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Gene: Mcc (MCC regulator of WNT signaling pathway) Rattus norvegicus

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Symbol:

Mcc

Name:

MCC regulator of WNT signaling pathway

RGD ID:

1561988

Description:

Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial cell migration; and negative regulation of epithelial cell proliferation. Predicted to be located in nucleus and plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human MCC (MCC regulator of WNT signaling pathway); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

colorectal mutant cancer protein-like; LOC100909795; LOC307449; MCC, WNT signaling pathway regulator; mutated in colorectal cancers; RGD1561988; similar to Colorectal mutant cancer protein (MCC protein)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MCC (MCC regulator of Wnt signaling pathway)	HGNC	Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Mus musculus (house mouse):	Mcc (mutated in colorectal cancers)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mcc (MCC regulator of WNT signaling pathway)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MCC (MCC regulator of WNT signaling pathway)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MCC (MCC regulator of WNT signaling pathway)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mcc (MCC regulator of WNT signaling pathway)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MCC (MCC regulator of WNT signaling pathway)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MCC (MCC regulator of WNT signaling pathway)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mcc (MCC regulator of WNT signaling pathway)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mcc (MCC regulator of WNT signaling pathway)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PXK (PX domain containing serine/threonine kinase like)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	MCC (MCC regulator of Wnt signaling pathway)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MCC (MCC regulator of Wnt signaling pathway)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mcc (mutated in colorectal cancers)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mcc (mutated in colorectal cancers)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mcc (MCC regulator of WNT signaling pathway)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mcc (MCC regulator of WNT signaling pathway)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG34404	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG34404	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mcc	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	37,042,350 - 37,517,114 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	37,049,253 - 37,517,076 (-)	Ensembl				GRCr8
mRatBN7.2	18	36,794,206 - 37,266,237 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	36,798,372 - 37,266,819 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	36,902,353 - 37,359,016 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	37,620,712 - 38,077,375 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	36,997,619 - 37,454,276 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	35,683,185 - 35,817,117 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0	1	12,006,663 - 12,128,849 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	12,006,660 - 12,128,845 (+)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	18	35,683,185 - 35,817,127 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	13,595,971 - 13,952,963 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	18	35,348,808 - 35,484,229 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	38,099,803 - 38,576,214	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Cytogenetic Map	18	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

colon carcinoma (ISO)

colorectal cancer (ISO)

Colorectal Neoplasms (ISO)

familial adenomatous polyposis (ISO)

intellectual disability (ISO)

prostate cancer (ISO)

rectal benign neoplasm (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (EXP)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

buta-1,3-diene (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

choline (ISO)

copper(II) chloride (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dichromium trioxide (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethyl methanesulfonate (ISO)

fluoranthene (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

inulin (ISO)

L-methionine (ISO)

lead diacetate (ISO)

leflunomide (ISO)

mercury dibromide (ISO)

methamphetamine (EXP)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel sulfate (ISO)

oxybenzone (EXP)

ozone (EXP,ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment of protein localization (ISO)

negative regulation of canonical Wnt signaling pathway (IBA,ISO)

negative regulation of epithelial cell migration (ISO)

negative regulation of epithelial cell proliferation (ISO)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (ISO)

nucleoplasm (ISO)

nucleus (ISO)

plasma membrane (ISO)

Molecular Function

calcium ion binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1848370	PMID:18591935	PMID:19555689	PMID:24824780

Genomics

Comparative Map Data

Mcc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	37,042,350 - 37,517,114 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	37,049,253 - 37,517,076 (-)	Ensembl				GRCr8
mRatBN7.2	18	36,794,206 - 37,266,237 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	36,798,372 - 37,266,819 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	36,902,353 - 37,359,016 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	37,620,712 - 38,077,375 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	36,997,619 - 37,454,276 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	35,683,185 - 35,817,117 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0	1	12,006,663 - 12,128,849 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	12,006,660 - 12,128,845 (+)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	18	35,683,185 - 35,817,127 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	13,595,971 - 13,952,963 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	18	35,348,808 - 35,484,229 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	38,099,803 - 38,576,214	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Cytogenetic Map	18	q11	NCBI

