Ap1s2 (adaptor related protein complex 1 subunit sigma 2) - Rat Genome Database

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Gene: Ap1s2 (adaptor related protein complex 1 subunit sigma 2) Rattus norvegicus
Analyze
Symbol: Ap1s2
Name: adaptor related protein complex 1 subunit sigma 2
RGD ID: 1561862
Description: Predicted to enable clathrin adaptor activity. Predicted to be involved in synaptic vesicle budding from endosome. Predicted to act upstream of or within several processes, including adipose tissue development; fat cell differentiation; and visual learning. Predicted to be located in several cellular components, including Golgi apparatus; clathrin-coated pit; and cytoplasmic vesicle membrane. Predicted to be part of AP-1 adaptor complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 5. Orthologous to human AP1S2 (adaptor related protein complex 1 subunit sigma 2); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adaptor-related protein complex 1, sigma 2 subunit; AP-1 complex subunit sigma-2; LOC302671; RGD1561862; similar to Adapter-related protein complex 1 sigma 1B subunit (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B s...; similar to Adapter-related protein complex 1 sigma 2 subunit (Sigma-adaptin 1B)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X34,204,601 - 34,230,819 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX34,204,603 - 34,228,529 (-)EnsemblGRCr8
mRatBN7.2X30,572,746 - 30,598,961 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,572,751 - 30,597,262 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX31,605,829 - 31,631,914 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X35,042,629 - 35,068,714 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X31,230,051 - 31,256,138 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X32,329,883 - 32,376,301 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,329,598 - 32,355,307 (-)Ensemblrn6Rnor6.0
Rnor_5.0X32,691,539 - 32,717,224 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X51,329,574 - 51,356,406 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX30,915,890 - 30,941,975 (-)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
N-nitrosodimethylamine  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. Page LJ, etal., J Cell Biol 1999 Sep 6;146(5):993-1004.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:20203623   PMID:24928897  


Genomics

Comparative Map Data
Ap1s2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X34,204,601 - 34,230,819 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX34,204,603 - 34,228,529 (-)EnsemblGRCr8
mRatBN7.2X30,572,746 - 30,598,961 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,572,751 - 30,597,262 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX31,605,829 - 31,631,914 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X35,042,629 - 35,068,714 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X31,230,051 - 31,256,138 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X32,329,883 - 32,376,301 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,329,598 - 32,355,307 (-)Ensemblrn6Rnor6.0
Rnor_5.0X32,691,539 - 32,717,224 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X51,329,574 - 51,356,406 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX30,915,890 - 30,941,975 (-)NCBICelera
Cytogenetic MapXq14NCBI
AP1S2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,825,806 - 15,854,813 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,825,806 - 15,854,931 (-)Ensemblhg38GRCh38
GRCh37X15,843,929 - 15,872,936 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,753,850 - 15,783,021 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X15,603,585 - 15,632,757NCBI
CeleraX19,961,411 - 19,990,500 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,597,581 - 13,626,785 (-)NCBIHuRef
CHM1_1X15,874,896 - 15,904,078 (-)NCBICHM1_1
T2T-CHM13v2.0X15,408,728 - 15,437,727 (-)NCBIT2T-CHM13v2.0
Ap1s2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,691,427 - 162,716,662 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX162,692,013 - 162,716,662 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X163,908,454 - 163,933,666 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX163,909,017 - 163,933,666 (+)Ensemblmm10GRCm38
MGSCv37X160,347,092 - 160,367,478 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X159,253,265 - 159,273,651 (+)NCBIMGSCv36mm8
CeleraX147,128,574 - 147,148,961 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX75.97NCBI
Ap1s2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555192,351,754 - 2,370,650 (+)NCBIChiLan1.0ChiLan1.0
AP1S2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X17,622,529 - 17,652,391 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X17,625,917 - 17,655,154 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X8,449,885 - 8,478,932 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X15,807,475 - 15,835,938 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,807,476 - 15,836,172 (-)EnsemblpanPan2panpan1.1
