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Gene: Prr7 (proline rich 7 (synaptic)) Rattus norvegicus

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Symbol:

Prr7

Name:

proline rich 7 (synaptic)

RGD ID:

1561898

Description:

Predicted to enable long-chain fatty acid binding activity; protein tyrosine kinase binding activity; and ubiquitin-like protein ligase binding activity. Involved in postsynapse to nucleus signaling pathway and regulation of transcription by RNA polymerase I. Located in neuron projection; nucleus; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human PRR7 (proline rich 7, synaptic); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

proline rich 7; proline-rich protein 7; synaptic proline-rich membrane protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRR7 (proline rich 7, synaptic)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Prr7 (proline rich 7 (synaptic))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prr7 (proline rich 7, synaptic)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRR7 (proline rich 7, synaptic)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRR7 (proline rich 7, synaptic)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prr7 (proline rich 7, synaptic)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRR7 (proline rich 7, synaptic)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRR7 (proline rich 7, synaptic)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prr7 (proline rich 7, synaptic)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Prr7 (proline rich 7, synaptic)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PRR7 (proline rich 7, synaptic)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Prr7 (proline rich 7 (synaptic))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	prr7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	prr7	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	9,170,405 - 9,178,814 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	9,170,411 - 9,179,361 (-)	Ensembl				GRCr8
mRatBN7.2	17	9,164,375 - 9,173,669 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	9,165,269 - 9,172,536 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	9,181,390 - 9,182,514 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	10,711,423 - 10,712,547 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	9,177,778 - 9,178,902 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	9,693,274 - 9,702,795 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	9,694,168 - 9,695,292 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	11,803,146 - 11,811,418 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	15,209,243 - 15,210,367 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	9,243,777 - 9,244,901 (-)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

amphetamine (EXP)

aristolochic acid A (ISO)

atrazine (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

bortezomib (ISO)

butan-1-ol (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chrysene (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

DDE (ISO)

deguelin (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

hydrogen peroxide (ISO)

indometacin (ISO)

lipopolysaccharide (ISO)

maneb (ISO)

methimazole (EXP)

N-Nitrosopyrrolidine (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

ozone (ISO)

paraquat (ISO)

perfluorooctanoic acid (EXP)

picoxystrobin (ISO)

pyridaben (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

testosterone (EXP)

tetraphene (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

urethane (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (IEA)

immune system process (IEA)

positive regulation of apoptotic process (IEA,ISO,ISS)

postsynapse to nucleus signaling pathway (IBA,IDA,IMP)

regulation of transcription by RNA polymerase I (IEA,IMP,ISO)

T cell differentiation (ISO)

Cellular Component

cytosol (IEA,ISO)

dendrite (IEA)

glutamatergic synapse (IDA,IEP,IMP)

neuron projection (IDA)

nucleoplasm (IEA,ISO)

nucleus (IBA,IDA,IEA)

perinuclear region of cytoplasm (IEA,ISO,ISS)

plasma membrane (IEA,ISO,ISS)

postsynaptic density (IDA)

postsynaptic density membrane (IEA)

postsynaptic density, intracellular component (IBA,IDA,IEP,IMP)

postsynaptic membrane (IEA)

synapse (IDA,IEA)

Molecular Function

long-chain fatty acid binding (IEA,ISO,ISS)

protein binding (IPI,ISO)

protein tyrosine kinase binding (IEA,ISO)

protein-containing complex binding (IPI)

ubiquitin-like protein ligase binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.	Kravchick DO, etal., EMBO J. 2016 Sep 1;35(17):1923-34. doi: 10.15252/embj.201593070. Epub 2016 Jul 25.
2.	Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor.	Murata Y, etal., Biochem Biophys Res Commun. 2005 Feb 4;327(1):183-91.
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:21460222	PMID:22871113	PMID:27657535	PMID:36150742