MCC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	113,022,106 - 113,488,453 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	113,022,106 - 113,488,823 (-)	Ensembl			hg38	GRCh38
GRCh37	5	112,357,803 - 112,824,150 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	112,385,695 - 112,852,426 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	112,389,427 - 112,658,201	NCBI
Celera	5	108,303,413 - 108,772,341 (-)	NCBI		Celera
Cytogenetic Map	5	q22.2	NCBI
HuRef	5	107,537,529 - 108,007,449 (-)	NCBI		HuRef
CHM1_1	5	111,791,093 - 112,258,011 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	113,532,656 - 114,001,170 (-)	NCBI		T2T-CHM13v2.0

Mcc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	44,558,127 - 44,945,573 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	44,558,127 - 44,945,249 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	44,425,060 - 44,812,182 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	44,425,060 - 44,812,182 (-)	Ensembl			mm10	GRCm38
MGSCv37	18	44,584,714 - 44,971,836 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	44,550,392 - 44,555,234 (-)	NCBI		MGSCv36	mm8
Celera	18	45,807,563 - 46,200,023 (-)	NCBI		Celera
Cytogenetic Map	18	B3	NCBI
cM Map	18	23.74	NCBI

Mcc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	32,928,519 - 33,264,727 (-)	Ensembl
ChiLan1.0	NW_004955408	32,928,519 - 33,265,049 (-)	NCBI	ChiLan1.0	ChiLan1.0

MCC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	108,274,421 - 108,743,460 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	106,428,077 - 106,895,611 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	108,382,066 - 108,845,503 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	114,184,907 - 114,457,400 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	114,184,907 - 114,647,847 (-)	Ensembl			panPan2	panpan1.1

MCC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	35,291,297 - 35,592,388 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	35,312,814 - 35,592,282 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	35,258,841 - 35,559,927 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	35,656,537 - 35,958,139 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	35,677,049 - 35,958,083 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	35,480,416 - 35,784,856 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	35,668,029 - 35,970,362 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	36,176,583 - 36,478,012 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mcc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	125,905,158 - 126,351,432 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936597	4,934,788 - 5,376,481 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936597	4,930,065 - 5,191,311 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MCC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	116,287,018 - 116,740,581 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	116,286,353 - 116,748,620 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	121,307,432 - 121,321,926 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MCC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	16,309,574 - 16,773,736 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	16,310,968 - 16,579,343 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666034	61,661,123 - 62,145,017 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mcc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	8,607,680 - 9,032,044 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624733	8,607,645 - 9,035,484 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mcc
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	229,762,556 - 229,802,275 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mcc
2293 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	205
Count of miRNA genes:	143
Interacting mature miRNAs:	158
Transcripts:	ENSRNOT00000015172
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	22015562	61600538	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26822186	71822186	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26822186	71822186	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26822186	71822186	Rat
1331727	Bp237	Blood pressure QTL 237	3.053		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	63968306	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26822186	71822186	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26822186	71822186	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26822186	71822186	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	31990891	76990891	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31610505	85493247	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	33379158	78379158	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4482648	49482648	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	31990891	76990891	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	54490981	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
11565454	Kidm59	Kidney mass QTL 59		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	7065728	52065728	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	4307354	49307354	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	33379158	78379158	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
2301409	Cm70	Cardiac mass QTL 70		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	18	7065728	52065728	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	33379158	78379158	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	33379158	78379158	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26822186	71822186	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31522783	76522783	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	33379158	78379158	Rat
12904716	Am21	Aortic mass QTL 21		0.005	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	7065728	52065728	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	33379158	78379158	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	33379158	78379158	Rat
12904714	Cm131	Cardiac mass QTL 131		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	7065728	52065728	Rat
12904715	Cm132	Cardiac mass QTL 132		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	7065728	52065728	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31610505	77371277	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	36121626	81121626	Rat
6903345	Bp349	Blood pressure QTL 349	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	15226101	42690662	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	31990891	76990891	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5460455	42690191	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	26415821	71415821	Rat
6903349	Bp351	Blood pressure QTL 351	3.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
6903351	Bp352	Blood pressure QTL 352	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31644508	79484311	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	44930869	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	12066482	57066482	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	31990891	76990891	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31610505	72538878	Rat