AP1S2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X12,075,797 - 12,105,911 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX12,076,724 - 12,103,654 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX11,926,084 - 11,956,371 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X12,037,006 - 12,067,314 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX12,037,006 - 12,067,320 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X12,106,135 - 12,136,551 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X12,093,621 - 12,123,810 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X12,118,821 - 12,149,359 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ap1s2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X5,251,240 - 5,289,320 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364705,257,542 - 5,289,469 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364705,260,984 - 5,301,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP1S2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,367,795 - 12,397,677 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X12,367,785 - 12,397,672 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,312,013 - 13,341,898 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AP1S2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,283,175 - 14,310,453 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605616,136,637 - 16,164,845 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap1s2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829608,065 - 634,479 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624829608,065 - 637,096 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ap1s2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X24,497,924 - 24,522,458 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ap1s2
84 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:431
Count of miRNA genes:216
Interacting mature miRNAs:268
Transcripts:ENSRNOT00000065075
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2447036044931007Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2447036045082063Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat

Markers in Region
RH130941  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X30,572,792 - 30,572,981 (+)MAPPERmRatBN7.2
Rnor_6.0X32,329,927 - 32,330,115NCBIRnor6.0
Rnor_5.0X32,691,585 - 32,691,773UniSTSRnor5.0
RGSC_v3.4X51,329,618 - 51,329,806UniSTSRGSC3.4
CeleraX30,915,934 - 30,916,122UniSTS
RH 3.4 MapX427.23UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001127531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC166480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000065075   ⟹   ENSRNOP00000063764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX34,204,603 - 34,228,529 (-)Ensembl
mRatBN7.2 EnsemblX30,572,751 - 30,597,262 (-)Ensembl
Rnor_6.0 EnsemblX32,329,883 - 32,355,307 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081652   ⟹   ENSRNOP00000070442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX34,218,668 - 34,228,529 (-)Ensembl
mRatBN7.2 EnsemblX30,573,222 - 30,597,262 (-)Ensembl
Rnor_6.0 EnsemblX32,329,598 - 32,355,296 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097825   ⟹   ENSRNOP00000086354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX30,576,666 - 30,597,262 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113986   ⟹   ENSRNOP00000082726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX34,204,815 - 34,228,529 (-)Ensembl
mRatBN7.2 EnsemblX30,573,222 - 30,597,262 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147578   ⟹   ENSRNOP00000100405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX34,208,970 - 34,228,529 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000174079   ⟹   ENSRNOP00000100135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX34,210,088 - 34,228,529 (-)Ensembl
RefSeq Acc Id: NM_001127531   ⟹   NP_001121003
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,204,601 - 34,230,684 (-)NCBI
mRatBN7.2X30,572,749 - 30,598,832 (-)NCBI
Rnor_6.0X32,329,883 - 32,355,307 (-)NCBI
Rnor_5.0X32,691,539 - 32,717,224 (-)NCBI
RGSC_v3.4X51,329,574 - 51,356,406 (-)RGD
CeleraX30,915,890 - 30,941,975 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256862   ⟹   XP_006256924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,208,518 - 34,230,817 (-)NCBI
mRatBN7.2X30,576,660 - 30,598,958 (-)NCBI
Rnor_6.0X32,333,795 - 32,355,441 (-)NCBI
Rnor_5.0X32,691,539 - 32,717,224 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099658   ⟹   XP_038955586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,208,518 - 34,230,819 (-)NCBI
mRatBN7.2X30,576,660 - 30,598,961 (-)NCBI
RefSeq Acc Id: XM_039099659   ⟹   XP_038955587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,209,844 - 34,230,819 (-)NCBI