Genomics

Comparative Map Data

Prr7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	9,170,405 - 9,178,814 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	9,170,411 - 9,179,361 (-)	Ensembl				GRCr8
mRatBN7.2	17	9,164,375 - 9,173,669 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	9,165,269 - 9,172,536 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	9,181,390 - 9,182,514 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	10,711,423 - 10,712,547 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	9,177,778 - 9,178,902 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	9,693,274 - 9,702,795 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	9,694,168 - 9,695,292 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	11,803,146 - 11,811,418 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	15,209,243 - 15,210,367 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	9,243,777 - 9,244,901 (-)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

PRR7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	177,445,995 - 177,456,286 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	177,446,445 - 177,456,291 (+)	Ensembl			hg38	GRCh38
GRCh37	5	176,872,996 - 176,883,287 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	176,806,400 - 176,815,889 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	176,806,401 - 176,815,889	NCBI
Celera	5	171,618,357 - 171,627,632 (-)	NCBI		Celera
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	171,794,261 - 171,803,535 (+)	NCBI		HuRef
CHM1_1	5	176,307,202 - 176,316,315 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	177,989,257 - 177,999,332 (+)	NCBI		T2T-CHM13v2.0

Prr7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	55,612,080 - 55,620,968 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	55,612,080 - 55,620,967 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	55,464,267 - 55,473,162 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	55,464,267 - 55,473,154 (+)	Ensembl			mm10	GRCm38
MGSCv37	13	55,565,628 - 55,574,516 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	55,481,647 - 55,482,774 (+)	NCBI		MGSCv36	mm8
Celera	13	56,518,298 - 56,527,198 (+)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	30.06	NCBI

Prr7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	29,692,004 - 29,695,113 (+)	Ensembl
ChiLan1.0	NW_004955408	29,685,254 - 29,695,113 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRR7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	172,530,012 - 172,540,600 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	170,669,548 - 170,680,144 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	172,748,020 - 172,757,989 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	179,818,184 - 179,820,471 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	179,818,184 - 179,821,479 (+)	Ensembl			panPan2	panpan1.1

PRR7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	35,913,300 - 35,923,823 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	35,913,472 - 35,943,221 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	35,880,991 - 35,882,194 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	36,280,009 - 36,281,212 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	36,280,090 - 36,281,075 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	36,105,275 - 36,106,470 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	36,291,229 - 36,292,426 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	36,800,703 - 36,801,904 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Prr7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	122,701,213 - 122,710,382 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936597	1,726,070 - 1,735,343 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936597	1,726,143 - 1,735,295 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRR7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	80,496,106 - 80,505,430 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	80,496,105 - 80,508,825 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PRR7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	79,458,347 - 79,467,421 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	79,466,186 - 79,467,257 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666075	10,650,015 - 10,659,071 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prr7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	12,632,309 - 12,633,729 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624733	12,632,297 - 12,633,521 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Prr7
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	73,780,510 - 73,789,129 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Prr7
27 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	69
Count of miRNA genes:	61
Interacting mature miRNAs:	68
Transcripts:	ENSRNOT00000036162
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	1	36045694	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	43999106	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4360057	27233623	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	1	21499218	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2120843	42054133	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4733534	49733534	Rat
1581553	Pur14	Proteinuria QTL 14	5.3	0.0001	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	17	7985243	16523460	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	8574342	32199534	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	6221998	58177198	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38037084	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31706603	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4733534	49733534	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	43999106	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4360057	27233623	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	43999106	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2120843	22087569	Rat
1549900	Iddm20	Insulin dependent diabetes mellitus QTL 20	3.7		pancreas integrity trait (VT:0010560)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	17	1	22181410	Rat
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22877318	Rat

Markers in Region

D17Rat106

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	17	9,180,366 - 9,180,510 (+)	Marker Load Pipeline
mRatBN7.2	17	9,175,224 - 9,175,368 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	9,704,124 - 9,704,267	NCBI	Rnor6.0
Rnor_5.0	17	11,813,108 - 11,813,251	UniSTS	Rnor5.0
RGSC_v3.4	17	15,219,198 - 15,219,342	RGD	RGSC3.4
RGSC_v3.4	17	15,219,199 - 15,219,342	UniSTS	RGSC3.4
Celera	17	9,253,733 - 9,253,877	UniSTS
RGSC_v3.1	17	15,219,199 - 15,219,342	RGD
RH 3.4 Map	17	79.2	UniSTS
RH 3.4 Map	17	79.2	RGD
RH 2.0 Map	17	42.9	RGD
SHRSP x BN Map	17	8.3	RGD
Cytogenetic Map	17	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	67	160	90	89	58	92	58	6	354	192	11	139	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276687	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000036162 ⟹ ENSRNOP00000038274