Markers in Region

D18Chm48

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	1	13,805,931 - 13,806,114	NCBI	Rnor5.0
Rnor_5.0	1	13,569,503 - 13,569,686	NCBI	Rnor5.0
Rnor_5.0	X	87,473,210 - 87,473,393	NCBI	Rnor5.0
Rnor_5.0	X	87,467,408 - 87,467,591	NCBI	Rnor5.0
RGSC_v3.4	18	38,369,050 - 38,369,232	UniSTS	RGSC3.4
Cytogenetic Map	18	q11	UniSTS

Tceb1l-rs1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	18	35,610,106 - 35,610,325	NCBI	Rnor5.0
Rnor_5.0	18	35,405,109 - 35,405,328	NCBI	Rnor5.0
Rnor_5.0	10	37,382,354 - 37,382,565	NCBI	Rnor5.0
RGSC_v3.4	10	37,679,722 - 37,679,932	UniSTS	RGSC3.4
RGSC_v3.4	18	38,158,463 - 38,158,681	UniSTS	RGSC3.4
Celera	10	35,770,882 - 35,771,092	UniSTS
Cytogenetic Map	18	q11	UniSTS
Cytogenetic Map	10	q22	UniSTS

RH144300

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	18	37,482,383 - 37,482,685 (+)	Marker Load Pipeline
mRatBN7.2	18	37,231,506 - 37,231,808 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	12,028,319 - 12,028,620	NCBI	Rnor6.0
Rnor_5.0	1	13,618,193 - 13,618,494	UniSTS	Rnor5.0
RGSC_v3.4	18	38,552,331 - 38,552,632	UniSTS	RGSC3.4
Cytogenetic Map	18	q11	UniSTS

BF390789

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	37,180,184 - 37,180,347 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	12,089,076 - 12,089,238	NCBI	Rnor6.0
Rnor_5.0	1	13,677,423 - 13,677,585	UniSTS	Rnor5.0
RGSC_v3.4	18	38,497,248 - 38,497,410	UniSTS	RGSC3.4
Cytogenetic Map	18	q11	UniSTS

AU049155

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	36,953,376 - 36,953,669 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	12,337,447 - 12,337,741	NCBI	Rnor6.0
Rnor_6.0	15	64,575,723 - 64,576,017	NCBI	Rnor6.0
Rnor_5.0	15	68,208,757 - 68,209,051	UniSTS	Rnor5.0
Rnor_5.0	1	13,923,668 - 13,923,962	UniSTS	Rnor5.0
RGSC_v3.4	18	38,264,260 - 38,264,554	UniSTS	RGSC3.4
Cytogenetic Map	18	q11	UniSTS

fc33h10.x1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	18	38,043,730 - 38,044,631	NCBI	Rnor5.0
Rnor_5.0	18	38,043,730 - 38,044,623	NCBI	Rnor5.0
Rnor_5.0	18	35,481,779 - 35,482,680	NCBI	Rnor5.0
Rnor_5.0	1	13,954,405 - 13,955,298	NCBI	Rnor5.0
Rnor_5.0	1	13,954,397 - 13,955,298	NCBI	Rnor5.0
Rnor_5.0	18	35,481,779 - 35,482,672	NCBI	Rnor5.0
RGSC_v3.4	18	38,228,930 - 38,229,830	UniSTS	RGSC3.4
RGSC_v3.4	18	38,228,930 - 38,229,822	UniSTS	RGSC3.4
Cytogenetic Map	18	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
22	12	73	195	125	120	77	98	77	12	414	216	11	162	91	111	43	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001170534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096843	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096844	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096848	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015172 ⟹ ENSRNOP00000015172