mRatBN7.2X30,576,660 - 30,598,961 (-)NCBI
RefSeq Acc Id: XM_039099660   ⟹   XP_038955588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,209,844 - 34,230,819 (-)NCBI
mRatBN7.2X30,576,660 - 30,598,961 (-)NCBI
RefSeq Acc Id: XR_005497961
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,204,601 - 34,230,818 (-)NCBI
mRatBN7.2X30,572,746 - 30,598,960 (-)NCBI
RefSeq Acc Id: NP_001121003   ⟸   NM_001127531
- UniProtKB: B2GV08 (UniProtKB/TrEMBL),   A6K2M2 (UniProtKB/TrEMBL),   F7F749 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256924   ⟸   XM_006256862
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000063764   ⟸   ENSRNOT00000065075
Ensembl Acc Id: ENSRNOP00000070442   ⟸   ENSRNOT00000081652
RefSeq Acc Id: XP_038955587   ⟸   XM_039099659
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A5U3 (UniProtKB/TrEMBL),   A6K2M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955588   ⟸   XM_039099660
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A5U3 (UniProtKB/TrEMBL),   A6K2M3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955586   ⟸   XM_039099658
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A5U3 (UniProtKB/TrEMBL),   A6K2M3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086354   ⟸   ENSRNOT00000097825
Ensembl Acc Id: ENSRNOP00000082726   ⟸   ENSRNOT00000113986
Ensembl Acc Id: ENSRNOP00000100405   ⟸   ENSRNOT00000147578
Ensembl Acc Id: ENSRNOP00000100135   ⟸   ENSRNOT00000174079
Protein Domains
AP complex mu/sigma subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GV08-F1-model_v2 AlphaFold B2GV08 1-157 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701801
Promoter ID:EPDNEW_R12325
Type:multiple initiation site
Name:Ap1s2_1
Description:adaptor-related protein complex 1, sigma 2 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X32,355,318 - 32,355,378EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561862 AgrOrtholog
BioCyc Gene G2FUF-2569 BioCyc
Ensembl Genes ENSRNOG00000038686 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065075 ENTREZGENE
  ENSRNOT00000065075.5 UniProtKB/TrEMBL
  ENSRNOT00000081652 ENTREZGENE
  ENSRNOT00000081652.3 UniProtKB/TrEMBL
  ENSRNOT00000113986.2 UniProtKB/TrEMBL
  ENSRNOT00000147578 ENTREZGENE
  ENSRNOT00000147578.1 UniProtKB/TrEMBL
  ENSRNOT00000174079 ENTREZGENE
  ENSRNOT00000174079.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.60 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9102341 IMAGE-MGC_LOAD
InterPro AP1_sigma UniProtKB/TrEMBL
  AP_complex_ssu UniProtKB/TrEMBL
  AP_mu_sigma_su UniProtKB/TrEMBL
  Clathrin_sigma/coatomer_zeta UniProtKB/TrEMBL
  Longin-like UniProtKB/TrEMBL
KEGG Report rno:302671 UniProtKB/TrEMBL
MGC_CLONE MGC:187937 IMAGE-MGC_LOAD
NCBI Gene 302671 ENTREZGENE
PANTHER PTHR11753 UniProtKB/TrEMBL
Pfam Clat_adaptor_s UniProtKB/TrEMBL
PharmGKB AP1S2 RGD
PhenoGen Ap1s2 PhenoGen
PIRSF AP_complex_sigma UniProtKB/TrEMBL
PROSITE CLAT_ADAPTOR_S UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038686 RatGTEx
Superfamily-SCOP Longin_like UniProtKB/TrEMBL
UniProt A0A0G2JXX9_RAT UniProtKB/TrEMBL
  A0A8I5ZVG9_RAT UniProtKB/TrEMBL
  A0A8I6A5U3 ENTREZGENE
  A0ABK0KYW8_RAT UniProtKB/TrEMBL
  A0ABK0LF93_RAT UniProtKB/TrEMBL
  A6K2M2 ENTREZGENE, UniProtKB/TrEMBL
  A6K2M3 ENTREZGENE, UniProtKB/TrEMBL
  B2GV08 ENTREZGENE
  F7F749 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2GV08 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap1s2  adaptor related protein complex 1 subunit sigma 2  Ap1s2  adaptor-related protein complex 1, sigma 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ap1s2  adaptor-related protein complex 1, sigma 2 subunit   Ap1s2_predicted  adaptor-related protein complex 1, sigma 2 subunit (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ap1s2_predicted  adaptor-related protein complex 1, sigma 2 subunit (predicted)  RGD1561862_predicted  similar to Adapter-related protein complex 1 sigma 2 subunit (Sigma-adaptin 1B) (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-10 RGD1561862_predicted  similar to Adapter-related protein complex 1 sigma 2 subunit (Sigma-adaptin 1B) (predicted)    similar to Adapter-related protein complex 1 sigma 1B subunit (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B s... (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1561862_predicted  similar to Adapter-related protein complex 1 sigma 1B subunit (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B s... (predicted)  LOC302671  similar to Adapter-related protein complex 1 sigma 1B subunit (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B s...  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302671  similar to Adapter-related protein complex 1 sigma 1B subunit (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B s...      Symbol and Name status set to provisional 70820 PROVISIONAL