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	9,170,411 - 9,179,361 (-)	Ensembl
mRatBN7.2 Ensembl	17	9,165,269 - 9,172,536 (-)	Ensembl
Rnor_6.0 Ensembl	17	9,694,168 - 9,695,292 (-)	Ensembl

RefSeq Acc Id:

NM_001109116 ⟹ NP_001102586

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,170,411 - 9,171,535 (-)	NCBI
mRatBN7.2	17	9,165,269 - 9,166,393 (-)	NCBI
Rnor_6.0	17	9,694,168 - 9,695,292 (-)	NCBI
Rnor_5.0	17	11,803,146 - 11,811,418 (-)	NCBI
RGSC_v3.4	17	15,209,243 - 15,210,367 (-)	RGD
Celera	17	9,243,777 - 9,244,901 (-)	RGD

Sequence:

show sequence

ATGGTGATGTCCCAGGGCACCTACACGTTCCTCACGTGCTTCGCCGGCTTCTGGCTCATCTGGG
GTCTCATCGTCCTGCTCTGCTGCTTCTGCAGCTTCCTGCGCCGCCGCCTCAAACGGCGCCAGGA
GGAGCGACTGAGGGAGCAGAACCTGCGCGCCCTGGAGCTGGAGCCCCTCGAGCTTGAGGGCAGC
CTGGCTGGAAGTCCTCCGGGCCTGGCGCCGCCACCGCCACCGCACCGCAGCCGTCTGGAGGCGC
CTGTGCACGCGCACTCGCACGTGCACGTGCACCCTCTGCTGCACCACGGGCCGGCGCAGCCGCA
CGCGCACCCGCACCCACACCATCACGCACTGCCGCACCCACCGCCGTCGCACCTCTCCGTGCCG
CCCCGGCCCTGGAGCTATCCGCGCCAAGCGGAATCGGACATGTCTAAGCCGCCGTGCTACGAGG
AGGCGGTGCTGATGGCCGAGCCGCCGCCGCCCTACAGCGAGGTGCTCACGGACACTCGCGGCCT
CTACCGCAAGATCGTCACGCCCTTTCTGAGCCGCCGCGACAGCGCGGAGAAGCAGGAGCAGCCG
CCTCCGAGTTACAAGCCTCTCTTCCTGGACCGGGGCTATACCTCGGCGCTGCATCTTCCCAGCG
CCCCGCGGCCCGCCGCCCCCTGCCCTGCCCTCTGTCTGCAGGCGGACCGCAGCCGCCGTGTCTT
CCCCAGCTGGACCGACTCAGAGCTCAGCAGCCGAGAGCCCCTGGAGCACGGAGCTTGGCGCCTG
CCCGTCTCCATCCCCTTGTTTGGGAGGACTACAGCCGTATAGAGGGGCGCTCGGCGTCCCGAGC
CCCACGGGCGAACTCCTAGCCTGACTGCGAGGCTTTTTAAATGCTTCCCTTGGACTGCAGGGAG
GGGTGGGGGGAGGGAGGGATTTCTTACCCTGTTTGTTACATTTTGAGGATAATAAAGGTGTGTG
ATCTGCTTTG

hide sequence

RefSeq Acc Id:

XM_006253652 ⟹ XP_006253714

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,170,405 - 9,178,814 (-)	NCBI
mRatBN7.2	17	9,164,375 - 9,173,669 (-)	NCBI
Rnor_6.0	17	9,693,274 - 9,702,518 (-)	NCBI
Rnor_5.0	17	11,803,146 - 11,811,418 (-)	NCBI