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	37,049,253 - 37,231,915 (-)	Ensembl
mRatBN7.2 Ensembl	18	36,798,372 - 36,955,066 (-)	Ensembl
Rnor_6.0 Ensembl	18	35,683,185 - 35,817,117 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079667 ⟹ ENSRNOP00000073806

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	37,049,253 - 37,517,076 (-)	Ensembl
mRatBN7.2 Ensembl	18	36,798,372 - 37,266,819 (-)	Ensembl
Rnor_6.0 Ensembl	18	35,683,501 - 35,780,519 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085714 ⟹ ENSRNOP00000071358

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	37,049,253 - 37,386,654 (-)	Ensembl
mRatBN7.2 Ensembl	18	36,798,372 - 37,073,955 (-)	Ensembl
Rnor_6.0 Ensembl	18	35,683,185 - 35,817,127 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093439 ⟹ ENSRNOP00000076146

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	12,006,660 - 12,128,845 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000133836 ⟹ ENSRNOP00000105408

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	37,049,253 - 37,324,376 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000144445 ⟹ ENSRNOP00000108634

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	37,049,253 - 37,506,049 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000171317 ⟹ ENSRNOP00000106311

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	37,049,253 - 37,324,376 (-)	Ensembl

RefSeq Acc Id:

NM_001170534 ⟹ NP_001164005

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,049,253 - 37,505,915 (-)	NCBI
mRatBN7.2	18	36,798,372 - 37,255,038 (-)	NCBI
Rnor_6.0	1	12,006,663 - 12,128,849 (+)	NCBI
Rnor_6.0	18	35,683,185 - 35,817,117 (-)	NCBI
Rnor_5.0	18	35,348,808 - 35,484,229 (-)	NCBI
Rnor_5.0	1	13,595,971 - 13,952,963 (+)	NCBI

Sequence:

