2_predicted  LON peptidase N-terminal domain and ring finger 2 (predicted)  RGD1562137_predicted  similar to FLJ45273 protein (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1562137_predicted  similar to FLJ45273 protein (predicted)  LOC301361  similar to FLJ45273 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC301361  similar to FLJ45273 protein      Symbol and Name status set to provisional 70820 PROVISIONAL