Sequence:

show sequence

CCGCTGCCTTCTCCAAGCTTGGGGTTCTGTCCGCTGGGCCGCTTGCCCCGAGGCAGGAAGACGA
GTTCGAGGAGGATGCCTGGGCCCGTCGCTCGCGGCCCCGGGTGAAGCAGGCCCGCGCCGGCCGG
CGCCATGGAAAGGAGAGGGAACCACAGTTGCCCCCCGCCGGCATGCGCGCCCATTGAGCCCCGC
CGCAGGCAGCCCCCGGCCGCAGGTCCCCGAGTGACACTGGCGGCACCTGGGAGCGTGGCGCGGC
CCCGGGGCCACGCCGAGGAGCCCAGCGTCCAGTAAAGCTGACGAGGACCTGCCGCTTGCGCCGC
AGCCATGGTGATGTCCCAGGGCACCTACACGTTCCTCACGTGCTTCGCCGGCTTCTGGCTCATC
TGGGGTCTCATCGTCCTGCTCTGCTGCTTCTGCAGCTTCCTGCGCCGCCGCCTCAAACGGCGCC
AGGAGGAGCGACTGAGGGAGCAGAACCTGCGCGCCCTGGAGCTGGAGCCCCTCGAGCTTGAGGG
CAGCCTGGCTGGAAGTCCTCCGGGCCTGGCGCCGCCACCGCCACCGCACCGCAGCCGTCTGGAG
GCGCCTGTGCACGCGCACTCGCACGTGCACGTGCACCCTCTGCTGCACCACGGGCCGGCGCAGC
CGCACGCGCACCCGCACCCACACCATCACGCACTGCCGCACCCACCGCCGTCGCACCTCTCCGT
GCCGCCCCGGCCCTGGAGCTATCCGCGCCAAGCGGAATCGGACATGTCTAAGCCGCCGTGCTAC
GAGGAGGCGGTGCTGATGGCCGAGCCGCCGCCGCCCTACAGCGAGGTGCTCACGGACACTCGCG
GCCTCTACCGCAAGATCGTCACGCCCTTTCTGAGCCGCCGCGACAGCGCGGAGAAGCAGGAGCA
GCCGCCTCCGAGTTACAAGCCTCTCTTCCTGGACCGGGGCTATACCTCGGCGCTGCATCTTCCC
AGCGCCCCGCGGCCCGCCGCCCCCTGCCCTGCCCTCTGTCTGCAGGCGGACCGCAGCCGCCGTG
TCTTCCCCAGCTGGACCGACTCAGAGCTCAGCAGCCGAGAGCCCCTGGAGCACGGAGCTTGGCG
CCTGCCCGTCTCCATCCCCTTGTTTGGGAGGACTACAGCCGTATAGAGGGGCGCTCGGCGTCCC
GAGCCCCACGGGCGAACTCCTAGCCTGACTGCGAGGCTTTTTAAATGCTTCCCTTGGACTGCAG
GGAGGGGTGGGGGGAGGGAGGGATTTCTTACCCTGTTTGTTACATTTTGAGGATAATAAAGGTG
TGTGATCTGCTTTGGTACAAGCGGAGGGGGATACCAGCTGCTTTAAGCACAAGGTGCTAGTGAC
CGGGCATGTTGGACCTTAGGGAAGTGCCCGAGTCCTGGCCTGGGGGCGGAGGGCGGGCATACGG
AGTTAGCCCTGGGAAACCAGAGGTTGCTTCTTAAGGGCGGGATGTTCCGGCTCCTTTTAACCAG
CTTTTGTGCGCCCCCTGTAGCCTCGGAGGTGATAGGAGTTGGGACGCGGGTCGTGAGGGCCGGC
GCCCACGCCAGATCAACCCCTGGAGGCCCAGAGCAGCAGGCCCGAAGGGATCTGGATTTCTTTA
TTAACAGACATGAGCACGACCCATTACATAAGTTTGTGCTTAAAAAAAAAAAAAGTTAATGTGA
AAAAGAACCCAAGCAGAGAGGAAGGAATTGGGGAGGGGCCACCCAAACCACTGGGTCCCATCAA
TAAACCCTGACTTGAATCACGCCTAGGACCTCCAGCCTGGGACCTGCCCGGCAGGAGAGGGCGG
GAAGCCAAGGGGCCCCAGGTGGGTCTGATAATTCCTTTCGACCAAGCAGCGAGGGTAAAGAGAA
GGGGTGGGGTCCCAGGGAGCCAGAGCCCACGAGCCATTTATTGCCATGTTTTAAATTTCGTGCA
AAATATCTGAAGCCCTGGATAGAGAATACAAAGTGATATTTTTTTTCCAAGAAACATAAAACTA
GGAAAAGTGATGGGGGGGAACATTTTCCCACCAGAACCCCCGACCCCCACCAGGTCCCAAGCAG
GGTGAGGCCTCCACCCTGGTCAGCTGAGCAGGAAGGACTAAGCTACAATCTGGTCTGGGCAGGA
AGGGGGTGGAATCTGCAACATTGTTTCAACTACCAACGGGAGGAAAACCAGTCAATTGTACAAG
TCTATCAACTTT