show sequence

TCCCTGGGGCGGGAGCGCGATGGCGGCTGCAAGCGCTTGCAGCAGCAACGGTAGCAGCAGCGAC
ACGTCCAGCACCGACGAGGAGGAGCGTCTGCGGCGGCTCTTCCAGACGTGCGACAGCGACGGCG
ATGGCTTCATCAGCTGGAATGACTTGCTAATGGTCTGCCGACAGGTGAATATGGAAGAGTCAGT
GGCTGAGATCATGAGCCAACTGGGCACAGATGAGAACGGGAAGATTTCCTTCCAAGACTTCACA
AGGTGCCACACGCAGCTTGTTAGAGAGATTAGGAAGGAGGAAGTAGACCTGTTCATGAAGTCAG
ACAAGTCTGGTAAAAAGAAGCTGAGGGAAAGAATCACTTCCTGGCCTACGAGAAGTGACAACAG
TCTGGGTGCTTTGTCAGCAACCAGGGAGAGCTGGGCGTATGATTCAGGTGCCAGGGATCTCCAG
AGCCCCGACTTGCAGAGCCAGCTGCCCCTCCAGAAGCTGCTGGAGTATGGTGAAAGCTCTTTGC
CTCAGCAGGCTGTGCTCCACAAGCTTCTCACGCAGTCCCCGAATTTTGGCACTTCTACAGGCGG
AAGCTATCTAGAGCTGGCCAGTACCCTCCACTTGGCAGCCCTGGCATCACTCAAGGGAGACATA
GTAGAGCTGAACAAACGTCTGCAACAAACAGAGCGTGAACGAGACCTCCTGGAAAAGACGTTGG
CCAAGGCACAGTGTGAGCAGTCACACCTCATGAGAGAGCATGAAGATGTTCAGGAACGCACGAC
ACTCCGCTATGAGGAGCGCATCACAGAGCTCCACAGCATCATTGCAGAACTCAACAAGAAGATA
GACCGCTTGCAAGGTACCACCATCAGGGAGGAAGATGAGTACTCAGAACTTCGGTCAGAGCTCA
GCCAGAGTCAACAAGAGGTCAATGAAGACTCCAGAAGTGTGGACCAAGACCAGACCTCTGTGTC
CATCCCTGAGAACCAGTCTACTATGGTCACTGCTGACATGGACAACTGCAGTGACTTGAACTCA
GAACTGCAGAGAGTGCTGACTGGTCTGGAGAGCGTTGTCTGTGGCAGGAAGAAGAGCAGCTGCA
GCCTCTCTGTGGCCGAGGTGGACAGGCACATTGAGCAGCTCACTACGGCCAGCGAGCACTGTGA
CTTGGCCATTAAGACAGTTGAGGAGATCGAGGGAGTCCTTGGTCGGGATCTGTATCCCAACCTG
ACTGAGGAGCGGTCCCGGTGGGAGAAAGAGCTGGCTGGATTGCGGGAAGAGAATGAAAGTCTGA
CAGCCATGCTGTGCAGCAAAGAGGAGGAGCTGAACCGAACCAAGGCCACTATGAATGCCATCCG
TGAGGAGCGGGACAGGCTTCGGAGGCGGGTCCGAGAGCTCCAAACTCGGCTGCAGAGTGTACAA
GCTACTGGACCTTCTAGCCCGGGTCGCCTCACTCCTGCCAATCGCCCAATTAACCCCAGCACTG
GGGAGCTAAGCACCAGCAGTAGCAGCAATGACATCCCCATCGCTAAGATTGCCGAGAGAGTAAA
GCTATCGAAGACGAGATCTGAATCCTCATCATCTGACAGACCAGTCCTGGGCTCAGAAATCAGT
AGTGTTGGGGTTTCCAGCAGTGTGGCAGAGCACCTGGCCCACTCACTTCAGGACTGCTCCAATA
TCCAGGAAATTTTTCAAACACTCTACTCACACGGATCTGCCATCTCTGAAAGCAAGATTAGAGA
GTTTGAGGTGGAAACGGAGCGGTTGAATAGTCGTATTGAACACCTCAAATCGCAAAATGATCTT
CTCACCATAACCCTGGAGGAATGTAAAAGCAACGCCGAAAGGATGAGCATGCTGGTGGGGAAGT
ACGAGTCCAATGCCACAGCCCTAAGGCTGGCCTTGCAGTACAGTGAGCAGTGCATAGAAGCCTA
TGAACTCCTGCTGGCCCTGGCTGAGACAGAGCAGAGCCTTATCCTGGGGCAATTCCGGGCAGCT
GGTGTGGGCTCCTCCCCTGGAGACCAGTCAGGGGATGAGAATATCACTCAGATGCTTAAGAGGG
CTCACGACTGCCGGAAGACTGCTGAGAACGCCGCCAAAGCCCTGCTCATGAAGCTGGATGGCAG
CTGTGGGGGAGCCTTCACAGTGGCTGGCTGCAGTGTGCAGCCCTGGGAGAGCCTGTCCTCCAAC
AGCCATACCAGCACAACTAGCTCTACAGCCAGCAGCTGTGACACAGAATTCACTAAAGAAGATG
AACAAAGGCTGAAGGATTATATCCAGCAGCTCAAGAATGACAGAGCTGCAGTCAAGCTGACCAT
GCTGGAGTTGGAGAGCATCCACATTGATCCACTCAGCTATGATGTCAAGCCAAGAGGCGACAGC
CAGAGGCTGGACCTGGAGAATGCCGTGCTGATGCAGGAGCTGATGGCCATGAAGGAGGAGATGG
CTGAGCTGAAAGCCCAGCTCTATCTGCTGGAGAAAGAGAAGAAAGCCCTGGAGCTGAAGCTGAG
CACGAGGGAAGCACAGGAGCAGGCCTATCTGGTGCACATCGAGCACCTCAAGTCTGAAGTGGAG
GAACAGAAGGAGCAACGGATGCGGTCCCTGAGCTCCACAAGCAGCAGCGGCAAAGAGAAGCCTG
GCAAGGAGAGTGCTGATGCTGCCTCCCCAGCTTTGTCACTGGCTGAACTAAGGACTAACAGTGA
CAGTGAGCTGGCCACTGAGTTTGCCAACGCCATCCGACGGGAAAAGAAGCTGAAGGCTAGAGTT
CAAGAGCTGGTCAGCGCCTTGGAAAGACTCACCAAAAGCAGTGAAATCAGACACCAGCAGTCGG
CAGAGTTTGTTAATGACCTGAAACGGGCCAACAGCAATCTGGTAGCTGCCTATGAAAAAGCAAA
GAAGAAGCATCAAAACAAGCTGAAGAAGCTGGAATCTCAGATGATGGCCATGGTGGAGCGACAT
GAGACCCAAGTGAGAATGCTGAAGCAGAGAATAGCACTGCTGGAGGAAGAGCATTCCAGGCCAC
ATACCAACGAAACTTCACTGTAACAGGCACTATGGTGGCAAAGCTCTGCCCGCAAGAGGCTAAC
CTGGAGCAGCTCTGGAGCCCAAGGAAGGAGGGACTGTTGGGATGAAGAGTGGAAAGGGATAGAG
GCTACAGGCTCCACCCTTGGGGGTGTGGGTATTGTGGATTATGTATGCATAGGTTCCAGCTGCT
CTAGGCCTGGCCGCAAAGGGCATCTACAATGGCTTCAGCCACAAGATTAGCCACACCTTGTTTC
TGCTTTCCCCATTACAGTTCTCAATTGTTCTGTGCTGCAGTGGGAATCCAAGCATTTGTGGATC
TCCAAGACTCCCCACCCCC

