Lonrf2 (LON peptidase N-terminal domain and ring finger 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lonrf2 (LON peptidase N-terminal domain and ring finger 2) Rattus norvegicus
Analyze
Symbol: Lonrf2
Name: LON peptidase N-terminal domain and ring finger 2
RGD ID: 1562137
Description: Predicted to enable metal ion binding activity. Predicted to be located in cytoplasm. Orthologous to human LONRF2 (LON peptidase N-terminal domain and ring finger 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC301361; LON peptidase N-terminal domain and RING finger protein 2; RGD1562137; similar to FLJ45273 protein
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8948,524,962 - 48,566,353 (-)NCBIGRCr8
mRatBN7.2941,033,125 - 41,070,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,034,628 - 41,070,649 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0945,468,001 - 45,506,448 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl945,466,688 - 45,505,767 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0945,161,417 - 45,200,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4937,793,985 - 37,829,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera938,783,004 - 38,821,241 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Lonrf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8948,524,962 - 48,566,353 (-)NCBIGRCr8
mRatBN7.2941,033,125 - 41,070,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,034,628 - 41,070,649 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0945,468,001 - 45,506,448 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl945,466,688 - 45,505,767 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0945,161,417 - 45,200,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4937,793,985 - 37,829,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera938,783,004 - 38,821,241 (-)NCBICelera
Cytogenetic Map9q22NCBI
LONRF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382100,271,875 - 100,322,501 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2100,271,875 - 100,322,501 (-)EnsemblGRCh38hg38GRCh38
GRCh372100,888,337 - 100,938,963 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362100,256,185 - 100,305,627 (-)NCBINCBI36Build 36hg18NCBI36
Celera295,094,286 - 95,143,712 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef294,654,510 - 94,703,915 (-)NCBIHuRef
CHM1_12100,894,158 - 100,943,545 (-)NCBICHM1_1
T2T-CHM13v2.02100,730,785 - 100,781,377 (-)NCBIT2T-CHM13v2.0
Lonrf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39138,832,750 - 38,875,768 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl138,832,726 - 38,875,792 (-)EnsemblGRCm39 Ensembl
GRCm38138,793,669 - 38,836,687 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl138,793,645 - 38,836,711 (-)EnsemblGRCm38mm10GRCm38
MGSCv37138,851,354 - 38,878,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36138,739,055 - 38,765,761 (-)NCBIMGSCv36mm8
Celera138,580,489 - 38,606,584 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map117.17NCBI
LONRF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21227,903,086 - 27,952,756 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A27,905,854 - 27,955,517 (+)NCBINHGRI_mPanPan1
PanPan1.12A101,255,118 - 101,303,103 (-)NCBIpanpan1.1PanPan1.1panPan2
LONRF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11042,378,459 - 42,412,871 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1042,378,475 - 42,410,076 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1042,301,779 - 42,334,721 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01043,246,934 - 43,279,880 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1043,246,934 - 43,279,340 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11042,967,873 - 43,000,816 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01043,241,595 - 43,274,524 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01043,431,190 - 43,464,138 (+)NCBIUU_Cfam_GSD_1.0
Lonrf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629285,944,309 - 85,984,539 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936661584,942 - 622,823 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936661584,948 - 623,507 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LONRF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl353,941,485 - 53,981,662 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1353,941,583 - 53,982,630 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2356,528,053 - 56,565,809 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LONRF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1144,014,773 - 4,055,193 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041171,630,965 - 171,672,349 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Lonrf2
124 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:83
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000033964
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 78 77 46 25 46 6 205 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000033964   ⟹   ENSRNOP00000037315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl941,034,628 - 41,070,649 (-)Ensembl
Rnor_6.0 Ensembl945,466,688 - 45,505,767 (-)Ensembl
RefSeq Acc Id: XM_006244869   ⟹   XP_006244931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8948,524,962 - 48,566,353 (-)NCBI
mRatBN7.2941,033,125 - 41,070,551 (-)NCBI
Rnor_6.0945,468,001 - 45,506,448 (-)NCBI
Rnor_5.0945,161,417 - 45,200,151 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006244931 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99208 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037315.5
RefSeq Acc Id: XP_006244931   ⟸   XM_006244869
- UniProtKB: D3ZX48 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037315   ⟸   ENSRNOT00000033964
Protein Domains
Lon N-terminal   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZX48-F1-model_v2 AlphaFold D3ZX48 1-535 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562137 AgrOrtholog
BioCyc Gene G2FUF-27766 BioCyc
Ensembl Genes ENSRNOG00000023312 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033964.5 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  2.30.130.40 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro Lon_prtase_N_sf UniProtKB/TrEMBL
  Lon_substr-bd UniProtKB/TrEMBL
  PUA-like_sf UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:301361 UniProtKB/TrEMBL
NCBI Gene 301361 ENTREZGENE
PANTHER LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 2 UniProtKB/TrEMBL
  RING FINGER PROTEIN 127 UniProtKB/TrEMBL
Pfam LON_substr_bdg UniProtKB/TrEMBL
  TPR_16 UniProtKB/TrEMBL
  TPR_19 UniProtKB/TrEMBL
  zf-C3HC4_2 UniProtKB/TrEMBL
PhenoGen Lonrf2 PhenoGen
PROSITE LON_N UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023312 RatGTEx
SMART LON UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
  SSF88697 UniProtKB/TrEMBL
UniProt D3ZX48 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Lonrf2  LON peptidase N-terminal domain and ring finger 2   Lonrf2_predicted  LON peptidase N-terminal domain and ring finger 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Lonrf2_predicted  LON peptidase N-terminal domain and ring finger 2 (predicted)  RGD1562137_predicted  similar to FLJ45273 protein (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1562137_predicted  similar to FLJ45273 protein (predicted)  LOC301361  similar to FLJ45273 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC301361  similar to FLJ45273 protein      Symbol and Name status set to provisional 70820 PROVISIONAL