hide sequence

RefSeq Acc Id:

XM_063276687 ⟹ XP_063132757

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,170,405 - 9,178,386 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102586	(Get FASTA)	NCBI Sequence Viewer
	XP_006253714	(Get FASTA)	NCBI Sequence Viewer
	XP_063132757	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL93984	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000038274.4
GenBank Protein	P0C6T3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001102586 ⟸ NM_001109116

- UniProtKB:

P0C6T3 (UniProtKB/Swiss-Prot), A6KAS6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGS
LAGSPPGLAPPPPPHRSRLEAPVHAHSHVHVHPLLHHGPAQPHAHPHPHHHALPHPPPSHLSVP
PRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQP
PPSYKPLFLDRGYTSALHLPSAPRPAAPCPALCLQADRSRRVFPSWTDSELSSREPLEHGAWRL
PVSIPLFGRTTAV

hide sequence

RefSeq Acc Id:	XP_006253714 ⟸ XM_006253652
- Peptide Label:	isoform X1
- UniProtKB:	P0C6T3 (UniProtKB/Swiss-Prot), A6KAS6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGS LAGSPPGLAPPPPPHRSRLEAPVHAHSHVHVHPLLHHGPAQPHAHPHPHHHALPHPPPSHLSVP PRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQP PPSYKPLFLDRGYTSALHLPSAPRPAAPCPALCLQADRSRRVFPSWTDSELSSREPLEHGAWRL PVSIPLFGRTTAV hide sequence

Ensembl Acc Id:

ENSRNOP00000038274 ⟸ ENSRNOT00000036162

RefSeq Acc Id:	XP_063132757 ⟸ XM_063276687
- Peptide Label:	isoform X1
- UniProtKB:	P0C6T3 (UniProtKB/Swiss-Prot), A6KAS6 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P0C6T3-F1-model_v2	AlphaFold	P0C6T3	1-269	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561898	AgrOrtholog
BioCyc Gene	G2FUF-10206	BioCyc
Ensembl Genes	ENSRNOG00000021447	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000036162.5	UniProtKB/Swiss-Prot
InterPro	WW_domain-binding	UniProtKB/Swiss-Prot
KEGG Report	rno:498704	UniProtKB/Swiss-Prot
NCBI Gene	498704	ENTREZGENE
PANTHER	PROLINE-RICH PROTEIN 7	UniProtKB/Swiss-Prot
	PTHR16209	UniProtKB/Swiss-Prot
PhenoGen	Prr7	PhenoGen
RatGTEx	ENSRNOG00000021447	RatGTEx
UniProt	A6KAS6	ENTREZGENE, UniProtKB/TrEMBL
	P0C6T3	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Prr7	proline rich 7 (synaptic)	Prr7	proline rich 7	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	Prr7	proline rich 7			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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