hide sequence

RefSeq Acc Id:

XM_039096841 ⟹ XP_038952769

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,042,350 - 37,517,082 (-)	NCBI
mRatBN7.2	18	36,794,206 - 37,266,206 (-)	NCBI

RefSeq Acc Id:

XM_039096842 ⟹ XP_038952770

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,042,350 - 37,517,114 (-)	NCBI
mRatBN7.2	18	36,794,206 - 37,266,237 (-)	NCBI

RefSeq Acc Id:

XM_039096843 ⟹ XP_038952771

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,042,350 - 37,517,082 (-)	NCBI
mRatBN7.2	18	36,794,206 - 37,266,206 (-)	NCBI

RefSeq Acc Id:

XM_039096844 ⟹ XP_038952772

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,042,350 - 37,517,083 (-)	NCBI
mRatBN7.2	18	36,794,206 - 37,266,192 (-)	NCBI

RefSeq Acc Id:

XM_039096845 ⟹ XP_038952773

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,042,350 - 37,517,108 (-)	NCBI
mRatBN7.2	18	36,794,206 - 37,266,228 (-)	NCBI

RefSeq Acc Id:

XM_039096846 ⟹ XP_038952774

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,042,350 - 37,324,261 (-)	NCBI
mRatBN7.2	18	36,794,206 - 37,073,364 (-)	NCBI

RefSeq Acc Id:

XM_039096847 ⟹ XP_038952775

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,042,350 - 37,208,772 (-)	NCBI
mRatBN7.2	18	36,794,206 - 36,957,781 (-)	NCBI

RefSeq Acc Id:

XM_039096848 ⟹ XP_038952776

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,042,350 - 37,227,464 (-)	NCBI
mRatBN7.2	18	36,794,206 - 36,976,589 (-)	NCBI

RefSeq Acc Id:

XM_039096849 ⟹ XP_038952777

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,042,350 - 37,205,646 (-)	NCBI
mRatBN7.2	18	36,794,206 - 36,954,765 (-)	NCBI

RefSeq Acc Id:

XM_063277360 ⟹ XP_063133430

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,042,350 - 37,517,082 (-)	NCBI

RefSeq Acc Id:

