Odam (odontogenic, ameloblast associated) - Rat Genome Database

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Pathways
Gene: Odam (odontogenic, ameloblast associated) Rattus norvegicus
Analyze
Symbol: Odam
Name: odontogenic, ameloblast associated
RGD ID: 1561883
Description: Involved in odontogenesis. Predicted to be located in cell periphery; extracellular space; and supramolecular fiber. Predicted to be active in cytoplasm and nucleus. Orthologous to human ODAM (odontogenic, ameloblast associated); INTERACTS WITH bisphenol A; cadmium dichloride; tributylstannane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Apin; APIN precursor; odontogenic ameloblast-associated protein; odontogenic, ameloblast asssociated
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,472,530 - 20,496,752 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1420,472,546 - 20,481,760 (-)EnsemblGRCr8
mRatBN7.21420,193,286 - 20,202,517 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,193,302 - 20,202,517 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1420,123,607 - 20,132,626 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01421,442,493 - 21,451,512 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,173,243 - 20,182,287 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,842,990 - 21,852,216 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,842,990 - 21,852,216 (-)Ensemblrn6Rnor6.0
Rnor_5.01421,753,075 - 21,767,321 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41421,714,378 - 21,724,054 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1419,595,876 - 19,605,037 (-)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell periphery  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
extracellular region  (IEA,ISO)
extracellular space  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
supramolecular fiber  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. Lee HK, etal., J Biol Chem. 2015 Jun 5;290(23):14740-53. doi: 10.1074/jbc.M115.648022. Epub 2015 Apr 24.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14647039   PMID:15234340   PMID:16674676   PMID:17647262   PMID:21092812   PMID:21154245   PMID:22387195  


