Vom2r57 (vomeronasal 2 receptor, 57) - Rat Genome Database

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Gene: Vom2r57 (vomeronasal 2 receptor, 57) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Vom2r57
Name: vomeronasal 2 receptor, 57
RGD ID: 1562007
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane; INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC299683; RGD1562007; similar to putative pheromone receptor (Go-VN4); vomeronasal 2 receptor 57
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8718,090,012 - 18,104,780 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl718,090,012 - 18,104,780 (-)EnsemblGRCr8
mRatBN7.2715,628,378 - 15,643,162 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl715,627,680 - 15,643,452 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx72,023,322 - 2,038,097 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.074,006,788 - 4,021,551 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0720,020,741 - 20,035,516 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0719,074,060 - 19,090,133 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl719,074,190 - 19,088,972 (-)Ensemblrn6Rnor6.0
Rnor_5.0719,253,651 - 19,269,964 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4718,299,280 - 18,314,068 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Cytogenetic Map7q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
Additional References at PubMed
PMID:17382427  


Genomics

Variants

.
Variants in Vom2r57
96 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:48
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000049266
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
D7Got9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2715,635,113 - 15,635,270 (+)MAPPERmRatBN7.2
Rnor_6.0722,934,699 - 22,934,855NCBIRnor6.0
Rnor_6.0719,080,931 - 19,081,087NCBIRnor6.0
Rnor_5.0723,091,178 - 23,091,334UniSTSRnor5.0
Rnor_5.0719,260,387 - 19,260,543UniSTSRnor5.0
RGSC_v3.4718,306,015 - 18,306,172RGDRGSC3.4
RGSC_v3.4718,306,016 - 18,306,172UniSTSRGSC3.4
RGSC_v3.1718,314,257 - 18,314,414RGD
RH 2.0 Map768.1RGD
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 6 34 23 19 7 6 7 6 41 24 22 4 26 12 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000049266   ⟹   ENSRNOP00000041673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl715,741,942 - 15,759,868 (-)Ensembl
Rnor_6.0 Ensembl719,074,190 - 19,088,972 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110061   ⟹   ENSRNOP00000087441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl715,627,680 - 15,643,452 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000162879   ⟹   ENSRNOP00000106149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl718,090,012 - 18,104,780 (-)Ensembl
RefSeq Acc Id: NM_001099474   ⟹   NP_001092944
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8718,090,012 - 18,104,780 (-)NCBI
mRatBN7.2715,628,378 - 15,643,162 (-)NCBI
Rnor_6.0719,074,195 - 19,088,972 (-)NCBI
Rnor_5.0719,253,651 - 19,269,964 (-)NCBI
RGSC_v3.4718,299,280 - 18,314,068 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001092944 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041673.6
  ENSRNOP00000106149
  ENSRNOP00000106149.1
RefSeq Acc Id: NP_001092944   ⟸   NM_001099474
- Peptide Label: precursor
- UniProtKB: A0A8I6A7S2 (UniProtKB/TrEMBL),   D3ZME2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041673   ⟸   ENSRNOT00000049266
Ensembl Acc Id: ENSRNOP00000087441   ⟸   ENSRNOT00000110061
Ensembl Acc Id: ENSRNOP00000106149   ⟸   ENSRNOT00000162879
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZME2-F1-model_v2 AlphaFold D3ZME2 1-861 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562007 AgrOrtholog
BioCyc Gene G2FUF-34684 BioCyc
Ensembl Genes ENSRNOG00000039136 Ensembl
  ENSRNOG00000063758 Ensembl
  ENSRNOG00000077825 UniProtKB/TrEMBL
  ENSRNOG00000084843 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049266.7 UniProtKB/TrEMBL
  ENSRNOT00000162879 ENTREZGENE
  ENSRNOT00000162879.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  GPCR_3 UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/TrEMBL
  GPCR_3_vmron_rcpt_2 UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
NCBI Gene 299683 ENTREZGENE
PANTHER PTHR24061 UniProtKB/TrEMBL
  VOMERONASAL 2, RECEPTOR 10-RELATED UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  NCD3G UniProtKB/TrEMBL
PhenoGen Vom2r57 PhenoGen
PRINTS GPCRMGR UniProtKB/TrEMBL
  VOMERONASL2R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039136 RatGTEx
  ENSRNOG00000063758 RatGTEx
  ENSRNOG00000077825 RatGTEx
  ENSRNOG00000084843 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt A0A8I6A7S2 ENTREZGENE
  A0ABK0LQR9_RAT UniProtKB/TrEMBL
  D3ZME2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-23 Vom2r57  vomeronasal 2 receptor, 57  RGD1562007  similar to putative pheromone receptor (Go-VN4)   Symbol and Name updated 1299863 APPROVED
2008-04-30 RGD1562007  similar to putative pheromone receptor (Go-VN4)   RGD1562007_predicted  similar to putative pheromone receptor (Go-VN4) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562007_predicted  similar to putative pheromone receptor (Go-VN4) (predicted)  LOC299683  similar to putative pheromone receptor (Go-VN4)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC299683  similar to putative pheromone receptor (Go-VN4)      Symbol and Name status set to provisional 70820 PROVISIONAL