XM_063277361 ⟹ XP_063133431

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	37,042,350 - 37,324,261 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001164005	(Get FASTA)	NCBI Sequence Viewer
	XP_038952769	(Get FASTA)	NCBI Sequence Viewer
	XP_038952770	(Get FASTA)	NCBI Sequence Viewer
	XP_038952771	(Get FASTA)	NCBI Sequence Viewer
	XP_038952772	(Get FASTA)	NCBI Sequence Viewer
	XP_038952773	(Get FASTA)	NCBI Sequence Viewer
	XP_038952774	(Get FASTA)	NCBI Sequence Viewer
	XP_038952775	(Get FASTA)	NCBI Sequence Viewer
	XP_038952776	(Get FASTA)	NCBI Sequence Viewer
	XP_038952777	(Get FASTA)	NCBI Sequence Viewer
	XP_063133430	(Get FASTA)	NCBI Sequence Viewer
	XP_063133431	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL84750	(Get FASTA)	NCBI Sequence Viewer
	EDL84751	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015172.9
	ENSRNOP00000071358.3
	ENSRNOP00000073806
	ENSRNOP00000073806.2
	ENSRNOP00000105408
	ENSRNOP00000105408.1
	ENSRNOP00000106311
	ENSRNOP00000106311.1
	ENSRNOP00000108634
	ENSRNOP00000108634.1

RefSeq Acc Id:

NP_001164005 ⟸ NM_001170534

- UniProtKB:

F1LZS6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAASACSSNGSSSDTSSTDEEERLRRLFQTCDSDGDGFISWNDLLMVCRQVNMEESVAEIMSQ
LGTDENGKISFQDFTRCHTQLVREIRKEEVDLFMKSDKSGKKKLRERITSWPTRSDNSLGALSA
TRESWAYDSGARDLQSPDLQSQLPLQKLLEYGESSLPQQAVLHKLLTQSPNFGTSTGGSYLELA
STLHLAALASLKGDIVELNKRLQQTERERDLLEKTLAKAQCEQSHLMREHEDVQERTTLRYEER
ITELHSIIAELNKKIDRLQGTTIREEDEYSELRSELSQSQQEVNEDSRSVDQDQTSVSIPENQS
TMVTADMDNCSDLNSELQRVLTGLESVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTV
EEIEGVLGRDLYPNLTEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRL
RRRVRELQTRLQSVQATGPSSPGRLTPANRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRS
ESSSSDRPVLGSEISSVGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETE
RLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLAL
AETEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFT
VAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESI
HIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQE
QAYLVHIEHLKSEVEEQKEQRMRSLSSTSSSGKEKPGKESADAASPALSLAELRTNSDSELATE
FANAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNK
LKKLESQMMAMVERHETQVRMLKQRIALLEEEHSRPHTNETSL

hide sequence

Ensembl Acc Id:

ENSRNOP00000073806 ⟸ ENSRNOT00000079667

Ensembl Acc Id:

ENSRNOP00000076146 ⟸ ENSRNOT00000093439

Ensembl Acc Id:

ENSRNOP00000071358 ⟸ ENSRNOT00000085714

Ensembl Acc Id:

ENSRNOP00000015172 ⟸ ENSRNOT00000015172

RefSeq Acc Id:	XP_038952770 ⟸ XM_039096842
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038952773 ⟸ XM_039096845
- Peptide Label:	isoform X3
- UniProtKB:	F1LZS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038952771 ⟸ XM_039096843
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2K6G7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038952769 ⟸ XM_039096841
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038952772 ⟸ XM_039096844
- Peptide Label:	isoform X3
- UniProtKB:	F1LZS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038952774 ⟸ XM_039096846
- Peptide Label:	isoform X5
- UniProtKB:	F1LZS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038952776 ⟸ XM_039096848
- Peptide Label:	isoform X8
- UniProtKB:	A6KUC0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038952775 ⟸ XM_039096847
- Peptide Label:	isoform X6
- UniProtKB:	F1LZS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038952777 ⟸ XM_039096849
- Peptide Label:	isoform X8
- UniProtKB:	A6KUC0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133430 ⟸ XM_063277360
- Peptide Label:	isoform X4
- UniProtKB:	F1LZS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133431 ⟸ XM_063277361
- Peptide Label:	isoform X7
- UniProtKB:	A0A0G2K098 (UniProtKB/TrEMBL), A6KUB9 (UniProtKB/TrEMBL), F1LZS6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000106311 ⟸ ENSRNOT00000171317