Genomics

Comparative Map Data
Odam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,472,530 - 20,496,752 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1420,472,546 - 20,481,760 (-)EnsemblGRCr8
mRatBN7.21420,193,286 - 20,202,517 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,193,302 - 20,202,517 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1420,123,607 - 20,132,626 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01421,442,493 - 21,451,512 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,173,243 - 20,182,287 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,842,990 - 21,852,216 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,842,990 - 21,852,216 (-)Ensemblrn6Rnor6.0
Rnor_5.01421,753,075 - 21,767,321 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41421,714,378 - 21,724,054 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1419,595,876 - 19,605,037 (-)NCBICelera
Cytogenetic Map14p21NCBI
ODAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38470,195,725 - 70,204,576 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl470,195,706 - 70,205,734 (+)Ensemblhg38GRCh38
GRCh37471,061,442 - 71,070,293 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36471,096,833 - 71,104,882 (+)NCBIBuild 36Build 36hg18NCBI36
Celera468,420,214 - 68,428,263 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef466,864,474 - 66,872,522 (+)NCBIHuRef
CHM1_1471,098,652 - 71,106,701 (+)NCBICHM1_1
T2T-CHM13v2.0473,535,038 - 73,543,889 (+)NCBIT2T-CHM13v2.0
Odam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39588,032,869 - 88,042,668 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl588,032,888 - 88,042,033 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38587,885,010 - 87,894,809 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl587,885,029 - 87,894,174 (+)Ensemblmm10GRCm38
MGSCv37588,314,720 - 88,321,770 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36588,962,048 - 88,968,733 (+)NCBIMGSCv36mm8
MGSCv36587,491,886 - 87,498,571 (+)NCBIMGSCv36mm8
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
Odam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554472,653,815 - 2,661,043 (-)Ensembl
ChiLan1.0NW_0049554472,653,815 - 2,661,043 (-)NCBIChiLan1.0ChiLan1.0
ODAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2359,878,118 - 59,887,218 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1460,074,401 - 60,083,715 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0454,019,039 - 54,028,085 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1460,362,655 - 60,370,747 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl460,362,655 - 60,370,747 (-)EnsemblpanPan2panpan1.1
ODAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11359,588,642 - 59,597,873 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1359,588,647 - 59,597,873 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1359,315,664 - 59,324,921 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01360,383,221 - 60,392,488 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1360,383,221 - 60,392,488 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11359,997,363 - 60,006,605 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01359,501,814 - 59,511,051 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01360,648,776 - 60,658,033 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Odam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528515,986,195 - 15,993,294 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365984,438,258 - 4,445,316 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365984,438,258 - 4,445,316 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ODAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl867,058,472 - 67,066,564 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1867,059,284 - 67,068,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28148,456,188 - 148,465,034 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ODAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1718,676,794 - 18,687,325 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl718,678,422 - 18,685,932 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660844,236,479 - 4,251,148 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Odam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248901,623,562 - 1,629,960 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248901,622,846 - 1,631,114 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Odam
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1111,078,909 - 1,088,205 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Odam
89 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000037003
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 1 10 19 11 8 1 18 1 1 47 32 1 14 11 51 7 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000037003   ⟹   ENSRNOP00000035991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1420,472,546 - 20,481,760 (-)Ensembl
mRatBN7.2 Ensembl1420,193,302 - 20,202,517 (-)Ensembl
Rnor_6.0 Ensembl1421,842,990 - 21,852,216 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103950   ⟹   ENSRNOP00000097228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1420,473,941 - 20,481,760 (-)Ensembl
mRatBN7.2 Ensembl1420,194,697 - 20,202,517 (-)Ensembl
RefSeq Acc Id: NM_001044274   ⟹   NP_001037739
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,472,530 - 20,481,760 (-)NCBI
mRatBN7.21420,193,286 - 20,202,517 (-)NCBI
Rnor_6.01421,842,990 - 21,852,216 (-)NCBI
Rnor_5.01421,753,075 - 21,767,321 (-)NCBI
RGSC_v3.41421,714,378 - 21,724,054 (-)RGD
Celera1419,595,876 - 19,605,037 (-)RGD
Sequence:
RefSeq Acc Id: XM_063273575   ⟹   XP_063129645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,472,530 - 20,496,752 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001037739 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129645 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABA54404 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035991
GenBank Protein Q3HS83 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001037739   ⟸   NM_001044274
- Peptide Label: precursor
- UniProtKB: Q3HS83 (UniProtKB/Swiss-Prot),   A0A8I6AW47 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035991   ⟸   ENSRNOT00000037003
Ensembl Acc Id: ENSRNOP00000097228   ⟸   ENSRNOT00000103950
RefSeq Acc Id: XP_063129645   ⟸   XM_063273575
- Peptide Label: isoform X1
- UniProtKB: F1LR01 (UniProtKB/TrEMBL),   A0A8I6AW47 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3HS83-F1-model_v2 AlphaFold Q3HS83 1-278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561883 AgrOrtholog
BioCyc Gene G2FUF-16139 BioCyc
Ensembl Genes ENSRNOG00000023372 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000037003 ENTREZGENE
InterPro Odam UniProtKB/Swiss-Prot
KEGG Report rno:641555 UniProtKB/Swiss-Prot
NCBI Gene 641555 ENTREZGENE
PANTHER ODONTOGENIC AMELOBLAST-ASSOCIATED PROTEIN UniProtKB/Swiss-Prot
  PTHR16237 UniProtKB/Swiss-Prot
Pfam ODAM UniProtKB/Swiss-Prot
PhenoGen Odam PhenoGen
RatGTEx ENSRNOG00000023372 RatGTEx
UniProt A0A8I6AW47 ENTREZGENE, UniProtKB/TrEMBL
  F1LR01 ENTREZGENE, UniProtKB/TrEMBL
  ODAM_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Odam  odontogenic, ameloblast associated  Odam  odontogenic, ameloblast asssociated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Odam  odontogenic, ameloblast asssociated  Apin  APIN precursor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 Apin  APIN precursor      Symbol and Name status set to provisional 70820 PROVISIONAL