Ensembl Acc Id:

ENSRNOP00000108634 ⟸ ENSRNOT00000144445

Ensembl Acc Id:

ENSRNOP00000105408 ⟸ ENSRNOT00000133836

Protein Domains

EF-hand Harmonin-binding protein USHBP1 PDZ-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K098-F1-model_v2	AlphaFold	A0A0G2K098	1-811	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561988	AgrOrtholog
BioCyc Gene	G2FUF-7658	BioCyc
Ensembl Genes	ENSRNOG00000011271	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000062232	Ensembl
Ensembl Transcript	ENSRNOT00000015172.9	UniProtKB/TrEMBL
	ENSRNOT00000079667	ENTREZGENE
	ENSRNOT00000079667.3	UniProtKB/TrEMBL
	ENSRNOT00000085714.3	UniProtKB/TrEMBL
	ENSRNOT00000133836	ENTREZGENE
	ENSRNOT00000133836.1	UniProtKB/TrEMBL
	ENSRNOT00000144445	ENTREZGENE
	ENSRNOT00000144445.1	UniProtKB/TrEMBL
	ENSRNOT00000171317	ENTREZGENE
	ENSRNOT00000171317.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.250.3110	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	USBP1-like	UniProtKB/TrEMBL
	USH1C-bd_PDZ_domain	UniProtKB/TrEMBL
NCBI Gene	307449	ENTREZGENE
PANTHER	COLORECTAL MUTANT CANCER PROTEIN	UniProtKB/TrEMBL
	PTHR23347	UniProtKB/TrEMBL
Pfam	EF-hand_7	UniProtKB/TrEMBL
	MCC-bdg_PDZ	UniProtKB/TrEMBL
PhenoGen	Mcc	PhenoGen
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011271	RatGTEx
	ENSRNOG00000062232	RatGTEx
SMART	EFh	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
UniProt	A0A0G2K098	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2K6G7	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LLJ8_RAT	UniProtKB/TrEMBL
	A0ABK0LWV2_RAT	UniProtKB/TrEMBL
	A0ABK0LX18_RAT	UniProtKB/TrEMBL
	A6KUB9	ENTREZGENE, UniProtKB/TrEMBL
	A6KUC0	ENTREZGENE, UniProtKB/TrEMBL
	F1LZS6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Mcc	MCC regulator of WNT signaling pathway	LOC100909795	colorectal mutant cancer protein-like	Data merged from RGD:6501555	737654	PROVISIONAL
2019-04-10	Mcc	MCC regulator of WNT signaling pathway	Mcc	MCC, WNT signaling pathway regulator	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2018-05-18	Mcc	MCC, WNT signaling pathway regulator	Mcc	mutated in colorectal cancers	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-05	LOC100909795	colorectal mutant cancer protein-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2009-06-22	Mcc	mutated in colorectal cancers	RGD1561988	similar to Colorectal mutant cancer protein (MCC protein)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-06-15	RGD1561988	similar to Colorectal mutant cancer protein (MCC protein)	Mcc_mapped	mutated in colorectal cancers (mapped)	Data merged from RGD:3059	1643240	APPROVED
2008-04-30	RGD1561988	similar to Colorectal mutant cancer protein (MCC protein)	RGD1561988_predicted	similar to Colorectal mutant cancer protein (MCC protein) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1561988_predicted	similar to Colorectal mutant cancer protein (MCC protein) (predicted)	LOC307449	similar to Colorectal mutant cancer protein (MCC protein)	Symbol and Name status set to approved	1299863	APPROVED
2005-11-17	Mcc_mapped	mutated in colorectal cancers (mapped)	Mcc	mutated in colorectal cancers	Symbol and Name updated	1556543	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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